MCM8 (minichromosome maintenance 8 homologous recombination repair factor)

Gene

• Entrez ID: 84515
• Gene name: Minichromosome maintenance 8 homologous recombination repair factor
• Gene symbol: MCM8
• Synonyms (NCBI Gene): C20orf154, POF10, dJ967N21.5
• Chromosome: 20
• Chromosome location: 20p12.3
• Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance prot

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs138761187	G>A	Pathogenic	Genic downstream transcript variant, splice acceptor variant
rs201115244	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs606231343	C>G	Pathogenic, not-provided	Coding sequence variant, genic upstream transcript variant, non coding transcript variant, missense variant
rs777947820	TTGA>-	Pathogenic	Non coding transcript variant, coding sequence variant, genic upstream transcript variant, frameshift variant
rs869320753	->TA	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016553	hsa-miR-193b-3p	Microarray	20304954
MIRT020992	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT048686	hsa-miR-99a-5p	CLASH	23622248
MIRT721969	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT721968	hsa-miR-148b-5p	HITS-CLIP	19536157
MIRT721967	hsa-miR-6874-3p	HITS-CLIP	19536157
MIRT721966	hsa-miR-1285-5p	HITS-CLIP	19536157
MIRT721965	hsa-miR-4762-5p	HITS-CLIP	19536157
MIRT721964	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT721962	hsa-miR-4277	HITS-CLIP	19536157
MIRT721963	hsa-miR-20a-3p	HITS-CLIP	19536157
MIRT721961	hsa-miR-544a	HITS-CLIP	19536157
MIRT625688	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT625687	hsa-miR-4711-3p	HITS-CLIP	23313552
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT625686	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT608300	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678313	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT678312	hsa-miR-4532	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT625688	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT625687	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625686	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT608300	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT662625	hsa-miR-1267	HITS-CLIP	23824327
MIRT662624	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT662623	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662622	hsa-miR-3135b	HITS-CLIP	23824327
MIRT662621	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT662620	hsa-miR-3652	HITS-CLIP	23824327
MIRT662619	hsa-miR-4430	HITS-CLIP	23824327
MIRT662618	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT662617	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT662616	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT662615	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT662614	hsa-miR-5698	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT625688	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT625687	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625686	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT608300	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT608305	hsa-miR-892a	HITS-CLIP	24906430
MIRT608304	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	24906430
MIRT608303	hsa-miR-4439	HITS-CLIP	24906430
MIRT608301	hsa-miR-943	HITS-CLIP	24906430
MIRT608300	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT515836	hsa-miR-4779	PAR-CLIP	21572407
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT515834	hsa-miR-665	PAR-CLIP	21572407
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	21572407
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT515830	hsa-miR-4683	PAR-CLIP	21572407
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT515828	hsa-miR-4266	PAR-CLIP	21572407
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT515826	hsa-miR-1273e	PAR-CLIP	21572407
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT515836	hsa-miR-4779	PAR-CLIP	23446348
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT515834	hsa-miR-665	PAR-CLIP	23446348
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT515830	hsa-miR-4683	PAR-CLIP	23446348
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT515828	hsa-miR-4266	PAR-CLIP	23446348
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT515826	hsa-miR-1273e	PAR-CLIP	23446348
MIRT020992	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440265	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT020992	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440265	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT662625	hsa-miR-1267	PAR-CLIP	27292025
MIRT662625	hsa-miR-1267	PAR-CLIP	27292025
MIRT662618	hsa-miR-143-5p	PAR-CLIP	27292025
MIRT662618	hsa-miR-143-5p	PAR-CLIP	27292025
MIRT662622	hsa-miR-3135b	PAR-CLIP	27292025
MIRT662622	hsa-miR-3135b	PAR-CLIP	27292025
MIRT662620	hsa-miR-3652	PAR-CLIP	27292025
MIRT662620	hsa-miR-3652	PAR-CLIP	27292025
MIRT662624	hsa-miR-367-5p	PAR-CLIP	27292025
MIRT662624	hsa-miR-367-5p	PAR-CLIP	27292025
MIRT662616	hsa-miR-4423-5p	PAR-CLIP	27292025
MIRT662616	hsa-miR-4423-5p	PAR-CLIP	27292025
MIRT662619	hsa-miR-4430	PAR-CLIP	27292025
MIRT662619	hsa-miR-4430	PAR-CLIP	27292025
MIRT662621	hsa-miR-504-3p	PAR-CLIP	27292025
MIRT662621	hsa-miR-504-3p	PAR-CLIP	27292025
MIRT662614	hsa-miR-5698	PAR-CLIP	27292025
MIRT662614	hsa-miR-5698	PAR-CLIP	27292025
MIRT662623	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT662623	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT662617	hsa-miR-6501-5p	PAR-CLIP	27292025
MIRT662617	hsa-miR-6501-5p	PAR-CLIP	27292025
MIRT662615	hsa-miR-744-3p	PAR-CLIP	27292025
MIRT662615	hsa-miR-744-3p	PAR-CLIP	27292025
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	27418678
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	27418678
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608302	hsa-miR-3136-5p	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT608303	hsa-miR-4439	HITS-CLIP	27418678
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	27418678
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	27418678
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575579	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	27418678
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	27418678
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608305	hsa-miR-892a	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT608301	hsa-miR-943	HITS-CLIP	27418678
MIRT721969	hsa-miR-216a-5p	HITS-CLIP	19536157
MIRT721968	hsa-miR-148b-5p	HITS-CLIP	19536157
MIRT721967	hsa-miR-6874-3p	HITS-CLIP	19536157
MIRT721966	hsa-miR-1285-5p	HITS-CLIP	19536157
MIRT721965	hsa-miR-4762-5p	HITS-CLIP	19536157
MIRT721964	hsa-miR-584-3p	HITS-CLIP	19536157
MIRT721962	hsa-miR-4277	HITS-CLIP	19536157
MIRT721963	hsa-miR-20a-3p	HITS-CLIP	19536157
MIRT721961	hsa-miR-544a	HITS-CLIP	19536157
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	23313552
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	23313552
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	23313552
MIRT575579	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT678313	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT678312	hsa-miR-4532	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT575579	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT662630	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT662629	hsa-miR-1297	HITS-CLIP	23824327
MIRT662628	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT662627	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT662626	hsa-miR-4465	HITS-CLIP	23824327
MIRT662625	hsa-miR-1267	HITS-CLIP	23824327
MIRT662624	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT662623	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662622	hsa-miR-3135b	HITS-CLIP	23824327
MIRT662621	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT662620	hsa-miR-3652	HITS-CLIP	23824327
MIRT662619	hsa-miR-4430	HITS-CLIP	23824327
MIRT662618	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT662617	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT662616	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT662615	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT662614	hsa-miR-5698	HITS-CLIP	23824327
MIRT631414	hsa-miR-8062	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT631413	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631412	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631411	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631410	hsa-miR-1976	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT631409	hsa-miR-4279	HITS-CLIP	23824327
MIRT575583	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT575582	hsa-miR-4711-3p	HITS-CLIP	23824327
MIRT575581	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT575580	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT575579	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT618679	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT618678	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT618676	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT618677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT618675	hsa-miR-4727-3p	HITS-CLIP	23824327
MIRT618674	hsa-miR-4460	HITS-CLIP	23824327
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT515836	hsa-miR-4779	PAR-CLIP	21572407
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT515834	hsa-miR-665	PAR-CLIP	21572407
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	21572407
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT515830	hsa-miR-4683	PAR-CLIP	21572407
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT515828	hsa-miR-4266	PAR-CLIP	21572407
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT515826	hsa-miR-1273e	PAR-CLIP	21572407
MIRT515837	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT515838	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT515836	hsa-miR-4779	PAR-CLIP	23446348
MIRT515835	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT515834	hsa-miR-665	PAR-CLIP	23446348
MIRT515833	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT515832	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT515831	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT515830	hsa-miR-4683	PAR-CLIP	23446348
MIRT515829	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT515828	hsa-miR-4266	PAR-CLIP	23446348
MIRT515827	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT515826	hsa-miR-1273e	PAR-CLIP	23446348
MIRT1137808	hsa-miR-1208	CLIP-seq
MIRT1137809	hsa-miR-122	CLIP-seq
MIRT1137810	hsa-miR-129-5p	CLIP-seq
MIRT1137811	hsa-miR-1302	CLIP-seq
MIRT1137812	hsa-miR-200b	CLIP-seq
MIRT1137813	hsa-miR-200c	CLIP-seq
MIRT1137814	hsa-miR-219-5p	CLIP-seq
MIRT1137815	hsa-miR-24	CLIP-seq
MIRT1137816	hsa-miR-3122	CLIP-seq
MIRT1137817	hsa-miR-3150a-5p	CLIP-seq
MIRT1137818	hsa-miR-3150b-5p	CLIP-seq
MIRT1137819	hsa-miR-3163	CLIP-seq
MIRT1137820	hsa-miR-337-3p	CLIP-seq
MIRT1137821	hsa-miR-3613-3p	CLIP-seq
MIRT1137822	hsa-miR-3650	CLIP-seq
MIRT1137823	hsa-miR-3685	CLIP-seq
MIRT1137824	hsa-miR-369-3p	CLIP-seq
MIRT1137825	hsa-miR-3714	CLIP-seq
MIRT1137826	hsa-miR-374a	CLIP-seq
MIRT1137827	hsa-miR-374b	CLIP-seq
MIRT1137828	hsa-miR-384	CLIP-seq
MIRT1137829	hsa-miR-3913-3p	CLIP-seq
MIRT1137830	hsa-miR-3913-5p	CLIP-seq
MIRT1137831	hsa-miR-4284	CLIP-seq
MIRT1137832	hsa-miR-429	CLIP-seq
MIRT1137833	hsa-miR-4298	CLIP-seq
MIRT1137834	hsa-miR-4445	CLIP-seq
MIRT1137835	hsa-miR-4457	CLIP-seq
MIRT1137836	hsa-miR-4474-3p	CLIP-seq
MIRT1137837	hsa-miR-4736	CLIP-seq
MIRT1137838	hsa-miR-4782-3p	CLIP-seq
MIRT1137839	hsa-miR-508-3p	CLIP-seq
MIRT1137840	hsa-miR-509-3p	CLIP-seq
MIRT1137841	hsa-miR-513b	CLIP-seq
MIRT1137842	hsa-miR-548an	CLIP-seq
MIRT1137843	hsa-miR-562	CLIP-seq
MIRT1137844	hsa-miR-940	CLIP-seq
MIRT1137808	hsa-miR-1208	CLIP-seq
MIRT1137810	hsa-miR-129-5p	CLIP-seq
MIRT1137811	hsa-miR-1302	CLIP-seq
MIRT1137812	hsa-miR-200b	CLIP-seq
MIRT1137813	hsa-miR-200c	CLIP-seq
MIRT1137816	hsa-miR-3122	CLIP-seq
MIRT1137819	hsa-miR-3163	CLIP-seq
MIRT2039122	hsa-miR-335	CLIP-seq
MIRT1137821	hsa-miR-3613-3p	CLIP-seq
MIRT1137824	hsa-miR-369-3p	CLIP-seq
MIRT1137825	hsa-miR-3714	CLIP-seq
MIRT1137826	hsa-miR-374a	CLIP-seq
MIRT1137827	hsa-miR-374b	CLIP-seq
MIRT1137829	hsa-miR-3913-3p	CLIP-seq
MIRT1137830	hsa-miR-3913-5p	CLIP-seq
MIRT1137832	hsa-miR-429	CLIP-seq
MIRT1137833	hsa-miR-4298	CLIP-seq
MIRT1137837	hsa-miR-4736	CLIP-seq
MIRT1137842	hsa-miR-548an	CLIP-seq
MIRT2039123	hsa-miR-627	CLIP-seq
MIRT1137844	hsa-miR-940	CLIP-seq
MIRT2269172	hsa-miR-1200	CLIP-seq
MIRT1137808	hsa-miR-1208	CLIP-seq
MIRT1137809	hsa-miR-122	CLIP-seq
MIRT2269173	hsa-miR-1229	CLIP-seq
MIRT2269174	hsa-miR-155	CLIP-seq
MIRT2269175	hsa-miR-186	CLIP-seq
MIRT1137814	hsa-miR-219-5p	CLIP-seq
MIRT1137819	hsa-miR-3163	CLIP-seq
MIRT2269176	hsa-miR-3183	CLIP-seq
MIRT1137821	hsa-miR-3613-3p	CLIP-seq
MIRT1137822	hsa-miR-3650	CLIP-seq
MIRT2269177	hsa-miR-3672	CLIP-seq
MIRT1137825	hsa-miR-3714	CLIP-seq
MIRT2269178	hsa-miR-4324	CLIP-seq
MIRT2269179	hsa-miR-4329	CLIP-seq
MIRT1137834	hsa-miR-4445	CLIP-seq
MIRT1137835	hsa-miR-4457	CLIP-seq
MIRT2269180	hsa-miR-4723-3p	CLIP-seq
MIRT1137837	hsa-miR-4736	CLIP-seq
MIRT1137838	hsa-miR-4782-3p	CLIP-seq
MIRT1137839	hsa-miR-508-3p	CLIP-seq
MIRT1137840	hsa-miR-509-3p	CLIP-seq
MIRT1137841	hsa-miR-513b	CLIP-seq
MIRT2269181	hsa-miR-544b	CLIP-seq
MIRT1137842	hsa-miR-548an	CLIP-seq
MIRT1137843	hsa-miR-562	CLIP-seq
MIRT2269182	hsa-miR-590-3p	CLIP-seq
MIRT1137844	hsa-miR-940	CLIP-seq
MIRT1137809	hsa-miR-122	CLIP-seq
MIRT2390736	hsa-miR-137	CLIP-seq
MIRT2568419	hsa-miR-1227	CLIP-seq
MIRT2568420	hsa-miR-1912	CLIP-seq
MIRT2568421	hsa-miR-3130-5p	CLIP-seq
MIRT2269177	hsa-miR-3672	CLIP-seq
MIRT2568422	hsa-miR-4482	CLIP-seq
MIRT2568423	hsa-miR-455-5p	CLIP-seq
MIRT2568424	hsa-miR-4715-3p	CLIP-seq
MIRT2568419	hsa-miR-1227	CLIP-seq
MIRT2568420	hsa-miR-1912	CLIP-seq
MIRT2568421	hsa-miR-3130-5p	CLIP-seq
MIRT2269177	hsa-miR-3672	CLIP-seq
MIRT2568422	hsa-miR-4482	CLIP-seq
MIRT2568423	hsa-miR-455-5p	CLIP-seq
MIRT2568424	hsa-miR-4715-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Unknown	16325355
MYCN	Activation	17826980

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA
GO:0000724	Process	Double-strand break repair via homologous recombination	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IMP	23401855
GO:0000724	Process	Double-strand break repair via homologous recombination	NAS	22771115
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	23401855
GO:0003697	Function	Single-stranded DNA binding	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	22540012, 23401855, 24299456, 25036637, 26300262, 31467087, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23401855, 26300262
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006260	Process	DNA replication	IGI	23401855
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	22771115
GO:0006974	Process	DNA damage response	IEA
GO:0007292	Process	Female gamete generation	IEA
GO:0007292	Process	Female gamete generation	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017116	Function	Single-stranded DNA helicase activity	IBA
GO:0019899	Function	Enzyme binding	IPI	23401855, 26215093, 26300262
GO:0032406	Function	MutLbeta complex binding	IDA	26300262
GO:0032407	Function	MutSalpha complex binding	IDA	26300262
GO:0032408	Function	MutSbeta complex binding	IDA	26300262
GO:0036298	Process	Recombinational interstrand cross-link repair	IMP	23401855
GO:0042555	Component	MCM complex	IBA
GO:0048232	Process	Male gamete generation	IEA
GO:0048232	Process	Male gamete generation	ISS
GO:0050821	Process	Protein stabilization	IMP	23401855, 26215093
GO:0070716	Process	Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	NAS	26300262
GO:0071168	Process	Protein localization to chromatin	IMP	23401855
GO:0097362	Component	MCM8-MCM9 complex	IDA	22771115, 23401855, 26215093, 26300262
GO:0097362	Component	MCM8-MCM9 complex	IEA
GO:0097362	Component	MCM8-MCM9 complex	IPI	26300262

Other IDs

• MIM: 608187
• HGNC: 16147
• e!Ensembl: ENSG00000125885

Protein

• UniProt ID: Q9UJA3
• Protein name: DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8)
• Protein function: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NB
• PDB: 6L0O, 7DP3, 7WI7, 7YOX, 8S91, 8S92, 8S94
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17207	MCM_OB	206 → 339	MCM OB domain	Domain
  PF00493	MCM	389 → 613	MCM P-loop domain	Domain
  PF17855	MCM_lid	664 → 748	MCM AAA-lid domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. {ECO:0000269|PubMed:12771218}.
• Sequence:

  MNGEYRGRGFGRGRFQSWKRGRGGGNFSGKWREREHRPDLSKTTGKRTSEQTPQFLLSTK
  TPQSMQSTLDRFIPYKGWKLYFSEVYSDSSPLIEKIQAFEKFFTRHIDLYDKDEIERKGS
  ILVDFKELTEGGEVTNLIPDIATELRDAPEKTLACMGLAIHQVLTKDLERHAAELQAQEG
  LSNDGETMVNVPHIHARVYNYEPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAF
  LCAACGEIQSFPLPDGKYSLPTKCPVPVCRGRSFTALRSSPLTVTMDWQSIKIQELMSDD
  QREAGRIPRTIECELVHDLVDSCVPGDTVTITGIVKVSNAEEGSRNKNDKCMFLLYIEAN
  SISNSKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAEENLFKLIVNSLCPVIFGHELV
  KAGLALALFGGSQKYADDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCGN
  TTTTSGLTVTLSKDSSSGDFALEAGALVLGDQGICGIDEFDKMGNQHQALLEAMEQQSIS
  LAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEH
  HDHLLSEHVIAIRAGKQRTISSATVARMNSQDSNTSVLEVVSEKPLSERLKVVPGETIDP
  IPHQLLRKYIGYARQYVYPRLSTEAARVLQDFYLELRKQSQRLNSSPITTRQLESLIRLT
  EARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQHGSGMSNRSTAKRFI
  SALNNVAERTYNNIFQFHQLRQIAKELNIQVADFENFIGSLNDQGYLLKKGPKVYQLQTM
  

• Sequence length: 840

Pathways

Reactome:

Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Azoospermia	Likely pathogenic	rs140044814	RCV001797582	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Premature ovarian failure 10	Likely pathogenic; Pathogenic	rs775156125, rs140773345, rs140044814, rs606231343, rs762416121, rs138761187, rs869320753, rs531099221, rs201115244	RCV001839421 RCV001356475 RCV005052841 RCV000162356 RCV005636732 RCV000190838 RCV000190839 RCV003389312 RCV001002743	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR POSITIVE BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MCM8-related disorder	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREECLAMPSIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY TRACT INFECTIOUS DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of colon	Adenocarcinoma Of Colon	BEFREE	12771218		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31323040		★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	Pubtator	35172124	Associate	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Azoospermia	Azoospermia	HPO_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	26823731		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	29059683		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	30194396		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	19448619	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36575045	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	36445337	Stimulate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	19448619	Associate	★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	12771218		★☆☆☆☆ Found in Text Mining only
Chromosomal Instability	Chromosomal instability	Pubtator	28863940	Associate	★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	12771218	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32841224	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	32841224	Associate	★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of ovary	Hypoplasia of the ovary	HPO_DG			★☆☆☆☆ Found in Text Mining only
Endocrine System Diseases	Endocrine system disease	Pubtator	25437880	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37349788	Associate	★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	32652893	Associate	★☆☆☆☆ Found in Text Mining only
Hematopoietic Neoplasms	Hematopoietic Neoplasms	BEFREE	31509747		★☆☆☆☆ Found in Text Mining only
Hepatoblastoma	Hepatoblastoma	Pubtator	37850543	Associate	★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Infertility	Infertility	Pubtator	32841224	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	30480765	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29463213, 30546424		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35360518	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	27695057	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Childhood Neoplasm	Malignant Neoplasm	BEFREE	23360674		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30194396		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	27695057		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28481876		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26823731, 28481876, 30648820		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	26823731		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12771218		★☆☆☆☆ Found in Text Mining only
NON RARE IN EUROPE: Primary ovarian failure	Ovarian Failure	Orphanet			★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	19448619	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Dysgenesis 2	Ovarian dysgenesis	Pubtator	25437880	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Failure, Premature	Ovarian Failure	GENOMICS_ENGLAND_DG	22771120		★☆☆☆☆ Found in Text Mining only
Ovarian Failure, Premature	Ovarian Failure	BEFREE	27573988, 27802094, 30276597, 30743181		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	28863940	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	27695057		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	27695057	Associate	★☆☆☆☆ Found in Text Mining only
Plexiform leiomyoma	Plexiform leiomyoma	GWASCAT_DG	30194396, 31649266		★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	27573988, 28863940, 30276597		★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	HPO_DG			★☆☆☆☆ Found in Text Mining only
PREMATURE OVARIAN FAILURE 10	Premature Ovarian Failure	UNIPROT_DG	25437880		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
PREMATURE OVARIAN FAILURE 10	Premature Ovarian Failure	CLINVAR_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
PREMATURE OVARIAN FAILURE 10	Premature Ovarian Failure	CTD_human_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Primary hypogonadism	Hypogonadism	BEFREE	25873734		★☆☆☆☆ Found in Text Mining only
Primary physiologic amenorrhea	Physiologic Amenorrhea	HPO_DG			★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28481876		★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	34404366	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	GWASCAT_DG	30194396, 31649266		★☆☆☆☆ Found in Text Mining only