Gene Gene information from NCBI Gene database.
Entrez ID 84109
Gene name Pyroglutamylated RFamide peptide receptor
Gene symbol QRFPR
Synonyms (NCBI Gene)
AQ27GPR103SP9155
Chromosome 4
Chromosome location 4q27
miRNA miRNA information provided by mirtarbase database.
768
miRTarBase ID miRNA Experiments Reference
MIRT709397 hsa-miR-2392 HITS-CLIP 19536157
MIRT709396 hsa-miR-3653-5p HITS-CLIP 19536157
MIRT709395 hsa-miR-1976 HITS-CLIP 19536157
MIRT709394 hsa-miR-6790-3p HITS-CLIP 19536157
MIRT709393 hsa-miR-6821-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IDA 12960173
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004983 Function Neuropeptide Y receptor activity IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606925 15565 ENSG00000186867
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96P65
Protein name Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
Protein function Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.
PDB 8WZ2 , 8ZH8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 62 332 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In per
Sequence
Sequence length 431
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Neuroactive ligand-receptor interaction   Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTOIMMUNE THYROID DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSORIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 26223541, 39755674 Associate
★☆☆☆☆
Found in Text Mining only
Alzheimer disease type 1 Alzheimer disease Pubtator 26223541 Inhibit
★☆☆☆☆
Found in Text Mining only
Alzheimer disease type 2 Alzheimer disease Pubtator 26223541 Associate
★☆☆☆☆
Found in Text Mining only
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 30483810
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 1 Diabetes mellitus, type 1 Pubtator 25936594 Associate
★☆☆☆☆
Found in Text Mining only
Hyperglycemia Hyperglycemia BEFREE 31084498
★☆☆☆☆
Found in Text Mining only
Intellectual Disability Intellectual developmental disorder Pubtator 34018631 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 30483810
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 35860189 Associate
★☆☆☆☆
Found in Text Mining only
Osteopenia Osteopenia BEFREE 16382160
★☆☆☆☆
Found in Text Mining only