Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84280
Gene name	BTB domain containing 10
Gene symbol	BTBD10
Synonyms (NCBI Gene)	GMRP-1GMRP1
Chromosome	11
Chromosome location	11p15.3

209

Show/Hide all (209)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019640	hsa-miR-340-5p	Sequencing	20371350
MIRT020297	hsa-miR-130b-3p	Sequencing	20371350
MIRT028112	hsa-miR-93-5p	Sequencing	20371350
MIRT031244	hsa-miR-19b-3p	Sequencing	20371350
MIRT043765	hsa-miR-328-3p	CLASH	23622248
MIRT826242	hsa-miR-1208	CLIP-seq
MIRT826243	hsa-miR-22	CLIP-seq
MIRT826244	hsa-miR-3150b-3p	CLIP-seq
MIRT826245	hsa-miR-3611	CLIP-seq
MIRT826246	hsa-miR-3692	CLIP-seq
MIRT826247	hsa-miR-4689	CLIP-seq
MIRT826248	hsa-miR-4709-3p	CLIP-seq
MIRT826249	hsa-miR-4784	CLIP-seq
MIRT826250	hsa-miR-498	CLIP-seq
MIRT826251	hsa-miR-584	CLIP-seq
MIRT1944315	hsa-miR-1270	CLIP-seq
MIRT1944316	hsa-miR-3545-3p	CLIP-seq
MIRT826246	hsa-miR-3692	CLIP-seq
MIRT1944317	hsa-miR-4490	CLIP-seq
MIRT1944318	hsa-miR-4509	CLIP-seq
MIRT1944319	hsa-miR-4539	CLIP-seq
MIRT1944320	hsa-miR-4639-3p	CLIP-seq
MIRT1944321	hsa-miR-4683	CLIP-seq
MIRT1944322	hsa-miR-4724-5p	CLIP-seq
MIRT1944323	hsa-miR-4744	CLIP-seq
MIRT1944324	hsa-miR-4766-5p	CLIP-seq
MIRT1944325	hsa-miR-516b	CLIP-seq
MIRT1944326	hsa-miR-579	CLIP-seq
MIRT1944327	hsa-miR-582-3p	CLIP-seq
MIRT1944328	hsa-miR-620	CLIP-seq
MIRT1944329	hsa-miR-760	CLIP-seq
MIRT2182847	hsa-miR-106a	CLIP-seq
MIRT2182848	hsa-miR-106b	CLIP-seq
MIRT1944315	hsa-miR-1270	CLIP-seq
MIRT2182849	hsa-miR-134	CLIP-seq
MIRT2182850	hsa-miR-142-5p	CLIP-seq
MIRT2182851	hsa-miR-17	CLIP-seq
MIRT2182852	hsa-miR-181a	CLIP-seq
MIRT2182853	hsa-miR-181b	CLIP-seq
MIRT2182854	hsa-miR-181c	CLIP-seq
MIRT2182855	hsa-miR-181d	CLIP-seq
MIRT2182856	hsa-miR-1910	CLIP-seq
MIRT2182857	hsa-miR-203	CLIP-seq
MIRT2182858	hsa-miR-20a	CLIP-seq
MIRT2182859	hsa-miR-20b	CLIP-seq
MIRT2182860	hsa-miR-3074-3p	CLIP-seq
MIRT2182861	hsa-miR-30a	CLIP-seq
MIRT2182862	hsa-miR-30b	CLIP-seq
MIRT2182863	hsa-miR-30c	CLIP-seq
MIRT2182864	hsa-miR-30d	CLIP-seq
MIRT2182865	hsa-miR-30e	CLIP-seq
MIRT2182866	hsa-miR-3118	CLIP-seq
MIRT2182867	hsa-miR-3164	CLIP-seq
MIRT2182868	hsa-miR-3200-5p	CLIP-seq
MIRT2182869	hsa-miR-340	CLIP-seq
MIRT1944316	hsa-miR-3545-3p	CLIP-seq
MIRT2182870	hsa-miR-3607-5p	CLIP-seq
MIRT2182871	hsa-miR-3609	CLIP-seq
MIRT2182872	hsa-miR-3660	CLIP-seq
MIRT2182873	hsa-miR-3680	CLIP-seq
MIRT2182874	hsa-miR-4262	CLIP-seq
MIRT1944317	hsa-miR-4490	CLIP-seq
MIRT2182875	hsa-miR-4501	CLIP-seq
MIRT1944318	hsa-miR-4509	CLIP-seq
MIRT2182876	hsa-miR-4526	CLIP-seq
MIRT1944319	hsa-miR-4539	CLIP-seq
MIRT2182877	hsa-miR-455-3p	CLIP-seq
MIRT1944320	hsa-miR-4639-3p	CLIP-seq
MIRT2182878	hsa-miR-4649-3p	CLIP-seq
MIRT1944321	hsa-miR-4683	CLIP-seq
MIRT2182879	hsa-miR-4719	CLIP-seq
MIRT1944322	hsa-miR-4724-5p	CLIP-seq
MIRT1944323	hsa-miR-4744	CLIP-seq
MIRT2182880	hsa-miR-4796-3p	CLIP-seq
MIRT2182881	hsa-miR-513b	CLIP-seq
MIRT1944325	hsa-miR-516b	CLIP-seq
MIRT2182882	hsa-miR-519d	CLIP-seq
MIRT2182883	hsa-miR-548ah	CLIP-seq
MIRT2182884	hsa-miR-548k	CLIP-seq
MIRT1944327	hsa-miR-582-3p	CLIP-seq
MIRT1944328	hsa-miR-620	CLIP-seq
MIRT1944329	hsa-miR-760	CLIP-seq
MIRT2182885	hsa-miR-93	CLIP-seq
MIRT1944315	hsa-miR-1270	CLIP-seq
MIRT2182857	hsa-miR-203	CLIP-seq
MIRT1944320	hsa-miR-4639-3p	CLIP-seq
MIRT1944321	hsa-miR-4683	CLIP-seq
MIRT1944325	hsa-miR-516b	CLIP-seq
MIRT1944328	hsa-miR-620	CLIP-seq
MIRT1944329	hsa-miR-760	CLIP-seq
MIRT2182847	hsa-miR-106a	CLIP-seq
MIRT2182848	hsa-miR-106b	CLIP-seq
MIRT2486480	hsa-miR-1178	CLIP-seq
MIRT1944315	hsa-miR-1270	CLIP-seq
MIRT2486481	hsa-miR-129-5p	CLIP-seq
MIRT2486482	hsa-miR-130a	CLIP-seq
MIRT2486483	hsa-miR-130b	CLIP-seq
MIRT2486484	hsa-miR-135a	CLIP-seq
MIRT2486485	hsa-miR-135b	CLIP-seq
MIRT2182850	hsa-miR-142-5p	CLIP-seq
MIRT2182851	hsa-miR-17	CLIP-seq
MIRT2182857	hsa-miR-203	CLIP-seq
MIRT2182858	hsa-miR-20a	CLIP-seq
MIRT2182859	hsa-miR-20b	CLIP-seq
MIRT2486486	hsa-miR-216a	CLIP-seq
MIRT2486487	hsa-miR-301a	CLIP-seq
MIRT2486488	hsa-miR-301b	CLIP-seq
MIRT2486489	hsa-miR-3146	CLIP-seq
MIRT2486490	hsa-miR-3163	CLIP-seq
MIRT2182868	hsa-miR-3200-5p	CLIP-seq
MIRT2182869	hsa-miR-340	CLIP-seq
MIRT1944316	hsa-miR-3545-3p	CLIP-seq
MIRT2182871	hsa-miR-3609	CLIP-seq
MIRT2486491	hsa-miR-3613-5p	CLIP-seq
MIRT2486492	hsa-miR-3662	CLIP-seq
MIRT2486493	hsa-miR-3664-5p	CLIP-seq
MIRT2486494	hsa-miR-3666	CLIP-seq
MIRT2486495	hsa-miR-3942-3p	CLIP-seq
MIRT2486496	hsa-miR-3945	CLIP-seq
MIRT2486497	hsa-miR-4253	CLIP-seq
MIRT2486498	hsa-miR-4295	CLIP-seq
MIRT1944317	hsa-miR-4490	CLIP-seq
MIRT1944318	hsa-miR-4509	CLIP-seq
MIRT1944319	hsa-miR-4539	CLIP-seq
MIRT2486499	hsa-miR-454	CLIP-seq
MIRT1944320	hsa-miR-4639-3p	CLIP-seq
MIRT2486500	hsa-miR-4662a-3p	CLIP-seq
MIRT1944321	hsa-miR-4683	CLIP-seq
MIRT2486501	hsa-miR-4698	CLIP-seq
MIRT2486502	hsa-miR-4711-5p	CLIP-seq
MIRT2486503	hsa-miR-4714-5p	CLIP-seq
MIRT1944322	hsa-miR-4724-5p	CLIP-seq
MIRT2486504	hsa-miR-4729	CLIP-seq
MIRT1944323	hsa-miR-4744	CLIP-seq
MIRT2486505	hsa-miR-4793-5p	CLIP-seq
MIRT2182880	hsa-miR-4796-3p	CLIP-seq
MIRT1944325	hsa-miR-516b	CLIP-seq
MIRT2486506	hsa-miR-519a	CLIP-seq
MIRT2486507	hsa-miR-519b-3p	CLIP-seq
MIRT2486508	hsa-miR-519c-3p	CLIP-seq
MIRT2182882	hsa-miR-519d	CLIP-seq
MIRT2182883	hsa-miR-548ah	CLIP-seq
MIRT2486509	hsa-miR-577	CLIP-seq
MIRT1944327	hsa-miR-582-3p	CLIP-seq
MIRT2486510	hsa-miR-587	CLIP-seq
MIRT1944328	hsa-miR-620	CLIP-seq
MIRT2486511	hsa-miR-656	CLIP-seq
MIRT1944329	hsa-miR-760	CLIP-seq
MIRT2486512	hsa-miR-891b	CLIP-seq
MIRT2182885	hsa-miR-93	CLIP-seq
MIRT2182847	hsa-miR-106a	CLIP-seq
MIRT2182848	hsa-miR-106b	CLIP-seq
MIRT2486480	hsa-miR-1178	CLIP-seq
MIRT1944315	hsa-miR-1270	CLIP-seq
MIRT2486481	hsa-miR-129-5p	CLIP-seq
MIRT2486482	hsa-miR-130a	CLIP-seq
MIRT2486483	hsa-miR-130b	CLIP-seq
MIRT2486484	hsa-miR-135a	CLIP-seq
MIRT2486485	hsa-miR-135b	CLIP-seq
MIRT2182850	hsa-miR-142-5p	CLIP-seq
MIRT2182851	hsa-miR-17	CLIP-seq
MIRT2182857	hsa-miR-203	CLIP-seq
MIRT2182858	hsa-miR-20a	CLIP-seq
MIRT2182859	hsa-miR-20b	CLIP-seq
MIRT2486486	hsa-miR-216a	CLIP-seq
MIRT2486487	hsa-miR-301a	CLIP-seq
MIRT2486488	hsa-miR-301b	CLIP-seq
MIRT2486489	hsa-miR-3146	CLIP-seq
MIRT2486490	hsa-miR-3163	CLIP-seq
MIRT2182869	hsa-miR-340	CLIP-seq
MIRT1944316	hsa-miR-3545-3p	CLIP-seq
MIRT2182871	hsa-miR-3609	CLIP-seq
MIRT2486491	hsa-miR-3613-5p	CLIP-seq
MIRT2486492	hsa-miR-3662	CLIP-seq
MIRT2486493	hsa-miR-3664-5p	CLIP-seq
MIRT2486494	hsa-miR-3666	CLIP-seq
MIRT2486495	hsa-miR-3942-3p	CLIP-seq
MIRT2486496	hsa-miR-3945	CLIP-seq
MIRT2486497	hsa-miR-4253	CLIP-seq
MIRT2486498	hsa-miR-4295	CLIP-seq
MIRT1944317	hsa-miR-4490	CLIP-seq
MIRT1944318	hsa-miR-4509	CLIP-seq
MIRT1944319	hsa-miR-4539	CLIP-seq
MIRT2486499	hsa-miR-454	CLIP-seq
MIRT1944320	hsa-miR-4639-3p	CLIP-seq
MIRT2486500	hsa-miR-4662a-3p	CLIP-seq
MIRT1944321	hsa-miR-4683	CLIP-seq
MIRT2486501	hsa-miR-4698	CLIP-seq
MIRT2486502	hsa-miR-4711-5p	CLIP-seq
MIRT2486503	hsa-miR-4714-5p	CLIP-seq
MIRT1944322	hsa-miR-4724-5p	CLIP-seq
MIRT2486504	hsa-miR-4729	CLIP-seq
MIRT1944323	hsa-miR-4744	CLIP-seq
MIRT2486505	hsa-miR-4793-5p	CLIP-seq
MIRT2182880	hsa-miR-4796-3p	CLIP-seq
MIRT1944325	hsa-miR-516b	CLIP-seq
MIRT2486506	hsa-miR-519a	CLIP-seq
MIRT2486507	hsa-miR-519b-3p	CLIP-seq
MIRT2486508	hsa-miR-519c-3p	CLIP-seq
MIRT2182882	hsa-miR-519d	CLIP-seq
MIRT2182883	hsa-miR-548ah	CLIP-seq
MIRT2486509	hsa-miR-577	CLIP-seq
MIRT1944327	hsa-miR-582-3p	CLIP-seq
MIRT2486510	hsa-miR-587	CLIP-seq
MIRT1944328	hsa-miR-620	CLIP-seq
MIRT2486511	hsa-miR-656	CLIP-seq
MIRT1944329	hsa-miR-760	CLIP-seq
MIRT2486512	hsa-miR-891b	CLIP-seq
MIRT2182885	hsa-miR-93	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	21145461, 21988832, 33961781, 34591642
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0044342	Process	Type B pancreatic cell proliferation	ISS
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS

MIM	HGNC	e!Ensembl
615933	21445	ENSG00000148925

Q9BSF8

Protein name

BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1)

Protein function

Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. {ECO:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16017	BTB_3	168 → 273	BTB/POZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma. {ECO:0000

Sequence

MAGRPHPYDGNSSDPENWDRKLHSRPRKLYKHSSTSSRIAKGGVDHTKMSLHGASGGHER
SRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASP
NGSISSAGNSSRNSSQSSSDGSCKTAGEMVFVYENAKEGARNIRTSERVTLIVDNTRFVV
DPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCP
DGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVAS
AQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLK
ERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCV
KSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIHPPSGNSDLDPDAQNPML

Sequence length

475

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	18160256		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	LHGDN	18160256		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	35608340	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	15556295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	15556295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15556295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	25772781	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35306527	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30843665	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

BTBD10 (BTB domain containing 10)