FAXC (failed axon connections homolog, metaxin like GST domain containing)

Gene

• Entrez ID: 84553
• Gene name: Failed axon connections homolog, metaxin like GST domain containing
• Gene symbol: FAXC
• Synonyms (NCBI Gene): C6orf168, dJ273F20
• Chromosome: 6
• Chromosome location: 6q16.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024842	hsa-miR-215-5p	Microarray	19074876
MIRT026241	hsa-miR-192-5p	Microarray	19074876
MIRT046397	hsa-miR-15b-5p	CLASH	23622248
MIRT042924	hsa-miR-324-3p	CLASH	23622248
MIRT709478	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT709477	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT709476	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT709475	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT709474	hsa-miR-3130-3p	HITS-CLIP	19536157
MIRT709473	hsa-miR-4252	HITS-CLIP	19536157
MIRT709472	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT636529	hsa-miR-143-3p	HITS-CLIP	21572407
MIRT636528	hsa-miR-4770	HITS-CLIP	21572407
MIRT636527	hsa-miR-6088	HITS-CLIP	21572407
MIRT636526	hsa-miR-4708-5p	HITS-CLIP	21572407
MIRT636525	hsa-miR-1273f	HITS-CLIP	21572407
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT636523	hsa-miR-4455	HITS-CLIP	21572407
MIRT636522	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT658276	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT658275	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT658274	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT658273	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT658272	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT658271	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT658270	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT658268	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT658269	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT658267	hsa-miR-4287	HITS-CLIP	23824327
MIRT658266	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT658265	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT318957	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT658264	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT658263	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT658262	hsa-miR-4279	HITS-CLIP	23824327
MIRT658261	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT658260	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT658259	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT658258	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT658257	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT658256	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT658255	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT658254	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT658253	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT658252	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT658251	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT658250	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT658249	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT658248	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT658247	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT658246	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT658245	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT658244	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT658243	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT658242	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT658241	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT658240	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT658239	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT658237	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT658238	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT658236	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT658235	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT658234	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT658233	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT638748	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT638747	hsa-miR-764	HITS-CLIP	23824327
MIRT638746	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638745	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT638744	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT638743	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT638742	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT638741	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT638740	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT638739	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT638738	hsa-miR-1913	HITS-CLIP	23824327
MIRT042924	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT638737	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT638736	hsa-miR-6131	HITS-CLIP	23824327
MIRT638735	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT638734	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT636529	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT636528	hsa-miR-4770	HITS-CLIP	23824327
MIRT636527	hsa-miR-6088	HITS-CLIP	23824327
MIRT636526	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT636525	hsa-miR-1273f	HITS-CLIP	23824327
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT636523	hsa-miR-4455	HITS-CLIP	23824327
MIRT636522	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT615457	hsa-miR-583	HITS-CLIP	23824327
MIRT615456	hsa-miR-3609	HITS-CLIP	23824327
MIRT615455	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT615454	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT615453	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT615452	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT615451	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT615450	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT615449	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT615448	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT615447	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT615446	hsa-miR-4796-3p	HITS-CLIP	23824327
MIRT615445	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615444	hsa-miR-5697	HITS-CLIP	23824327
MIRT615443	hsa-miR-1297	HITS-CLIP	23824327
MIRT615442	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT615441	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT615440	hsa-miR-4465	HITS-CLIP	23824327
MIRT615439	hsa-miR-498	HITS-CLIP	23824327
MIRT615438	hsa-miR-1305	HITS-CLIP	23824327
MIRT615437	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT445199	hsa-miR-4662a-3p	PAR-CLIP	22100165
MIRT445198	hsa-miR-362-5p	PAR-CLIP	22100165
MIRT445197	hsa-miR-500b-5p	PAR-CLIP	22100165
MIRT445196	hsa-miR-501-5p	PAR-CLIP	22100165
MIRT445194	hsa-miR-4635	PAR-CLIP	22100165
MIRT445195	hsa-miR-488-3p	PAR-CLIP	22100165
MIRT636525	hsa-miR-1273f	HITS-CLIP	27418678
MIRT636525	hsa-miR-1273f	HITS-CLIP	27418678
MIRT636525	hsa-miR-1273f	HITS-CLIP	27418678
MIRT636529	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT636529	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT636529	hsa-miR-143-3p	HITS-CLIP	27418678
MIRT636523	hsa-miR-4455	HITS-CLIP	27418678
MIRT636523	hsa-miR-4455	HITS-CLIP	27418678
MIRT636523	hsa-miR-4455	HITS-CLIP	27418678
MIRT636523	hsa-miR-4455	HITS-CLIP	27418678
MIRT636526	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT636526	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT636526	hsa-miR-4708-5p	HITS-CLIP	27418678
MIRT636528	hsa-miR-4770	HITS-CLIP	27418678
MIRT636528	hsa-miR-4770	HITS-CLIP	27418678
MIRT636528	hsa-miR-4770	HITS-CLIP	27418678
MIRT636522	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT636522	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT636522	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT636522	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT636527	hsa-miR-6088	HITS-CLIP	27418678
MIRT636527	hsa-miR-6088	HITS-CLIP	27418678
MIRT636527	hsa-miR-6088	HITS-CLIP	27418678
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT709478	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT709477	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT709476	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT709475	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT709474	hsa-miR-3130-3p	HITS-CLIP	19536157
MIRT709473	hsa-miR-4252	HITS-CLIP	19536157
MIRT709472	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT636529	hsa-miR-143-3p	HITS-CLIP	21572407
MIRT636528	hsa-miR-4770	HITS-CLIP	21572407
MIRT636527	hsa-miR-6088	HITS-CLIP	21572407
MIRT636526	hsa-miR-4708-5p	HITS-CLIP	21572407
MIRT636525	hsa-miR-1273f	HITS-CLIP	21572407
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT636523	hsa-miR-4455	HITS-CLIP	21572407
MIRT636522	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT658276	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT658275	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT658274	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT658273	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT658272	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT658271	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT658270	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT658268	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT658269	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT658267	hsa-miR-4287	HITS-CLIP	23824327
MIRT658266	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT658265	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT318957	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT658264	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT658263	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT658262	hsa-miR-4279	HITS-CLIP	23824327
MIRT658261	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT658260	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT658259	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT658258	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT658257	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT658256	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT658255	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT658254	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT658253	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT658252	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT658251	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT658250	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT658249	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT658248	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT658247	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT658246	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT658245	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT658244	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT658243	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT658242	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT658241	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT658240	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT658239	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT658237	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT658238	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT658236	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT658235	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT658234	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT658233	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT638748	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT638747	hsa-miR-764	HITS-CLIP	23824327
MIRT638746	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638745	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT638744	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT638743	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT638742	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT638741	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT638740	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT638739	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT638738	hsa-miR-1913	HITS-CLIP	23824327
MIRT042924	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT638737	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT638736	hsa-miR-6131	HITS-CLIP	23824327
MIRT638735	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT638734	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT636529	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT636528	hsa-miR-4770	HITS-CLIP	23824327
MIRT636527	hsa-miR-6088	HITS-CLIP	23824327
MIRT636526	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT636525	hsa-miR-1273f	HITS-CLIP	23824327
MIRT636524	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT636523	hsa-miR-4455	HITS-CLIP	23824327
MIRT636522	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT615457	hsa-miR-583	HITS-CLIP	23824327
MIRT615456	hsa-miR-3609	HITS-CLIP	23824327
MIRT615455	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT615454	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT615453	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT615452	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT615451	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT615450	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT615449	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT615448	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT615447	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT615446	hsa-miR-4796-3p	HITS-CLIP	23824327
MIRT615445	hsa-miR-329-5p	HITS-CLIP	23824327
MIRT615444	hsa-miR-5697	HITS-CLIP	23824327
MIRT615443	hsa-miR-1297	HITS-CLIP	23824327
MIRT615442	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT615441	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT615440	hsa-miR-4465	HITS-CLIP	23824327
MIRT615439	hsa-miR-498	HITS-CLIP	23824327
MIRT615438	hsa-miR-1305	HITS-CLIP	23824327
MIRT615437	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT445199	hsa-miR-4662a-3p	PAR-CLIP	22100165
MIRT445198	hsa-miR-362-5p	PAR-CLIP	22100165
MIRT445197	hsa-miR-500b-5p	PAR-CLIP	22100165
MIRT445196	hsa-miR-501-5p	PAR-CLIP	22100165
MIRT445194	hsa-miR-4635	PAR-CLIP	22100165
MIRT445195	hsa-miR-488-3p	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5TGI0
• Protein name: Failed axon connections homolog
• Protein function: May play a role in axonal development.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17172	GST_N_4	117 → 212	Glutathione S-transferase N-terminal domain	Domain
  PF17171	GST_C_6	263 → 326	Glutathione S-transferase, C-terminal domain	Domain

• Sequence:

  MHWGVGFASSRPCVVDLSWNQSISFFGWWAGSEEPFSFYGDIIAFPLQDYGGIMAGLGSD
  PWWKKTLYLTGGALLAAAAYLLHELLVIRKQQEIDSKDAIILHQFARPNNGVPSLSPFCL
  KMETYLRMADLPYQNYFGGKLSAQGKMPWIEYNHEKVSGTEFIIDFLEEKLGVNLNKNLG
  PHERAISRAVTKMVEEHFYWTLAYCQWVDNLNETRKMLSLSGGGPFSNLLRWVVCHITKG
  IVKREMHGHGIGRFSEEEIYMLMEKDMRSLAGLLGDKKYIMGPKLSTLDATVFGHLAQAM
  WTLPGTRPERLIKGELINLAMYCERIRRKFWPEWHHDDDNTIYESEESSEGSKTHTPLLD
  FSFYSRTETFEDEGAENSFSRTPDTDFTGHSLFDSDVDMDDYTDHEQCK

• Sequence length: 409

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CIRRHOSIS OF LIVER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROLIFERATIVE DIABETIC RETINOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations