Gene Gene information from NCBI Gene database.
Entrez ID 84135
Gene name UTP15 small subunit processome component
Gene symbol UTP15
Synonyms (NCBI Gene)
NET21
Chromosome 5
Chromosome location 5q13.2
miRNA miRNA information provided by mirtarbase database.
397
miRTarBase ID miRNA Experiments Reference
MIRT001398 hsa-miR-16-5p pSILAC 18668040
MIRT028625 hsa-miR-30a-5p Proteomics 18668040
MIRT001398 hsa-miR-16-5p Proteomics;Other 18668040
MIRT032450 hsa-let-7b-5p Proteomics 18668040
MIRT051670 hsa-let-7e-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0001650 Component Fibrillar center IDA 24219289
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 22916032, 24219289, 28514442, 33961781
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616194 25758 ENSG00000164338
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TED0
Protein name U3 small nucleolar RNA-associated protein 15 homolog
Protein function Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the
PDB 7MQ8 , 7MQ9 , 7MQA , 7RUO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 112 150 WD domain, G-beta repeat Repeat
PF00400 WD40 154 193 WD domain, G-beta repeat Repeat
PF00400 WD40 197 233 WD domain, G-beta repeat Repeat
PF00400 WD40 238 276 WD domain, G-beta repeat Repeat
PF09384 UTP15_C 343 490 UTP15 C terminal Family
Sequence
MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASS
RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEG
HTKAVHTVDFTADKYHVVSGADDYTVKLWD
IPNSKEILTFKEHSDYVRCGCASKLNPDLF
ITGSYDHTVKMFD
ARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQL
LVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS
TTSYKVVHSFDYAASILSLALAHE
DETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKH
LELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISH
VLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQREL
LETLGMMDML
FATMRRKEGTSVLEHTSDGFPENKKIES
Sequence length 518
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ribosome biogenesis in eukaryotes   Major pathway of rRNA processing in the nucleolus and cytosol
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HEARING LOSS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Malignant Neoplasms Malignant Neoplasm BEFREE 29878866
★☆☆☆☆
Found in Text Mining only