Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84532
Gene name	Acyl-CoA synthetase short chain family member 1
Gene symbol	ACSS1
Synonyms (NCBI Gene)	ACAS2LACECS1AceCS2L
Chromosome	20
Chromosome location	20p11.21
Summary	This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding mul

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025533	hsa-miR-34a-5p	Proteomics	21566225
MIRT025533	hsa-miR-34a-5p	Proteomics	21566225
MIRT050224	hsa-miR-25-3p	CLASH	23622248
MIRT046084	hsa-miR-125b-5p	CLASH	23622248
MIRT045786	hsa-miR-191-5p	CLASH	23622248
MIRT763705	hsa-miR-1915	CLIP-seq
MIRT763706	hsa-miR-224	CLIP-seq
MIRT763707	hsa-miR-23a	CLIP-seq
MIRT763708	hsa-miR-23b	CLIP-seq
MIRT763709	hsa-miR-23c	CLIP-seq
MIRT763710	hsa-miR-3667-3p	CLIP-seq
MIRT763711	hsa-miR-3918	CLIP-seq
MIRT763712	hsa-miR-4311	CLIP-seq
MIRT763713	hsa-miR-4494	CLIP-seq
MIRT763714	hsa-miR-4512	CLIP-seq
MIRT763715	hsa-miR-4685-5p	CLIP-seq
MIRT763716	hsa-miR-4704-5p	CLIP-seq
MIRT763717	hsa-miR-4726-3p	CLIP-seq
MIRT763718	hsa-miR-4733-5p	CLIP-seq
MIRT763719	hsa-miR-499a-5p	CLIP-seq
MIRT763720	hsa-miR-617	CLIP-seq
MIRT1925081	hsa-miR-147	CLIP-seq
MIRT763705	hsa-miR-1915	CLIP-seq
MIRT1925082	hsa-miR-3151	CLIP-seq
MIRT1925083	hsa-miR-3192	CLIP-seq
MIRT1925084	hsa-miR-3194-5p	CLIP-seq
MIRT1925085	hsa-miR-342-5p	CLIP-seq
MIRT763710	hsa-miR-3667-3p	CLIP-seq
MIRT1925086	hsa-miR-3691-3p	CLIP-seq
MIRT1925087	hsa-miR-3911	CLIP-seq
MIRT763711	hsa-miR-3918	CLIP-seq
MIRT1925088	hsa-miR-4314	CLIP-seq
MIRT1925089	hsa-miR-4447	CLIP-seq
MIRT1925090	hsa-miR-4472	CLIP-seq
MIRT1925091	hsa-miR-4488	CLIP-seq
MIRT763714	hsa-miR-4512	CLIP-seq
MIRT1925092	hsa-miR-4535	CLIP-seq
MIRT1925093	hsa-miR-4639-5p	CLIP-seq
MIRT1925094	hsa-miR-4646-5p	CLIP-seq
MIRT1925095	hsa-miR-4651	CLIP-seq
MIRT1925096	hsa-miR-4664-5p	CLIP-seq
MIRT763715	hsa-miR-4685-5p	CLIP-seq
MIRT1925097	hsa-miR-4697-5p	CLIP-seq
MIRT763717	hsa-miR-4726-3p	CLIP-seq
MIRT763718	hsa-miR-4733-5p	CLIP-seq
MIRT1925098	hsa-miR-4776-5p	CLIP-seq
MIRT1925099	hsa-miR-491-5p	CLIP-seq
MIRT1925100	hsa-miR-492	CLIP-seq
MIRT1925101	hsa-miR-516b	CLIP-seq
MIRT1925102	hsa-miR-608	CLIP-seq
MIRT1925103	hsa-miR-644	CLIP-seq
MIRT2166534	hsa-miR-1193	CLIP-seq
MIRT2166535	hsa-miR-1225-5p	CLIP-seq
MIRT2166536	hsa-miR-1226	CLIP-seq
MIRT2166537	hsa-miR-1243	CLIP-seq
MIRT2166538	hsa-miR-125a-5p	CLIP-seq
MIRT2166539	hsa-miR-125b	CLIP-seq
MIRT2166540	hsa-miR-1266	CLIP-seq
MIRT2166541	hsa-miR-1291	CLIP-seq
MIRT2166542	hsa-miR-1299	CLIP-seq
MIRT2166543	hsa-miR-1343	CLIP-seq
MIRT2166544	hsa-miR-136	CLIP-seq
MIRT1925081	hsa-miR-147	CLIP-seq
MIRT2166545	hsa-miR-1470	CLIP-seq
MIRT2166546	hsa-miR-151-3p	CLIP-seq
MIRT763706	hsa-miR-224	CLIP-seq
MIRT2166547	hsa-miR-2277-3p	CLIP-seq
MIRT2166548	hsa-miR-27a	CLIP-seq
MIRT2166549	hsa-miR-27b	CLIP-seq
MIRT2166550	hsa-miR-3064-3p	CLIP-seq
MIRT2166551	hsa-miR-3065-3p	CLIP-seq
MIRT2166552	hsa-miR-3117-5p	CLIP-seq
MIRT2166553	hsa-miR-3132	CLIP-seq
MIRT2166554	hsa-miR-3141	CLIP-seq
MIRT1925082	hsa-miR-3151	CLIP-seq
MIRT2166555	hsa-miR-3179	CLIP-seq
MIRT2166556	hsa-miR-3185	CLIP-seq
MIRT1925083	hsa-miR-3192	CLIP-seq
MIRT2166557	hsa-miR-335	CLIP-seq
MIRT1925085	hsa-miR-342-5p	CLIP-seq
MIRT2166558	hsa-miR-3529	CLIP-seq
MIRT2166559	hsa-miR-3607-5p	CLIP-seq
MIRT2166560	hsa-miR-3613-3p	CLIP-seq
MIRT2166561	hsa-miR-3616-3p	CLIP-seq
MIRT2166562	hsa-miR-3622a-3p	CLIP-seq
MIRT2166563	hsa-miR-3622b-3p	CLIP-seq
MIRT2166564	hsa-miR-3649	CLIP-seq
MIRT763710	hsa-miR-3667-3p	CLIP-seq
MIRT2166565	hsa-miR-3677-5p	CLIP-seq
MIRT1925086	hsa-miR-3691-3p	CLIP-seq
MIRT2166566	hsa-miR-379	CLIP-seq
MIRT1925087	hsa-miR-3911	CLIP-seq
MIRT2166567	hsa-miR-3922-5p	CLIP-seq
MIRT2166568	hsa-miR-409-3p	CLIP-seq
MIRT2166569	hsa-miR-4263	CLIP-seq
MIRT2166570	hsa-miR-4284	CLIP-seq
MIRT763712	hsa-miR-4311	CLIP-seq
MIRT1925088	hsa-miR-4314	CLIP-seq
MIRT2166571	hsa-miR-4318	CLIP-seq
MIRT2166572	hsa-miR-4319	CLIP-seq
MIRT2166573	hsa-miR-4428	CLIP-seq
MIRT1925089	hsa-miR-4447	CLIP-seq
MIRT2166574	hsa-miR-4457	CLIP-seq
MIRT2166575	hsa-miR-4463	CLIP-seq
MIRT2166576	hsa-miR-4469	CLIP-seq
MIRT1925090	hsa-miR-4472	CLIP-seq
MIRT2166577	hsa-miR-4476	CLIP-seq
MIRT2166578	hsa-miR-4481	CLIP-seq
MIRT1925091	hsa-miR-4488	CLIP-seq
MIRT2166579	hsa-miR-4499	CLIP-seq
MIRT2166580	hsa-miR-4518	CLIP-seq
MIRT2166581	hsa-miR-4528	CLIP-seq
MIRT1925092	hsa-miR-4535	CLIP-seq
MIRT2166582	hsa-miR-4635	CLIP-seq
MIRT1925094	hsa-miR-4646-5p	CLIP-seq
MIRT1925095	hsa-miR-4651	CLIP-seq
MIRT1925096	hsa-miR-4664-5p	CLIP-seq
MIRT2166583	hsa-miR-4666-5p	CLIP-seq
MIRT2166584	hsa-miR-4667-3p	CLIP-seq
MIRT2166585	hsa-miR-4667-5p	CLIP-seq
MIRT2166586	hsa-miR-4682	CLIP-seq
MIRT1925097	hsa-miR-4697-5p	CLIP-seq
MIRT2166587	hsa-miR-4700-5p	CLIP-seq
MIRT2166588	hsa-miR-4709-3p	CLIP-seq
MIRT2166589	hsa-miR-4721	CLIP-seq
MIRT2166590	hsa-miR-4724-3p	CLIP-seq
MIRT2166591	hsa-miR-4731-3p	CLIP-seq
MIRT2166592	hsa-miR-4732-3p	CLIP-seq
MIRT2166593	hsa-miR-4733-3p	CLIP-seq
MIRT2166594	hsa-miR-4745-5p	CLIP-seq
MIRT2166595	hsa-miR-4757-5p	CLIP-seq
MIRT2166596	hsa-miR-4768-3p	CLIP-seq
MIRT1925098	hsa-miR-4776-5p	CLIP-seq
MIRT2166597	hsa-miR-4782-5p	CLIP-seq
MIRT2166598	hsa-miR-4789-5p	CLIP-seq
MIRT2166599	hsa-miR-4797-5p	CLIP-seq
MIRT2166600	hsa-miR-4801	CLIP-seq
MIRT2166601	hsa-miR-4803	CLIP-seq
MIRT2166602	hsa-miR-483-3p	CLIP-seq
MIRT2166603	hsa-miR-486-3p	CLIP-seq
MIRT1925099	hsa-miR-491-5p	CLIP-seq
MIRT1925100	hsa-miR-492	CLIP-seq
MIRT2166604	hsa-miR-510	CLIP-seq
MIRT2166605	hsa-miR-512-5p	CLIP-seq
MIRT2166606	hsa-miR-513a-5p	CLIP-seq
MIRT1925101	hsa-miR-516b	CLIP-seq
MIRT2166607	hsa-miR-548b-3p	CLIP-seq
MIRT2166608	hsa-miR-548c-3p	CLIP-seq
MIRT2166609	hsa-miR-576-5p	CLIP-seq
MIRT2166610	hsa-miR-582-3p	CLIP-seq
MIRT2166611	hsa-miR-583	CLIP-seq
MIRT2166612	hsa-miR-606	CLIP-seq
MIRT1925102	hsa-miR-608	CLIP-seq
MIRT2166613	hsa-miR-637	CLIP-seq
MIRT1925103	hsa-miR-644	CLIP-seq
MIRT2166614	hsa-miR-663b	CLIP-seq
MIRT2166615	hsa-miR-670	CLIP-seq
MIRT2166616	hsa-miR-7	CLIP-seq
MIRT2166617	hsa-miR-759	CLIP-seq
MIRT2166618	hsa-miR-885-5p	CLIP-seq
MIRT2166619	hsa-miR-936	CLIP-seq
MIRT2166556	hsa-miR-3185	CLIP-seq
MIRT2166582	hsa-miR-4635	CLIP-seq
MIRT2166588	hsa-miR-4709-3p	CLIP-seq
MIRT2166597	hsa-miR-4782-5p	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003987	Function	Acetate-CoA ligase activity	EXP	16788062
GO:0003987	Function	Acetate-CoA ligase activity	IBA
GO:0003987	Function	Acetate-CoA ligase activity	IDA	16788062
GO:0003987	Function	Acetate-CoA ligase activity	IEA
GO:0005515	Function	Protein binding	IPI	16788062, 19535340, 25416956, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	16788062
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006068	Process	Ethanol catabolic process	TAS
GO:0006085	Process	Acetyl-CoA biosynthetic process	IBA
GO:0006085	Process	Acetyl-CoA biosynthetic process	IDA	16788062
GO:0006085	Process	Acetyl-CoA biosynthetic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016208	Function	AMP binding	IEA
GO:0016405	Function	CoA-ligase activity	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0016878	Function	Acid-thiol ligase activity	IEA
GO:0019413	Process	Acetate biosynthetic process	IEA
GO:0019427	Process	Acetyl-CoA biosynthetic process from acetate	IEA
GO:0019542	Process	Propionate biosynthetic process	IEA
GO:0050218	Function	Propionate-CoA ligase activity	IEA
GO:0050218	Function	Propionate-CoA ligase activity	ISS

MIM	HGNC	e!Ensembl
614355	16091	ENSG00000154930

Q9NUB1

Protein name

Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1) (Propionate--CoA ligase) (EC 6.2.1.17)

Protein function

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utili

PDB

3GLR , 3GLT , 3GLU , 4BVE , 4BVF , 4BVG , 4C78 , 5Y4H , 5YTK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16177	ACAS_N	58 → 114	Acetyl-coenzyme A synthetase N-terminus	Family
PF00501	AMP-binding	115 → 556	AMP-binding enzyme	Family
PF13193	AMP-binding_C	564 → 642	AMP-binding enzyme C-terminal domain	Domain

Sequence

MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPA
LSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVR
KSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVA
AMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVK
HCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGM
PKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLF
ESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPI
NCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVL
MDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEG
GYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKD
SAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELG
DTTTLEDPSIIAEILSVYQKCKDKQAAAK

Sequence length

689

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Propanoate metabolism Metabolic pathways Carbon metabolism		Ethanol oxidation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bladder Neoplasm	Bladder Neoplasm	BEFREE	29568353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33667222	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	27357947, 27363021	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	29568353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27713423		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	29503142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26655911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	29568353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26655911, 27713423		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	27539851		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	21211798		★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26655911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31750240		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polyp of large intestine	Polyp Of Large Intestine	BEFREE	27713423		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	29444517, 29503142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	25173755	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	33667222	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACSS1 (acyl-CoA synthetase short chain family member 1)