Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84263
Gene name	Hydroxysteroid dehydrogenase like 2
Gene symbol	HSDL2
Synonyms (NCBI Gene)	C9orf99SDR13C1
Chromosome	9
Chromosome location	9q32

156

Show/Hide all (156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000865	hsa-miR-15a-5p	Microarray	18362358
MIRT000864	hsa-miR-16-5p	Microarray	18362358
MIRT043745	hsa-miR-328-3p	CLASH	23622248
MIRT756041	hsa-miR-26a-5p	Luciferase reporter assayWestern blottingqRT-PCRImmunohistochemistry (IHC)Flow cytometry	35948893
MIRT1055674	hsa-miR-2467-3p	CLIP-seq
MIRT1055675	hsa-miR-4422	CLIP-seq
MIRT1055676	hsa-miR-516a-3p	CLIP-seq
MIRT1055677	hsa-miR-103a	CLIP-seq
MIRT1055678	hsa-miR-107	CLIP-seq
MIRT1055679	hsa-miR-1182	CLIP-seq
MIRT1055680	hsa-miR-1323	CLIP-seq
MIRT1055681	hsa-miR-138	CLIP-seq
MIRT1055682	hsa-miR-183	CLIP-seq
MIRT1055683	hsa-miR-193a-5p	CLIP-seq
MIRT1055684	hsa-miR-2053	CLIP-seq
MIRT1055685	hsa-miR-224	CLIP-seq
MIRT1055686	hsa-miR-300	CLIP-seq
MIRT1055687	hsa-miR-302f	CLIP-seq
MIRT1055688	hsa-miR-3132	CLIP-seq
MIRT1055689	hsa-miR-3182	CLIP-seq
MIRT1055690	hsa-miR-3183	CLIP-seq
MIRT1055691	hsa-miR-338-5p	CLIP-seq
MIRT1055692	hsa-miR-3545-3p	CLIP-seq
MIRT1055693	hsa-miR-375	CLIP-seq
MIRT1055694	hsa-miR-381	CLIP-seq
MIRT1055695	hsa-miR-4273	CLIP-seq
MIRT1055696	hsa-miR-4278	CLIP-seq
MIRT1055697	hsa-miR-4451	CLIP-seq
MIRT1055698	hsa-miR-4484	CLIP-seq
MIRT1055699	hsa-miR-4659a-3p	CLIP-seq
MIRT1055700	hsa-miR-4659b-3p	CLIP-seq
MIRT1055701	hsa-miR-4666-3p	CLIP-seq
MIRT1055702	hsa-miR-4677-5p	CLIP-seq
MIRT1055703	hsa-miR-4716-3p	CLIP-seq
MIRT1055704	hsa-miR-4720-3p	CLIP-seq
MIRT1055705	hsa-miR-4723-3p	CLIP-seq
MIRT1055706	hsa-miR-4781-3p	CLIP-seq
MIRT1055707	hsa-miR-4786-3p	CLIP-seq
MIRT1055708	hsa-miR-4804-3p	CLIP-seq
MIRT1055709	hsa-miR-548an	CLIP-seq
MIRT1055710	hsa-miR-548o	CLIP-seq
MIRT1055711	hsa-miR-550b	CLIP-seq
MIRT2012777	hsa-miR-1267	CLIP-seq
MIRT2012778	hsa-miR-3180-5p	CLIP-seq
MIRT2012779	hsa-miR-4274	CLIP-seq
MIRT2012780	hsa-miR-4519	CLIP-seq
MIRT2012781	hsa-miR-4661-5p	CLIP-seq
MIRT2012782	hsa-miR-495	CLIP-seq
MIRT2012783	hsa-miR-520a-5p	CLIP-seq
MIRT2012784	hsa-miR-525-5p	CLIP-seq
MIRT2012785	hsa-miR-579	CLIP-seq
MIRT2012786	hsa-miR-944	CLIP-seq
MIRT2245105	hsa-miR-1976	CLIP-seq
MIRT2547977	hsa-miR-181a	CLIP-seq
MIRT2547978	hsa-miR-181b	CLIP-seq
MIRT2547979	hsa-miR-181c	CLIP-seq
MIRT2547980	hsa-miR-181d	CLIP-seq
MIRT2547981	hsa-miR-23a	CLIP-seq
MIRT2547982	hsa-miR-23b	CLIP-seq
MIRT2547983	hsa-miR-23c	CLIP-seq
MIRT2547984	hsa-miR-4262	CLIP-seq
MIRT2547985	hsa-miR-1193	CLIP-seq
MIRT2547986	hsa-miR-1273f	CLIP-seq
MIRT2547987	hsa-miR-127-5p	CLIP-seq
MIRT2547988	hsa-miR-1343	CLIP-seq
MIRT2547989	hsa-miR-136	CLIP-seq
MIRT2547990	hsa-miR-143	CLIP-seq
MIRT2547991	hsa-miR-185	CLIP-seq
MIRT2547992	hsa-miR-203	CLIP-seq
MIRT1055684	hsa-miR-2053	CLIP-seq
MIRT2547993	hsa-miR-21	CLIP-seq
MIRT2547994	hsa-miR-3156-3p	CLIP-seq
MIRT2547995	hsa-miR-3163	CLIP-seq
MIRT2547996	hsa-miR-3198	CLIP-seq
MIRT2547997	hsa-miR-3690	CLIP-seq
MIRT2547998	hsa-miR-421	CLIP-seq
MIRT2547999	hsa-miR-4254	CLIP-seq
MIRT2548000	hsa-miR-4272	CLIP-seq
MIRT2548001	hsa-miR-4301	CLIP-seq
MIRT2548002	hsa-miR-4306	CLIP-seq
MIRT2548003	hsa-miR-4307	CLIP-seq
MIRT2548004	hsa-miR-4309	CLIP-seq
MIRT2548005	hsa-miR-432	CLIP-seq
MIRT2548006	hsa-miR-4453	CLIP-seq
MIRT2548007	hsa-miR-4494	CLIP-seq
MIRT2548008	hsa-miR-4534	CLIP-seq
MIRT2548009	hsa-miR-4538	CLIP-seq
MIRT2548010	hsa-miR-4644	CLIP-seq
MIRT2548011	hsa-miR-4653-3p	CLIP-seq
MIRT2548012	hsa-miR-4659a-5p	CLIP-seq
MIRT2548013	hsa-miR-4659b-5p	CLIP-seq
MIRT2548014	hsa-miR-4666-5p	CLIP-seq
MIRT2548015	hsa-miR-4708-5p	CLIP-seq
MIRT2548016	hsa-miR-4738-3p	CLIP-seq
MIRT2548017	hsa-miR-4770	CLIP-seq
MIRT2548018	hsa-miR-4776-3p	CLIP-seq
MIRT2548019	hsa-miR-4780	CLIP-seq
MIRT2548020	hsa-miR-4802-3p	CLIP-seq
MIRT2548021	hsa-miR-4803	CLIP-seq
MIRT2548022	hsa-miR-548ac	CLIP-seq
MIRT2548023	hsa-miR-548ae	CLIP-seq
MIRT2548024	hsa-miR-548aj	CLIP-seq
MIRT2548025	hsa-miR-548am	CLIP-seq
MIRT2548026	hsa-miR-548d-3p	CLIP-seq
MIRT2548027	hsa-miR-548g	CLIP-seq
MIRT2548028	hsa-miR-548x	CLIP-seq
MIRT2548029	hsa-miR-548z	CLIP-seq
MIRT2548030	hsa-miR-561	CLIP-seq
MIRT2548031	hsa-miR-590-5p	CLIP-seq
MIRT2548032	hsa-miR-676	CLIP-seq
MIRT2548033	hsa-miR-877	CLIP-seq
MIRT2547985	hsa-miR-1193	CLIP-seq
MIRT2547986	hsa-miR-1273f	CLIP-seq
MIRT2547987	hsa-miR-127-5p	CLIP-seq
MIRT2547988	hsa-miR-1343	CLIP-seq
MIRT2547989	hsa-miR-136	CLIP-seq
MIRT2682466	hsa-miR-140-3p	CLIP-seq
MIRT2547990	hsa-miR-143	CLIP-seq
MIRT2547991	hsa-miR-185	CLIP-seq
MIRT2547992	hsa-miR-203	CLIP-seq
MIRT2547993	hsa-miR-21	CLIP-seq
MIRT2547994	hsa-miR-3156-3p	CLIP-seq
MIRT2547995	hsa-miR-3163	CLIP-seq
MIRT2547996	hsa-miR-3198	CLIP-seq
MIRT2547997	hsa-miR-3690	CLIP-seq
MIRT2547998	hsa-miR-421	CLIP-seq
MIRT2547999	hsa-miR-4254	CLIP-seq
MIRT2548000	hsa-miR-4272	CLIP-seq
MIRT2548001	hsa-miR-4301	CLIP-seq
MIRT2548002	hsa-miR-4306	CLIP-seq
MIRT2548003	hsa-miR-4307	CLIP-seq
MIRT2548004	hsa-miR-4309	CLIP-seq
MIRT2548005	hsa-miR-432	CLIP-seq
MIRT2548007	hsa-miR-4494	CLIP-seq
MIRT2548008	hsa-miR-4534	CLIP-seq
MIRT2548010	hsa-miR-4644	CLIP-seq
MIRT2548011	hsa-miR-4653-3p	CLIP-seq
MIRT2548014	hsa-miR-4666-5p	CLIP-seq
MIRT2548015	hsa-miR-4708-5p	CLIP-seq
MIRT2548016	hsa-miR-4738-3p	CLIP-seq
MIRT2682467	hsa-miR-4769-3p	CLIP-seq
MIRT2548017	hsa-miR-4770	CLIP-seq
MIRT2548019	hsa-miR-4780	CLIP-seq
MIRT2548020	hsa-miR-4802-3p	CLIP-seq
MIRT2548021	hsa-miR-4803	CLIP-seq
MIRT2548022	hsa-miR-548ac	CLIP-seq
MIRT2548023	hsa-miR-548ae	CLIP-seq
MIRT2548024	hsa-miR-548aj	CLIP-seq
MIRT2548025	hsa-miR-548am	CLIP-seq
MIRT2548026	hsa-miR-548d-3p	CLIP-seq
MIRT2548027	hsa-miR-548g	CLIP-seq
MIRT2548028	hsa-miR-548x	CLIP-seq
MIRT2548029	hsa-miR-548z	CLIP-seq
MIRT2548030	hsa-miR-561	CLIP-seq
MIRT2548031	hsa-miR-590-5p	CLIP-seq
MIRT2548032	hsa-miR-676	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	38820148
GO:0005739	Component	Mitochondrion	IEA
GO:0005777	Component	Peroxisome	IDA	19703561
GO:0005777	Component	Peroxisome	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016229	Function	Steroid dehydrogenase activity	IDA	19703561
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0042632	Process	Cholesterol homeostasis	IEA
GO:0042632	Process	Cholesterol homeostasis	IMP	38820148

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q6YN16

Protein name

Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1)

Protein function

Has apparently no steroid dehydrogenase activity (PubMed:19703561). Controls bile acid (BA) and lipid metabolism in response to nutritional cues (PubMed:38820148).

PDB

3KVO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00106	adh_short	11 → 209	short chain dehydrogenase	Domain
PF02036	SCP2	310 → 412	SCP-2 sterol transfer family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12834046}.

Sequence

MLPNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEE
IEAVGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDL
MMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVL
GMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKSFTG
NFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQ
LQPKPRSGAVEETFRIVKDSLSDDVVKATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGE
PSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNARL

Sequence length

418

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (27)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	34857756	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	31217732		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31372054		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33738911	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	31217732		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	29894468		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	30410369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	34857756	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	30410369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	27658777		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	27658777	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	27658777		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	27658777, 30410369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	27658777	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	33049985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	CTD_human_DG	25058030		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Lymphatic Metastasis	BEFREE	29894468		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	33738911	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31372054		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	CTD_human_DG	25058030		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	29894468		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	31217732		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30410369		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29894468		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	29894468		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	31101684		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	33738911, 35948893	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HSDL2 (hydroxysteroid dehydrogenase like 2)