FAR1 (fatty acyl-CoA reductase 1)

Gene

• Entrez ID: 84188
• Gene name: Fatty acyl-CoA reductase 1
• Gene symbol: FAR1
• Synonyms (NCBI Gene): CSPSD, MLSTD2, PFCRD, SDR10E1
• Chromosome: 11
• Chromosome location: 11p15.3
• Summary: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs724159962	C>T	Pathogenic	Coding sequence variant, stop gained
rs724159963	A>G	Pathogenic	Coding sequence variant, missense variant
rs727502796	AGTAGTCTATCCA>T	Pathogenic	Coding sequence variant, inframe indel
rs1057517926	G>A,T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1591268116	G>A	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005244	hsa-miR-155-5p	pSILAC	18668040
MIRT005244	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT022825	hsa-miR-124-3p	Microarray	18668037
MIRT027338	hsa-miR-101-3p	Sequencing	20371350
MIRT042376	hsa-miR-484	CLASH	23622248
MIRT038835	hsa-miR-93-3p	CLASH	23622248
MIRT005244	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT005244	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT129544	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT129552	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT129543	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT989233	hsa-miR-101	CLIP-seq
MIRT989234	hsa-miR-105	CLIP-seq
MIRT989235	hsa-miR-1183	CLIP-seq
MIRT989236	hsa-miR-1252	CLIP-seq
MIRT989237	hsa-miR-128	CLIP-seq
MIRT989238	hsa-miR-1321	CLIP-seq
MIRT989239	hsa-miR-1323	CLIP-seq
MIRT989240	hsa-miR-141	CLIP-seq
MIRT989241	hsa-miR-142-5p	CLIP-seq
MIRT989242	hsa-miR-144	CLIP-seq
MIRT989243	hsa-miR-181a	CLIP-seq
MIRT989244	hsa-miR-181b	CLIP-seq
MIRT989245	hsa-miR-181c	CLIP-seq
MIRT989246	hsa-miR-181d	CLIP-seq
MIRT989247	hsa-miR-190	CLIP-seq
MIRT989248	hsa-miR-190b	CLIP-seq
MIRT989249	hsa-miR-1976	CLIP-seq
MIRT989250	hsa-miR-200a	CLIP-seq
MIRT989251	hsa-miR-2117	CLIP-seq
MIRT989252	hsa-miR-216a	CLIP-seq
MIRT989253	hsa-miR-25	CLIP-seq
MIRT989254	hsa-miR-2964a-3p	CLIP-seq
MIRT989255	hsa-miR-3065-3p	CLIP-seq
MIRT989256	hsa-miR-3143	CLIP-seq
MIRT989257	hsa-miR-3145-5p	CLIP-seq
MIRT989258	hsa-miR-3146	CLIP-seq
MIRT989259	hsa-miR-3148	CLIP-seq
MIRT989260	hsa-miR-3150b-3p	CLIP-seq
MIRT989261	hsa-miR-3160-3p	CLIP-seq
MIRT989262	hsa-miR-3161	CLIP-seq
MIRT989263	hsa-miR-3174	CLIP-seq
MIRT989264	hsa-miR-3180-5p	CLIP-seq
MIRT989265	hsa-miR-3185	CLIP-seq
MIRT989266	hsa-miR-3190	CLIP-seq
MIRT989267	hsa-miR-32	CLIP-seq
MIRT989268	hsa-miR-325	CLIP-seq
MIRT989269	hsa-miR-33a	CLIP-seq
MIRT989270	hsa-miR-33b	CLIP-seq
MIRT989271	hsa-miR-340	CLIP-seq
MIRT989272	hsa-miR-342-3p	CLIP-seq
MIRT989273	hsa-miR-34c-3p	CLIP-seq
MIRT989274	hsa-miR-363	CLIP-seq
MIRT989275	hsa-miR-3646	CLIP-seq
MIRT989276	hsa-miR-3662	CLIP-seq
MIRT989277	hsa-miR-367	CLIP-seq
MIRT989278	hsa-miR-3671	CLIP-seq
MIRT989279	hsa-miR-3677-5p	CLIP-seq
MIRT989280	hsa-miR-3688-3p	CLIP-seq
MIRT989281	hsa-miR-370	CLIP-seq
MIRT989282	hsa-miR-374c	CLIP-seq
MIRT989283	hsa-miR-382	CLIP-seq
MIRT989284	hsa-miR-3920	CLIP-seq
MIRT989285	hsa-miR-3935	CLIP-seq
MIRT989286	hsa-miR-3977	CLIP-seq
MIRT989287	hsa-miR-425	CLIP-seq
MIRT989288	hsa-miR-4262	CLIP-seq
MIRT989289	hsa-miR-4273	CLIP-seq
MIRT989290	hsa-miR-4278	CLIP-seq
MIRT989291	hsa-miR-4302	CLIP-seq
MIRT989292	hsa-miR-4307	CLIP-seq
MIRT989293	hsa-miR-4325	CLIP-seq
MIRT989294	hsa-miR-4427	CLIP-seq
MIRT989295	hsa-miR-4457	CLIP-seq
MIRT989296	hsa-miR-4477b	CLIP-seq
MIRT989297	hsa-miR-448	CLIP-seq
MIRT989298	hsa-miR-4481	CLIP-seq
MIRT989299	hsa-miR-4487	CLIP-seq
MIRT989300	hsa-miR-4491	CLIP-seq
MIRT989301	hsa-miR-4503	CLIP-seq
MIRT989302	hsa-miR-450b-5p	CLIP-seq
MIRT989303	hsa-miR-4517	CLIP-seq
MIRT989304	hsa-miR-4635	CLIP-seq
MIRT989305	hsa-miR-4639-5p	CLIP-seq
MIRT989306	hsa-miR-4646-3p	CLIP-seq
MIRT989307	hsa-miR-4657	CLIP-seq
MIRT989308	hsa-miR-4661-3p	CLIP-seq
MIRT989309	hsa-miR-4668-5p	CLIP-seq
MIRT989310	hsa-miR-4693-5p	CLIP-seq
MIRT989311	hsa-miR-4696	CLIP-seq
MIRT989312	hsa-miR-4711-5p	CLIP-seq
MIRT989313	hsa-miR-4716-3p	CLIP-seq
MIRT989314	hsa-miR-4719	CLIP-seq
MIRT989315	hsa-miR-4720-5p	CLIP-seq
MIRT989316	hsa-miR-4724-5p	CLIP-seq
MIRT989317	hsa-miR-4729	CLIP-seq
MIRT989318	hsa-miR-4731-3p	CLIP-seq
MIRT989319	hsa-miR-4733-3p	CLIP-seq
MIRT989320	hsa-miR-4739	CLIP-seq
MIRT989321	hsa-miR-4745-5p	CLIP-seq
MIRT989322	hsa-miR-4753-3p	CLIP-seq
MIRT989323	hsa-miR-4756-5p	CLIP-seq
MIRT989324	hsa-miR-4757-5p	CLIP-seq
MIRT989325	hsa-miR-4758-5p	CLIP-seq
MIRT989326	hsa-miR-4760-3p	CLIP-seq
MIRT989327	hsa-miR-4762-5p	CLIP-seq
MIRT989328	hsa-miR-4763-5p	CLIP-seq
MIRT989329	hsa-miR-4784	CLIP-seq
MIRT989330	hsa-miR-4789-5p	CLIP-seq
MIRT989331	hsa-miR-4799-3p	CLIP-seq
MIRT989332	hsa-miR-4801	CLIP-seq
MIRT989333	hsa-miR-4803	CLIP-seq
MIRT989334	hsa-miR-507	CLIP-seq
MIRT989335	hsa-miR-508-5p	CLIP-seq
MIRT989336	hsa-miR-513b	CLIP-seq
MIRT989337	hsa-miR-513c	CLIP-seq
MIRT989338	hsa-miR-514b-5p	CLIP-seq
MIRT989339	hsa-miR-520a-5p	CLIP-seq
MIRT989340	hsa-miR-520d-5p	CLIP-seq
MIRT989341	hsa-miR-520g	CLIP-seq
MIRT989342	hsa-miR-520h	CLIP-seq
MIRT989343	hsa-miR-524-5p	CLIP-seq
MIRT989344	hsa-miR-525-5p	CLIP-seq
MIRT989345	hsa-miR-526b	CLIP-seq
MIRT989346	hsa-miR-543	CLIP-seq
MIRT989347	hsa-miR-548a-3p	CLIP-seq
MIRT989348	hsa-miR-548ac	CLIP-seq
MIRT989349	hsa-miR-548d-3p	CLIP-seq
MIRT989350	hsa-miR-548e	CLIP-seq
MIRT989351	hsa-miR-548f	CLIP-seq
MIRT989352	hsa-miR-548o	CLIP-seq
MIRT989353	hsa-miR-548p	CLIP-seq
MIRT989354	hsa-miR-548z	CLIP-seq
MIRT989355	hsa-miR-556-3p	CLIP-seq
MIRT989356	hsa-miR-557	CLIP-seq
MIRT989357	hsa-miR-558	CLIP-seq
MIRT989358	hsa-miR-578	CLIP-seq
MIRT989359	hsa-miR-579	CLIP-seq
MIRT989360	hsa-miR-586	CLIP-seq
MIRT989361	hsa-miR-625	CLIP-seq
MIRT989362	hsa-miR-628-3p	CLIP-seq
MIRT989363	hsa-miR-642b	CLIP-seq
MIRT989364	hsa-miR-651	CLIP-seq
MIRT989365	hsa-miR-655	CLIP-seq
MIRT989366	hsa-miR-664	CLIP-seq
MIRT989367	hsa-miR-765	CLIP-seq
MIRT989368	hsa-miR-889	CLIP-seq
MIRT989369	hsa-miR-92a	CLIP-seq
MIRT989370	hsa-miR-92b	CLIP-seq
MIRT1548584	hsa-miR-3912	CLIP-seq
MIRT989358	hsa-miR-578	CLIP-seq
MIRT989233	hsa-miR-101	CLIP-seq
MIRT989234	hsa-miR-105	CLIP-seq
MIRT989235	hsa-miR-1183	CLIP-seq
MIRT1993133	hsa-miR-1197	CLIP-seq
MIRT1993134	hsa-miR-1264	CLIP-seq
MIRT1993135	hsa-miR-132	CLIP-seq
MIRT989239	hsa-miR-1323	CLIP-seq
MIRT1993136	hsa-miR-1324	CLIP-seq
MIRT989242	hsa-miR-144	CLIP-seq
MIRT1993137	hsa-miR-186	CLIP-seq
MIRT989247	hsa-miR-190	CLIP-seq
MIRT989248	hsa-miR-190b	CLIP-seq
MIRT989249	hsa-miR-1976	CLIP-seq
MIRT1993138	hsa-miR-2053	CLIP-seq
MIRT1993139	hsa-miR-212	CLIP-seq
MIRT1993140	hsa-miR-224	CLIP-seq
MIRT1993141	hsa-miR-2355-5p	CLIP-seq
MIRT989253	hsa-miR-25	CLIP-seq
MIRT1993142	hsa-miR-297	CLIP-seq
MIRT1993143	hsa-miR-298	CLIP-seq
MIRT1993144	hsa-miR-299-3p	CLIP-seq
MIRT1993145	hsa-miR-3117-3p	CLIP-seq
MIRT1993146	hsa-miR-3130-3p	CLIP-seq
MIRT1993147	hsa-miR-3145-3p	CLIP-seq
MIRT989257	hsa-miR-3145-5p	CLIP-seq
MIRT1993148	hsa-miR-3158-3p	CLIP-seq
MIRT989262	hsa-miR-3161	CLIP-seq
MIRT1993149	hsa-miR-3163	CLIP-seq
MIRT989267	hsa-miR-32	CLIP-seq
MIRT1993150	hsa-miR-337-3p	CLIP-seq
MIRT1993151	hsa-miR-3613-3p	CLIP-seq
MIRT989274	hsa-miR-363	CLIP-seq
MIRT989277	hsa-miR-367	CLIP-seq
MIRT989278	hsa-miR-3671	CLIP-seq
MIRT1993152	hsa-miR-3679-3p	CLIP-seq
MIRT1993153	hsa-miR-3691-3p	CLIP-seq
MIRT989281	hsa-miR-370	CLIP-seq
MIRT1993154	hsa-miR-371b-5p	CLIP-seq
MIRT989282	hsa-miR-374c	CLIP-seq
MIRT1993155	hsa-miR-3910	CLIP-seq
MIRT989284	hsa-miR-3920	CLIP-seq
MIRT1993156	hsa-miR-3942-3p	CLIP-seq
MIRT1993157	hsa-miR-3976	CLIP-seq
MIRT989286	hsa-miR-3977	CLIP-seq
MIRT1993158	hsa-miR-409-3p	CLIP-seq
MIRT1993159	hsa-miR-421	CLIP-seq
MIRT1993160	hsa-miR-4255	CLIP-seq
MIRT1993161	hsa-miR-4263	CLIP-seq
MIRT1993162	hsa-miR-4265	CLIP-seq
MIRT1993163	hsa-miR-4296	CLIP-seq
MIRT989291	hsa-miR-4302	CLIP-seq
MIRT1993164	hsa-miR-4322	CLIP-seq
MIRT1993165	hsa-miR-4326	CLIP-seq
MIRT1993166	hsa-miR-4328	CLIP-seq
MIRT1993167	hsa-miR-4417	CLIP-seq
MIRT1993168	hsa-miR-4423-5p	CLIP-seq
MIRT1993169	hsa-miR-4424	CLIP-seq
MIRT1993170	hsa-miR-4426	CLIP-seq
MIRT1993171	hsa-miR-4437	CLIP-seq
MIRT1993172	hsa-miR-4446-3p	CLIP-seq
MIRT1993173	hsa-miR-4474-5p	CLIP-seq
MIRT1993174	hsa-miR-4477a	CLIP-seq
MIRT1993175	hsa-miR-4480	CLIP-seq
MIRT989300	hsa-miR-4491	CLIP-seq
MIRT1993176	hsa-miR-4495	CLIP-seq
MIRT989302	hsa-miR-450b-5p	CLIP-seq
MIRT1993177	hsa-miR-4528	CLIP-seq
MIRT1993178	hsa-miR-4633-5p	CLIP-seq
MIRT1993179	hsa-miR-4637	CLIP-seq
MIRT1993180	hsa-miR-4640-5p	CLIP-seq
MIRT1993181	hsa-miR-4647	CLIP-seq
MIRT1993182	hsa-miR-4652-3p	CLIP-seq
MIRT989307	hsa-miR-4657	CLIP-seq
MIRT1993183	hsa-miR-4659a-3p	CLIP-seq
MIRT1993184	hsa-miR-4659b-3p	CLIP-seq
MIRT1993185	hsa-miR-466	CLIP-seq
MIRT1993186	hsa-miR-4662b	CLIP-seq
MIRT1993187	hsa-miR-4680-5p	CLIP-seq
MIRT989311	hsa-miR-4696	CLIP-seq
MIRT1993188	hsa-miR-4697-3p	CLIP-seq
MIRT1993189	hsa-miR-4698	CLIP-seq
MIRT1993190	hsa-miR-4709-5p	CLIP-seq
MIRT1993191	hsa-miR-4726-5p	CLIP-seq
MIRT989326	hsa-miR-4760-3p	CLIP-seq
MIRT1993192	hsa-miR-4760-5p	CLIP-seq
MIRT1993193	hsa-miR-4788	CLIP-seq
MIRT989330	hsa-miR-4789-5p	CLIP-seq
MIRT1993194	hsa-miR-4793-3p	CLIP-seq
MIRT989333	hsa-miR-4803	CLIP-seq
MIRT1993195	hsa-miR-491-3p	CLIP-seq
MIRT989334	hsa-miR-507	CLIP-seq
MIRT989335	hsa-miR-508-5p	CLIP-seq
MIRT1993196	hsa-miR-5096	CLIP-seq
MIRT989340	hsa-miR-520d-5p	CLIP-seq
MIRT989343	hsa-miR-524-5p	CLIP-seq
MIRT1993197	hsa-miR-548an	CLIP-seq
MIRT1993198	hsa-miR-548c-3p	CLIP-seq
MIRT989352	hsa-miR-548o	CLIP-seq
MIRT1993199	hsa-miR-550b	CLIP-seq
MIRT989356	hsa-miR-557	CLIP-seq
MIRT1993200	hsa-miR-562	CLIP-seq
MIRT1993201	hsa-miR-567	CLIP-seq
MIRT1993202	hsa-miR-569	CLIP-seq
MIRT989359	hsa-miR-579	CLIP-seq
MIRT1993203	hsa-miR-618	CLIP-seq
MIRT989365	hsa-miR-655	CLIP-seq
MIRT1993204	hsa-miR-656	CLIP-seq
MIRT989369	hsa-miR-92a	CLIP-seq
MIRT989370	hsa-miR-92b	CLIP-seq
MIRT1993133	hsa-miR-1197	CLIP-seq
MIRT2227042	hsa-miR-1270	CLIP-seq
MIRT2227043	hsa-miR-1273f	CLIP-seq
MIRT989239	hsa-miR-1323	CLIP-seq
MIRT1993136	hsa-miR-1324	CLIP-seq
MIRT2227044	hsa-miR-149	CLIP-seq
MIRT2227045	hsa-miR-155	CLIP-seq
MIRT989243	hsa-miR-181a	CLIP-seq
MIRT989244	hsa-miR-181b	CLIP-seq
MIRT989245	hsa-miR-181c	CLIP-seq
MIRT989246	hsa-miR-181d	CLIP-seq
MIRT2227046	hsa-miR-185	CLIP-seq
MIRT989247	hsa-miR-190	CLIP-seq
MIRT989248	hsa-miR-190b	CLIP-seq
MIRT989249	hsa-miR-1976	CLIP-seq
MIRT989253	hsa-miR-25	CLIP-seq
MIRT989254	hsa-miR-2964a-3p	CLIP-seq
MIRT2227047	hsa-miR-299-5p	CLIP-seq
MIRT2227048	hsa-miR-3064-5p	CLIP-seq
MIRT989255	hsa-miR-3065-3p	CLIP-seq
MIRT1993145	hsa-miR-3117-3p	CLIP-seq
MIRT2227049	hsa-miR-3126-3p	CLIP-seq
MIRT989259	hsa-miR-3148	CLIP-seq
MIRT1993149	hsa-miR-3163	CLIP-seq
MIRT989263	hsa-miR-3174	CLIP-seq
MIRT989264	hsa-miR-3180-5p	CLIP-seq
MIRT989267	hsa-miR-32	CLIP-seq
MIRT1993150	hsa-miR-337-3p	CLIP-seq
MIRT1993151	hsa-miR-3613-3p	CLIP-seq
MIRT989274	hsa-miR-363	CLIP-seq
MIRT989276	hsa-miR-3662	CLIP-seq
MIRT989277	hsa-miR-367	CLIP-seq
MIRT989279	hsa-miR-3677-5p	CLIP-seq
MIRT2227050	hsa-miR-3682-5p	CLIP-seq
MIRT989281	hsa-miR-370	CLIP-seq
MIRT2227051	hsa-miR-377	CLIP-seq
MIRT2227052	hsa-miR-3924	CLIP-seq
MIRT2227053	hsa-miR-3941	CLIP-seq
MIRT1993156	hsa-miR-3942-3p	CLIP-seq
MIRT2227054	hsa-miR-3974	CLIP-seq
MIRT989286	hsa-miR-3977	CLIP-seq
MIRT2227055	hsa-miR-3978	CLIP-seq
MIRT1993159	hsa-miR-421	CLIP-seq
MIRT1993160	hsa-miR-4255	CLIP-seq
MIRT989288	hsa-miR-4262	CLIP-seq
MIRT2227056	hsa-miR-4272	CLIP-seq
MIRT989291	hsa-miR-4302	CLIP-seq
MIRT2227057	hsa-miR-4306	CLIP-seq
MIRT989293	hsa-miR-4325	CLIP-seq
MIRT1993165	hsa-miR-4326	CLIP-seq
MIRT1993166	hsa-miR-4328	CLIP-seq
MIRT2227058	hsa-miR-4420	CLIP-seq
MIRT1993170	hsa-miR-4426	CLIP-seq
MIRT989298	hsa-miR-4481	CLIP-seq
MIRT1993176	hsa-miR-4495	CLIP-seq
MIRT989301	hsa-miR-4503	CLIP-seq
MIRT989303	hsa-miR-4517	CLIP-seq
MIRT2227059	hsa-miR-4531	CLIP-seq
MIRT2227060	hsa-miR-4534	CLIP-seq
MIRT2227061	hsa-miR-4643	CLIP-seq
MIRT2227062	hsa-miR-4644	CLIP-seq
MIRT1993181	hsa-miR-4647	CLIP-seq
MIRT1993182	hsa-miR-4652-3p	CLIP-seq
MIRT1993185	hsa-miR-466	CLIP-seq
MIRT1993186	hsa-miR-4662b	CLIP-seq
MIRT989309	hsa-miR-4668-5p	CLIP-seq
MIRT2227063	hsa-miR-4672	CLIP-seq
MIRT989310	hsa-miR-4693-5p	CLIP-seq
MIRT1993188	hsa-miR-4697-3p	CLIP-seq
MIRT1993189	hsa-miR-4698	CLIP-seq
MIRT2227064	hsa-miR-4699-3p	CLIP-seq
MIRT1993190	hsa-miR-4709-5p	CLIP-seq
MIRT989313	hsa-miR-4716-3p	CLIP-seq
MIRT2227065	hsa-miR-4724-3p	CLIP-seq
MIRT989316	hsa-miR-4724-5p	CLIP-seq
MIRT2227066	hsa-miR-4742-3p	CLIP-seq
MIRT989321	hsa-miR-4745-5p	CLIP-seq
MIRT989324	hsa-miR-4757-5p	CLIP-seq
MIRT989325	hsa-miR-4758-5p	CLIP-seq
MIRT989326	hsa-miR-4760-3p	CLIP-seq
MIRT1993192	hsa-miR-4760-5p	CLIP-seq
MIRT2227067	hsa-miR-4761-5p	CLIP-seq
MIRT2227068	hsa-miR-4775	CLIP-seq
MIRT2227069	hsa-miR-4789-3p	CLIP-seq
MIRT2227070	hsa-miR-4794	CLIP-seq
MIRT989333	hsa-miR-4803	CLIP-seq
MIRT2227071	hsa-miR-498	CLIP-seq
MIRT1993196	hsa-miR-5096	CLIP-seq
MIRT989337	hsa-miR-513c	CLIP-seq
MIRT989338	hsa-miR-514b-5p	CLIP-seq
MIRT989339	hsa-miR-520a-5p	CLIP-seq
MIRT989344	hsa-miR-525-5p	CLIP-seq
MIRT989347	hsa-miR-548a-3p	CLIP-seq
MIRT989350	hsa-miR-548e	CLIP-seq
MIRT989351	hsa-miR-548f	CLIP-seq
MIRT989352	hsa-miR-548o	CLIP-seq
MIRT989355	hsa-miR-556-3p	CLIP-seq
MIRT2227072	hsa-miR-561	CLIP-seq
MIRT1993201	hsa-miR-567	CLIP-seq
MIRT2227073	hsa-miR-620	CLIP-seq
MIRT989361	hsa-miR-625	CLIP-seq
MIRT2227074	hsa-miR-628-5p	CLIP-seq
MIRT2227075	hsa-miR-630	CLIP-seq
MIRT2227076	hsa-miR-875-3p	CLIP-seq
MIRT989368	hsa-miR-889	CLIP-seq
MIRT989369	hsa-miR-92a	CLIP-seq
MIRT989370	hsa-miR-92b	CLIP-seq
MIRT2387892	hsa-miR-3160-5p	CLIP-seq
MIRT2387893	hsa-miR-4446-5p	CLIP-seq
MIRT2387894	hsa-miR-4755-5p	CLIP-seq
MIRT2227071	hsa-miR-498	CLIP-seq
MIRT2387895	hsa-miR-670	CLIP-seq
MIRT989234	hsa-miR-105	CLIP-seq
MIRT1993133	hsa-miR-1197	CLIP-seq
MIRT2530864	hsa-miR-1245b-5p	CLIP-seq
MIRT1993134	hsa-miR-1264	CLIP-seq
MIRT989239	hsa-miR-1323	CLIP-seq
MIRT2530865	hsa-miR-138	CLIP-seq
MIRT989243	hsa-miR-181a	CLIP-seq
MIRT989244	hsa-miR-181b	CLIP-seq
MIRT989245	hsa-miR-181c	CLIP-seq
MIRT989246	hsa-miR-181d	CLIP-seq
MIRT989249	hsa-miR-1976	CLIP-seq
MIRT2530866	hsa-miR-202	CLIP-seq
MIRT1993138	hsa-miR-2053	CLIP-seq
MIRT989252	hsa-miR-216a	CLIP-seq
MIRT1993145	hsa-miR-3117-3p	CLIP-seq
MIRT2530867	hsa-miR-3129-3p	CLIP-seq
MIRT1993146	hsa-miR-3130-3p	CLIP-seq
MIRT2530868	hsa-miR-3142	CLIP-seq
MIRT989259	hsa-miR-3148	CLIP-seq
MIRT2530869	hsa-miR-3156-3p	CLIP-seq
MIRT989265	hsa-miR-3185	CLIP-seq
MIRT989272	hsa-miR-342-3p	CLIP-seq
MIRT2530870	hsa-miR-345	CLIP-seq
MIRT989273	hsa-miR-34c-3p	CLIP-seq
MIRT1993151	hsa-miR-3613-3p	CLIP-seq
MIRT2530871	hsa-miR-361-3p	CLIP-seq
MIRT2530872	hsa-miR-3620	CLIP-seq
MIRT989275	hsa-miR-3646	CLIP-seq
MIRT989276	hsa-miR-3662	CLIP-seq
MIRT989278	hsa-miR-3671	CLIP-seq
MIRT2530873	hsa-miR-3689d	CLIP-seq
MIRT1993153	hsa-miR-3691-3p	CLIP-seq
MIRT989281	hsa-miR-370	CLIP-seq
MIRT2530874	hsa-miR-371-5p	CLIP-seq
MIRT1993154	hsa-miR-371b-5p	CLIP-seq
MIRT2530875	hsa-miR-376a	CLIP-seq
MIRT2530876	hsa-miR-376b	CLIP-seq
MIRT989283	hsa-miR-382	CLIP-seq
MIRT2530877	hsa-miR-3913-3p	CLIP-seq
MIRT2530878	hsa-miR-3973	CLIP-seq
MIRT989286	hsa-miR-3977	CLIP-seq
MIRT1993158	hsa-miR-409-3p	CLIP-seq
MIRT2530879	hsa-miR-409-5p	CLIP-seq
MIRT2530880	hsa-miR-4254	CLIP-seq
MIRT989288	hsa-miR-4262	CLIP-seq
MIRT2530881	hsa-miR-4293	CLIP-seq
MIRT2530882	hsa-miR-4301	CLIP-seq
MIRT2530883	hsa-miR-4308	CLIP-seq
MIRT989293	hsa-miR-4325	CLIP-seq
MIRT1993168	hsa-miR-4423-5p	CLIP-seq
MIRT2530884	hsa-miR-4450	CLIP-seq
MIRT2530885	hsa-miR-4456	CLIP-seq
MIRT989295	hsa-miR-4457	CLIP-seq
MIRT989297	hsa-miR-448	CLIP-seq
MIRT1993175	hsa-miR-4480	CLIP-seq
MIRT989314	hsa-miR-4719	CLIP-seq
MIRT2530886	hsa-miR-4735-5p	CLIP-seq
MIRT1993192	hsa-miR-4760-5p	CLIP-seq
MIRT989327	hsa-miR-4762-5p	CLIP-seq
MIRT989328	hsa-miR-4763-5p	CLIP-seq
MIRT989330	hsa-miR-4789-5p	CLIP-seq
MIRT1993194	hsa-miR-4793-3p	CLIP-seq
MIRT989333	hsa-miR-4803	CLIP-seq
MIRT2530887	hsa-miR-489	CLIP-seq
MIRT2530888	hsa-miR-491-5p	CLIP-seq
MIRT2530889	hsa-miR-499-3p	CLIP-seq
MIRT2530890	hsa-miR-499a-3p	CLIP-seq
MIRT2530891	hsa-miR-501-3p	CLIP-seq
MIRT2530892	hsa-miR-502-3p	CLIP-seq
MIRT989336	hsa-miR-513b	CLIP-seq
MIRT989337	hsa-miR-513c	CLIP-seq
MIRT989338	hsa-miR-514b-5p	CLIP-seq
MIRT989340	hsa-miR-520d-5p	CLIP-seq
MIRT989341	hsa-miR-520g	CLIP-seq
MIRT989342	hsa-miR-520h	CLIP-seq
MIRT989343	hsa-miR-524-5p	CLIP-seq
MIRT2530893	hsa-miR-541	CLIP-seq
MIRT989347	hsa-miR-548a-3p	CLIP-seq
MIRT2530894	hsa-miR-548aa	CLIP-seq
MIRT989348	hsa-miR-548ac	CLIP-seq
MIRT989349	hsa-miR-548d-3p	CLIP-seq
MIRT989350	hsa-miR-548e	CLIP-seq
MIRT989351	hsa-miR-548f	CLIP-seq
MIRT989352	hsa-miR-548o	CLIP-seq
MIRT989354	hsa-miR-548z	CLIP-seq
MIRT1993202	hsa-miR-569	CLIP-seq
MIRT2530895	hsa-miR-570	CLIP-seq
MIRT989363	hsa-miR-642b	CLIP-seq
MIRT2530896	hsa-miR-654-5p	CLIP-seq
MIRT989366	hsa-miR-664	CLIP-seq
MIRT2530897	hsa-miR-942	CLIP-seq
MIRT1993133	hsa-miR-1197	CLIP-seq
MIRT1993134	hsa-miR-1264	CLIP-seq
MIRT989239	hsa-miR-1323	CLIP-seq
MIRT2530865	hsa-miR-138	CLIP-seq
MIRT989240	hsa-miR-141	CLIP-seq
MIRT2227045	hsa-miR-155	CLIP-seq
MIRT989243	hsa-miR-181a	CLIP-seq
MIRT989244	hsa-miR-181b	CLIP-seq
MIRT989245	hsa-miR-181c	CLIP-seq
MIRT989246	hsa-miR-181d	CLIP-seq
MIRT989249	hsa-miR-1976	CLIP-seq
MIRT989250	hsa-miR-200a	CLIP-seq
MIRT2530866	hsa-miR-202	CLIP-seq
MIRT1993138	hsa-miR-2053	CLIP-seq
MIRT989252	hsa-miR-216a	CLIP-seq
MIRT989255	hsa-miR-3065-3p	CLIP-seq
MIRT1993145	hsa-miR-3117-3p	CLIP-seq
MIRT2530867	hsa-miR-3129-3p	CLIP-seq
MIRT1993146	hsa-miR-3130-3p	CLIP-seq
MIRT2530869	hsa-miR-3156-3p	CLIP-seq
MIRT989263	hsa-miR-3174	CLIP-seq
MIRT989265	hsa-miR-3185	CLIP-seq
MIRT989272	hsa-miR-342-3p	CLIP-seq
MIRT2530870	hsa-miR-345	CLIP-seq
MIRT989273	hsa-miR-34c-3p	CLIP-seq
MIRT1993151	hsa-miR-3613-3p	CLIP-seq
MIRT2530871	hsa-miR-361-3p	CLIP-seq
MIRT2530872	hsa-miR-3620	CLIP-seq
MIRT989275	hsa-miR-3646	CLIP-seq
MIRT989276	hsa-miR-3662	CLIP-seq
MIRT989278	hsa-miR-3671	CLIP-seq
MIRT989279	hsa-miR-3677-5p	CLIP-seq
MIRT2530873	hsa-miR-3689d	CLIP-seq
MIRT989281	hsa-miR-370	CLIP-seq
MIRT2530874	hsa-miR-371-5p	CLIP-seq
MIRT1993154	hsa-miR-371b-5p	CLIP-seq
MIRT2227052	hsa-miR-3924	CLIP-seq
MIRT2680764	hsa-miR-3936	CLIP-seq
MIRT2530878	hsa-miR-3973	CLIP-seq
MIRT989286	hsa-miR-3977	CLIP-seq
MIRT1993158	hsa-miR-409-3p	CLIP-seq
MIRT2530879	hsa-miR-409-5p	CLIP-seq
MIRT2530880	hsa-miR-4254	CLIP-seq
MIRT989288	hsa-miR-4262	CLIP-seq
MIRT2530881	hsa-miR-4293	CLIP-seq
MIRT2530882	hsa-miR-4301	CLIP-seq
MIRT2530883	hsa-miR-4308	CLIP-seq
MIRT1993168	hsa-miR-4423-5p	CLIP-seq
MIRT2530884	hsa-miR-4450	CLIP-seq
MIRT2530885	hsa-miR-4456	CLIP-seq
MIRT989295	hsa-miR-4457	CLIP-seq
MIRT1993175	hsa-miR-4480	CLIP-seq
MIRT989298	hsa-miR-4481	CLIP-seq
MIRT1993187	hsa-miR-4680-5p	CLIP-seq
MIRT989314	hsa-miR-4719	CLIP-seq
MIRT2680765	hsa-miR-4728-3p	CLIP-seq
MIRT2530886	hsa-miR-4735-5p	CLIP-seq
MIRT989321	hsa-miR-4745-5p	CLIP-seq
MIRT989324	hsa-miR-4757-5p	CLIP-seq
MIRT989325	hsa-miR-4758-5p	CLIP-seq
MIRT1993192	hsa-miR-4760-5p	CLIP-seq
MIRT989327	hsa-miR-4762-5p	CLIP-seq
MIRT989330	hsa-miR-4789-5p	CLIP-seq
MIRT1993194	hsa-miR-4793-3p	CLIP-seq
MIRT989333	hsa-miR-4803	CLIP-seq
MIRT2530888	hsa-miR-491-5p	CLIP-seq
MIRT989336	hsa-miR-513b	CLIP-seq
MIRT989337	hsa-miR-513c	CLIP-seq
MIRT2680766	hsa-miR-514	CLIP-seq
MIRT2680767	hsa-miR-514b-3p	CLIP-seq
MIRT989338	hsa-miR-514b-5p	CLIP-seq
MIRT989341	hsa-miR-520g	CLIP-seq
MIRT989342	hsa-miR-520h	CLIP-seq
MIRT2530893	hsa-miR-541	CLIP-seq
MIRT2530894	hsa-miR-548aa	CLIP-seq
MIRT989348	hsa-miR-548ac	CLIP-seq
MIRT1993198	hsa-miR-548c-3p	CLIP-seq
MIRT989349	hsa-miR-548d-3p	CLIP-seq
MIRT989352	hsa-miR-548o	CLIP-seq
MIRT989354	hsa-miR-548z	CLIP-seq
MIRT2680768	hsa-miR-549	CLIP-seq
MIRT1993202	hsa-miR-569	CLIP-seq
MIRT2530895	hsa-miR-570	CLIP-seq
MIRT2680769	hsa-miR-576-3p	CLIP-seq
MIRT2680770	hsa-miR-576-5p	CLIP-seq
MIRT1993203	hsa-miR-618	CLIP-seq
MIRT989363	hsa-miR-642b	CLIP-seq
MIRT2530896	hsa-miR-654-5p	CLIP-seq
MIRT989366	hsa-miR-664	CLIP-seq
MIRT2530897	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	20071337
GO:0005777	Component	Peroxisome	IEA
GO:0005778	Component	Peroxisomal membrane	HDA	21525035
GO:0005778	Component	Peroxisomal membrane	IDA	24108123
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005778	Component	Peroxisomal membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008610	Process	Lipid biosynthetic process	IEA
GO:0008611	Process	Ether lipid biosynthetic process	IDA	24108123
GO:0008611	Process	Ether lipid biosynthetic process	IMP	20071337
GO:0010025	Process	Wax biosynthetic process	IEA
GO:0010025	Process	Wax biosynthetic process	ISS
GO:0010025	Process	Wax biosynthetic process	TAS
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016491	Function	Oxidoreductase activity	TAS
GO:0016620	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA
GO:0035336	Process	Long-chain fatty-acyl-CoA metabolic process	IBA
GO:0035336	Process	Long-chain fatty-acyl-CoA metabolic process	IDA	15220348
GO:0046474	Process	Glycerophospholipid biosynthetic process	IDA	20071337
GO:0080019	Function	Alcohol-forming very long-chain fatty acyl-CoA reductase activity	IBA
GO:0080019	Function	Alcohol-forming very long-chain fatty acyl-CoA reductase activity	IEA
GO:0102965	Function	Alcohol-forming long-chain fatty acyl-CoA reductase activity	IDA	15220348, 20071337, 24108123
GO:0102965	Function	Alcohol-forming long-chain fatty acyl-CoA reductase activity	IEA
GO:1901568	Process	Fatty acid derivative metabolic process	IEA

Other IDs

• MIM: 616107
• HGNC: 26222
• e!Ensembl: ENSG00000197601

Protein

• UniProt ID: Q8WVX9
• Protein name: Fatty acyl-CoA reductase 1 (FAR1) (EC 1.2.1.84) (Male sterility domain-containing protein 2)
• Protein function: Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123, PubMed:35238077). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07993	NAD_binding_4	15 → 285	Male sterility protein	Family
  PF03015	Sterile	356 → 448	Male sterility protein	Family

• Sequence:

  MVSIPEYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVL
  SGKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNEN
  LRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDS
  LEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPF
  PGWIDNFNGPSGLFIAAGKGILRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRPRNI
  MVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAP
  AFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKT
  FNIDVRQLHWAEYIENYCLGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWR
  IFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY

• Sequence length: 515

Pathways

KEGG:

Peroxisome

Reactome:

Wax biosynthesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
CATARACTS, SPASTIC PARAPARESIS, AND SPEECH DELAY	Likely pathogenic; Pathogenic	rs12799308, rs1057517926	RCV003329180 RCV004786679 RCV002446947 RCV003152710	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
CATARACTS, SPASTIC PARAPLEGIA, AND SPEECH DELAY	Likely pathogenic; Pathogenic	rs1057517926, rs12799308	RCV001431536 RCV001431538 RCV001431540	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
FAR1-related neurodevelopmental disorder	Likely pathogenic; Pathogenic	rs12799308	RCV001796073	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Fatty acyl-CoA reductase 1 deficiency	Likely pathogenic; Pathogenic	rs727502796, rs724159962, rs724159963, rs1591268116	RCV000149592 RCV000149593 RCV000149594 RCV000985084	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 9A	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DESBUQUOIS SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAR1-related disorder	Likely benign; Conflicting classifications of pathogenicity; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEROXISOMAL FATTY ACYL-COA REDUCTASE 1 DISORDER	—	HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPASTIC PARAPARESIS-CATARACTS-SPEECH DELAY SYNDROME	—	GWAS catalog, Orphanet GWAS catalog, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cataract	Cataract	BEFREE	25439727		★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	25439727, 33239752	Associate	★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebral Palsy	Cerebral palsy	Pubtator	33239752	Associate	★☆☆☆☆ Found in Text Mining only
Chondrodysplasia Punctata Rhizomelic	Chondrodysplasia	Pubtator	25439727	Associate	★☆☆☆☆ Found in Text Mining only
Chondrodysplasia Punctata, Rhizomelic	Chondrodysplasia Punctata	BEFREE	27616591		★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	30572792		★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	33239752	Associate	★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	30572792		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	25439727	Associate	★☆☆☆☆ Found in Text Mining only
Fatty acyl-CoA reductase 1 deficiency	Fatty Acyl-CoA Reductase Deficiency	Orphanet			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	25439727	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Macrotia	Macrotia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	Pubtator	25439727	Associate	★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Nervous System Diseases	Nervous system disease	Pubtator	33239752	Associate	★☆☆☆☆ Found in Text Mining only
Paraparesis Spastic	Paraparesis	Pubtator	33239752	Associate	★☆☆☆☆ Found in Text Mining only
PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER	Peroxisomal fatty ACYL-CoA reductase 1 disorder	ORPHANET_DG	25439727		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER	Peroxisomal fatty ACYL-CoA reductase 1 disorder	GENOMICS_ENGLAND_DG	25439727		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER	Peroxisomal fatty ACYL-CoA reductase 1 disorder	UNIPROT_DG	25439727		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEROXISOMAL FATTY ACYL-CoA REDUCTASE 1 DISORDER	Peroxisomal fatty ACYL-CoA reductase 1 disorder	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe intellectual disability	Mental retardation	BEFREE	25439727		★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia Hereditary	Hereditary spastic paraplegia	Pubtator	33239752	Associate	★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia, Hereditary	Spastic paraplegia	BEFREE	31616253		★☆☆☆☆ Found in Text Mining only