ZNRF3 (zinc and ring finger 3)

Gene

• Entrez ID: 84133
• Gene name: Zinc and ring finger 3
• Gene symbol: ZNRF3
• Synonyms (NCBI Gene): BK747E2.3, RNF203
• Chromosome: 22
• Chromosome location: 22q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027017	hsa-miR-103a-3p	Sequencing	20371350
MIRT031450	hsa-miR-16-5p	Sequencing	20371350
MIRT042789	hsa-miR-339-5p	CLASH	23622248
MIRT438327	hsa-miR-146b-5p	qRT-PCR	24064622
MIRT438327	hsa-miR-146b-5p	qRT-PCR	24064622
MIRT462929	hsa-miR-34b-3p	PAR-CLIP	23592263
MIRT462928	hsa-miR-890	PAR-CLIP	23592263
MIRT370507	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT370516	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT370517	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT370519	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT370506	hsa-miR-940	PAR-CLIP	23592263
MIRT462927	hsa-miR-25-3p	PAR-CLIP	23592263
MIRT462926	hsa-miR-32-5p	PAR-CLIP	23592263
MIRT462925	hsa-miR-363-3p	PAR-CLIP	23592263
MIRT462924	hsa-miR-367-3p	PAR-CLIP	23592263
MIRT462923	hsa-miR-92a-3p	PAR-CLIP	23592263
MIRT462922	hsa-miR-92b-3p	PAR-CLIP	23592263
MIRT462921	hsa-miR-3614-5p	PAR-CLIP	23592263
MIRT462920	hsa-miR-6500-3p	PAR-CLIP	23592263
MIRT462919	hsa-miR-4257	PAR-CLIP	23592263
MIRT462918	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT462917	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT462916	hsa-miR-1292-3p	PAR-CLIP	23592263
MIRT462915	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT462914	hsa-miR-1827	PAR-CLIP	23592263
MIRT462913	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT462912	hsa-miR-6134	PAR-CLIP	23592263
MIRT462911	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT462910	hsa-miR-6086	PAR-CLIP	23592263
MIRT462909	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT462908	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT462907	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT462906	hsa-miR-711	PAR-CLIP	23592263
MIRT462905	hsa-miR-3612	PAR-CLIP	23592263
MIRT462904	hsa-miR-650	PAR-CLIP	23592263
MIRT462903	hsa-miR-1294	PAR-CLIP	23592263
MIRT462902	hsa-miR-7703	PAR-CLIP	23592263
MIRT462901	hsa-miR-4325	PAR-CLIP	23592263
MIRT462900	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT462899	hsa-miR-4776-5p	PAR-CLIP	23592263
MIRT462898	hsa-miR-4535	PAR-CLIP	23592263
MIRT462897	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT087424	hsa-miR-15a-5p	PAR-CLIP	22100165
MIRT087425	hsa-miR-15b-5p	PAR-CLIP	22100165
MIRT031450	hsa-miR-16-5p	PAR-CLIP	22100165
MIRT087426	hsa-miR-195-5p	PAR-CLIP	22100165
MIRT087428	hsa-miR-424-5p	PAR-CLIP	22100165
MIRT087429	hsa-miR-497-5p	PAR-CLIP	22100165
MIRT087435	hsa-miR-6838-5p	PAR-CLIP	22100165
MIRT444126	hsa-miR-503-5p	PAR-CLIP	22100165
MIRT444125	hsa-miR-646	PAR-CLIP	22100165
MIRT444124	hsa-miR-103b	PAR-CLIP	22100165
MIRT444123	hsa-miR-3661	PAR-CLIP	22100165
MIRT444122	hsa-miR-631	PAR-CLIP	22100165
MIRT087431	hsa-miR-4524a-5p	PAR-CLIP	22100165
MIRT087433	hsa-miR-4524b-5p	PAR-CLIP	22100165
MIRT444121	hsa-miR-376a-3p	PAR-CLIP	22100165
MIRT444120	hsa-miR-376b-3p	PAR-CLIP	22100165
MIRT444119	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT444118	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT438327	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	26549292
MIRT438327	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR	25547151
MIRT438327	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR	25547151
MIRT462917	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT462917	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT462916	hsa-miR-1292-3p	PAR-CLIP	26701625
MIRT462916	hsa-miR-1292-3p	PAR-CLIP	26701625
MIRT462903	hsa-miR-1294	PAR-CLIP	26701625
MIRT462903	hsa-miR-1294	PAR-CLIP	26701625
MIRT462914	hsa-miR-1827	PAR-CLIP	26701625
MIRT462914	hsa-miR-1827	PAR-CLIP	26701625
MIRT370507	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT370507	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT462909	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT462909	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT462905	hsa-miR-3612	PAR-CLIP	26701625
MIRT462905	hsa-miR-3612	PAR-CLIP	26701625
MIRT462911	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT462911	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT462919	hsa-miR-4257	PAR-CLIP	26701625
MIRT462919	hsa-miR-4257	PAR-CLIP	26701625
MIRT462898	hsa-miR-4535	PAR-CLIP	26701625
MIRT462898	hsa-miR-4535	PAR-CLIP	26701625
MIRT462900	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT462900	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT462899	hsa-miR-4776-5p	PAR-CLIP	26701625
MIRT462899	hsa-miR-4776-5p	PAR-CLIP	26701625
MIRT462910	hsa-miR-6086	PAR-CLIP	26701625
MIRT462910	hsa-miR-6086	PAR-CLIP	26701625
MIRT462912	hsa-miR-6134	PAR-CLIP	26701625
MIRT462912	hsa-miR-6134	PAR-CLIP	26701625
MIRT462907	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT462907	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT462904	hsa-miR-650	PAR-CLIP	26701625
MIRT462904	hsa-miR-650	PAR-CLIP	26701625
MIRT370516	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT370516	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT462897	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT462897	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT462906	hsa-miR-711	PAR-CLIP	26701625
MIRT462906	hsa-miR-711	PAR-CLIP	26701625
MIRT462913	hsa-miR-7854-3p	PAR-CLIP	26701625
MIRT462913	hsa-miR-7854-3p	PAR-CLIP	26701625
MIRT462929	hsa-miR-34b-3p	PAR-CLIP	23592263
MIRT462928	hsa-miR-890	PAR-CLIP	23592263
MIRT370507	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT370516	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT370517	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT370519	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT370506	hsa-miR-940	PAR-CLIP	23592263
MIRT462927	hsa-miR-25-3p	PAR-CLIP	23592263
MIRT462926	hsa-miR-32-5p	PAR-CLIP	23592263
MIRT462925	hsa-miR-363-3p	PAR-CLIP	23592263
MIRT462924	hsa-miR-367-3p	PAR-CLIP	23592263
MIRT462923	hsa-miR-92a-3p	PAR-CLIP	23592263
MIRT462922	hsa-miR-92b-3p	PAR-CLIP	23592263
MIRT462921	hsa-miR-3614-5p	PAR-CLIP	23592263
MIRT462920	hsa-miR-6500-3p	PAR-CLIP	23592263
MIRT462919	hsa-miR-4257	PAR-CLIP	23592263
MIRT462918	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT462917	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT462916	hsa-miR-1292-3p	PAR-CLIP	23592263
MIRT462915	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT462914	hsa-miR-1827	PAR-CLIP	23592263
MIRT462913	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT462912	hsa-miR-6134	PAR-CLIP	23592263
MIRT462911	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT462910	hsa-miR-6086	PAR-CLIP	23592263
MIRT462909	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT462908	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT462907	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT462906	hsa-miR-711	PAR-CLIP	23592263
MIRT462905	hsa-miR-3612	PAR-CLIP	23592263
MIRT462904	hsa-miR-650	PAR-CLIP	23592263
MIRT462903	hsa-miR-1294	PAR-CLIP	23592263
MIRT462902	hsa-miR-7703	PAR-CLIP	23592263
MIRT462901	hsa-miR-4325	PAR-CLIP	23592263
MIRT462900	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT462899	hsa-miR-4776-5p	PAR-CLIP	23592263
MIRT462898	hsa-miR-4535	PAR-CLIP	23592263
MIRT462897	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT087424	hsa-miR-15a-5p	PAR-CLIP	22100165
MIRT087425	hsa-miR-15b-5p	PAR-CLIP	22100165
MIRT031450	hsa-miR-16-5p	PAR-CLIP	22100165
MIRT087426	hsa-miR-195-5p	PAR-CLIP	22100165
MIRT087428	hsa-miR-424-5p	PAR-CLIP	22100165
MIRT087429	hsa-miR-497-5p	PAR-CLIP	22100165
MIRT087435	hsa-miR-6838-5p	PAR-CLIP	22100165
MIRT444126	hsa-miR-503-5p	PAR-CLIP	22100165
MIRT444125	hsa-miR-646	PAR-CLIP	22100165
MIRT444124	hsa-miR-103b	PAR-CLIP	22100165
MIRT444123	hsa-miR-3661	PAR-CLIP	22100165
MIRT444122	hsa-miR-631	PAR-CLIP	22100165
MIRT087431	hsa-miR-4524a-5p	PAR-CLIP	22100165
MIRT087433	hsa-miR-4524b-5p	PAR-CLIP	22100165
MIRT444121	hsa-miR-376a-3p	PAR-CLIP	22100165
MIRT444120	hsa-miR-376b-3p	PAR-CLIP	22100165
MIRT444119	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT444118	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT1543316	hsa-miR-1262	CLIP-seq
MIRT1543317	hsa-miR-24	CLIP-seq
MIRT1543318	hsa-miR-25	CLIP-seq
MIRT1543319	hsa-miR-3122	CLIP-seq
MIRT1543320	hsa-miR-32	CLIP-seq
MIRT1543321	hsa-miR-34b	CLIP-seq
MIRT1543322	hsa-miR-3620	CLIP-seq
MIRT1543323	hsa-miR-3622a-3p	CLIP-seq
MIRT1543324	hsa-miR-3622b-3p	CLIP-seq
MIRT1543325	hsa-miR-363	CLIP-seq
MIRT1543326	hsa-miR-367	CLIP-seq
MIRT1543327	hsa-miR-3689a-3p	CLIP-seq
MIRT1543328	hsa-miR-3689c	CLIP-seq
MIRT1543329	hsa-miR-3913-5p	CLIP-seq
MIRT1543330	hsa-miR-3929	CLIP-seq
MIRT1543331	hsa-miR-4254	CLIP-seq
MIRT1543332	hsa-miR-4284	CLIP-seq
MIRT1543333	hsa-miR-4308	CLIP-seq
MIRT1543334	hsa-miR-4419b	CLIP-seq
MIRT1543335	hsa-miR-4455	CLIP-seq
MIRT1543336	hsa-miR-4478	CLIP-seq
MIRT1543337	hsa-miR-4633-3p	CLIP-seq
MIRT1543338	hsa-miR-4701-3p	CLIP-seq
MIRT1543339	hsa-miR-4728-5p	CLIP-seq
MIRT1543340	hsa-miR-485-5p	CLIP-seq
MIRT1543341	hsa-miR-508-5p	CLIP-seq
MIRT1543342	hsa-miR-520d-5p	CLIP-seq
MIRT1543343	hsa-miR-524-5p	CLIP-seq
MIRT1543344	hsa-miR-541	CLIP-seq
MIRT1543345	hsa-miR-544b	CLIP-seq
MIRT1543346	hsa-miR-583	CLIP-seq
MIRT1543347	hsa-miR-609	CLIP-seq
MIRT1543348	hsa-miR-654-5p	CLIP-seq
MIRT1543349	hsa-miR-661	CLIP-seq
MIRT1543350	hsa-miR-766	CLIP-seq
MIRT1543351	hsa-miR-92a	CLIP-seq
MIRT1543352	hsa-miR-92b	CLIP-seq
MIRT1543353	hsa-miR-1228	CLIP-seq
MIRT1543354	hsa-miR-1275	CLIP-seq
MIRT1543355	hsa-miR-3064-3p	CLIP-seq
MIRT1543321	hsa-miR-34b	CLIP-seq
MIRT1543335	hsa-miR-4455	CLIP-seq
MIRT1543356	hsa-miR-4488	CLIP-seq
MIRT1543357	hsa-miR-4665-5p	CLIP-seq
MIRT1543358	hsa-miR-4697-5p	CLIP-seq
MIRT1543347	hsa-miR-609	CLIP-seq
MIRT1543359	hsa-miR-877	CLIP-seq
MIRT1555870	hsa-miR-1267	CLIP-seq
MIRT1555871	hsa-miR-2053	CLIP-seq
MIRT1555872	hsa-miR-4506	CLIP-seq
MIRT1555873	hsa-miR-569	CLIP-seq
MIRT1555874	hsa-miR-670	CLIP-seq
MIRT1555875	hsa-miR-759	CLIP-seq
MIRT2163881	hsa-miR-1184	CLIP-seq
MIRT2163882	hsa-miR-1207-5p	CLIP-seq
MIRT1543316	hsa-miR-1262	CLIP-seq
MIRT2163883	hsa-miR-1289	CLIP-seq
MIRT2163884	hsa-miR-129-5p	CLIP-seq
MIRT2163885	hsa-miR-136	CLIP-seq
MIRT2163886	hsa-miR-147	CLIP-seq
MIRT2163887	hsa-miR-15a	CLIP-seq
MIRT2163888	hsa-miR-15b	CLIP-seq
MIRT2163889	hsa-miR-16	CLIP-seq
MIRT2163890	hsa-miR-1909	CLIP-seq
MIRT2163891	hsa-miR-1913	CLIP-seq
MIRT2163892	hsa-miR-195	CLIP-seq
MIRT2163893	hsa-miR-2113	CLIP-seq
MIRT2163894	hsa-miR-223	CLIP-seq
MIRT2163895	hsa-miR-296-3p	CLIP-seq
MIRT2163896	hsa-miR-30a	CLIP-seq
MIRT2163897	hsa-miR-30b	CLIP-seq
MIRT2163898	hsa-miR-30c	CLIP-seq
MIRT2163899	hsa-miR-30d	CLIP-seq
MIRT2163900	hsa-miR-30e	CLIP-seq
MIRT2163901	hsa-miR-3136-3p	CLIP-seq
MIRT2163902	hsa-miR-3173-3p	CLIP-seq
MIRT2163903	hsa-miR-3198	CLIP-seq
MIRT2163904	hsa-miR-3200-5p	CLIP-seq
MIRT2163905	hsa-miR-324-3p	CLIP-seq
MIRT2163906	hsa-miR-330-3p	CLIP-seq
MIRT2163907	hsa-miR-34a	CLIP-seq
MIRT1543321	hsa-miR-34b	CLIP-seq
MIRT2163908	hsa-miR-34c-5p	CLIP-seq
MIRT2163909	hsa-miR-3617	CLIP-seq
MIRT1543327	hsa-miR-3689a-3p	CLIP-seq
MIRT1543328	hsa-miR-3689c	CLIP-seq
MIRT2163910	hsa-miR-3714	CLIP-seq
MIRT1543330	hsa-miR-3929	CLIP-seq
MIRT2163911	hsa-miR-3936	CLIP-seq
MIRT2163912	hsa-miR-424	CLIP-seq
MIRT2163913	hsa-miR-4251	CLIP-seq
MIRT2163914	hsa-miR-4294	CLIP-seq
MIRT2163915	hsa-miR-4309	CLIP-seq
MIRT2163916	hsa-miR-4313	CLIP-seq
MIRT2163917	hsa-miR-4328	CLIP-seq
MIRT2163918	hsa-miR-4329	CLIP-seq
MIRT1543334	hsa-miR-4419b	CLIP-seq
MIRT2163919	hsa-miR-4421	CLIP-seq
MIRT2163920	hsa-miR-4444	CLIP-seq
MIRT1543335	hsa-miR-4455	CLIP-seq
MIRT2163921	hsa-miR-4461	CLIP-seq
MIRT2163922	hsa-miR-4474-3p	CLIP-seq
MIRT1543336	hsa-miR-4478	CLIP-seq
MIRT2163923	hsa-miR-449a	CLIP-seq
MIRT2163924	hsa-miR-449b	CLIP-seq
MIRT2163925	hsa-miR-4502	CLIP-seq
MIRT2163926	hsa-miR-4524	CLIP-seq
MIRT2163927	hsa-miR-4540	CLIP-seq
MIRT2163928	hsa-miR-4639-3p	CLIP-seq
MIRT2163929	hsa-miR-4676-5p	CLIP-seq
MIRT2163930	hsa-miR-4684-5p	CLIP-seq
MIRT2163931	hsa-miR-4690-3p	CLIP-seq
MIRT1543338	hsa-miR-4701-3p	CLIP-seq
MIRT2163932	hsa-miR-4717-3p	CLIP-seq
MIRT2163933	hsa-miR-4720-3p	CLIP-seq
MIRT2163934	hsa-miR-4721	CLIP-seq
MIRT1543339	hsa-miR-4728-5p	CLIP-seq
MIRT2163935	hsa-miR-4736	CLIP-seq
MIRT2163936	hsa-miR-4753-3p	CLIP-seq
MIRT2163937	hsa-miR-4763-3p	CLIP-seq
MIRT2163938	hsa-miR-4779	CLIP-seq
MIRT2163939	hsa-miR-4786-3p	CLIP-seq
MIRT2163940	hsa-miR-4803	CLIP-seq
MIRT2163941	hsa-miR-4804-3p	CLIP-seq
MIRT1543340	hsa-miR-485-5p	CLIP-seq
MIRT2163942	hsa-miR-488	CLIP-seq
MIRT2163943	hsa-miR-497	CLIP-seq
MIRT2163944	hsa-miR-548an	CLIP-seq
MIRT2163945	hsa-miR-556-3p	CLIP-seq
MIRT2163946	hsa-miR-575	CLIP-seq
MIRT2163947	hsa-miR-582-5p	CLIP-seq
MIRT2163948	hsa-miR-589	CLIP-seq
MIRT2163949	hsa-miR-599	CLIP-seq
MIRT2163950	hsa-miR-604	CLIP-seq
MIRT1543347	hsa-miR-609	CLIP-seq
MIRT2163951	hsa-miR-641	CLIP-seq
MIRT2163952	hsa-miR-644	CLIP-seq
MIRT2163953	hsa-miR-647	CLIP-seq
MIRT2163881	hsa-miR-1184	CLIP-seq
MIRT2383073	hsa-miR-1205	CLIP-seq
MIRT2383074	hsa-miR-1253	CLIP-seq
MIRT1543316	hsa-miR-1262	CLIP-seq
MIRT2383075	hsa-miR-1285	CLIP-seq
MIRT2163883	hsa-miR-1289	CLIP-seq
MIRT2383076	hsa-miR-1302	CLIP-seq
MIRT2163885	hsa-miR-136	CLIP-seq
MIRT2163887	hsa-miR-15a	CLIP-seq
MIRT2163888	hsa-miR-15b	CLIP-seq
MIRT2163889	hsa-miR-16	CLIP-seq
MIRT2383077	hsa-miR-185	CLIP-seq
MIRT2163892	hsa-miR-195	CLIP-seq
MIRT1543318	hsa-miR-25	CLIP-seq
MIRT2383078	hsa-miR-302a	CLIP-seq
MIRT2383079	hsa-miR-302b	CLIP-seq
MIRT2383080	hsa-miR-302c	CLIP-seq
MIRT2383081	hsa-miR-302d	CLIP-seq
MIRT2383082	hsa-miR-302e	CLIP-seq
MIRT2383083	hsa-miR-3148	CLIP-seq
MIRT2383084	hsa-miR-3153	CLIP-seq
MIRT2383085	hsa-miR-3154	CLIP-seq
MIRT2383086	hsa-miR-3158-5p	CLIP-seq
MIRT2383087	hsa-miR-3177-5p	CLIP-seq
MIRT2383088	hsa-miR-3179	CLIP-seq
MIRT2383089	hsa-miR-3180-5p	CLIP-seq
MIRT2383090	hsa-miR-3187-5p	CLIP-seq
MIRT2163903	hsa-miR-3198	CLIP-seq
MIRT1543320	hsa-miR-32	CLIP-seq
MIRT2383091	hsa-miR-335	CLIP-seq
MIRT1543321	hsa-miR-34b	CLIP-seq
MIRT2383092	hsa-miR-3607-5p	CLIP-seq
MIRT1543323	hsa-miR-3622a-3p	CLIP-seq
MIRT1543324	hsa-miR-3622b-3p	CLIP-seq
MIRT2383093	hsa-miR-3622b-5p	CLIP-seq
MIRT1543325	hsa-miR-363	CLIP-seq
MIRT1543326	hsa-miR-367	CLIP-seq
MIRT1543327	hsa-miR-3689a-3p	CLIP-seq
MIRT1543328	hsa-miR-3689c	CLIP-seq
MIRT2383094	hsa-miR-372	CLIP-seq
MIRT2383095	hsa-miR-373	CLIP-seq
MIRT1543330	hsa-miR-3929	CLIP-seq
MIRT2163911	hsa-miR-3936	CLIP-seq
MIRT2163912	hsa-miR-424	CLIP-seq
MIRT2163913	hsa-miR-4251	CLIP-seq
MIRT2163914	hsa-miR-4294	CLIP-seq
MIRT2383096	hsa-miR-4298	CLIP-seq
MIRT2383097	hsa-miR-4305	CLIP-seq
MIRT2383098	hsa-miR-4306	CLIP-seq
MIRT2163915	hsa-miR-4309	CLIP-seq
MIRT2163918	hsa-miR-4329	CLIP-seq
MIRT1543334	hsa-miR-4419b	CLIP-seq
MIRT1543335	hsa-miR-4455	CLIP-seq
MIRT2383099	hsa-miR-4468	CLIP-seq
MIRT1543336	hsa-miR-4478	CLIP-seq
MIRT2383100	hsa-miR-4501	CLIP-seq
MIRT2383101	hsa-miR-4504	CLIP-seq
MIRT2383102	hsa-miR-4519	CLIP-seq
MIRT2163926	hsa-miR-4524	CLIP-seq
MIRT2163928	hsa-miR-4639-3p	CLIP-seq
MIRT2383103	hsa-miR-4644	CLIP-seq
MIRT2383104	hsa-miR-4648	CLIP-seq
MIRT2383105	hsa-miR-4668-5p	CLIP-seq
MIRT1543338	hsa-miR-4701-3p	CLIP-seq
MIRT1543339	hsa-miR-4728-5p	CLIP-seq
MIRT2163940	hsa-miR-4803	CLIP-seq
MIRT1543340	hsa-miR-485-5p	CLIP-seq
MIRT2163943	hsa-miR-497	CLIP-seq
MIRT2383106	hsa-miR-503	CLIP-seq
MIRT1543341	hsa-miR-508-5p	CLIP-seq
MIRT2383107	hsa-miR-519a	CLIP-seq
MIRT2383108	hsa-miR-519b-3p	CLIP-seq
MIRT2383109	hsa-miR-519c-3p	CLIP-seq
MIRT2383110	hsa-miR-520a-3p	CLIP-seq
MIRT2383111	hsa-miR-520b	CLIP-seq
MIRT2383112	hsa-miR-520c-3p	CLIP-seq
MIRT2383113	hsa-miR-520d-3p	CLIP-seq
MIRT2383114	hsa-miR-520e	CLIP-seq
MIRT2383115	hsa-miR-548p	CLIP-seq
MIRT2383116	hsa-miR-570	CLIP-seq
MIRT2163947	hsa-miR-582-5p	CLIP-seq
MIRT2383117	hsa-miR-603	CLIP-seq
MIRT1543347	hsa-miR-609	CLIP-seq
MIRT2383118	hsa-miR-612	CLIP-seq
MIRT1543349	hsa-miR-661	CLIP-seq
MIRT1543350	hsa-miR-766	CLIP-seq
MIRT1543351	hsa-miR-92a	CLIP-seq
MIRT1543352	hsa-miR-92b	CLIP-seq
MIRT1543321	hsa-miR-34b	CLIP-seq
MIRT1543319	hsa-miR-3122	CLIP-seq
MIRT2464753	hsa-miR-3613-3p	CLIP-seq
MIRT1543323	hsa-miR-3622a-3p	CLIP-seq
MIRT1543324	hsa-miR-3622b-3p	CLIP-seq
MIRT1543327	hsa-miR-3689a-3p	CLIP-seq
MIRT1543328	hsa-miR-3689c	CLIP-seq
MIRT2464754	hsa-miR-371-5p	CLIP-seq
MIRT2464755	hsa-miR-371b-5p	CLIP-seq
MIRT1543329	hsa-miR-3913-5p	CLIP-seq
MIRT1543335	hsa-miR-4455	CLIP-seq
MIRT1543339	hsa-miR-4728-5p	CLIP-seq
MIRT1543344	hsa-miR-541	CLIP-seq
MIRT1543345	hsa-miR-544b	CLIP-seq
MIRT2163944	hsa-miR-548an	CLIP-seq
MIRT1543347	hsa-miR-609	CLIP-seq
MIRT1543348	hsa-miR-654-5p	CLIP-seq
MIRT2673533	hsa-miR-10a	CLIP-seq
MIRT2673534	hsa-miR-10b	CLIP-seq
MIRT1543319	hsa-miR-3122	CLIP-seq
MIRT1543321	hsa-miR-34b	CLIP-seq
MIRT1543323	hsa-miR-3622a-3p	CLIP-seq
MIRT1543324	hsa-miR-3622b-3p	CLIP-seq
MIRT1543327	hsa-miR-3689a-3p	CLIP-seq
MIRT1543328	hsa-miR-3689c	CLIP-seq
MIRT1543329	hsa-miR-3913-5p	CLIP-seq
MIRT1543330	hsa-miR-3929	CLIP-seq
MIRT1543334	hsa-miR-4419b	CLIP-seq
MIRT2163919	hsa-miR-4421	CLIP-seq
MIRT1543336	hsa-miR-4478	CLIP-seq
MIRT2163930	hsa-miR-4684-5p	CLIP-seq
MIRT1543339	hsa-miR-4728-5p	CLIP-seq
MIRT1543340	hsa-miR-485-5p	CLIP-seq
MIRT1543344	hsa-miR-541	CLIP-seq
MIRT1543345	hsa-miR-544b	CLIP-seq
MIRT2673535	hsa-miR-593	CLIP-seq
MIRT1543348	hsa-miR-654-5p	CLIP-seq
MIRT2673533	hsa-miR-10a	CLIP-seq
MIRT2673534	hsa-miR-10b	CLIP-seq
MIRT2163882	hsa-miR-1207-5p	CLIP-seq
MIRT1543354	hsa-miR-1275	CLIP-seq
MIRT2163890	hsa-miR-1909	CLIP-seq
MIRT1543319	hsa-miR-3122	CLIP-seq
MIRT1543321	hsa-miR-34b	CLIP-seq
MIRT1543323	hsa-miR-3622a-3p	CLIP-seq
MIRT1543324	hsa-miR-3622b-3p	CLIP-seq
MIRT1543327	hsa-miR-3689a-3p	CLIP-seq
MIRT1543328	hsa-miR-3689c	CLIP-seq
MIRT1543329	hsa-miR-3913-5p	CLIP-seq
MIRT1543330	hsa-miR-3929	CLIP-seq
MIRT2696423	hsa-miR-4264	CLIP-seq
MIRT1543334	hsa-miR-4419b	CLIP-seq
MIRT2163919	hsa-miR-4421	CLIP-seq
MIRT1543335	hsa-miR-4455	CLIP-seq
MIRT1543336	hsa-miR-4478	CLIP-seq
MIRT1543356	hsa-miR-4488	CLIP-seq
MIRT1543357	hsa-miR-4665-5p	CLIP-seq
MIRT2163930	hsa-miR-4684-5p	CLIP-seq
MIRT1543358	hsa-miR-4697-5p	CLIP-seq
MIRT1543339	hsa-miR-4728-5p	CLIP-seq
MIRT2163937	hsa-miR-4763-3p	CLIP-seq
MIRT2696424	hsa-miR-4797-3p	CLIP-seq
MIRT1543340	hsa-miR-485-5p	CLIP-seq
MIRT2696425	hsa-miR-486-3p	CLIP-seq
MIRT1543344	hsa-miR-541	CLIP-seq
MIRT1543345	hsa-miR-544b	CLIP-seq
MIRT2673535	hsa-miR-593	CLIP-seq
MIRT1543347	hsa-miR-609	CLIP-seq
MIRT1543348	hsa-miR-654-5p	CLIP-seq
MIRT1543359	hsa-miR-877	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	22575959
GO:0005109	Function	Frizzled binding	IBA
GO:0005109	Function	Frizzled binding	IEA
GO:0005109	Function	Frizzled binding	IPI	22575959
GO:0005515	Function	Protein binding	IPI	22575959, 24165923, 29769720, 31073040, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22575959
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	22575959
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016567	Process	Protein ubiquitination	IDA	22575959
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0038018	Process	Wnt receptor catabolic process	IBA
GO:0038018	Process	Wnt receptor catabolic process	IEA
GO:0038018	Process	Wnt receptor catabolic process	IMP	22575959
GO:0038018	Process	Wnt receptor catabolic process	TAS	24431302
GO:0046872	Function	Metal ion binding	IEA
GO:0060173	Process	Limb development	ISS
GO:0060828	Process	Regulation of canonical Wnt signaling pathway	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	TAS	24431302
GO:0072089	Process	Stem cell proliferation	IEA
GO:0072089	Process	Stem cell proliferation	ISS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	22575959
GO:2000050	Process	Regulation of non-canonical Wnt signaling pathway	IEA
GO:2000051	Process	Negative regulation of non-canonical Wnt signaling pathway	IMP	22575959
GO:2000095	Process	Regulation of Wnt signaling pathway, planar cell polarity pathway	IEA

Other IDs

• MIM: 612062
• HGNC: 18126
• e!Ensembl: ENSG00000183579

Protein

• UniProt ID: Q9ULT6
• Protein name: E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)
• Protein function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical
• PDB: 8G4Y, 8XFP, 8XFS, 8XFT, 8Y69
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18212	ZNRF_3_ecto	101 → 208	ZNRF-3 Ectodomain	Domain
  PF17123	zf-RING_11	292 → 320	RING-like zinc finger	Domain

• Sequence:

  MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAF
  VEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGW
  VGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPV
  VYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKI
  KLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKY
  IDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQ
  RVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYP
  PLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYP
  EQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVCS
  GYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYR
  SRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVST
  CSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSP
  AGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPCC
  FYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDL
  GLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAV
  RANFPSALQDTQESSTTATEAAGPRSHSADSSSPGA

• Sequence length: 936

Pathways

KEGG:

Wnt signaling pathway

Reactome:

Regulation of FZD by ubiquitination

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
ZNRF3-related disorder	Pathogenic	rs2517532919, rs2517585923, rs2517589753, rs2517591405, rs2517591470, rs2517591496, rs2517591567	RCV004574948 RCV004574951 RCV004574953 RCV004574954 RCV004574955 RCV004574956 RCV004574957	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of large intestine	Colorectal Cancer	CGI_DG			★☆☆☆☆ Found in Text Mining only
Adrenocortical carcinoma	Adrenocortical carcinoma	CTD_human_DG	24747642		★☆☆☆☆ Found in Text Mining only
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	25490274, 29581542, 29872083, 33513905, 33564960	Associate	★☆☆☆☆ Found in Text Mining only
Adrenocortical carcinoma	Adrenocortical carcinoma	BEFREE	26739091		★☆☆☆☆ Found in Text Mining only
Agenesis of corpus callosum	Agenesis Of Corpus Callosum	BEFREE	24747642, 25490274, 26739091, 29872083		★☆☆☆☆ Found in Text Mining only
Angle Closure Glaucoma	Angle Closure Glaucoma	BEFREE	30348125		★☆☆☆☆ Found in Text Mining only
Aplasia Cutis Congenita	Aplasia Cutis Congenita	BEFREE	24747642, 25490274, 26739091, 29872083		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	29059683		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinogenesis	Carcinogenesis	Pubtator	27661107, 33513905, 35040131	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	40264052	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	28901451	Associate	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	38189041	Associate	★☆☆☆☆ Found in Text Mining only
Disorder of Sex Development 46 XY	46, xy disorder of sex development	Pubtator	36631813	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	30816445	Associate	★☆☆☆☆ Found in Text Mining only
Gastric Adenocarcinoma	Gastric Cancer	BEFREE	23504200		★☆☆☆☆ Found in Text Mining only
Glaucoma Angle Closure	Angle closure glaucoma	Pubtator	30348125	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	CTD_human_DG	25086665, 26098869		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	27352324		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23504200, 27162353, 27352324, 27448298, 27661107, 27733215		★☆☆☆☆ Found in Text Mining only
Microphthalmos	Microphthalmos	BEFREE	30348125		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	27733215		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23504200, 24747642, 26023187, 26739091, 27352324, 27448298, 27661107, 29497989, 29872083		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	26549292, 29088784		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	GWASCAT_DG	25086665, 29422604		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic Neoplasm	Pancreatic Neoplasm	CTD_human_DG	25086665, 26098869		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	26098869	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	25547151, 27448298		★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	Pubtator	39536727	Associate	★☆☆☆☆ Found in Text Mining only
Primary angle-closure glaucoma	Angle closure glaucoma	BEFREE	30348125		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	34716314	Associate	★☆☆☆☆ Found in Text Mining only
Severe myopia	Myopia	BEFREE	26485405		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	30816445		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	27352324		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	25547151	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	27448298		★☆☆☆☆ Found in Text Mining only