Gene Gene information from NCBI Gene database.
Entrez ID 84458
Gene name Ligand dependent nuclear receptor corepressor
Gene symbol LCOR
Synonyms (NCBI Gene)
C10orf12MLR2
Chromosome 10
Chromosome location 10q24.1
Summary LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528])
miRNA miRNA information provided by mirtarbase database.
1189
miRTarBase ID miRNA Experiments Reference
MIRT007027 hsa-miR-615-3p Luciferase reporter assay 21565892
MIRT016678 hsa-miR-425-5p Sequencing 20371350
MIRT018627 hsa-miR-335-5p Microarray 18185580
MIRT027215 hsa-miR-103a-3p Sequencing 20371350
MIRT027388 hsa-miR-101-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 12535528
GO:0001222 Function Transcription corepressor binding IPI 29628311
GO:0003677 Function DNA binding IEA
GO:0003714 Function Transcription corepressor activity IDA 12535528
GO:0005515 Function Protein binding IPI 20211142, 25416956, 27705803, 28514442, 29628311, 31041561, 31515488, 32296183, 33961781, 35016035, 35271311
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607698 29503 ENSG00000196233
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96JN0
Protein name Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)
Protein function May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcri
PDB 2COB , 6V3X , 6V3Y
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05225 HTH_psq 350 395 helix-turn-helix, Psq domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12535528}.
Sequence
MQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVTTSPTAATTQNPVLSKLLMAD
QDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHSPGCSSTQGNGRPGRPSQYR
PDGLRSGDGVPPRSLQDGTREGFGHSTSLKVPLARSLQISEELLSRNQLSTAASLGPSGL
QNHGQHLILSREASWAKPHYEFNLSRMKFRGNGALSNISDLPFLAENSAFPKMALQAKQD
GKKDVSHSSPVDLKIPQVRGMDLSWESRTGDQYSYSSLVMGSQTESALSKKLRAILPKQS
RKSMLDAGPDSWGSDAEQSTSGQPYPTSDQEGDPGSKQPRKKRGRYRQYNSEILEEAISV
VMSGKMSVSKAQSIYGIPHSTLEYKVKERLGTLKN
PPKKKMKLMRSEGPDVSVKIELDPQ
GEAAQSANESKNE
Sequence length 433
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Polycomb repressive complex  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MULTIPLE MYELOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOPATHY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Prostate cancer Uncertain significance ClinVar
GWAS catalog
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
PROSTATE CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 32699331 Associate
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 29748186
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 29748186
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 28414308, 30007204
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 19744932, 32157438 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 32157438 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 29453334 Associate
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Endometrial neoplasm Pubtator 34410950 Associate
★☆☆☆☆
Found in Text Mining only
Fatty Liver Fatty Liver BEFREE 21827732
★☆☆☆☆
Found in Text Mining only
Generalized Thyroid Hormone Resistance Thyroid Hormone Resistance BEFREE 12511610
★☆☆☆☆
Found in Text Mining only