Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84206
Gene name	Mex-3 RNA binding family member B
Gene symbol	MEX3B
Synonyms (NCBI Gene)	MEX-3BRKHD3RNF195
Chromosome	15
Chromosome location	15q25.2
Summary	This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to th

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Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024256	hsa-miR-215-5p	Microarray	19074876
MIRT026856	hsa-miR-192-5p	Microarray	19074876
MIRT040581	hsa-miR-92b-3p	CLASH	23622248
MIRT1145433	hsa-miR-1178	CLIP-seq
MIRT1145434	hsa-miR-1231	CLIP-seq
MIRT1145435	hsa-miR-1297	CLIP-seq
MIRT1145436	hsa-miR-1323	CLIP-seq
MIRT1145437	hsa-miR-136	CLIP-seq
MIRT1145438	hsa-miR-147	CLIP-seq
MIRT1145439	hsa-miR-155	CLIP-seq
MIRT1145440	hsa-miR-200b	CLIP-seq
MIRT1145441	hsa-miR-200c	CLIP-seq
MIRT1145442	hsa-miR-2116	CLIP-seq
MIRT1145443	hsa-miR-26a	CLIP-seq
MIRT1145444	hsa-miR-26b	CLIP-seq
MIRT1145445	hsa-miR-3154	CLIP-seq
MIRT1145446	hsa-miR-3163	CLIP-seq
MIRT1145447	hsa-miR-323-3p	CLIP-seq
MIRT1145448	hsa-miR-3655	CLIP-seq
MIRT1145449	hsa-miR-3671	CLIP-seq
MIRT1145450	hsa-miR-369-3p	CLIP-seq
MIRT1145451	hsa-miR-374a	CLIP-seq
MIRT1145452	hsa-miR-374b	CLIP-seq
MIRT1145453	hsa-miR-374c	CLIP-seq
MIRT1145454	hsa-miR-4255	CLIP-seq
MIRT1145455	hsa-miR-4288	CLIP-seq
MIRT1145456	hsa-miR-429	CLIP-seq
MIRT1145457	hsa-miR-4428	CLIP-seq
MIRT1145458	hsa-miR-4434	CLIP-seq
MIRT1145459	hsa-miR-4465	CLIP-seq
MIRT1145460	hsa-miR-4477a	CLIP-seq
MIRT1145461	hsa-miR-4484	CLIP-seq
MIRT1145462	hsa-miR-4503	CLIP-seq
MIRT1145463	hsa-miR-4516	CLIP-seq
MIRT1145464	hsa-miR-452	CLIP-seq
MIRT1145465	hsa-miR-4533	CLIP-seq
MIRT1145466	hsa-miR-4539	CLIP-seq
MIRT1145467	hsa-miR-4659a-5p	CLIP-seq
MIRT1145468	hsa-miR-4659b-5p	CLIP-seq
MIRT1145469	hsa-miR-4668-3p	CLIP-seq
MIRT1145470	hsa-miR-4676-3p	CLIP-seq
MIRT1145471	hsa-miR-4677-5p	CLIP-seq
MIRT1145472	hsa-miR-4733-5p	CLIP-seq
MIRT1145473	hsa-miR-4742-3p	CLIP-seq
MIRT1145474	hsa-miR-4747-5p	CLIP-seq
MIRT1145475	hsa-miR-4753-5p	CLIP-seq
MIRT1145476	hsa-miR-4762-5p	CLIP-seq
MIRT1145477	hsa-miR-4776-3p	CLIP-seq
MIRT1145478	hsa-miR-4797-3p	CLIP-seq
MIRT1145479	hsa-miR-487a	CLIP-seq
MIRT1145480	hsa-miR-499-3p	CLIP-seq
MIRT1145481	hsa-miR-499a-3p	CLIP-seq
MIRT1145482	hsa-miR-545	CLIP-seq
MIRT1145483	hsa-miR-548a-3p	CLIP-seq
MIRT1145484	hsa-miR-548a-5p	CLIP-seq
MIRT1145485	hsa-miR-548ab	CLIP-seq
MIRT1145486	hsa-miR-548ak	CLIP-seq
MIRT1145487	hsa-miR-548an	CLIP-seq
MIRT1145488	hsa-miR-548b-5p	CLIP-seq
MIRT1145489	hsa-miR-548c-5p	CLIP-seq
MIRT1145490	hsa-miR-548d-5p	CLIP-seq
MIRT1145491	hsa-miR-548e	CLIP-seq
MIRT1145492	hsa-miR-548f	CLIP-seq
MIRT1145493	hsa-miR-548h	CLIP-seq
MIRT1145494	hsa-miR-548i	CLIP-seq
MIRT1145495	hsa-miR-548j	CLIP-seq
MIRT1145496	hsa-miR-548k	CLIP-seq
MIRT1145497	hsa-miR-548l	CLIP-seq
MIRT1145498	hsa-miR-548o	CLIP-seq
MIRT1145499	hsa-miR-548w	CLIP-seq
MIRT1145500	hsa-miR-548y	CLIP-seq
MIRT1145501	hsa-miR-559	CLIP-seq
MIRT1145502	hsa-miR-607	CLIP-seq
MIRT1145503	hsa-miR-632	CLIP-seq
MIRT1145504	hsa-miR-655	CLIP-seq
MIRT1145505	hsa-miR-802	CLIP-seq
MIRT2041397	hsa-miR-101	CLIP-seq
MIRT2041398	hsa-miR-3613-3p	CLIP-seq
MIRT2041399	hsa-miR-3668	CLIP-seq
MIRT1145450	hsa-miR-369-3p	CLIP-seq
MIRT2041400	hsa-miR-3924	CLIP-seq
MIRT1145460	hsa-miR-4477a	CLIP-seq
MIRT2041401	hsa-miR-4643	CLIP-seq
MIRT2041402	hsa-miR-466	CLIP-seq
MIRT2041403	hsa-miR-4724-3p	CLIP-seq
MIRT2041404	hsa-miR-4789-3p	CLIP-seq
MIRT2041405	hsa-miR-4795-3p	CLIP-seq
MIRT1145479	hsa-miR-487a	CLIP-seq
MIRT1145433	hsa-miR-1178	CLIP-seq
MIRT1145434	hsa-miR-1231	CLIP-seq
MIRT1145435	hsa-miR-1297	CLIP-seq
MIRT1145436	hsa-miR-1323	CLIP-seq
MIRT1145437	hsa-miR-136	CLIP-seq
MIRT1145440	hsa-miR-200b	CLIP-seq
MIRT1145441	hsa-miR-200c	CLIP-seq
MIRT2271013	hsa-miR-2054	CLIP-seq
MIRT1145443	hsa-miR-26a	CLIP-seq
MIRT1145444	hsa-miR-26b	CLIP-seq
MIRT2271014	hsa-miR-28-3p	CLIP-seq
MIRT2271015	hsa-miR-3074-3p	CLIP-seq
MIRT2271016	hsa-miR-30a	CLIP-seq
MIRT2271017	hsa-miR-30b	CLIP-seq
MIRT2271018	hsa-miR-30c	CLIP-seq
MIRT2271019	hsa-miR-30d	CLIP-seq
MIRT2271020	hsa-miR-30e	CLIP-seq
MIRT1145446	hsa-miR-3163	CLIP-seq
MIRT1145447	hsa-miR-323-3p	CLIP-seq
MIRT2271021	hsa-miR-323b-5p	CLIP-seq
MIRT2271022	hsa-miR-337-3p	CLIP-seq
MIRT2271023	hsa-miR-34c-3p	CLIP-seq
MIRT2041398	hsa-miR-3613-3p	CLIP-seq
MIRT1145448	hsa-miR-3655	CLIP-seq
MIRT2041399	hsa-miR-3668	CLIP-seq
MIRT1145449	hsa-miR-3671	CLIP-seq
MIRT1145450	hsa-miR-369-3p	CLIP-seq
MIRT1145451	hsa-miR-374a	CLIP-seq
MIRT1145452	hsa-miR-374b	CLIP-seq
MIRT2041400	hsa-miR-3924	CLIP-seq
MIRT2271024	hsa-miR-3941	CLIP-seq
MIRT1145455	hsa-miR-4288	CLIP-seq
MIRT1145456	hsa-miR-429	CLIP-seq
MIRT2271025	hsa-miR-4420	CLIP-seq
MIRT2271026	hsa-miR-4427	CLIP-seq
MIRT1145459	hsa-miR-4465	CLIP-seq
MIRT1145461	hsa-miR-4484	CLIP-seq
MIRT1145462	hsa-miR-4503	CLIP-seq
MIRT1145464	hsa-miR-452	CLIP-seq
MIRT1145466	hsa-miR-4539	CLIP-seq
MIRT2041401	hsa-miR-4643	CLIP-seq
MIRT2041402	hsa-miR-466	CLIP-seq
MIRT1145469	hsa-miR-4668-3p	CLIP-seq
MIRT2271027	hsa-miR-4672	CLIP-seq
MIRT1145470	hsa-miR-4676-3p	CLIP-seq
MIRT2271028	hsa-miR-4699-5p	CLIP-seq
MIRT2041403	hsa-miR-4724-3p	CLIP-seq
MIRT2271029	hsa-miR-4724-5p	CLIP-seq
MIRT2271030	hsa-miR-4728-3p	CLIP-seq
MIRT2271031	hsa-miR-4731-5p	CLIP-seq
MIRT1145472	hsa-miR-4733-5p	CLIP-seq
MIRT1145476	hsa-miR-4762-5p	CLIP-seq
MIRT2041404	hsa-miR-4789-3p	CLIP-seq
MIRT2041405	hsa-miR-4795-3p	CLIP-seq
MIRT1145478	hsa-miR-4797-3p	CLIP-seq
MIRT1145479	hsa-miR-487a	CLIP-seq
MIRT1145480	hsa-miR-499-3p	CLIP-seq
MIRT1145481	hsa-miR-499a-3p	CLIP-seq
MIRT1145482	hsa-miR-545	CLIP-seq
MIRT1145484	hsa-miR-548a-5p	CLIP-seq
MIRT1145485	hsa-miR-548ab	CLIP-seq
MIRT1145486	hsa-miR-548ak	CLIP-seq
MIRT1145487	hsa-miR-548an	CLIP-seq
MIRT1145488	hsa-miR-548b-5p	CLIP-seq
MIRT1145489	hsa-miR-548c-5p	CLIP-seq
MIRT1145490	hsa-miR-548d-5p	CLIP-seq
MIRT1145493	hsa-miR-548h	CLIP-seq
MIRT1145494	hsa-miR-548i	CLIP-seq
MIRT1145495	hsa-miR-548j	CLIP-seq
MIRT1145496	hsa-miR-548k	CLIP-seq
MIRT1145497	hsa-miR-548l	CLIP-seq
MIRT1145498	hsa-miR-548o	CLIP-seq
MIRT1145499	hsa-miR-548w	CLIP-seq
MIRT1145500	hsa-miR-548y	CLIP-seq
MIRT1145501	hsa-miR-559	CLIP-seq
MIRT2271032	hsa-miR-584	CLIP-seq
MIRT2271033	hsa-miR-591	CLIP-seq
MIRT1145502	hsa-miR-607	CLIP-seq
MIRT1145503	hsa-miR-632	CLIP-seq
MIRT1145505	hsa-miR-802	CLIP-seq
MIRT1145437	hsa-miR-136	CLIP-seq
MIRT1145446	hsa-miR-3163	CLIP-seq
MIRT1145469	hsa-miR-4668-3p	CLIP-seq
MIRT1145472	hsa-miR-4733-5p	CLIP-seq
MIRT1145483	hsa-miR-548a-3p	CLIP-seq
MIRT1145491	hsa-miR-548e	CLIP-seq
MIRT1145492	hsa-miR-548f	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IDA	23408853
GO:0000932	Component	P-body	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IDA	23408853
GO:0003723	Function	RNA binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	36931259
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006468	Process	Protein phosphorylation	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0046777	Process	Protein autophosphorylation	ISS
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
611008	25297	ENSG00000183496

Q6ZN04

Protein name

RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195)

Protein function

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00013	KH_1	67 → 129	KH domain	Domain
PF00013	KH_1	162 → 223	KH domain	Domain
PF13920	zf-C3HC4_3	514 → 564		Domain

Tissue specificity

TISSUE SPECIFICITY: Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level. {ECO:0000269|PubMed:17267406}.

Sequence

MPSSLFADLERNGSGGGGGGSSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPR
KKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDV
AMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKG
ATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDEND
FHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSY
FGGGTSSSAAATQRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGGEASVPSPDGCPELQ
PTFDPAPAPPPGAPLIWAQFERSPGGGPAAPVSSSCSSSASSSASSSSVVFPGGGASAPS
NANLGLLVHRRLHPGTSCPRLSPPLHMAPGAGEHHLARRVRSDPGGGGLAYAAYANGLGA
QLPGLQPSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCM
ECANRICEKSEPECPVCHTAVTQAIRIFS

Sequence length

569

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OTOSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORY PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bone Diseases Metabolic	Bone disease	Pubtator	36077598	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic rhinosinusitis with nasal polyps	Rhinosinusitis With Nasal Polyps	BEFREE	31330219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypereosinophilic Syndrome	Hypereosinophilic syndrome	Pubtator	36976645	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29496759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasal Polyps	Nasal polyp	Pubtator	36976645	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	36077598	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MEX3B (mex-3 RNA binding family member B)