POLR1B (RNA polymerase I subunit B)

Gene

• Entrez ID: 84172
• Gene name: RNA polymerase I subunit B
• Gene symbol: POLR1B
• Synonyms (NCBI Gene): A135, RPA135, RPA2, Rpo1-2, TCS4
• Chromosome: 2
• Chromosome location: 2q14.1
• Summary: Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. M

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020763	hsa-miR-155-5p	Proteomics	18668040
MIRT032367	hsa-let-7b-5p	Proteomics	18668040
MIRT044045	hsa-miR-365a-3p	CLASH	23622248
MIRT674333	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT674332	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT674331	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT674330	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT674329	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT674328	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT674327	hsa-miR-4269	HITS-CLIP	23824327
MIRT674326	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT674325	hsa-miR-5693	HITS-CLIP	23824327
MIRT674324	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT674323	hsa-miR-4673	HITS-CLIP	23824327
MIRT674322	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT674321	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674320	hsa-miR-4284	HITS-CLIP	23824327
MIRT674319	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT674318	hsa-miR-1972	HITS-CLIP	23824327
MIRT674317	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT505875	hsa-miR-4295	PAR-CLIP	20371350
MIRT505876	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT505874	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT505873	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT505872	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT505871	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT505870	hsa-miR-3666	PAR-CLIP	20371350
MIRT505869	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT505868	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT505867	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT505866	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT505865	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT505864	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT505863	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT505862	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT505861	hsa-miR-548a-5p	PAR-CLIP	20371350
MIRT505860	hsa-miR-548ab	PAR-CLIP	20371350
MIRT505859	hsa-miR-548ad-5p	PAR-CLIP	20371350
MIRT505858	hsa-miR-548ae-5p	PAR-CLIP	20371350
MIRT505857	hsa-miR-548ak	PAR-CLIP	20371350
MIRT505856	hsa-miR-548am-5p	PAR-CLIP	20371350
MIRT505855	hsa-miR-548ap-5p	PAR-CLIP	20371350
MIRT505854	hsa-miR-548aq-5p	PAR-CLIP	20371350
MIRT505853	hsa-miR-548ar-5p	PAR-CLIP	20371350
MIRT505852	hsa-miR-548as-5p	PAR-CLIP	20371350
MIRT505851	hsa-miR-548au-5p	PAR-CLIP	20371350
MIRT505850	hsa-miR-548ay-5p	PAR-CLIP	20371350
MIRT505849	hsa-miR-548b-5p	PAR-CLIP	20371350
MIRT505848	hsa-miR-548bb-5p	PAR-CLIP	20371350
MIRT505847	hsa-miR-548c-5p	PAR-CLIP	20371350
MIRT505846	hsa-miR-548d-5p	PAR-CLIP	20371350
MIRT505845	hsa-miR-548h-5p	PAR-CLIP	20371350
MIRT505844	hsa-miR-548i	PAR-CLIP	20371350
MIRT505843	hsa-miR-548j-5p	PAR-CLIP	20371350
MIRT505842	hsa-miR-548o-5p	PAR-CLIP	20371350
MIRT505841	hsa-miR-548w	PAR-CLIP	20371350
MIRT505840	hsa-miR-548y	PAR-CLIP	20371350
MIRT505839	hsa-miR-559	PAR-CLIP	20371350
MIRT505838	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT505837	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT505836	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT044045	hsa-miR-365a-3p	PAR-CLIP	20371350
MIRT505835	hsa-miR-365b-3p	PAR-CLIP	20371350
MIRT505833	hsa-miR-6165	PAR-CLIP	20371350
MIRT505834	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT505832	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT505831	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT505875	hsa-miR-4295	PAR-CLIP	23446348
MIRT505876	hsa-miR-454-3p	PAR-CLIP	23446348
MIRT505874	hsa-miR-301b-3p	PAR-CLIP	23446348
MIRT505873	hsa-miR-130b-3p	PAR-CLIP	23446348
MIRT505872	hsa-miR-301a-3p	PAR-CLIP	23446348
MIRT505871	hsa-miR-130a-3p	PAR-CLIP	23446348
MIRT505870	hsa-miR-3666	PAR-CLIP	23446348
MIRT505869	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT505868	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT505867	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT505866	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT505865	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT505864	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT505863	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT505862	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT505861	hsa-miR-548a-5p	PAR-CLIP	23446348
MIRT505860	hsa-miR-548ab	PAR-CLIP	23446348
MIRT505859	hsa-miR-548ad-5p	PAR-CLIP	23446348
MIRT505858	hsa-miR-548ae-5p	PAR-CLIP	23446348
MIRT505857	hsa-miR-548ak	PAR-CLIP	23446348
MIRT505856	hsa-miR-548am-5p	PAR-CLIP	23446348
MIRT505855	hsa-miR-548ap-5p	PAR-CLIP	23446348
MIRT505854	hsa-miR-548aq-5p	PAR-CLIP	23446348
MIRT505853	hsa-miR-548ar-5p	PAR-CLIP	23446348
MIRT505852	hsa-miR-548as-5p	PAR-CLIP	23446348
MIRT505851	hsa-miR-548au-5p	PAR-CLIP	23446348
MIRT505850	hsa-miR-548ay-5p	PAR-CLIP	23446348
MIRT505849	hsa-miR-548b-5p	PAR-CLIP	23446348
MIRT505848	hsa-miR-548bb-5p	PAR-CLIP	23446348
MIRT505847	hsa-miR-548c-5p	PAR-CLIP	23446348
MIRT505846	hsa-miR-548d-5p	PAR-CLIP	23446348
MIRT505845	hsa-miR-548h-5p	PAR-CLIP	23446348
MIRT505844	hsa-miR-548i	PAR-CLIP	23446348
MIRT505843	hsa-miR-548j-5p	PAR-CLIP	23446348
MIRT505842	hsa-miR-548o-5p	PAR-CLIP	23446348
MIRT505841	hsa-miR-548w	PAR-CLIP	23446348
MIRT505840	hsa-miR-548y	PAR-CLIP	23446348
MIRT505839	hsa-miR-559	PAR-CLIP	23446348
MIRT505838	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT505837	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT505836	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT044045	hsa-miR-365a-3p	PAR-CLIP	23446348
MIRT505835	hsa-miR-365b-3p	PAR-CLIP	23446348
MIRT505833	hsa-miR-6165	PAR-CLIP	23446348
MIRT505834	hsa-miR-4766-5p	PAR-CLIP	23446348
MIRT505832	hsa-miR-873-5p	PAR-CLIP	23446348
MIRT505831	hsa-miR-3064-3p	PAR-CLIP	23446348
MIRT444830	hsa-miR-1264	PAR-CLIP	22100165
MIRT444829	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT444828	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT444827	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT444826	hsa-miR-4635	PAR-CLIP	22100165
MIRT444825	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT444830	hsa-miR-1264	PAR-CLIP	22100165
MIRT444829	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT444828	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT444827	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT444826	hsa-miR-4635	PAR-CLIP	22100165
MIRT444825	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT441587	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT441586	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT441585	hsa-miR-5197-5p	PAR-CLIP	22100165
MIRT441584	hsa-miR-3926	PAR-CLIP	22100165
MIRT441583	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT441582	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT441581	hsa-miR-548s	PAR-CLIP	22100165
MIRT674333	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT674332	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT674331	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT674330	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT674329	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT674328	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT674327	hsa-miR-4269	HITS-CLIP	23824327
MIRT674326	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT674325	hsa-miR-5693	HITS-CLIP	23824327
MIRT674324	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT674323	hsa-miR-4673	HITS-CLIP	23824327
MIRT674322	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT674321	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT674320	hsa-miR-4284	HITS-CLIP	23824327
MIRT674319	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT674318	hsa-miR-1972	HITS-CLIP	23824327
MIRT674317	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT505875	hsa-miR-4295	PAR-CLIP	20371350
MIRT505876	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT505874	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT505873	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT505872	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT505871	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT505870	hsa-miR-3666	PAR-CLIP	20371350
MIRT505869	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT505868	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT505867	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT505866	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT505865	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT505864	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT505863	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT505862	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT505861	hsa-miR-548a-5p	PAR-CLIP	20371350
MIRT505860	hsa-miR-548ab	PAR-CLIP	20371350
MIRT505859	hsa-miR-548ad-5p	PAR-CLIP	20371350
MIRT505858	hsa-miR-548ae-5p	PAR-CLIP	20371350
MIRT505857	hsa-miR-548ak	PAR-CLIP	20371350
MIRT505856	hsa-miR-548am-5p	PAR-CLIP	20371350
MIRT505855	hsa-miR-548ap-5p	PAR-CLIP	20371350
MIRT505854	hsa-miR-548aq-5p	PAR-CLIP	20371350
MIRT505853	hsa-miR-548ar-5p	PAR-CLIP	20371350
MIRT505852	hsa-miR-548as-5p	PAR-CLIP	20371350
MIRT505851	hsa-miR-548au-5p	PAR-CLIP	20371350
MIRT505850	hsa-miR-548ay-5p	PAR-CLIP	20371350
MIRT505849	hsa-miR-548b-5p	PAR-CLIP	20371350
MIRT505848	hsa-miR-548bb-5p	PAR-CLIP	20371350
MIRT505847	hsa-miR-548c-5p	PAR-CLIP	20371350
MIRT505846	hsa-miR-548d-5p	PAR-CLIP	20371350
MIRT505845	hsa-miR-548h-5p	PAR-CLIP	20371350
MIRT505844	hsa-miR-548i	PAR-CLIP	20371350
MIRT505843	hsa-miR-548j-5p	PAR-CLIP	20371350
MIRT505842	hsa-miR-548o-5p	PAR-CLIP	20371350
MIRT505841	hsa-miR-548w	PAR-CLIP	20371350
MIRT505840	hsa-miR-548y	PAR-CLIP	20371350
MIRT505839	hsa-miR-559	PAR-CLIP	20371350
MIRT505838	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT505837	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT505836	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT044045	hsa-miR-365a-3p	PAR-CLIP	20371350
MIRT505835	hsa-miR-365b-3p	PAR-CLIP	20371350
MIRT505833	hsa-miR-6165	PAR-CLIP	20371350
MIRT505834	hsa-miR-4766-5p	PAR-CLIP	20371350
MIRT505832	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT505831	hsa-miR-3064-3p	PAR-CLIP	20371350
MIRT505875	hsa-miR-4295	PAR-CLIP	23446348
MIRT505876	hsa-miR-454-3p	PAR-CLIP	23446348
MIRT505874	hsa-miR-301b-3p	PAR-CLIP	23446348
MIRT505873	hsa-miR-130b-3p	PAR-CLIP	23446348
MIRT505872	hsa-miR-301a-3p	PAR-CLIP	23446348
MIRT505871	hsa-miR-130a-3p	PAR-CLIP	23446348
MIRT505870	hsa-miR-3666	PAR-CLIP	23446348
MIRT505869	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT505868	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT505867	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT505866	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT505865	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT505864	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT505863	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT505862	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT505861	hsa-miR-548a-5p	PAR-CLIP	23446348
MIRT505860	hsa-miR-548ab	PAR-CLIP	23446348
MIRT505859	hsa-miR-548ad-5p	PAR-CLIP	23446348
MIRT505858	hsa-miR-548ae-5p	PAR-CLIP	23446348
MIRT505857	hsa-miR-548ak	PAR-CLIP	23446348
MIRT505856	hsa-miR-548am-5p	PAR-CLIP	23446348
MIRT505855	hsa-miR-548ap-5p	PAR-CLIP	23446348
MIRT505854	hsa-miR-548aq-5p	PAR-CLIP	23446348
MIRT505853	hsa-miR-548ar-5p	PAR-CLIP	23446348
MIRT505852	hsa-miR-548as-5p	PAR-CLIP	23446348
MIRT505851	hsa-miR-548au-5p	PAR-CLIP	23446348
MIRT505850	hsa-miR-548ay-5p	PAR-CLIP	23446348
MIRT505849	hsa-miR-548b-5p	PAR-CLIP	23446348
MIRT505848	hsa-miR-548bb-5p	PAR-CLIP	23446348
MIRT505847	hsa-miR-548c-5p	PAR-CLIP	23446348
MIRT505846	hsa-miR-548d-5p	PAR-CLIP	23446348
MIRT505845	hsa-miR-548h-5p	PAR-CLIP	23446348
MIRT505844	hsa-miR-548i	PAR-CLIP	23446348
MIRT505843	hsa-miR-548j-5p	PAR-CLIP	23446348
MIRT505842	hsa-miR-548o-5p	PAR-CLIP	23446348
MIRT505841	hsa-miR-548w	PAR-CLIP	23446348
MIRT505840	hsa-miR-548y	PAR-CLIP	23446348
MIRT505839	hsa-miR-559	PAR-CLIP	23446348
MIRT505838	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT505837	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT505836	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT044045	hsa-miR-365a-3p	PAR-CLIP	23446348
MIRT505835	hsa-miR-365b-3p	PAR-CLIP	23446348
MIRT505833	hsa-miR-6165	PAR-CLIP	23446348
MIRT505834	hsa-miR-4766-5p	PAR-CLIP	23446348
MIRT505832	hsa-miR-873-5p	PAR-CLIP	23446348
MIRT505831	hsa-miR-3064-3p	PAR-CLIP	23446348
MIRT444830	hsa-miR-1264	PAR-CLIP	22100165
MIRT444829	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT444828	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT444827	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT444826	hsa-miR-4635	PAR-CLIP	22100165
MIRT444825	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT444830	hsa-miR-1264	PAR-CLIP	22100165
MIRT444829	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT444828	hsa-miR-410-3p	PAR-CLIP	22100165
MIRT444827	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT444826	hsa-miR-4635	PAR-CLIP	22100165
MIRT444825	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT441587	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT441586	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT441585	hsa-miR-5197-5p	PAR-CLIP	22100165
MIRT441584	hsa-miR-3926	PAR-CLIP	22100165
MIRT441583	hsa-miR-374a-5p	PAR-CLIP	22100165
MIRT441582	hsa-miR-374b-5p	PAR-CLIP	22100165
MIRT441581	hsa-miR-548s	PAR-CLIP	22100165
MIRT1248249	hsa-miR-1226	CLIP-seq
MIRT1248250	hsa-miR-1228	CLIP-seq
MIRT1248251	hsa-miR-128	CLIP-seq
MIRT1248252	hsa-miR-2054	CLIP-seq
MIRT1248253	hsa-miR-224	CLIP-seq
MIRT1248254	hsa-miR-24	CLIP-seq
MIRT1248255	hsa-miR-25	CLIP-seq
MIRT1248256	hsa-miR-3156-3p	CLIP-seq
MIRT1248257	hsa-miR-32	CLIP-seq
MIRT1248258	hsa-miR-363	CLIP-seq
MIRT1248259	hsa-miR-367	CLIP-seq
MIRT1248260	hsa-miR-374a	CLIP-seq
MIRT1248261	hsa-miR-374b	CLIP-seq
MIRT1248262	hsa-miR-376a	CLIP-seq
MIRT1248263	hsa-miR-376b	CLIP-seq
MIRT1248264	hsa-miR-421	CLIP-seq
MIRT1248265	hsa-miR-4289	CLIP-seq
MIRT1248266	hsa-miR-4301	CLIP-seq
MIRT1248267	hsa-miR-4436a	CLIP-seq
MIRT1248268	hsa-miR-4639-5p	CLIP-seq
MIRT1248269	hsa-miR-4676-5p	CLIP-seq
MIRT1248270	hsa-miR-4700-3p	CLIP-seq
MIRT1248271	hsa-miR-4704-3p	CLIP-seq
MIRT1248272	hsa-miR-4709-5p	CLIP-seq
MIRT1248273	hsa-miR-4733-3p	CLIP-seq
MIRT1248274	hsa-miR-513a-5p	CLIP-seq
MIRT1248275	hsa-miR-575	CLIP-seq
MIRT1248276	hsa-miR-633	CLIP-seq
MIRT1248277	hsa-miR-92a	CLIP-seq
MIRT1248278	hsa-miR-92b	CLIP-seq
MIRT1248279	hsa-miR-10a	CLIP-seq
MIRT1248280	hsa-miR-10b	CLIP-seq
MIRT1248250	hsa-miR-1228	CLIP-seq
MIRT1248281	hsa-miR-1254	CLIP-seq
MIRT1248282	hsa-miR-1267	CLIP-seq
MIRT1248283	hsa-miR-1270	CLIP-seq
MIRT1248284	hsa-miR-1278	CLIP-seq
MIRT1248251	hsa-miR-128	CLIP-seq
MIRT1248285	hsa-miR-143	CLIP-seq
MIRT1248286	hsa-miR-153	CLIP-seq
MIRT1248287	hsa-miR-219-5p	CLIP-seq
MIRT1248254	hsa-miR-24	CLIP-seq
MIRT1248288	hsa-miR-3116	CLIP-seq
MIRT1248289	hsa-miR-3149	CLIP-seq
MIRT1248290	hsa-miR-3156-5p	CLIP-seq
MIRT1248291	hsa-miR-3200-3p	CLIP-seq
MIRT1248292	hsa-miR-323-3p	CLIP-seq
MIRT1248293	hsa-miR-33a	CLIP-seq
MIRT1248294	hsa-miR-33b	CLIP-seq
MIRT1248295	hsa-miR-3613-5p	CLIP-seq
MIRT1248296	hsa-miR-3974	CLIP-seq
MIRT1248297	hsa-miR-4307	CLIP-seq
MIRT1248298	hsa-miR-4327	CLIP-seq
MIRT1248267	hsa-miR-4436a	CLIP-seq
MIRT1248299	hsa-miR-4445	CLIP-seq
MIRT1248300	hsa-miR-448	CLIP-seq
MIRT1248301	hsa-miR-4509	CLIP-seq
MIRT1248269	hsa-miR-4676-5p	CLIP-seq
MIRT1248302	hsa-miR-4683	CLIP-seq
MIRT1248303	hsa-miR-4696	CLIP-seq
MIRT1248270	hsa-miR-4700-3p	CLIP-seq
MIRT1248271	hsa-miR-4704-3p	CLIP-seq
MIRT1248304	hsa-miR-4744	CLIP-seq
MIRT1248305	hsa-miR-4752	CLIP-seq
MIRT1248306	hsa-miR-4770	CLIP-seq
MIRT1248307	hsa-miR-4782-3p	CLIP-seq
MIRT1248308	hsa-miR-491-3p	CLIP-seq
MIRT1248309	hsa-miR-508-3p	CLIP-seq
MIRT1248274	hsa-miR-513a-5p	CLIP-seq
MIRT1248310	hsa-miR-550a	CLIP-seq
MIRT1248311	hsa-miR-556-3p	CLIP-seq
MIRT1248312	hsa-miR-567	CLIP-seq
MIRT1248313	hsa-miR-568	CLIP-seq
MIRT1248275	hsa-miR-575	CLIP-seq
MIRT1248314	hsa-miR-620	CLIP-seq
MIRT1248315	hsa-miR-661	CLIP-seq
MIRT1248316	hsa-miR-890	CLIP-seq
MIRT1248250	hsa-miR-1228	CLIP-seq
MIRT2073291	hsa-miR-1236	CLIP-seq
MIRT2073292	hsa-miR-1293	CLIP-seq
MIRT2073293	hsa-miR-1912	CLIP-seq
MIRT2073294	hsa-miR-3130-5p	CLIP-seq
MIRT1248292	hsa-miR-323-3p	CLIP-seq
MIRT1248293	hsa-miR-33a	CLIP-seq
MIRT1248294	hsa-miR-33b	CLIP-seq
MIRT2073295	hsa-miR-3545-3p	CLIP-seq
MIRT2073296	hsa-miR-3680	CLIP-seq
MIRT2073297	hsa-miR-370	CLIP-seq
MIRT1248264	hsa-miR-421	CLIP-seq
MIRT1248298	hsa-miR-4327	CLIP-seq
MIRT1248267	hsa-miR-4436a	CLIP-seq
MIRT2073298	hsa-miR-4482	CLIP-seq
MIRT2073299	hsa-miR-4483	CLIP-seq
MIRT1248269	hsa-miR-4676-5p	CLIP-seq
MIRT2073300	hsa-miR-4680-5p	CLIP-seq
MIRT1248270	hsa-miR-4700-3p	CLIP-seq
MIRT1248271	hsa-miR-4704-3p	CLIP-seq
MIRT1248272	hsa-miR-4709-5p	CLIP-seq
MIRT2073301	hsa-miR-4729	CLIP-seq
MIRT2073302	hsa-miR-500a	CLIP-seq
MIRT1248274	hsa-miR-513a-5p	CLIP-seq
MIRT1248311	hsa-miR-556-3p	CLIP-seq
MIRT1248275	hsa-miR-575	CLIP-seq
MIRT2073303	hsa-miR-656	CLIP-seq
MIRT2300388	hsa-miR-1182	CLIP-seq
MIRT2300389	hsa-miR-141	CLIP-seq
MIRT2300390	hsa-miR-142-5p	CLIP-seq
MIRT2300391	hsa-miR-193a-5p	CLIP-seq
MIRT2300392	hsa-miR-200a	CLIP-seq
MIRT2300393	hsa-miR-340	CLIP-seq
MIRT2073297	hsa-miR-370	CLIP-seq
MIRT1248267	hsa-miR-4436a	CLIP-seq
MIRT1248270	hsa-miR-4700-3p	CLIP-seq
MIRT1248279	hsa-miR-10a	CLIP-seq
MIRT1248280	hsa-miR-10b	CLIP-seq
MIRT2300388	hsa-miR-1182	CLIP-seq
MIRT1248250	hsa-miR-1228	CLIP-seq
MIRT2073292	hsa-miR-1293	CLIP-seq
MIRT2300391	hsa-miR-193a-5p	CLIP-seq
MIRT2597125	hsa-miR-194	CLIP-seq
MIRT2597126	hsa-miR-216a	CLIP-seq
MIRT1248287	hsa-miR-219-5p	CLIP-seq
MIRT2597127	hsa-miR-3163	CLIP-seq
MIRT2597128	hsa-miR-3165	CLIP-seq
MIRT1248292	hsa-miR-323-3p	CLIP-seq
MIRT2597129	hsa-miR-335	CLIP-seq
MIRT2597130	hsa-miR-3591-3p	CLIP-seq
MIRT2597131	hsa-miR-3614-5p	CLIP-seq
MIRT2597132	hsa-miR-3650	CLIP-seq
MIRT2597133	hsa-miR-380	CLIP-seq
MIRT2597134	hsa-miR-4282	CLIP-seq
MIRT1248297	hsa-miR-4307	CLIP-seq
MIRT1248299	hsa-miR-4445	CLIP-seq
MIRT2597135	hsa-miR-4452	CLIP-seq
MIRT1248300	hsa-miR-448	CLIP-seq
MIRT2073299	hsa-miR-4483	CLIP-seq
MIRT2597136	hsa-miR-4490	CLIP-seq
MIRT2597137	hsa-miR-4495	CLIP-seq
MIRT1248307	hsa-miR-4782-3p	CLIP-seq
MIRT2597138	hsa-miR-490-3p	CLIP-seq
MIRT2073302	hsa-miR-500a	CLIP-seq
MIRT1248309	hsa-miR-508-3p	CLIP-seq
MIRT2597139	hsa-miR-513c	CLIP-seq
MIRT2597140	hsa-miR-514b-5p	CLIP-seq
MIRT2597141	hsa-miR-548c-3p	CLIP-seq
MIRT1248311	hsa-miR-556-3p	CLIP-seq
MIRT1248312	hsa-miR-567	CLIP-seq
MIRT2597142	hsa-miR-630	CLIP-seq
MIRT2597143	hsa-miR-649	CLIP-seq
MIRT2597144	hsa-miR-664	CLIP-seq
MIRT1248279	hsa-miR-10a	CLIP-seq
MIRT1248280	hsa-miR-10b	CLIP-seq
MIRT1248250	hsa-miR-1228	CLIP-seq
MIRT2073292	hsa-miR-1293	CLIP-seq
MIRT2688345	hsa-miR-140-3p	CLIP-seq
MIRT2597126	hsa-miR-216a	CLIP-seq
MIRT1248287	hsa-miR-219-5p	CLIP-seq
MIRT2597127	hsa-miR-3163	CLIP-seq
MIRT2597128	hsa-miR-3165	CLIP-seq
MIRT1248292	hsa-miR-323-3p	CLIP-seq
MIRT2597129	hsa-miR-335	CLIP-seq
MIRT2597130	hsa-miR-3591-3p	CLIP-seq
MIRT2597131	hsa-miR-3614-5p	CLIP-seq
MIRT2597132	hsa-miR-3650	CLIP-seq
MIRT2597134	hsa-miR-4282	CLIP-seq
MIRT1248297	hsa-miR-4307	CLIP-seq
MIRT1248299	hsa-miR-4445	CLIP-seq
MIRT2597135	hsa-miR-4452	CLIP-seq
MIRT1248300	hsa-miR-448	CLIP-seq
MIRT2073299	hsa-miR-4483	CLIP-seq
MIRT2597136	hsa-miR-4490	CLIP-seq
MIRT1248307	hsa-miR-4782-3p	CLIP-seq
MIRT2597138	hsa-miR-490-3p	CLIP-seq
MIRT2073302	hsa-miR-500a	CLIP-seq
MIRT1248309	hsa-miR-508-3p	CLIP-seq
MIRT2597139	hsa-miR-513c	CLIP-seq
MIRT2597140	hsa-miR-514b-5p	CLIP-seq
MIRT2688346	hsa-miR-548ae	CLIP-seq
MIRT2688347	hsa-miR-548aj	CLIP-seq
MIRT2688348	hsa-miR-548am	CLIP-seq
MIRT2597141	hsa-miR-548c-3p	CLIP-seq
MIRT2688349	hsa-miR-548x	CLIP-seq
MIRT1248311	hsa-miR-556-3p	CLIP-seq
MIRT1248312	hsa-miR-567	CLIP-seq
MIRT2597142	hsa-miR-630	CLIP-seq
MIRT2597143	hsa-miR-649	CLIP-seq
MIRT2597144	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	IDA	34671025, 36271492
GO:0003899	Function	DNA-directed RNA polymerase activity	IEA
GO:0005515	Function	Protein binding	IPI	16514417, 19214185, 20208542, 26496610, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005694	Component	Chromosome	ISS
GO:0005730	Component	Nucleolus	IEA
GO:0005736	Component	RNA polymerase I complex	IBA
GO:0005736	Component	RNA polymerase I complex	IDA	34671025, 36271492
GO:0005736	Component	RNA polymerase I complex	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0007566	Process	Embryo implantation	IEA
GO:0008270	Function	Zinc ion binding	IDA	34671025, 34887565
GO:0008270	Function	Zinc ion binding	IEA
GO:0009303	Process	RRNA transcription	IEA
GO:0014029	Process	Neural crest formation	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0017126	Process	Nucleologenesis	IEA
GO:0032549	Function	Ribonucleoside binding	IEA
GO:0034062	Function	5'-3' RNA polymerase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0071667	Function	DNA/RNA hybrid binding	IDA	34671025
GO:0071667	Function	DNA/RNA hybrid binding	IEA

Other IDs

• MIM: 602000
• HGNC: 20454
• e!Ensembl: ENSG00000125630

Protein

• UniProt ID: Q9H9Y6
• Protein name: DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)
• Protein function: Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene cluster
• PDB: 7OB9, 7OBA, 7OBB, 7VBA, 7VBB, 7VBC, 8A43
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04563	RNA_pol_Rpb2_1	37 → 422	RNA polymerase beta subunit	Family
  PF04561	RNA_pol_Rpb2_2	186 → 375	RNA polymerase Rpb2, domain 2	Domain
  PF04565	RNA_pol_Rpb2_3	455 → 520	RNA polymerase Rpb2, domain 3	Domain
  PF06883	RNA_pol_Rpa2_4	563 → 621	RNA polymerase I, Rpa2 specific domain	Domain
  PF00562	RNA_pol_Rpb2_6	670 → 1031	RNA polymerase Rpb2, domain 6	Domain
  PF04560	RNA_pol_Rpb2_7	1033 → 1135	RNA polymerase Rpb2, domain 7	Domain

• Sequence:

  MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQA
  IPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINW
  AVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIR
  MLIMPRRNFPIAMIRPKWKTRGPGYTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIY
  RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQV
  LNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFALAKGE
  CMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF
  TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAK
  MRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVT
  PIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPM
  TGKPSLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQE
  LFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSP
  LVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID
  LSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY
  YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAE
  DMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALE
  YFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDR
  VTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLSPL
  LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDVV

• Sequence length: 1135

Pathways

KEGG:

RNA polymerase

Reactome:

B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
POLR1B-related disorder	Pathogenic	rs1684813071	RCV003945916	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Treacher Collins syndrome	Pathogenic	rs1684443250, rs1684813071	RCV003319220 RCV003319221 RCV003319222	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Treacher Collins syndrome 4	Likely pathogenic; Pathogenic	rs2467555675, rs1684443250, rs1684813071	RCV004585128 RCV001200056 RCV001200057 RCV001200058	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Germ cell tumor of testis	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MANDIBULOFACIAL DYSOSTOSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREACHER-COLLINS SYNDROME	—	Orphanet Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Ataxia Telangiectasia	Ataxia telangiectasia	Pubtator	11359916	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	11895905		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	11895905, 28007956, 28837865		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	11895905	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	11895905	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Ductal Breast	Ductal carcinoma of breast	Pubtator	11895905	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma in Situ	Carcinoma in situ	Pubtator	11895905	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	17361204, 28389531, 33627384	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	31297992	Associate	★☆☆☆☆ Found in Text Mining only
Ductal Breast Carcinoma	Breast Carcinoma	BEFREE	11895905		★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP D2	Fanconi Anemia	BEFREE	15661754		★☆☆☆☆ Found in Text Mining only
Hereditary Melanoma	Hereditary cutaneous melanoma	BEFREE	9508376		★☆☆☆☆ Found in Text Mining only
Kallmann Syndrome	Kallmann syndrome	Pubtator	37378431	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	17361204	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	11895905, 28007956, 28837865		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31036418		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	21137066		★☆☆☆☆ Found in Text Mining only
Mandibulofacial Dysostosis	Mandibulofacial Dysostosis	BEFREE	31649276		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Endocrine Neoplasia	Multiple Endocrine Neoplasia	LHGDN	12509449		★☆☆☆☆ Found in Text Mining only
Multiple Endocrine Neoplasia Type 1	Multiple Endocrine Neoplasia	BEFREE	28007956		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11895905, 21137066		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29601948		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	33260035	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32862594	Associate	★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	25890248	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	37864896	Associate	★☆☆☆☆ Found in Text Mining only