Gene Gene information from NCBI Gene database.
Entrez ID 8455
Gene name Attractin
Gene symbol ATRN
Synonyms (NCBI Gene)
DPPT-LMGCA
Chromosome 20
Chromosome location 20p13
Summary This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune ce
miRNA miRNA information provided by mirtarbase database.
582
miRTarBase ID miRNA Experiments Reference
MIRT714954 hsa-miR-3662 HITS-CLIP 19536157
MIRT714953 hsa-miR-3168 HITS-CLIP 19536157
MIRT714952 hsa-miR-148b-5p HITS-CLIP 19536157
MIRT714951 hsa-miR-6874-3p HITS-CLIP 19536157
MIRT714950 hsa-miR-5584-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space HDA 16502470
GO:0005615 Component Extracellular space IDA 17261078
GO:0005615 Component Extracellular space TAS 9736737
GO:0005794 Component Golgi apparatus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603130 885 ENSG00000088812
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75882
Protein name Attractin (DPPT-L) (Mahogany homolog)
Protein function Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity rec
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00431 CUB 132 245 CUB domain Domain
PF01344 Kelch_1 340 384 Kelch motif Repeat
PF13964 Kelch_6 391 440 Repeat
PF01344 Kelch_1 554 606 Kelch motif Repeat
PF00059 Lectin_C 805 920 Lectin C-type domain Domain
PF01437 PSI 932 983 Plexin repeat Family
PF01437 PSI 986 1061 Plexin repeat Family
Tissue specificity TISSUE SPECIFICITY: Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very
Sequence
MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPR
LLLLLLLLSPPLLLLLLPCEAEAAAAAAAVSGSAAAEAKECDRPCVNGGRCNPGTGQCVC
PAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATE
CSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTG
FNITY
SFDMCPNNCSGRGECKISNSSDTVECECSENWKGEACDIPHCTDNCGFPHRGICN
SSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYM
FNHSDYNMVLAYDLASREWLPLNR
SVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNE
LRVFHIHNESWVLLTPKAKE
QYAVVGHSAHIVTLKNGRVVMLVIFGHCPLYGYISNVQEY
DLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVD
TQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRW
SVLPRP
DLHHDVNRFGHSAVLHNSTMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAA
GPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDC
HWCNDHCVPRNHSCSEGQISIFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQEC
IALPENICGIGWHLVGNSCLKITTAKENYDNAKLFCRNHNALLASLTTQKKVEFVLKQLR
IMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPS
TRGLKAATCINPLNGSVCER
PANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVD
SNAYVASFPFGQCMEWYTMSTCP
PENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGS
YKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCP
ACQCNGHSKCINQSICEKC
ENLTTGKHCETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGDECQLC
EVENRYQGNPLRGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINAS
KNFNLNITWAASFSAGTQAGEEMPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFVYVSNF
TWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREM
QQMASRPFASVNVALETDEEPPDLIGGSIKTVPKPIALEPCFGNKAAVLSVFVRLPRGLG
GIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI
Sequence length 1429
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
22
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRN-related disorder Likely benign; Benign; Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autism Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anaplastic astrocytoma Anaplastic Astrocytoma BEFREE 17085642
★☆☆☆☆
Found in Text Mining only
Asthma Asthma GWASCAT_DG 25918132
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Astrocytoma Astrocytoma BEFREE 17085642
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Cardiomyopathy BEFREE 23398819
★☆☆☆☆
Found in Text Mining only
Common Variable Immunodeficiency Common variable immunodeficiency Pubtator 11168005 Associate
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 11394875, 17085642
★☆☆☆☆
Found in Text Mining only
Leukodystrophy Leukodystrophy BEFREE 28493104
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of skin Skin cancer BEFREE 19384953
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 11394875, 17085642
★☆☆☆☆
Found in Text Mining only
Obesity Obesity BEFREE 10086355, 14994991
★☆☆☆☆
Found in Text Mining only