Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84451
Gene name	Mitogen-activated protein kinase kinase kinase 21
Gene symbol	MAP3K21
Synonyms (NCBI Gene)	MLK4dJ862P8.3
Chromosome	1
Chromosome location	1q42.2

Show/Hide all (40)

miRTarBase ID	miRNA	Experiments	Reference
MIRT656208	hsa-miR-8485	HITS-CLIP	23824327
MIRT656207	hsa-miR-8064	HITS-CLIP	23824327
MIRT566778	hsa-miR-375	PAR-CLIP	20371350
MIRT064182	hsa-miR-548m	PAR-CLIP	20371350
MIRT064184	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT064190	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT566777	hsa-miR-4804-3p	PAR-CLIP	20371350
MIRT566776	hsa-miR-4720-3p	PAR-CLIP	20371350
MIRT064185	hsa-miR-3935	PAR-CLIP	20371350
MIRT064177	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT064181	hsa-miR-1206	PAR-CLIP	20371350
MIRT064191	hsa-miR-6853-3p	PAR-CLIP	20371350
MIRT566775	hsa-miR-5696	PAR-CLIP	20371350
MIRT064179	hsa-miR-579-3p	PAR-CLIP	20371350
MIRT064189	hsa-miR-664b-3p	PAR-CLIP	20371350
MIRT566774	hsa-miR-6739-3p	PAR-CLIP	20371350
MIRT064238	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT064235	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT112968	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT064260	hsa-miR-216b-5p	PAR-CLIP	21572407
MIRT556114	hsa-miR-3120-3p	PAR-CLIP	21572407
MIRT556113	hsa-miR-4747-3p	PAR-CLIP	21572407
MIRT064264	hsa-miR-1245b-5p	PAR-CLIP	21572407
MIRT064262	hsa-miR-3142	PAR-CLIP	21572407
MIRT064263	hsa-miR-4650-5p	PAR-CLIP	21572407
MIRT556112	hsa-miR-6728-3p	PAR-CLIP	21572407
MIRT556111	hsa-miR-5704	PAR-CLIP	21572407
MIRT556110	hsa-miR-1295a	PAR-CLIP	21572407
MIRT504297	hsa-miR-543	PAR-CLIP	23446348
MIRT337093	hsa-miR-548ag	PAR-CLIP	23446348
MIRT337094	hsa-miR-548ai	PAR-CLIP	23446348
MIRT337098	hsa-miR-548ba	PAR-CLIP	23446348
MIRT337092	hsa-miR-570-5p	PAR-CLIP	23446348
MIRT064183	hsa-miR-4289	PAR-CLIP	23446348
MIRT337090	hsa-miR-551a	PAR-CLIP	23446348
MIRT337091	hsa-miR-551b-3p	PAR-CLIP	23446348
MIRT504296	hsa-miR-493-3p	PAR-CLIP	23446348
MIRT504294	hsa-miR-3143	PAR-CLIP	23446348
MIRT504295	hsa-miR-218-5p	PAR-CLIP	23446348
MIRT504293	hsa-miR-302c-5p	PAR-CLIP	23446348

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004706	Function	JUN kinase kinase kinase activity	ISS
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	20936779, 26859459, 32707033
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006468	Process	Protein phosphorylation	ISS
GO:0007165	Process	Signal transduction	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0046777	Process	Protein autophosphorylation	ISS
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
614793	29798	ENSG00000143674

Q5TCX8

Protein name

Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)

Protein function

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

PDB

4UYA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14604	SH3_9	45 → 98	Variant SH3 domain	Domain
PF07714	PK_Tyr_Ser-Thr	124 → 398	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
KTSRPSIYELEKEFLS

Sequence length

1036

Interactions

View interactions

	KEGG
	MAPK signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DENTAL ENAMEL HYPOPLASIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	30552384		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cap Myopathy	Cap myopathy	Pubtator	29453410	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	31701729	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	26637668		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23319808, 31701729		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31701729	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	26859459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	26859459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31071576		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	31071576		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30552384		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30233678, 30552384		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	26637668		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23319808, 26637668, 30552384, 31701729		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30552384		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	37594950	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MAP3K21 (mitogen-activated protein kinase kinase kinase 21)