Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84465
Gene name	Multiple EGF like domains 11
Gene symbol	MEGF11
Synonyms (NCBI Gene)	-
Chromosome	15
Chromosome location	15q22.31

Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016854	hsa-miR-335-5p	Microarray	18185580
MIRT2040446	hsa-miR-1324	CLIP-seq
MIRT2040447	hsa-miR-181a	CLIP-seq
MIRT2040448	hsa-miR-181b	CLIP-seq
MIRT2040449	hsa-miR-181c	CLIP-seq
MIRT2040450	hsa-miR-181d	CLIP-seq
MIRT2040451	hsa-miR-190	CLIP-seq
MIRT2040452	hsa-miR-190b	CLIP-seq
MIRT2040453	hsa-miR-193a-3p	CLIP-seq
MIRT2040454	hsa-miR-193b	CLIP-seq
MIRT2040455	hsa-miR-3619-3p	CLIP-seq
MIRT2040456	hsa-miR-4262	CLIP-seq
MIRT2040457	hsa-miR-4643	CLIP-seq
MIRT2040458	hsa-miR-4776-5p	CLIP-seq
MIRT2040459	hsa-miR-543	CLIP-seq
MIRT2040460	hsa-miR-892b	CLIP-seq
MIRT2270217	hsa-miR-125a-3p	CLIP-seq
MIRT2270218	hsa-miR-200b	CLIP-seq
MIRT2270219	hsa-miR-200c	CLIP-seq
MIRT2270220	hsa-miR-3934	CLIP-seq
MIRT2270221	hsa-miR-3942-3p	CLIP-seq
MIRT2270222	hsa-miR-429	CLIP-seq
MIRT2270223	hsa-miR-4427	CLIP-seq
MIRT2270224	hsa-miR-450b-3p	CLIP-seq
MIRT2270225	hsa-miR-4680-3p	CLIP-seq
MIRT2270226	hsa-miR-4713-3p	CLIP-seq
MIRT2270227	hsa-miR-500a	CLIP-seq
MIRT2270228	hsa-miR-516b	CLIP-seq
MIRT2270229	hsa-miR-548a-5p	CLIP-seq
MIRT2270230	hsa-miR-548ab	CLIP-seq
MIRT2270231	hsa-miR-548ak	CLIP-seq
MIRT2270232	hsa-miR-548b-5p	CLIP-seq
MIRT2270233	hsa-miR-548c-5p	CLIP-seq
MIRT2270234	hsa-miR-548d-5p	CLIP-seq
MIRT2270235	hsa-miR-548h	CLIP-seq
MIRT2270236	hsa-miR-548i	CLIP-seq
MIRT2270237	hsa-miR-548j	CLIP-seq
MIRT2270238	hsa-miR-548k	CLIP-seq
MIRT2270239	hsa-miR-548l	CLIP-seq
MIRT2270240	hsa-miR-548w	CLIP-seq
MIRT2270241	hsa-miR-548y	CLIP-seq
MIRT2270242	hsa-miR-559	CLIP-seq
MIRT2270243	hsa-miR-638	CLIP-seq
MIRT2270244	hsa-miR-764	CLIP-seq
MIRT2270245	hsa-miR-769-3p	CLIP-seq
MIRT2040446	hsa-miR-1324	CLIP-seq
MIRT2040451	hsa-miR-190	CLIP-seq
MIRT2040452	hsa-miR-190b	CLIP-seq
MIRT2569340	hsa-miR-3134	CLIP-seq
MIRT2040455	hsa-miR-3619-3p	CLIP-seq
MIRT2569341	hsa-miR-362-5p	CLIP-seq
MIRT2569342	hsa-miR-3935	CLIP-seq
MIRT2569343	hsa-miR-3977	CLIP-seq
MIRT2569344	hsa-miR-4534	CLIP-seq
MIRT2040458	hsa-miR-4776-5p	CLIP-seq
MIRT2569345	hsa-miR-4793-5p	CLIP-seq
MIRT2569346	hsa-miR-500b	CLIP-seq
MIRT2569347	hsa-miR-502-5p	CLIP-seq
MIRT2569348	hsa-miR-513b	CLIP-seq
MIRT2569349	hsa-miR-562	CLIP-seq
MIRT2569350	hsa-miR-767-3p	CLIP-seq
MIRT2040446	hsa-miR-1324	CLIP-seq
MIRT2040451	hsa-miR-190	CLIP-seq
MIRT2040452	hsa-miR-190b	CLIP-seq
MIRT2569340	hsa-miR-3134	CLIP-seq
MIRT2040455	hsa-miR-3619-3p	CLIP-seq
MIRT2569341	hsa-miR-362-5p	CLIP-seq
MIRT2569343	hsa-miR-3977	CLIP-seq
MIRT2569344	hsa-miR-4534	CLIP-seq
MIRT2040458	hsa-miR-4776-5p	CLIP-seq
MIRT2569345	hsa-miR-4793-5p	CLIP-seq
MIRT2569346	hsa-miR-500b	CLIP-seq
MIRT2569347	hsa-miR-502-5p	CLIP-seq
MIRT2569348	hsa-miR-513b	CLIP-seq
MIRT2569350	hsa-miR-767-3p	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0010842	Process	Retina layer formation	ISS
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0034109	Process	Homotypic cell-cell adhesion	ISS

MIM	HGNC	e!Ensembl
612454	29635	ENSG00000157890

A6BM72

Protein name

Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11)

Protein function

May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12661	hEGF	191 → 210	Human growth factor-like EGF	Domain
PF12661	hEGF	234 → 253	Human growth factor-like EGF	Domain
PF00053	Laminin_EGF	275 → 320	Laminin EGF domain	Domain
PF00053	Laminin_EGF	313 → 358	Laminin EGF domain	Domain
PF00053	Laminin_EGF	361 → 409	Laminin EGF domain	Domain
PF12661	hEGF	452 → 471	Human growth factor-like EGF	Domain
PF00053	Laminin_EGF	579 → 622	Laminin EGF domain	Domain
PF00053	Laminin_EGF	618 → 666	Laminin EGF domain	Domain
PF00053	Laminin_EGF	667 → 708	Laminin EGF domain	Domain
PF12661	hEGF	712 → 731	Human growth factor-like EGF	Domain
PF00053	Laminin_EGF	748 → 798	Laminin EGF domain	Domain
PF00053	Laminin_EGF	796 → 832	Laminin EGF domain	Domain

Sequence

MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNW
FKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHC
EPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGT
HGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTC
HHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDR
CQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTL
PCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITG
GCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPC
PSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSH
ADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGF
RGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFG
QDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSA
EDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCE
QRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISP
ALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDY
SLSGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPES
SYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSH
IPGHYDLLPVRQSPANGPSQDKQS

Sequence length

1044

Interactions

View interactions

	KEGG
	Efferocytosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GASTRIC CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HODGKINS LYMPHOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHOID LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	22675446	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	32415115	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MEGF11 (multiple EGF like domains 11)