Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84232
Gene name	MAF1 negative regulator of RNA polymerase III
Gene symbol	MAF1
Synonyms (NCBI Gene)	-
Chromosome	8
Chromosome location	8q24.3
Summary	This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and repress

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Show/Hide all (167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041940	hsa-miR-484	CLASH	23622248
MIRT439156	hsa-let-7c-5p	3'LIFE	25074381
MIRT439156	hsa-let-7c-5p	3'LIFE	25074381
MIRT1125193	hsa-miR-103a	CLIP-seq
MIRT1125194	hsa-miR-107	CLIP-seq
MIRT1125195	hsa-miR-1184	CLIP-seq
MIRT1125196	hsa-miR-148a	CLIP-seq
MIRT1125197	hsa-miR-148b	CLIP-seq
MIRT1125198	hsa-miR-152	CLIP-seq
MIRT1125199	hsa-miR-214	CLIP-seq
MIRT1125200	hsa-miR-3117-5p	CLIP-seq
MIRT1125201	hsa-miR-3184	CLIP-seq
MIRT1125202	hsa-miR-3186-3p	CLIP-seq
MIRT1125203	hsa-miR-3609	CLIP-seq
MIRT1125204	hsa-miR-3619-5p	CLIP-seq
MIRT1125205	hsa-miR-3926	CLIP-seq
MIRT1125206	hsa-miR-3978	CLIP-seq
MIRT1125207	hsa-miR-423-5p	CLIP-seq
MIRT1125208	hsa-miR-4294	CLIP-seq
MIRT1125209	hsa-miR-4433	CLIP-seq
MIRT1125210	hsa-miR-4447	CLIP-seq
MIRT1125211	hsa-miR-4472	CLIP-seq
MIRT1125212	hsa-miR-4649-3p	CLIP-seq
MIRT1125213	hsa-miR-4649-5p	CLIP-seq
MIRT1125214	hsa-miR-4722-5p	CLIP-seq
MIRT1125215	hsa-miR-520g	CLIP-seq
MIRT1125216	hsa-miR-520h	CLIP-seq
MIRT1125217	hsa-miR-545	CLIP-seq
MIRT1125218	hsa-miR-548ah	CLIP-seq
MIRT1125219	hsa-miR-552	CLIP-seq
MIRT1125220	hsa-miR-558	CLIP-seq
MIRT1125221	hsa-miR-761	CLIP-seq
MIRT1125222	hsa-miR-936	CLIP-seq
MIRT2035306	hsa-miR-1207-3p	CLIP-seq
MIRT2035307	hsa-miR-122	CLIP-seq
MIRT2035308	hsa-miR-134	CLIP-seq
MIRT1125196	hsa-miR-148a	CLIP-seq
MIRT1125197	hsa-miR-148b	CLIP-seq
MIRT1125198	hsa-miR-152	CLIP-seq
MIRT2035309	hsa-miR-1587	CLIP-seq
MIRT2035310	hsa-miR-1915	CLIP-seq
MIRT2035311	hsa-miR-2861	CLIP-seq
MIRT1125200	hsa-miR-3117-5p	CLIP-seq
MIRT2035312	hsa-miR-3118	CLIP-seq
MIRT2035313	hsa-miR-3135b	CLIP-seq
MIRT2035314	hsa-miR-3136-3p	CLIP-seq
MIRT2035315	hsa-miR-3150a-3p	CLIP-seq
MIRT2035316	hsa-miR-3151	CLIP-seq
MIRT2035317	hsa-miR-3175	CLIP-seq
MIRT1125202	hsa-miR-3186-3p	CLIP-seq
MIRT2035318	hsa-miR-34a	CLIP-seq
MIRT2035319	hsa-miR-34c-5p	CLIP-seq
MIRT2035320	hsa-miR-3652	CLIP-seq
MIRT2035321	hsa-miR-3677-3p	CLIP-seq
MIRT2035322	hsa-miR-3688-5p	CLIP-seq
MIRT2035323	hsa-miR-370	CLIP-seq
MIRT1125205	hsa-miR-3926	CLIP-seq
MIRT2035324	hsa-miR-3944-5p	CLIP-seq
MIRT2035325	hsa-miR-4267	CLIP-seq
MIRT2035326	hsa-miR-4430	CLIP-seq
MIRT1125210	hsa-miR-4447	CLIP-seq
MIRT1125211	hsa-miR-4472	CLIP-seq
MIRT2035327	hsa-miR-4492	CLIP-seq
MIRT2035328	hsa-miR-4498	CLIP-seq
MIRT2035329	hsa-miR-449a	CLIP-seq
MIRT2035330	hsa-miR-449b	CLIP-seq
MIRT2035331	hsa-miR-4534	CLIP-seq
MIRT1125213	hsa-miR-4649-5p	CLIP-seq
MIRT2035332	hsa-miR-4655-5p	CLIP-seq
MIRT2035333	hsa-miR-4656	CLIP-seq
MIRT2035334	hsa-miR-4667-5p	CLIP-seq
MIRT2035335	hsa-miR-4674	CLIP-seq
MIRT2035336	hsa-miR-4675	CLIP-seq
MIRT2035337	hsa-miR-4700-5p	CLIP-seq
MIRT2035338	hsa-miR-4731-5p	CLIP-seq
MIRT2035339	hsa-miR-4741	CLIP-seq
MIRT2035340	hsa-miR-541	CLIP-seq
MIRT1125219	hsa-miR-552	CLIP-seq
MIRT2035341	hsa-miR-574-5p	CLIP-seq
MIRT2035342	hsa-miR-579	CLIP-seq
MIRT2035343	hsa-miR-646	CLIP-seq
MIRT2035344	hsa-miR-648	CLIP-seq
MIRT2035345	hsa-miR-654-5p	CLIP-seq
MIRT2035346	hsa-miR-762	CLIP-seq
MIRT2035347	hsa-miR-885-3p	CLIP-seq
MIRT1125222	hsa-miR-936	CLIP-seq
MIRT2035348	hsa-miR-939	CLIP-seq
MIRT2265820	hsa-miR-1224-3p	CLIP-seq
MIRT2265821	hsa-miR-1260	CLIP-seq
MIRT2265822	hsa-miR-1260b	CLIP-seq
MIRT2265823	hsa-miR-1280	CLIP-seq
MIRT1125196	hsa-miR-148a	CLIP-seq
MIRT1125197	hsa-miR-148b	CLIP-seq
MIRT1125198	hsa-miR-152	CLIP-seq
MIRT1125199	hsa-miR-214	CLIP-seq
MIRT2265824	hsa-miR-2392	CLIP-seq
MIRT1125200	hsa-miR-3117-5p	CLIP-seq
MIRT2035314	hsa-miR-3136-3p	CLIP-seq
MIRT1125201	hsa-miR-3184	CLIP-seq
MIRT1125202	hsa-miR-3186-3p	CLIP-seq
MIRT1125204	hsa-miR-3619-5p	CLIP-seq
MIRT2035323	hsa-miR-370	CLIP-seq
MIRT1125205	hsa-miR-3926	CLIP-seq
MIRT2265825	hsa-miR-3945	CLIP-seq
MIRT1125206	hsa-miR-3978	CLIP-seq
MIRT1125207	hsa-miR-423-5p	CLIP-seq
MIRT2265826	hsa-miR-4253	CLIP-seq
MIRT2265827	hsa-miR-4268	CLIP-seq
MIRT1125208	hsa-miR-4294	CLIP-seq
MIRT2265828	hsa-miR-4313	CLIP-seq
MIRT1125209	hsa-miR-4433	CLIP-seq
MIRT1125210	hsa-miR-4447	CLIP-seq
MIRT1125211	hsa-miR-4472	CLIP-seq
MIRT2265829	hsa-miR-4481	CLIP-seq
MIRT2035331	hsa-miR-4534	CLIP-seq
MIRT1125212	hsa-miR-4649-3p	CLIP-seq
MIRT1125213	hsa-miR-4649-5p	CLIP-seq
MIRT2035332	hsa-miR-4655-5p	CLIP-seq
MIRT1125214	hsa-miR-4722-5p	CLIP-seq
MIRT2265830	hsa-miR-4733-3p	CLIP-seq
MIRT2265831	hsa-miR-4736	CLIP-seq
MIRT2265832	hsa-miR-4745-5p	CLIP-seq
MIRT2265833	hsa-miR-4758-5p	CLIP-seq
MIRT2265834	hsa-miR-532-3p	CLIP-seq
MIRT2035340	hsa-miR-541	CLIP-seq
MIRT1125219	hsa-miR-552	CLIP-seq
MIRT2265835	hsa-miR-628-5p	CLIP-seq
MIRT2035345	hsa-miR-654-5p	CLIP-seq
MIRT1125221	hsa-miR-761	CLIP-seq
MIRT2390448	hsa-miR-127-5p	CLIP-seq
MIRT1125196	hsa-miR-148a	CLIP-seq
MIRT1125197	hsa-miR-148b	CLIP-seq
MIRT1125198	hsa-miR-152	CLIP-seq
MIRT1125200	hsa-miR-3117-5p	CLIP-seq
MIRT1125202	hsa-miR-3186-3p	CLIP-seq
MIRT2390449	hsa-miR-320e	CLIP-seq
MIRT1125205	hsa-miR-3926	CLIP-seq
MIRT2265827	hsa-miR-4268	CLIP-seq
MIRT1125210	hsa-miR-4447	CLIP-seq
MIRT1125211	hsa-miR-4472	CLIP-seq
MIRT1125213	hsa-miR-4649-5p	CLIP-seq
MIRT1125219	hsa-miR-552	CLIP-seq
MIRT1125196	hsa-miR-148a	CLIP-seq
MIRT1125197	hsa-miR-148b	CLIP-seq
MIRT1125198	hsa-miR-152	CLIP-seq
MIRT1125200	hsa-miR-3117-5p	CLIP-seq
MIRT1125202	hsa-miR-3186-3p	CLIP-seq
MIRT1125205	hsa-miR-3926	CLIP-seq
MIRT1125213	hsa-miR-4649-5p	CLIP-seq
MIRT2035306	hsa-miR-1207-3p	CLIP-seq
MIRT2035310	hsa-miR-1915	CLIP-seq
MIRT2035315	hsa-miR-3150a-3p	CLIP-seq
MIRT2035317	hsa-miR-3175	CLIP-seq
MIRT2035334	hsa-miR-4667-5p	CLIP-seq
MIRT2035337	hsa-miR-4700-5p	CLIP-seq
MIRT2035338	hsa-miR-4731-5p	CLIP-seq
MIRT2565183	hsa-miR-4757-5p	CLIP-seq
MIRT2035348	hsa-miR-939	CLIP-seq
MIRT2035306	hsa-miR-1207-3p	CLIP-seq
MIRT2035310	hsa-miR-1915	CLIP-seq
MIRT2035315	hsa-miR-3150a-3p	CLIP-seq
MIRT2035317	hsa-miR-3175	CLIP-seq
MIRT2035334	hsa-miR-4667-5p	CLIP-seq
MIRT2035337	hsa-miR-4700-5p	CLIP-seq
MIRT2035338	hsa-miR-4731-5p	CLIP-seq
MIRT2565183	hsa-miR-4757-5p	CLIP-seq
MIRT2035348	hsa-miR-939	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000994	Function	RNA polymerase III core binding	IBA
GO:0001002	Function	RNA polymerase III type 1 promoter sequence-specific DNA binding	IDA	20233713
GO:0001003	Function	RNA polymerase III type 2 promoter sequence-specific DNA binding	IDA	20233713
GO:0001006	Function	RNA polymerase III type 3 promoter sequence-specific DNA binding	IDA	20233713
GO:0005515	Function	Protein binding	IPI	18377933, 19060904, 21383183, 26030842, 28514442, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20233713
GO:0005634	Component	Nucleus	IDA	20543138
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	20233713
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0016479	Process	Negative regulation of transcription by RNA polymerase I	IDA	17499043
GO:0016480	Process	Negative regulation of transcription by RNA polymerase III	IBA
GO:0016480	Process	Negative regulation of transcription by RNA polymerase III	IDA	17499043, 18377933, 20233713
GO:0016480	Process	Negative regulation of transcription by RNA polymerase III	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050811	Function	GABA receptor binding	IEA
GO:0060077	Component	Inhibitory synapse	IEA

MIM	HGNC	e!Ensembl
610210	24966	ENSG00000179632

Q9H063

Protein name

Repressor of RNA polymerase III transcription MAF1 homolog

Protein function

Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding

PDB

3NR5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09174	Maf1	25 → 202	Maf1 regulator	Family

Sequence

MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMFKQFCQEGQPHVLEALS
PPQTSGLSPSRLSKSQGGEEEGPLSDKCSRKTLFYLIATLNESFRPDYDFSTARSHEFSR
EPSLSWVVNAVNCSLFSAVREDFKDLKPQLWNAVDEEICLAECDIYSYNPDLDSDPFGED
GSLWSFNYFFYNKRLKRIVFFSCRSISGSTYTPSEAGNELDMELGEEEVEEESRSGGSGA
EETSTMEEDRVPVICI

Sequence length

256

Interactions

View interactions

	Reactome
			Regulation of PTEN gene transcription

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	37801436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30628658		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30628658, 37801436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	17499043		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	17499043	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	17499043		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31645432		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	29108454	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	30628658	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26173035, 29407795, 31645432		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	26173035		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25502566, 30628658, 31645432		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	26173035		★★★★★ ★☆☆☆☆ Found in Text Mining only

MAF1 (MAF1 negative regulator of RNA polymerase III)