Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84128
Gene name	WD repeat domain 75
Gene symbol	WDR75
Synonyms (NCBI Gene)	NET16UTP17
Chromosome	2
Chromosome location	2q32.2

102

Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028674	hsa-miR-30a-5p	Proteomics	18668040
MIRT031984	hsa-miR-16-5p	Proteomics	18668040
MIRT032487	hsa-let-7b-5p	Proteomics	18668040
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT664004	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT664003	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT664002	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT664001	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT664000	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT663999	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT663998	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT663997	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT663996	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT663995	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT663993	hsa-miR-7977	HITS-CLIP	23824327
MIRT663994	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT663992	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT663991	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT663990	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT663989	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT663988	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT663987	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT663986	hsa-miR-3689c	HITS-CLIP	23824327
MIRT663984	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT663985	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT663983	hsa-miR-1228-5p	HITS-CLIP	23824327
MIRT663982	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT663981	hsa-miR-3122	HITS-CLIP	23824327
MIRT663980	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT663979	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT663978	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT664004	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT664003	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT664002	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT664001	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT664000	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT663999	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT663998	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT663997	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT663996	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT663995	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT663993	hsa-miR-7977	HITS-CLIP	23824327
MIRT663994	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT663992	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT663991	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT663990	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT663989	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT663988	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT663987	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT663986	hsa-miR-3689c	HITS-CLIP	23824327
MIRT663984	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT663985	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT663983	hsa-miR-1228-5p	HITS-CLIP	23824327
MIRT663982	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT663981	hsa-miR-3122	HITS-CLIP	23824327
MIRT663980	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT663979	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT663978	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT1491445	hsa-miR-3613-3p	CLIP-seq
MIRT1491446	hsa-miR-4666-3p	CLIP-seq
MIRT2148148	hsa-miR-4661-3p	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	17699751
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0032040	Component	Small-subunit processome	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0045943	Process	Positive regulation of transcription by RNA polymerase I	IBA
GO:0045943	Process	Positive regulation of transcription by RNA polymerase I	IEA
GO:0045943	Process	Positive regulation of transcription by RNA polymerase I	IMP	17699751
GO:2000234	Process	Positive regulation of rRNA processing	IBA
GO:2000234	Process	Positive regulation of rRNA processing	IMP	17699751

MIM	HGNC	e!Ensembl
620341	25725	ENSG00000115368

Q8IWA0

Protein name

WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)

Protein function

Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and

PDB

7MQ8 , 7MQ9 , 7MQA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	47 → 86	WD domain, G-beta repeat	Repeat
PF00400	WD40	192 → 231	WD domain, G-beta repeat	Repeat

Sequence

MVEEENIRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLV
TGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVN
KEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSV
YFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYT
YTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP
AGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQF
YSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMK
LWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSD
IYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAG
KIRHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQ
SSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFTSEAYQWLNRSQFYFLT
KSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQ
LPLTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESE
DSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDYSWIAAL

Sequence length

830

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		Major pathway of rRNA processing in the nucleolus and cytosol

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRONCHIAL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29658574	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	39438952	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	39438952	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

WDR75 (WD repeat domain 75)