Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84256
Gene name	FLYWCH-type zinc finger 1
Gene symbol	FLYWCH1
Synonyms (NCBI Gene)	-
Chromosome	16
Chromosome location	16p13.3

225

Show/Hide all (225)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017432	hsa-miR-335-5p	Microarray	18185580
MIRT049470	hsa-miR-92a-3p	CLASH	23622248
MIRT719763	hsa-miR-3687	HITS-CLIP	19536157
MIRT719762	hsa-miR-4442	HITS-CLIP	19536157
MIRT719761	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT719760	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT719759	hsa-miR-1288-3p	HITS-CLIP	19536157
MIRT719758	hsa-miR-615-5p	HITS-CLIP	19536157
MIRT719757	hsa-miR-7704	HITS-CLIP	19536157
MIRT719756	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT719755	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT719763	hsa-miR-3687	HITS-CLIP	19536157
MIRT719762	hsa-miR-4442	HITS-CLIP	19536157
MIRT719761	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT719760	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT719759	hsa-miR-1288-3p	HITS-CLIP	19536157
MIRT719758	hsa-miR-615-5p	HITS-CLIP	19536157
MIRT719757	hsa-miR-7704	HITS-CLIP	19536157
MIRT719756	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT719755	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT719763	hsa-miR-3687	HITS-CLIP	19536157
MIRT719762	hsa-miR-4442	HITS-CLIP	19536157
MIRT719761	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT719760	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT719759	hsa-miR-1288-3p	HITS-CLIP	19536157
MIRT719758	hsa-miR-615-5p	HITS-CLIP	19536157
MIRT719757	hsa-miR-7704	HITS-CLIP	19536157
MIRT719756	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT719755	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT719763	hsa-miR-3687	HITS-CLIP	19536157
MIRT719762	hsa-miR-4442	HITS-CLIP	19536157
MIRT719761	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT719760	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT719759	hsa-miR-1288-3p	HITS-CLIP	19536157
MIRT719758	hsa-miR-615-5p	HITS-CLIP	19536157
MIRT719757	hsa-miR-7704	HITS-CLIP	19536157
MIRT719756	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT719755	hsa-miR-3152-5p	HITS-CLIP	19536157
MIRT999276	hsa-miR-1197	CLIP-seq
MIRT999277	hsa-miR-1200	CLIP-seq
MIRT999278	hsa-miR-1207-5p	CLIP-seq
MIRT999279	hsa-miR-1224-5p	CLIP-seq
MIRT999280	hsa-miR-1270	CLIP-seq
MIRT999281	hsa-miR-1273	CLIP-seq
MIRT999282	hsa-miR-1273f	CLIP-seq
MIRT999283	hsa-miR-1285	CLIP-seq
MIRT999284	hsa-miR-134	CLIP-seq
MIRT999285	hsa-miR-1343	CLIP-seq
MIRT999286	hsa-miR-139-3p	CLIP-seq
MIRT999287	hsa-miR-143	CLIP-seq
MIRT999288	hsa-miR-214	CLIP-seq
MIRT999289	hsa-miR-2467-3p	CLIP-seq
MIRT999290	hsa-miR-3118	CLIP-seq
MIRT999291	hsa-miR-3148	CLIP-seq
MIRT999292	hsa-miR-3150b-3p	CLIP-seq
MIRT999293	hsa-miR-3159	CLIP-seq
MIRT999294	hsa-miR-3187-5p	CLIP-seq
MIRT999295	hsa-miR-3192	CLIP-seq
MIRT999296	hsa-miR-331-3p	CLIP-seq
MIRT999297	hsa-miR-3619-5p	CLIP-seq
MIRT999298	hsa-miR-3620	CLIP-seq
MIRT999299	hsa-miR-3622b-5p	CLIP-seq
MIRT999300	hsa-miR-3683	CLIP-seq
MIRT999301	hsa-miR-3688-3p	CLIP-seq
MIRT999302	hsa-miR-3937	CLIP-seq
MIRT999303	hsa-miR-4267	CLIP-seq
MIRT999304	hsa-miR-4292	CLIP-seq
MIRT999305	hsa-miR-4324	CLIP-seq
MIRT999306	hsa-miR-4449	CLIP-seq
MIRT999307	hsa-miR-4450	CLIP-seq
MIRT999308	hsa-miR-4639-5p	CLIP-seq
MIRT999309	hsa-miR-4640-5p	CLIP-seq
MIRT999310	hsa-miR-4645-3p	CLIP-seq
MIRT999311	hsa-miR-4667-5p	CLIP-seq
MIRT999312	hsa-miR-4683	CLIP-seq
MIRT999313	hsa-miR-4689	CLIP-seq
MIRT999314	hsa-miR-4690-5p	CLIP-seq
MIRT999315	hsa-miR-4700-5p	CLIP-seq
MIRT999316	hsa-miR-4701-5p	CLIP-seq
MIRT999317	hsa-miR-4708-5p	CLIP-seq
MIRT999318	hsa-miR-4720-5p	CLIP-seq
MIRT999319	hsa-miR-4726-5p	CLIP-seq
MIRT999320	hsa-miR-4731-5p	CLIP-seq
MIRT999321	hsa-miR-4736	CLIP-seq
MIRT999322	hsa-miR-4751	CLIP-seq
MIRT999323	hsa-miR-4763-3p	CLIP-seq
MIRT999324	hsa-miR-4764-5p	CLIP-seq
MIRT999325	hsa-miR-4770	CLIP-seq
MIRT999326	hsa-miR-4783-3p	CLIP-seq
MIRT999327	hsa-miR-4784	CLIP-seq
MIRT999328	hsa-miR-4799-3p	CLIP-seq
MIRT999329	hsa-miR-485-5p	CLIP-seq
MIRT999330	hsa-miR-510	CLIP-seq
MIRT999331	hsa-miR-542-3p	CLIP-seq
MIRT999332	hsa-miR-544	CLIP-seq
MIRT999333	hsa-miR-544b	CLIP-seq
MIRT999334	hsa-miR-576-3p	CLIP-seq
MIRT999335	hsa-miR-588	CLIP-seq
MIRT999336	hsa-miR-612	CLIP-seq
MIRT999337	hsa-miR-620	CLIP-seq
MIRT999338	hsa-miR-634	CLIP-seq
MIRT999339	hsa-miR-761	CLIP-seq
MIRT999340	hsa-miR-769-5p	CLIP-seq
MIRT999341	hsa-miR-885-3p	CLIP-seq
MIRT1996112	hsa-miR-1269	CLIP-seq
MIRT1996113	hsa-miR-1269b	CLIP-seq
MIRT1996114	hsa-miR-1288	CLIP-seq
MIRT1996115	hsa-miR-149	CLIP-seq
MIRT1996116	hsa-miR-198	CLIP-seq
MIRT1996117	hsa-miR-2392	CLIP-seq
MIRT999289	hsa-miR-2467-3p	CLIP-seq
MIRT1996118	hsa-miR-3120-3p	CLIP-seq
MIRT1996119	hsa-miR-3173-5p	CLIP-seq
MIRT999295	hsa-miR-3192	CLIP-seq
MIRT999296	hsa-miR-331-3p	CLIP-seq
MIRT1996120	hsa-miR-3661	CLIP-seq
MIRT1996121	hsa-miR-3690	CLIP-seq
MIRT1996122	hsa-miR-378	CLIP-seq
MIRT1996123	hsa-miR-378b	CLIP-seq
MIRT1996124	hsa-miR-378c	CLIP-seq
MIRT1996125	hsa-miR-378d	CLIP-seq
MIRT1996126	hsa-miR-378e	CLIP-seq
MIRT1996127	hsa-miR-378f	CLIP-seq
MIRT1996128	hsa-miR-378h	CLIP-seq
MIRT1996129	hsa-miR-378i	CLIP-seq
MIRT1996130	hsa-miR-3974	CLIP-seq
MIRT1996131	hsa-miR-422a	CLIP-seq
MIRT1996132	hsa-miR-4265	CLIP-seq
MIRT1996133	hsa-miR-4296	CLIP-seq
MIRT1996134	hsa-miR-4308	CLIP-seq
MIRT1996135	hsa-miR-4322	CLIP-seq
MIRT1996136	hsa-miR-4417	CLIP-seq
MIRT1996137	hsa-miR-4434	CLIP-seq
MIRT1996138	hsa-miR-4476	CLIP-seq
MIRT1996139	hsa-miR-4514	CLIP-seq
MIRT1996140	hsa-miR-4515	CLIP-seq
MIRT1996141	hsa-miR-4516	CLIP-seq
MIRT1996142	hsa-miR-4535	CLIP-seq
MIRT999308	hsa-miR-4639-5p	CLIP-seq
MIRT999309	hsa-miR-4640-5p	CLIP-seq
MIRT1996143	hsa-miR-4645-5p	CLIP-seq
MIRT1996144	hsa-miR-4673	CLIP-seq
MIRT1996145	hsa-miR-4690-3p	CLIP-seq
MIRT1996146	hsa-miR-4692	CLIP-seq
MIRT999319	hsa-miR-4726-5p	CLIP-seq
MIRT1996147	hsa-miR-4740-5p	CLIP-seq
MIRT1996148	hsa-miR-485-3p	CLIP-seq
MIRT1996149	hsa-miR-492	CLIP-seq
MIRT1996150	hsa-miR-524-3p	CLIP-seq
MIRT1996151	hsa-miR-525-3p	CLIP-seq
MIRT999331	hsa-miR-542-3p	CLIP-seq
MIRT999332	hsa-miR-544	CLIP-seq
MIRT1996152	hsa-miR-564	CLIP-seq
MIRT1996153	hsa-miR-631	CLIP-seq
MIRT1996154	hsa-miR-873	CLIP-seq
MIRT1996155	hsa-miR-892b	CLIP-seq
MIRT999278	hsa-miR-1207-5p	CLIP-seq
MIRT2230157	hsa-miR-3189-5p	CLIP-seq
MIRT999321	hsa-miR-4736	CLIP-seq
MIRT999323	hsa-miR-4763-3p	CLIP-seq
MIRT2230158	hsa-miR-4786-3p	CLIP-seq
MIRT999281	hsa-miR-1273	CLIP-seq
MIRT999283	hsa-miR-1285	CLIP-seq
MIRT999284	hsa-miR-134	CLIP-seq
MIRT999290	hsa-miR-3118	CLIP-seq
MIRT999294	hsa-miR-3187-5p	CLIP-seq
MIRT999300	hsa-miR-3683	CLIP-seq
MIRT2388026	hsa-miR-383	CLIP-seq
MIRT999308	hsa-miR-4639-5p	CLIP-seq
MIRT999310	hsa-miR-4645-3p	CLIP-seq
MIRT2388027	hsa-miR-4772-5p	CLIP-seq
MIRT999331	hsa-miR-542-3p	CLIP-seq
MIRT999332	hsa-miR-544	CLIP-seq
MIRT999336	hsa-miR-612	CLIP-seq
MIRT1996115	hsa-miR-149	CLIP-seq
MIRT2533978	hsa-miR-185	CLIP-seq
MIRT1996117	hsa-miR-2392	CLIP-seq
MIRT2533979	hsa-miR-3121-5p	CLIP-seq
MIRT2533980	hsa-miR-3154	CLIP-seq
MIRT2533981	hsa-miR-3157-5p	CLIP-seq
MIRT2533982	hsa-miR-3176	CLIP-seq
MIRT2533983	hsa-miR-3179	CLIP-seq
MIRT1996120	hsa-miR-3661	CLIP-seq
MIRT2533984	hsa-miR-3922-3p	CLIP-seq
MIRT2533985	hsa-miR-4306	CLIP-seq
MIRT1996142	hsa-miR-4535	CLIP-seq
MIRT999309	hsa-miR-4640-5p	CLIP-seq
MIRT2533986	hsa-miR-4644	CLIP-seq
MIRT2533987	hsa-miR-4685-5p	CLIP-seq
MIRT2533988	hsa-miR-4691-3p	CLIP-seq
MIRT999319	hsa-miR-4726-5p	CLIP-seq
MIRT2533989	hsa-miR-4738-5p	CLIP-seq
MIRT2533990	hsa-miR-4757-5p	CLIP-seq
MIRT2533991	hsa-miR-4763-5p	CLIP-seq
MIRT2533992	hsa-miR-4775	CLIP-seq
MIRT1996149	hsa-miR-492	CLIP-seq
MIRT2533993	hsa-miR-629	CLIP-seq
MIRT1996153	hsa-miR-631	CLIP-seq
MIRT1996115	hsa-miR-149	CLIP-seq
MIRT2533978	hsa-miR-185	CLIP-seq
MIRT1996117	hsa-miR-2392	CLIP-seq
MIRT2533979	hsa-miR-3121-5p	CLIP-seq
MIRT2533980	hsa-miR-3154	CLIP-seq
MIRT2533981	hsa-miR-3157-5p	CLIP-seq
MIRT2533982	hsa-miR-3176	CLIP-seq
MIRT2533983	hsa-miR-3179	CLIP-seq
MIRT2681052	hsa-miR-3202	CLIP-seq
MIRT1996120	hsa-miR-3661	CLIP-seq
MIRT2533984	hsa-miR-3922-3p	CLIP-seq
MIRT2533985	hsa-miR-4306	CLIP-seq
MIRT2681053	hsa-miR-4533	CLIP-seq
MIRT1996142	hsa-miR-4535	CLIP-seq
MIRT999309	hsa-miR-4640-5p	CLIP-seq
MIRT2533986	hsa-miR-4644	CLIP-seq
MIRT2533987	hsa-miR-4685-5p	CLIP-seq
MIRT2533988	hsa-miR-4691-3p	CLIP-seq
MIRT999319	hsa-miR-4726-5p	CLIP-seq
MIRT2533989	hsa-miR-4738-5p	CLIP-seq
MIRT2533990	hsa-miR-4757-5p	CLIP-seq
MIRT2533991	hsa-miR-4763-5p	CLIP-seq
MIRT2533992	hsa-miR-4775	CLIP-seq
MIRT1996149	hsa-miR-492	CLIP-seq
MIRT2533993	hsa-miR-629	CLIP-seq
MIRT1996153	hsa-miR-631	CLIP-seq
MIRT2681054	hsa-miR-890	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	30097457
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0001223	Function	Transcription coactivator binding	IPI	30097457
GO:0003677	Function	DNA binding	IEA
GO:0003714	Function	Transcription corepressor activity	IDA	30097457
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005667	Component	Transcription regulator complex	IMP	30097457
GO:0005694	Component	Chromosome	IEA
GO:0005721	Component	Pericentric heterochromatin	IDA	34408139
GO:0005829	Component	Cytosol	IDA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	33924684
GO:0008270	Function	Zinc ion binding	IEA
GO:0016604	Component	Nuclear body	IDA	33924684
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
620431	25404	ENSG00000059122

Q4VC44

Protein name

FLYWCH-type zinc finger-containing protein 1

Protein function

Transcription cofactor (PubMed:30097457). Negatively regulates transcription activation by catenin beta-1 CTNNB1, perhaps acting by competing with TCF4 for CTNNB1 binding (PubMed:30097457). May play a role in DNA-damage response signaling (PubMe

PDB

2RPR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15423	FLYWCH_N	1 → 107	FLYWCH-type zinc finger-containing protein	Family
PF04500	FLYWCH	116 → 174	FLYWCH zinc finger domain	Domain
PF16662	FLYWCH_u	175 → 224		Disordered
PF04500	FLYWCH	273 → 331	FLYWCH zinc finger domain	Domain
PF16662	FLYWCH_u	332 → 393		Disordered
PF04500	FLYWCH	421 → 479	FLYWCH zinc finger domain	Domain
PF16662	FLYWCH_u	480 → 532		Disordered
PF04500	FLYWCH	509 → 567	FLYWCH zinc finger domain	Domain
PF16662	FLYWCH_u	568 → 586		Disordered
PF04500	FLYWCH	600 → 658	FLYWCH zinc finger domain	Domain
PF16662	FLYWCH_u	659 → 684		Disordered

Sequence

MPLPEPSEQEGESVKAGQEPSPKPGTDVIPAAPRKPREFSKLVLLTASDQDEDGVGSKPQ
EVHCVLSLEMAGPATLASTLQILPVEEQGGVVQPALEMPEQKCSKLDAAAPQSLEFLRTP
FGGRLLVLESFLYKQEKAVGDKVYWKCRQHAELGCRGRAITRGLRATVMRGHCHAPDEQG
LEARRQREKLPSLALPEGLGEPQGPEGPGGRVEEPLEGVGPWQCPEEPEPTPGLVLSKPA
LEEEEAPRALSLLSLPPKKRSILGLGQARPLEFLRTCYGGSFLVHESFLYKREKAVGDKV
YWTCRDHALHGCRSRAITQGQRVTVMRGHCHQPDMEGLEARRQQEKAVETLQAGQDGPGS
QVDTLLRGVDSLLYRRGPGPLTLTRPRPRKRAKVEDQELPTQPEAPDEHQDMDADPGGPE
FLKTPLGGSFLVYESFLYRREKAAGEKVYWTCRDQARMGCRSRAITQGRRVTVMRGHCHP
PDLGGLEALRQREKRPNTAQRGSPGGPEFLKTPLGGSFLVYESFLYRREKAAGEKVYWTC
RDQARMGCRSRAITQGRRVMVMRRHCHPPDLGGLEALRQREHFPNLAQWDSPDPLRPLEF
LRTSLGGRFLVHESFLYRKEKAAGEKVYWMCRDQARLGCRSRAITQGHRIMVMRSHCHQP
DLAGLEALRQRERLPTTAQQEDPEKIQVQLCFKTCSPESQQIYGDIKDVRLDGESQ

Sequence length

716

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
RUSSELL-SILVER SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SIALOLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	40191655	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30097457		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30097457	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	25578447		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	31167387	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31167387		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitral Valve Prolapse	Mitral valve prolapse	Pubtator	29762926	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Secondary malignant neoplasm of colon and/or rectum	Colorectal Neoplasms	BEFREE	30097457		★★★★★ ★☆☆☆☆ Found in Text Mining only

FLYWCH1 (FLYWCH-type zinc finger 1)