Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84439
Gene name	HHIP like 1
Gene symbol	HHIPL1
Synonyms (NCBI Gene)	KIAA1822UNQ9245
Chromosome	14
Chromosome location	14q32.2
Summary	This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. [provided by RefSeq, Jul 2016]

139

Show/Hide all (139)

miRTarBase ID	miRNA	Experiments	Reference
MIRT641073	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT641072	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT641071	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT641070	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT647356	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT641069	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647354	hsa-miR-891b	HITS-CLIP	23824327
MIRT647353	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT647352	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT647351	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT641067	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT641074	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT641073	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT641072	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT641071	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT641070	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT647356	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT641069	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641068	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647355	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT647354	hsa-miR-891b	HITS-CLIP	23824327
MIRT647353	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT647352	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT647351	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT641067	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT641074	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT641073	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT641072	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT641071	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT641070	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT641069	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641068	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT641067	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT475700	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT475699	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT475698	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT475697	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT475696	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT475695	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT475693	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT475694	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT475692	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT475691	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT475690	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT475689	hsa-miR-940	PAR-CLIP	23592263
MIRT475688	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT475687	hsa-miR-1827	PAR-CLIP	23592263
MIRT475686	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT475685	hsa-miR-3612	PAR-CLIP	23592263
MIRT475684	hsa-miR-650	PAR-CLIP	23592263
MIRT475683	hsa-miR-6801-5p	PAR-CLIP	23592263
MIRT475681	hsa-miR-3650	PAR-CLIP	23592263
MIRT641073	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT641072	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT641071	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT641070	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT647356	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT641069	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT647354	hsa-miR-891b	HITS-CLIP	23824327
MIRT647353	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT647352	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT647351	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT641067	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT641074	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT641073	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT641072	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT641071	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT641070	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT647356	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT641069	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641068	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT647355	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT647354	hsa-miR-891b	HITS-CLIP	23824327
MIRT647353	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT647352	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT647351	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT641067	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT641074	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT641073	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT641072	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT641071	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT641070	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT641069	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT641068	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT641067	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT475700	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT475699	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT475698	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT475697	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT475696	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT475695	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT475693	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT475694	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT475692	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT475691	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT475690	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT475689	hsa-miR-940	PAR-CLIP	23592263
MIRT475688	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT475687	hsa-miR-1827	PAR-CLIP	23592263
MIRT475686	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT475685	hsa-miR-3612	PAR-CLIP	23592263
MIRT475684	hsa-miR-650	PAR-CLIP	23592263
MIRT475683	hsa-miR-6801-5p	PAR-CLIP	23592263
MIRT475681	hsa-miR-3650	PAR-CLIP	23592263
MIRT1045016	hsa-miR-149	CLIP-seq
MIRT1045017	hsa-miR-193a-5p	CLIP-seq
MIRT1045018	hsa-miR-1972	CLIP-seq
MIRT1045019	hsa-miR-1976	CLIP-seq
MIRT1045020	hsa-miR-3189-3p	CLIP-seq
MIRT1045021	hsa-miR-3665	CLIP-seq
MIRT1045022	hsa-miR-4268	CLIP-seq
MIRT1045023	hsa-miR-4312	CLIP-seq
MIRT1045024	hsa-miR-4468	CLIP-seq
MIRT1045025	hsa-miR-4650-5p	CLIP-seq
MIRT1045026	hsa-miR-4691-5p	CLIP-seq
MIRT1045027	hsa-miR-4717-5p	CLIP-seq
MIRT1045028	hsa-miR-4722-3p	CLIP-seq
MIRT1045029	hsa-miR-483-3p	CLIP-seq
MIRT1045030	hsa-miR-550a	CLIP-seq
MIRT1045031	hsa-miR-603	CLIP-seq
MIRT1045032	hsa-miR-764	CLIP-seq
MIRT2242245	hsa-miR-4726-3p	CLIP-seq
MIRT2242246	hsa-miR-665	CLIP-seq
MIRT2242247	hsa-miR-124	CLIP-seq
MIRT2242248	hsa-miR-3160-3p	CLIP-seq
MIRT2242249	hsa-miR-3202	CLIP-seq
MIRT2242250	hsa-miR-3652	CLIP-seq
MIRT2242251	hsa-miR-3915	CLIP-seq
MIRT2242252	hsa-miR-3928	CLIP-seq
MIRT2242253	hsa-miR-4430	CLIP-seq
MIRT2242254	hsa-miR-4446-3p	CLIP-seq
MIRT2242255	hsa-miR-4476	CLIP-seq
MIRT2242256	hsa-miR-4492	CLIP-seq
MIRT2242257	hsa-miR-4493	CLIP-seq
MIRT2242258	hsa-miR-4498	CLIP-seq
MIRT2242259	hsa-miR-4520a-3p	CLIP-seq
MIRT2242260	hsa-miR-4638-3p	CLIP-seq
MIRT2242261	hsa-miR-506	CLIP-seq
MIRT2242262	hsa-miR-762	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005575	Component	Cellular_component	ND
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0007224	Process	Smoothened signaling pathway	IEA
GO:0008150	Process	Biological_process	ND
GO:0008283	Process	Cell population proliferation	IEA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IEA
GO:0060840	Process	Artery development	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q96JK4

Protein name

HHIP-like protein 1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03024	Folate_rec	22 → 183	Folate receptor family	Domain
PF07995	GSDH	193 → 527	Glucose / Sorbosone dehydrogenase	Domain
PF00530	SRCR	679 → 776	Scavenger receptor cysteine-rich domain	Domain

Sequence

MARARAGALLALWVLGAAAHPQCLDFRPPFRPTQPLRLCAQYSDFGCCDEGRDAELTRRF
WALASRVDAAEWAACAGYARDLLCQECSPYAAHLYDAEDPFTPLRTVPGLCQDYCLDMWH
KCRGLFRHLSTDQELWALEGNLARFCRYLSLDDTDYCFPYLLVNKNLNSNLGHVVADAKG
CLQLCLEEVANGLRNPVAMVHARDGTHRFFVAEQVGLVWAYLPDRSRLGKPFLNISRVVL
TSPWEGDERGFLGIAFHPSFQHNRRLYVYYSVGIRSSEWIRISEFRVSEDDENAVDHSSE
RIILEVKEPASNHNGGQLLFGDDGYLYIFTGDGGMAGDPFGTFGNAQNKSALLGKVLRID
VDRKERGLPYGIPPDNPFVGDPAAQPEVYALGVRNMWRCSFDRGDPSSGTGRGRLFCGDV
GQNKFEEVDVVERGGNYGWRAREGFECYDRSLCANTSLNDLLPIFAYPHTVGKSVTGGYV
YRGCEYPNLNGLYIFGDFMSGRLMSLQENPGTGQWQYSEICMGHGQTCEFPGLINNYYPY
IISFGEDEAGELYFMSTGEPSATAPRGVVYKIIDASRRAPPGKCQIQPAQVKIRSRLIPF
VPKEKFIPKTRSTPRPTARAPTRAPRRGRPTAAPPAPTPRPARPTQQPGSRRGGGRRRGR
LNSASRAFRDGEVRLVRPAGLSSGSGRVEVFVGGRWGTVCDDSWNISGAAVVCRQLGFAY
AVRAVKRAEFGQGGSLPILLDDVRCAGWERNLLECQHNGVGTHNCEHDEDAGVVCSHQNP
DL

Sequence length

782

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARPAL TUNNEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	CTD, GWAS catalog CTD, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ATHEROSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenoma	Adenoma	BEFREE	23045325	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	24573017, 31163988	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	24573017, 31163988	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	29655894	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	CTD_human_DG	21378990	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	31163988	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	CTD_human_DG	21378990	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	GWASDB_DG	23202125	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	26343387, 28714975, 29212778	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	BEFREE	31163988	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1	Coronary artery disease	GWASDB_DG	23202125	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASDB_DG	21378990	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary heart disease	Coronary Heart Disease	GWASCAT_DG	21378990	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary heart disease	Coronary Heart Disease	BEFREE	31163988	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	BEFREE	29655894	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

HHIPL1 (HHIP like 1)