Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84129
Gene name	Acyl-CoA dehydrogenase family member 11
Gene symbol	ACAD11
Synonyms (NCBI Gene)	ACAD-11
Chromosome	3
Chromosome location	3q22.1
Summary	This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provid

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miRTarBase ID	miRNA	Experiments
MIRT761412	hsa-miR-132	CLIP-seq
MIRT761413	hsa-miR-150	CLIP-seq
MIRT761414	hsa-miR-1976	CLIP-seq
MIRT761415	hsa-miR-212	CLIP-seq
MIRT761416	hsa-miR-3117-3p	CLIP-seq
MIRT761417	hsa-miR-3140-5p	CLIP-seq
MIRT761418	hsa-miR-3169	CLIP-seq
MIRT761419	hsa-miR-3908	CLIP-seq
MIRT761420	hsa-miR-3942-5p	CLIP-seq
MIRT761421	hsa-miR-4423-5p	CLIP-seq
MIRT761422	hsa-miR-4703-5p	CLIP-seq
MIRT761423	hsa-miR-4722-3p	CLIP-seq
MIRT761424	hsa-miR-4759	CLIP-seq
MIRT761425	hsa-miR-4766-3p	CLIP-seq
MIRT761426	hsa-miR-4781-3p	CLIP-seq
MIRT761427	hsa-miR-562	CLIP-seq
MIRT761428	hsa-miR-579	CLIP-seq
MIRT761429	hsa-miR-720	CLIP-seq
MIRT761413	hsa-miR-150	CLIP-seq
MIRT761423	hsa-miR-4722-3p	CLIP-seq
MIRT2165746	hsa-miR-1183	CLIP-seq
MIRT761413	hsa-miR-150	CLIP-seq
MIRT761416	hsa-miR-3117-3p	CLIP-seq
MIRT2165747	hsa-miR-3150a-5p	CLIP-seq
MIRT2165748	hsa-miR-3150b-5p	CLIP-seq
MIRT761418	hsa-miR-3169	CLIP-seq
MIRT2165749	hsa-miR-4693-5p	CLIP-seq
MIRT761424	hsa-miR-4759	CLIP-seq
MIRT761427	hsa-miR-562	CLIP-seq
MIRT2468304	hsa-miR-105	CLIP-seq
MIRT2468305	hsa-miR-10a	CLIP-seq
MIRT2468306	hsa-miR-10b	CLIP-seq
MIRT2468307	hsa-miR-1283	CLIP-seq
MIRT2468308	hsa-miR-140-3p	CLIP-seq
MIRT761413	hsa-miR-150	CLIP-seq
MIRT761414	hsa-miR-1976	CLIP-seq
MIRT2468309	hsa-miR-203	CLIP-seq
MIRT2468310	hsa-miR-221	CLIP-seq
MIRT2468311	hsa-miR-222	CLIP-seq
MIRT2468312	hsa-miR-3120-3p	CLIP-seq
MIRT2468313	hsa-miR-3121-3p	CLIP-seq
MIRT2468314	hsa-miR-3646	CLIP-seq
MIRT2468315	hsa-miR-3671	CLIP-seq
MIRT2468316	hsa-miR-409-3p	CLIP-seq
MIRT2468317	hsa-miR-4310	CLIP-seq
MIRT2468318	hsa-miR-4517	CLIP-seq
MIRT2468319	hsa-miR-4539	CLIP-seq
MIRT2468320	hsa-miR-4698	CLIP-seq
MIRT2468321	hsa-miR-4712-3p	CLIP-seq
MIRT2468322	hsa-miR-4719	CLIP-seq
MIRT761423	hsa-miR-4722-3p	CLIP-seq
MIRT2468323	hsa-miR-4724-5p	CLIP-seq
MIRT2468324	hsa-miR-4725-5p	CLIP-seq
MIRT2468325	hsa-miR-4780	CLIP-seq
MIRT761426	hsa-miR-4781-3p	CLIP-seq
MIRT2468326	hsa-miR-504	CLIP-seq
MIRT2468327	hsa-miR-548aa	CLIP-seq
MIRT2468328	hsa-miR-548v	CLIP-seq
MIRT2468329	hsa-miR-549	CLIP-seq
MIRT2468330	hsa-miR-550b	CLIP-seq
MIRT761427	hsa-miR-562	CLIP-seq
MIRT2468331	hsa-miR-607	CLIP-seq
MIRT2468305	hsa-miR-10a	CLIP-seq
MIRT2468306	hsa-miR-10b	CLIP-seq
MIRT2468308	hsa-miR-140-3p	CLIP-seq
MIRT2468309	hsa-miR-203	CLIP-seq
MIRT2468312	hsa-miR-3120-3p	CLIP-seq
MIRT2468313	hsa-miR-3121-3p	CLIP-seq
MIRT2468314	hsa-miR-3646	CLIP-seq
MIRT2468317	hsa-miR-4310	CLIP-seq
MIRT2468319	hsa-miR-4539	CLIP-seq
MIRT2468320	hsa-miR-4698	CLIP-seq
MIRT2468322	hsa-miR-4719	CLIP-seq
MIRT2468323	hsa-miR-4724-5p	CLIP-seq
MIRT2468324	hsa-miR-4725-5p	CLIP-seq
MIRT2468325	hsa-miR-4780	CLIP-seq
MIRT2468326	hsa-miR-504	CLIP-seq
MIRT2468327	hsa-miR-548aa	CLIP-seq
MIRT2468328	hsa-miR-548v	CLIP-seq
MIRT2468329	hsa-miR-549	CLIP-seq
MIRT2468330	hsa-miR-550b	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003995	Function	Acyl-CoA dehydrogenase activity	IBA
GO:0003995	Function	Acyl-CoA dehydrogenase activity	IEA
GO:0003995	Function	Acyl-CoA dehydrogenase activity	TAS
GO:0004466	Function	Long-chain fatty acyl-CoA dehydrogenase activity	IDA	21237683
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	21237683
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005777	Component	Peroxisome	IEA
GO:0005777	Component	Peroxisome	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0006635	Process	Fatty acid beta-oxidation	TAS
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0017099	Function	Very-long-chain fatty acyl-CoA dehydrogenase activity	IDA	21237683
GO:0031966	Component	Mitochondrial membrane	IDA	21237683
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA
GO:0033539	Process	Fatty acid beta-oxidation using acyl-CoA dehydrogenase	IDA	21237683
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0070991	Function	Medium-chain fatty acyl-CoA dehydrogenase activity	IDA	21237683

MIM	HGNC	e!Ensembl
614288	30211	ENSG00000240303

Q709F0

Protein name

Acyl-CoA dehydrogenase family member 11 (ACAD-11) (EC 1.3.8.-)

Protein function

Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (PubMed:21237683). Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fat

PDB

2WBI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01636	APH	45 → 288	Phosphotransferase enzyme family	Family
PF02771	Acyl-CoA_dh_N	376 → 499	Acyl-CoA dehydrogenase, N-terminal domain	Domain
PF02770	Acyl-CoA_dh_M	503 → 606	Acyl-CoA dehydrogenase, middle domain	Domain
PF00441	Acyl-CoA_dh_1	618 → 769	Acyl-CoA dehydrogenase, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in brain followed by liver, heart and kidney. {ECO:0000269|PubMed:21237683}.

Sequence

MKPGATGESDLAEVLPQHKFDSKSLEAYLNQHLSGFGAEREATLTIAQYRAGKSNPTFYL
QKGFQTYVLRKKPPGSLLPKAHQIDREFKVQKALFSIGFPVPKPILYCSDTSVIGTEFYV
MEHVQGRIFRDLTIPGLSPAERSAIYVATVETLAQLHSLNIQSLQLEGYGIGAGYCKRQV
STWTKQYQAAAHQDIPAMQQLSEWLMKNLPDNDNEENLIHGDFRLDNIVFHPKECRVIAV
LDWELSTIGHPLSDLAHFSLFYFWPRTVPMINQGSYSENSGIPSMEELISIYCRCRGINS
ILPNWNFFLALSYFKMAGIAQGVYSRYLLGNNSSEDSFLFANIVQPLAETGLQLSKRTFS
TVLPQIDTTGQLFVQTRKGQEVLIKVKHFMKQHILPAEKEVTEFYVQNENSVDKWGKPLV
IDKLKEMAKVEGLWNLFLPAVSGLSHVDYALIAEETGKCFFAPDVFNCQAPDTGNMEVLH
LYGSEEQKKQWLEPLLQGNITSCFCMTEPDVASSDATNIECSIQRDEDSYVINGKKWWSS
GAGNPKCKIAIVLGRTQNTSLSRHKQHSMILVPMNTPGVKIIRPLSVFGYTDNFHGGHFE
IHFNQVRVPATNLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAF
KKKLYAHEVVAHWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSK
IVDWAIQVCGGAGVSQDYPLANMYAITRVLRLADGPDEVHLSAIATMELRDQAKRLTAKI

Sequence length

780

Interactions

View interactions

	Reactome
			Mitochondrial Fatty Acid Beta-Oxidation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 44	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	38297313	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACAD11 (acyl-CoA dehydrogenase family member 11)