TXNDC2 (thioredoxin domain containing 2)

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Gene Gene information from NCBI Gene database.
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Entrez ID 84203
Gene name Thioredoxin domain containing 2
Gene symbol TXNDC2
Synonyms (NCBI Gene)
SPTRXSPTRX1
Chromosome 18
Chromosome location 18p11.22
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0004791 Function Thioredoxin-disulfide reductase (NADPH) activity IDA 11399755
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm IDA 11399755
GO:0005737 Component Cytoplasm IEA
GO:0007283 Process Spermatogenesis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
617790 16470 ENSG00000168454
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86VQ3
Protein name Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1)
Protein function Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulf
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin 450 → 551 Thioredoxin Domain
Tissue specificity TISSUE SPECIFICITY: Testis-specific. Only expressed during spermiogenesis, prominently in round and elongating spermatids. {ECO:0000269|PubMed:11399755}.
Sequence 
MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQA
KEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP
KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP
KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP
KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP
KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP
KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSP
KSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWC
GPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGA
LKEKLEAVIAELK
Sequence length 553
Interactions View interactions

No strongly related genes found yet for TXNDC2.

No additional diseases found yet through genes similar to TXNDC2.