Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84498
Gene name	Family with sequence similarity 120 member B
Gene symbol	FAM120B
Synonyms (NCBI Gene)	CCPGKIAA1838PGCC1SAN1dJ894D12.1
Chromosome	6
Chromosome location	6q27

Show/Hide all (69)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017257	hsa-miR-335-5p	Microarray	18185580
MIRT568787	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT568786	hsa-miR-4433a-3p	PAR-CLIP	20371350
MIRT568785	hsa-miR-6859-3p	PAR-CLIP	20371350
MIRT568784	hsa-miR-6846-3p	PAR-CLIP	20371350
MIRT568783	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT568787	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT568786	hsa-miR-4433a-3p	PAR-CLIP	20371350
MIRT568785	hsa-miR-6859-3p	PAR-CLIP	20371350
MIRT568784	hsa-miR-6846-3p	PAR-CLIP	20371350
MIRT568783	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT568787	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT568786	hsa-miR-4433a-3p	PAR-CLIP	20371350
MIRT568785	hsa-miR-6859-3p	PAR-CLIP	20371350
MIRT568784	hsa-miR-6846-3p	PAR-CLIP	20371350
MIRT568783	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT568787	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT568786	hsa-miR-4433a-3p	PAR-CLIP	20371350
MIRT568785	hsa-miR-6859-3p	PAR-CLIP	20371350
MIRT568784	hsa-miR-6846-3p	PAR-CLIP	20371350
MIRT568783	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT978253	hsa-miR-3689a-3p	CLIP-seq
MIRT978254	hsa-miR-3689c	CLIP-seq
MIRT978255	hsa-miR-4419a	CLIP-seq
MIRT978256	hsa-miR-4510	CLIP-seq
MIRT978257	hsa-miR-4728-5p	CLIP-seq
MIRT2224218	hsa-miR-185	CLIP-seq
MIRT2224219	hsa-miR-3065-5p	CLIP-seq
MIRT2224220	hsa-miR-4306	CLIP-seq
MIRT2224221	hsa-miR-4644	CLIP-seq
MIRT2224222	hsa-miR-4786-3p	CLIP-seq
MIRT2224218	hsa-miR-185	CLIP-seq
MIRT2528070	hsa-miR-2052	CLIP-seq
MIRT2528071	hsa-miR-219-5p	CLIP-seq
MIRT2224219	hsa-miR-3065-5p	CLIP-seq
MIRT2528072	hsa-miR-4269	CLIP-seq
MIRT2224220	hsa-miR-4306	CLIP-seq
MIRT2528073	hsa-miR-4445	CLIP-seq
MIRT2528074	hsa-miR-4514	CLIP-seq
MIRT2528075	hsa-miR-4640-5p	CLIP-seq
MIRT2528076	hsa-miR-4643	CLIP-seq
MIRT2224221	hsa-miR-4644	CLIP-seq
MIRT2528077	hsa-miR-4692	CLIP-seq
MIRT2528078	hsa-miR-4699-5p	CLIP-seq
MIRT2528079	hsa-miR-4726-5p	CLIP-seq
MIRT2528080	hsa-miR-4742-5p	CLIP-seq
MIRT2528081	hsa-miR-4782-3p	CLIP-seq
MIRT2224222	hsa-miR-4786-3p	CLIP-seq
MIRT2528082	hsa-miR-494	CLIP-seq
MIRT2528083	hsa-miR-508-3p	CLIP-seq
MIRT2224218	hsa-miR-185	CLIP-seq
MIRT2528070	hsa-miR-2052	CLIP-seq
MIRT2528071	hsa-miR-219-5p	CLIP-seq
MIRT2224219	hsa-miR-3065-5p	CLIP-seq
MIRT2528072	hsa-miR-4269	CLIP-seq
MIRT2224220	hsa-miR-4306	CLIP-seq
MIRT2528073	hsa-miR-4445	CLIP-seq
MIRT2528074	hsa-miR-4514	CLIP-seq
MIRT2528075	hsa-miR-4640-5p	CLIP-seq
MIRT2528076	hsa-miR-4643	CLIP-seq
MIRT2224221	hsa-miR-4644	CLIP-seq
MIRT2528077	hsa-miR-4692	CLIP-seq
MIRT2528078	hsa-miR-4699-5p	CLIP-seq
MIRT2528079	hsa-miR-4726-5p	CLIP-seq
MIRT2528080	hsa-miR-4742-5p	CLIP-seq
MIRT2528081	hsa-miR-4782-3p	CLIP-seq
MIRT2224222	hsa-miR-4786-3p	CLIP-seq
MIRT2528082	hsa-miR-494	CLIP-seq
MIRT2528083	hsa-miR-508-3p	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0035357	Process	Peroxisome proliferator activated receptor signaling pathway	IBA
GO:0035357	Process	Peroxisome proliferator activated receptor signaling pathway	IEA
GO:0045444	Process	Fat cell differentiation	IBA
GO:0045444	Process	Fat cell differentiation	IEA

MIM	HGNC	e!Ensembl
612266	21109	ENSG00000112584

Q96EK7

Protein name

Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B)

Protein function

Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14585507}.

Sequence

MGVRGLQGFVGSTCPHICTVVNFKELAEHHRSKYPGCTPTIVVDAMCCLRYWYTPESWIC
GGQWREYFSALRDFVKTFTAAGIKLIFFFDGMVEQDKRDEWVKRRLKNNREISRIFHYIK
SHKEQPGRNMFFIPSGLAVFTRFALKTLGQETLCSLQEADYEVASYGLQHNCLGILGEDT
DYLIYDTCPYFSISELCLESLDTVMLCREKLCESLGLCVADLPLLACLLGNDIIPEGMFE
SFRYKCLSSYTSVKENFDKKGNIILAVSDHISKVLYLYQGEKKLEEILPLGPNKALFYKG
MASYLLPGQKSPWFFQKPKGVITLDKQVISTSSDAESREEVPMCSDAESRQEVPMCTGPE
SRREVPVYTDSEPRQEVPMCSDPEPRQEVPTCTGPESRREVPMCSDPEPRQEVPMCTGPE
ARQEVPMYTDSEPRQEVPMYTDSEPRQEVPMYTGSEPRQEVPMYTGPESRQEVPMYTGPE
SRQEVLIRTDPESRQEIMCTGHESKQEVPICTDPISKQEDSMCTHAEINQKLPVATDFEF
KLEALMCTNPEIKQEDPTNVGPEVKQQVTMVSDTEILKVARTHHVQAESYLVYNIMSSGE
IECSNTLEDELDQALPSQAFIYRPIRQRVYSLLLEDCQDVTSTCLAVKEWFVYPGNPLRH
PDLVRPLQMTIPGGTPSLKILWLNQEPEIQVRRLDTLLACFNLSSSREELQAVESPFQAL
CCLLIYLFVQVDTLCLEDLHAFIAQALCLQGKSTSQLVNLQPDYINPRAVQLGSLLVRGL
TTLVLVNSACGFPWKTSDFMPWNVFDGKLFHQKYLQSEKGYAVEVLLEQNRSRLTKFHNL
KAVVCKACMKENRRITGRAHWGSHHAGRWGRQGSSYHRTGSGYSRSSQGQPWRDQGPGSR
QYEHDQWRRY

Sequence length

910

Interactions

View interactions

	Reactome
			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BEHCET'S SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DILATED CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDIOPATHIC DILATED CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	16945141	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi Anemia	BEFREE	29968717		★★★★★ ★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	Anemia	BEFREE	29968717		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	36475386, 36759259	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

FAM120B (family with sequence similarity 120 member B)