ABLIM2 (actin binding LIM protein family member 2)

Gene

• Entrez ID: 84448
• Gene name: Actin binding LIM protein family member 2
• Gene symbol: ABLIM2
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4p16.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT760922	hsa-miR-1255a	CLIP-seq
MIRT760923	hsa-miR-1255b	CLIP-seq
MIRT760924	hsa-miR-1291	CLIP-seq
MIRT760925	hsa-miR-2467-5p	CLIP-seq
MIRT760926	hsa-miR-3188	CLIP-seq
MIRT760927	hsa-miR-3194-3p	CLIP-seq
MIRT760928	hsa-miR-3975	CLIP-seq
MIRT760929	hsa-miR-4293	CLIP-seq
MIRT760930	hsa-miR-4649-3p	CLIP-seq
MIRT760931	hsa-miR-4732-3p	CLIP-seq
MIRT760932	hsa-miR-485-5p	CLIP-seq
MIRT760933	hsa-miR-5096	CLIP-seq
MIRT760934	hsa-miR-513a-5p	CLIP-seq
MIRT760935	hsa-miR-516b	CLIP-seq
MIRT760936	hsa-miR-544b	CLIP-seq
MIRT760937	hsa-miR-550a	CLIP-seq
MIRT760938	hsa-miR-3155	CLIP-seq
MIRT760939	hsa-miR-3155b	CLIP-seq
MIRT760940	hsa-miR-3180-5p	CLIP-seq
MIRT760941	hsa-miR-3929	CLIP-seq
MIRT760942	hsa-miR-4307	CLIP-seq
MIRT760943	hsa-miR-4329	CLIP-seq
MIRT760944	hsa-miR-4419b	CLIP-seq
MIRT760945	hsa-miR-4478	CLIP-seq
MIRT760946	hsa-miR-484	CLIP-seq
MIRT760938	hsa-miR-3155	CLIP-seq
MIRT760939	hsa-miR-3155b	CLIP-seq
MIRT760940	hsa-miR-3180-5p	CLIP-seq
MIRT760946	hsa-miR-484	CLIP-seq
MIRT2383778	hsa-miR-146b-3p	CLIP-seq
MIRT760938	hsa-miR-3155	CLIP-seq
MIRT760939	hsa-miR-3155b	CLIP-seq
MIRT2383779	hsa-miR-339-5p	CLIP-seq
MIRT2383780	hsa-miR-3655	CLIP-seq
MIRT2383781	hsa-miR-431	CLIP-seq
MIRT2383782	hsa-miR-4421	CLIP-seq
MIRT2383783	hsa-miR-4646-3p	CLIP-seq
MIRT2383784	hsa-miR-4780	CLIP-seq
MIRT760946	hsa-miR-484	CLIP-seq
MIRT2383785	hsa-miR-489	CLIP-seq
MIRT2383786	hsa-miR-623	CLIP-seq
MIRT2383787	hsa-miR-653	CLIP-seq
MIRT2468005	hsa-miR-1231	CLIP-seq
MIRT2468006	hsa-miR-1273g	CLIP-seq
MIRT2468007	hsa-miR-3127-5p	CLIP-seq
MIRT2468008	hsa-miR-323b-5p	CLIP-seq
MIRT2468009	hsa-miR-4270	CLIP-seq
MIRT2468010	hsa-miR-4288	CLIP-seq
MIRT2468011	hsa-miR-4441	CLIP-seq
MIRT2468012	hsa-miR-632	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	26871637, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	IDA	17194709
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0030032	Process	Lamellipodium assembly	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051015	Function	Actin filament binding	IBA

Other IDs

• MIM: 612544
• HGNC: 19195
• e!Ensembl: ENSG00000163995

Protein

• UniProt ID: Q6H8Q1
• Protein name: Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2)
• Protein function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
• PDB: 1V6G, 1WIG, 2L3X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00412	LIM	24 → 79	LIM domain	Domain
  PF00412	LIM	83 → 137	LIM domain	Domain
  PF00412	LIM	153 → 208	LIM domain	Domain
  PF00412	LIM	212 → 266	LIM domain	Domain
  PF16182	AbLIM_anchor	276 → 453	Putative adherens-junction anchoring region of AbLIM	Family
  PF16182	AbLIM_anchor	442 → 575	Putative adherens-junction anchoring region of AbLIM	Family
  PF02209	VHP	576 → 611	Villin headpiece domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in skeletal muscle. {ECO:0000269|PubMed:17194709}.
• Sequence:

  MSAVSQPQAAPSPLEKSPSTAILCNTCGNVCKGEVLRVQDKYFHIKCFVCKACGCDLAEG
  GFFVRQGEYICTLDYQRLYGTRCFSCDQFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGD
  RVTFNGKECMCQKCSLPVSVGSSAHLSQGLRSCGGCGTEIKNGQALVALDKHWHLGCFKC
  KSCGKLLNAEYISKDGLPYCEADYHAKFGIRCDSCEKYITGRVLEAGEKHYHPSCALCVR
  CGQMFAEGEEMYLQGSSIWHPACRQAARTEDRNKETRTSSESIISVPASSTSGSPSRVIY
  AKLGGEILDYRDLAALPKSKAIYDIDRPDMISYSPYISHSAGDRQSYGEGDQDDRSYKQC
  RTSSPSSTGSVSLGRYTPTSRSPQHYSRPGSESGRSTPSLSVLSDSKPPPSTYQQAPRHF
  HVPDTGVKDNIYRKPPIYRQHAARRSDGEDGSLDQDNRKKSSWLMLKGDADTRTNSPDLD
  TQSLSHSSGTDRDPLQRMAGDSFHSRFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDAS
  WGMREYKIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWK
  RNDLKKKALLF

• Sequence length: 611

Pathways

KEGG:

Axon guidance

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DIFFUSE GASTRIC ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	31755389	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	26634245		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	31755389	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	31755389		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	29924424	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only