NLRC5 (NLR family CARD domain containing 5)

Gene

• Entrez ID: 84166
• Gene name: NLR family CARD domain containing 5
• Gene symbol: NLRC5
• Synonyms (NCBI Gene): CLR16.1, NOD27, NOD4
• Chromosome: 16
• Chromosome location: 16q13
• Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT725318	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT725317	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT725316	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT725315	hsa-miR-940	HITS-CLIP	19536157
MIRT725314	hsa-miR-3126-3p	HITS-CLIP	19536157
MIRT725313	hsa-miR-4514	HITS-CLIP	19536157
MIRT725312	hsa-miR-4692	HITS-CLIP	19536157
MIRT725311	hsa-miR-3158-5p	HITS-CLIP	19536157
MIRT725310	hsa-miR-1184	HITS-CLIP	19536157
MIRT725309	hsa-miR-1205	HITS-CLIP	19536157
MIRT725308	hsa-miR-17-3p	HITS-CLIP	19536157
MIRT725307	hsa-miR-4794	HITS-CLIP	19536157
MIRT725306	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT725305	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT725303	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT725304	hsa-miR-4736	HITS-CLIP	19536157
MIRT725302	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT725301	hsa-miR-6511b-5p	HITS-CLIP	19536157
MIRT725300	hsa-miR-6811-5p	HITS-CLIP	19536157
MIRT725299	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT440105	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440105	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT725318	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT725317	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT725316	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT725315	hsa-miR-940	HITS-CLIP	19536157
MIRT725314	hsa-miR-3126-3p	HITS-CLIP	19536157
MIRT725313	hsa-miR-4514	HITS-CLIP	19536157
MIRT725312	hsa-miR-4692	HITS-CLIP	19536157
MIRT725311	hsa-miR-3158-5p	HITS-CLIP	19536157
MIRT725310	hsa-miR-1184	HITS-CLIP	19536157
MIRT725309	hsa-miR-1205	HITS-CLIP	19536157
MIRT725308	hsa-miR-17-3p	HITS-CLIP	19536157
MIRT725307	hsa-miR-4794	HITS-CLIP	19536157
MIRT725306	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT725305	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT725303	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT725304	hsa-miR-4736	HITS-CLIP	19536157
MIRT725302	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT725301	hsa-miR-6511b-5p	HITS-CLIP	19536157
MIRT725300	hsa-miR-6811-5p	HITS-CLIP	19536157
MIRT725299	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT1187203	hsa-miR-1262	CLIP-seq
MIRT1187204	hsa-miR-1293	CLIP-seq
MIRT1187205	hsa-miR-1343	CLIP-seq
MIRT1187206	hsa-miR-147	CLIP-seq
MIRT1187207	hsa-miR-3165	CLIP-seq
MIRT1187208	hsa-miR-362-5p	CLIP-seq
MIRT1187209	hsa-miR-3667-3p	CLIP-seq
MIRT1187210	hsa-miR-378g	CLIP-seq
MIRT1187211	hsa-miR-425	CLIP-seq
MIRT1187212	hsa-miR-4258	CLIP-seq
MIRT1187213	hsa-miR-4289	CLIP-seq
MIRT1187214	hsa-miR-4483	CLIP-seq
MIRT1187215	hsa-miR-4691-5p	CLIP-seq
MIRT1187216	hsa-miR-4701-3p	CLIP-seq
MIRT1187217	hsa-miR-4755-3p	CLIP-seq
MIRT1187218	hsa-miR-500b	CLIP-seq
MIRT1187219	hsa-miR-501-5p	CLIP-seq
MIRT1187220	hsa-miR-515-5p	CLIP-seq
MIRT1187221	hsa-miR-579	CLIP-seq
MIRT2054217	hsa-miR-103a	CLIP-seq
MIRT2054218	hsa-miR-107	CLIP-seq
MIRT2054219	hsa-miR-1197	CLIP-seq
MIRT2054220	hsa-miR-1224-5p	CLIP-seq
MIRT2054221	hsa-miR-125a-5p	CLIP-seq
MIRT2054222	hsa-miR-125b	CLIP-seq
MIRT2054223	hsa-miR-1286	CLIP-seq
MIRT2054224	hsa-miR-1288	CLIP-seq
MIRT2054225	hsa-miR-214	CLIP-seq
MIRT2054226	hsa-miR-3169	CLIP-seq
MIRT2054227	hsa-miR-3619-5p	CLIP-seq
MIRT2054228	hsa-miR-4287	CLIP-seq
MIRT2054229	hsa-miR-4319	CLIP-seq
MIRT2054230	hsa-miR-4418	CLIP-seq
MIRT2054231	hsa-miR-4436a	CLIP-seq
MIRT2054232	hsa-miR-4469	CLIP-seq
MIRT2054233	hsa-miR-4685-3p	CLIP-seq
MIRT2054234	hsa-miR-4732-3p	CLIP-seq
MIRT2054235	hsa-miR-4751	CLIP-seq
MIRT2054236	hsa-miR-509-3-5p	CLIP-seq
MIRT2054237	hsa-miR-509-5p	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2054239	hsa-miR-670	CLIP-seq
MIRT2054240	hsa-miR-761	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2054217	hsa-miR-103a	CLIP-seq
MIRT2054218	hsa-miR-107	CLIP-seq
MIRT2054219	hsa-miR-1197	CLIP-seq
MIRT2054220	hsa-miR-1224-5p	CLIP-seq
MIRT2054221	hsa-miR-125a-5p	CLIP-seq
MIRT2054222	hsa-miR-125b	CLIP-seq
MIRT2054223	hsa-miR-1286	CLIP-seq
MIRT2054224	hsa-miR-1288	CLIP-seq
MIRT1187206	hsa-miR-147	CLIP-seq
MIRT2581589	hsa-miR-1909	CLIP-seq
MIRT2581590	hsa-miR-198	CLIP-seq
MIRT2054225	hsa-miR-214	CLIP-seq
MIRT2581591	hsa-miR-2355-3p	CLIP-seq
MIRT2581592	hsa-miR-3064-3p	CLIP-seq
MIRT2581593	hsa-miR-3121-5p	CLIP-seq
MIRT2054226	hsa-miR-3169	CLIP-seq
MIRT2581594	hsa-miR-33a	CLIP-seq
MIRT2581595	hsa-miR-33b	CLIP-seq
MIRT2581596	hsa-miR-3613-3p	CLIP-seq
MIRT2054227	hsa-miR-3619-5p	CLIP-seq
MIRT2581597	hsa-miR-377	CLIP-seq
MIRT2581598	hsa-miR-410	CLIP-seq
MIRT2581599	hsa-miR-4267	CLIP-seq
MIRT2054228	hsa-miR-4287	CLIP-seq
MIRT1187213	hsa-miR-4289	CLIP-seq
MIRT2054229	hsa-miR-4319	CLIP-seq
MIRT2054230	hsa-miR-4418	CLIP-seq
MIRT2054231	hsa-miR-4436a	CLIP-seq
MIRT2054232	hsa-miR-4469	CLIP-seq
MIRT2581600	hsa-miR-451	CLIP-seq
MIRT2581601	hsa-miR-4646-3p	CLIP-seq
MIRT2054233	hsa-miR-4685-3p	CLIP-seq
MIRT2581602	hsa-miR-4713-5p	CLIP-seq
MIRT2054234	hsa-miR-4732-3p	CLIP-seq
MIRT2581603	hsa-miR-4733-5p	CLIP-seq
MIRT2054235	hsa-miR-4751	CLIP-seq
MIRT2581604	hsa-miR-4789-3p	CLIP-seq
MIRT2054236	hsa-miR-509-3-5p	CLIP-seq
MIRT2054237	hsa-miR-509-5p	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2581605	hsa-miR-586	CLIP-seq
MIRT2581606	hsa-miR-662	CLIP-seq
MIRT2054239	hsa-miR-670	CLIP-seq
MIRT2054240	hsa-miR-761	CLIP-seq
MIRT2054220	hsa-miR-1224-5p	CLIP-seq
MIRT2054221	hsa-miR-125a-5p	CLIP-seq
MIRT2054222	hsa-miR-125b	CLIP-seq
MIRT2054224	hsa-miR-1288	CLIP-seq
MIRT1187206	hsa-miR-147	CLIP-seq
MIRT2581589	hsa-miR-1909	CLIP-seq
MIRT2581590	hsa-miR-198	CLIP-seq
MIRT2581591	hsa-miR-2355-3p	CLIP-seq
MIRT2581592	hsa-miR-3064-3p	CLIP-seq
MIRT2581593	hsa-miR-3121-5p	CLIP-seq
MIRT2054226	hsa-miR-3169	CLIP-seq
MIRT2581596	hsa-miR-3613-3p	CLIP-seq
MIRT2581597	hsa-miR-377	CLIP-seq
MIRT2581598	hsa-miR-410	CLIP-seq
MIRT2581599	hsa-miR-4267	CLIP-seq
MIRT2054228	hsa-miR-4287	CLIP-seq
MIRT1187213	hsa-miR-4289	CLIP-seq
MIRT2054229	hsa-miR-4319	CLIP-seq
MIRT2054230	hsa-miR-4418	CLIP-seq
MIRT2054232	hsa-miR-4469	CLIP-seq
MIRT2581600	hsa-miR-451	CLIP-seq
MIRT2581601	hsa-miR-4646-3p	CLIP-seq
MIRT2054233	hsa-miR-4685-3p	CLIP-seq
MIRT2581602	hsa-miR-4713-5p	CLIP-seq
MIRT2054234	hsa-miR-4732-3p	CLIP-seq
MIRT2581603	hsa-miR-4733-5p	CLIP-seq
MIRT2054235	hsa-miR-4751	CLIP-seq
MIRT2581604	hsa-miR-4789-3p	CLIP-seq
MIRT2054236	hsa-miR-509-3-5p	CLIP-seq
MIRT2054237	hsa-miR-509-5p	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2581605	hsa-miR-586	CLIP-seq
MIRT2581606	hsa-miR-662	CLIP-seq
MIRT2054239	hsa-miR-670	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	20639463
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	20434986
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20639463
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	20061403, 20434986
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA	20639463
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0009617	Process	Response to bacterium	IEA
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	20434986
GO:0043549	Process	Regulation of kinase activity	IDA	20434986
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IMP	20434986
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	IBA
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	IDA	20639463
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20639463
GO:0051607	Process	Defense response to virus	IEP	20061403
GO:0060335	Process	Positive regulation of type II interferon-mediated signaling pathway	IDA	20061403
GO:0060335	Process	Positive regulation of type II interferon-mediated signaling pathway	IMP	20639463
GO:0060339	Process	Negative regulation of type I interferon-mediated signaling pathway	IBA
GO:0060339	Process	Negative regulation of type I interferon-mediated signaling pathway	IDA	20434986
GO:0060339	Process	Negative regulation of type I interferon-mediated signaling pathway	IEA
GO:0060340	Process	Positive regulation of type I interferon-mediated signaling pathway	IDA	20061403

Other IDs

• MIM: 613537
• HGNC: 29933
• e!Ensembl: ENSG00000140853

Protein

• UniProt ID: Q86WI3
• Protein name: Protein NLRC5 (Caterpiller protein 16.1) (CLR16.1) (Nucleotide-binding oligomerization domain protein 27) (Nucleotide-binding oligomerization domain protein 4)
• Protein function: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269|P
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18461	Atypical_Card	1 → 95	Atypical caspase recruitment domain	Domain
  PF05729	NACHT	222 → 383	NACHT domain	Domain
  PF17776	NLRC4_HD2	514 → 629	NLRC4 helical domain HD2	Domain
  PF13516	LRR_6	869 → 891	Leucine Rich repeat	Repeat
  PF13516	LRR_6	1006 → 1025	Leucine Rich repeat	Repeat
  PF13516	LRR_6	1604 → 1627	Leucine Rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate. {ECO:0000269|PubMed:20061403, ECO:0000269|PubMed:20434986}.
• Sequence:

  MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNK
  LHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTSQLGAEGKSQPESQLHHGL
  KRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQPHAFHQVYVPPI
  LRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVNKGPRVTVLLGKAGMGKTTLAHR
  LCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD
  QVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAA
  MVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLL
  PDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDI
  APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQY
  VTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK
  KLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEH
  REAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLG
  LAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSN
  SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGA
  QSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA
  RKLDLSNNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAF
  LDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEG
  AARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDK
  TSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLEL
  QLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRS
  LHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGL
  RCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSR
  EDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAG
  LFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVAL
  RLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFR
  LTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHL
  LLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGD
  AGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL
  GLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELP
  LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKR
  VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQP
  QAPWGT

• Sequence length: 1866

Pathways

Reactome:

DDX58/IFIH1-mediated induction of interferon-alpha/beta
Negative regulators of DDX58/IFIH1 signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FATTY LIVER, ALCOHOLIC	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUTROPENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance; Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anaplasia	Anaplasia	BEFREE	31253783		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	30644097		★☆☆☆☆ Found in Text Mining only
Chronic Periodontitis	Periodontitis	BEFREE	28122660		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29408916, 29762254		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26378020, 29408916	Associate	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30543814		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASDB_DG	21347282		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	29070585		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	29070585		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	36898736	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	29070585, 29655162		★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	Pubtator	29327327	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	32431202	Inhibit	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	35174769, 35880269	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	30316442		★☆☆☆☆ Found in Text Mining only
Fibroid Tumor	Leiomyoma	BEFREE	30316442		★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	26592197, 27525969, 28713900, 31293340		★☆☆☆☆ Found in Text Mining only
Glomerulonephritis Membranous	Membranous glomerulonephritis	Pubtator	40018947	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	38231444	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	36694434	Associate	★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	BEFREE	30453994		★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	31824312		★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	31186034	Associate	★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	BEFREE	29655162, 29907459		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26975630, 30543814		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	28085900	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus nephritis	Pubtator	31186034	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30426081		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27162338, 28215281, 28261210, 28718425, 29762254, 30543814, 30706093		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33547395	Associate	★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	28098136	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26975630, 29900056, 30426081, 30706093		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	28947923	Associate	★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	29327327	Associate	★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	BEFREE	28122660		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	28865311, 31694750		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31746301		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	38231444	Associate	★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	29692724		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30426081		★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	30316442		★☆☆☆☆ Found in Text Mining only
Vasculitis	Vasculitis	Pubtator	31186034	Stimulate	★☆☆☆☆ Found in Text Mining only