Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84083
Gene name	Zinc finger RANBP2-type containing 3
Gene symbol	ZRANB3
Synonyms (NCBI Gene)	4933425L19RikAH2
Chromosome	2
Chromosome location	2q21.3

Show/Hide all (30)

miRTarBase ID	miRNA	Experiments	Reference
MIRT563178	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT563177	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT563176	hsa-miR-575	PAR-CLIP	20371350
MIRT563175	hsa-miR-6890-5p	PAR-CLIP	20371350
MIRT563174	hsa-miR-193b-5p	PAR-CLIP	20371350
MIRT563173	hsa-miR-4662a-5p	PAR-CLIP	20371350
MIRT563172	hsa-miR-3170	PAR-CLIP	20371350
MIRT563170	hsa-miR-6855-5p	PAR-CLIP	20371350
MIRT563171	hsa-miR-5096	PAR-CLIP	20371350
MIRT563178	hsa-miR-6858-3p	PAR-CLIP	20371350
MIRT563177	hsa-miR-4676-5p	PAR-CLIP	20371350
MIRT563176	hsa-miR-575	PAR-CLIP	20371350
MIRT563175	hsa-miR-6890-5p	PAR-CLIP	20371350
MIRT563174	hsa-miR-193b-5p	PAR-CLIP	20371350
MIRT563173	hsa-miR-4662a-5p	PAR-CLIP	20371350
MIRT563172	hsa-miR-3170	PAR-CLIP	20371350
MIRT563170	hsa-miR-6855-5p	PAR-CLIP	20371350
MIRT563171	hsa-miR-5096	PAR-CLIP	20371350
MIRT2163997	hsa-miR-30a	CLIP-seq
MIRT2163998	hsa-miR-30b	CLIP-seq
MIRT2163999	hsa-miR-30c	CLIP-seq
MIRT2164000	hsa-miR-30d	CLIP-seq
MIRT2164001	hsa-miR-30e	CLIP-seq
MIRT2164002	hsa-miR-331-5p	CLIP-seq
MIRT2164003	hsa-miR-4461	CLIP-seq
MIRT2164004	hsa-miR-4495	CLIP-seq
MIRT2164005	hsa-miR-4693-3p	CLIP-seq
MIRT2164002	hsa-miR-331-5p	CLIP-seq
MIRT2164003	hsa-miR-4461	CLIP-seq
MIRT2164005	hsa-miR-4693-3p	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003678	Function	DNA helicase activity	IDA	21078962
GO:0003824	Function	Catalytic activity	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004520	Function	DNA endonuclease activity	IBA
GO:0004520	Function	DNA endonuclease activity	IDA	22759634
GO:0005515	Function	Protein binding	IPI	22704558, 22705370, 22759634
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0006281	Process	DNA repair	IBA
GO:0006281	Process	DNA repair	IDA	22759634
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	22704558, 22705370, 22759634
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009411	Process	Response to UV	IDA	22704558
GO:0016787	Function	Hydrolase activity	IEA
GO:0031297	Process	Replication fork processing	IBA
GO:0031297	Process	Replication fork processing	IDA	22704558, 22705370
GO:0036310	Function	ATP-dependent DNA/DNA annealing activity	IDA	21078962, 22704558, 22705370
GO:0043596	Component	Nuclear replication fork	IBA
GO:0043596	Component	Nuclear replication fork	IDA	22704558, 22705370, 22759634
GO:0046872	Function	Metal ion binding	IEA
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IDA	22704558, 22705370, 22759634
GO:0071932	Process	Replication fork reversal	IDA	22704558

MIM	HGNC	e!Ensembl
615655	25249	ENSG00000121988

Q5FWF4

Protein name

DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)]

Protein function

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubM

PDB

5MKW , 5MLO , 5MLW , 5YD8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00176	SNF2_N	43 → 319	SNF2 family N-terminal domain	Family
PF00271	Helicase_C	324 → 435	Helicase conserved C-terminal domain	Family
PF00641	zf-RanBP	621 → 650	Zn-finger in Ran binding protein and others	Domain
PF01844	HNH	1009 → 1051	HNH endonuclease	Family

Sequence

MPRVHNIKKSLTPHISCVTNESDNLLDFLPDRLRAKLLPFQKDGIIFALKRNGRCMVADE
MGLGKTIQAIGITYFYKEEWPLLIVVPSSLRYPWTEEIEKWIPELSPEEINVIQNKTDVR
RMSTSKVTVLGYGLLTADAKTLIDALNNQNFKVVIVDESHYMKSRNATRSRILLPIVQKA
RRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCNAHIRYFGKRPQWDCRGAS
NLNELHQLLSDIMIRRLKTEVLTQLPPKVRQRIPFDLPSAAAKELNTSFEEWEKIMRTPN
SGAMETVMGLITRMFKQTAIAKAGAVKDYIKMMLQNDSLKFLVFAHHLSMLQACTEAVIE
NKTRYIRIDGSVSSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYWD
PGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDTLMWGMLNRKAQVTGSTLNGRKEKIQAE
EGDKEKWDFLQFAEAWTPNDSSEELRKEALFTHFEKEKQHDIRSFFVPQPKKRQLMTSCD
ESKRFREENTVVSSDPTKTAARDIIDYESDVEPETKRLKLAASEDHCSPSEETPSQSKQI
RTPLVESVQEAKAQLTTPAFPVEGWQCSLCTYINNSELPYCEMCETPQGSAVMQIDSLNH
IQDKNEKDDSQKDTSKKVQTISDCEKQALAQSEPGQLADSKEETPKIEKEDGLTSQPGNE
QWKSSDTLPVYDTLMFCASRNTDRIHIYTKDGKQMSCNFIPLDIKLDLWEDLPASFQLKQ
YRSLILRFVREWSSLTAMKQRIIRKSGQLFCSPILALEEITKQQTKQNCTKRYITKEDVA
VASMDKVKNVGGHVRLITKESRPRDPFTKKLLEDGACVPFLNPYTVQADLTVKPSTSKGY
LQAVDNEGNPLCLRCQQPTCQTKQACKANSWDSRFCSLKCQEEFWIRSNNSYLRAKVFET
EHGVCQLCNVNAQELFLRLRDAPKSQRKNLLYATWTSKLPLEQLNEMIRNPGEGHFWQVD
HIKPVYGGGGQCSLDNLQTLCTVCHKERTARQAKERSQVRRQSLASKHGSDITRFLVKK

Sequence length

1079

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MORBID OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30936075		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital cataract	Congenital Cataract	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Development Disorder	BEFREE	28954549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31324766, 31520154		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	31324766		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi anemia	Pubtator	37036693	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	30936075		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	30610086	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28621305, 28954549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcornea	Microcornea	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	33523105	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schimke immunoosseous dysplasia	Spondyloepiphyseal dysplasia nephrotic syndrome	BEFREE	22704558		★★★★★ ★☆☆☆☆ Found in Text Mining only
Warburg Sjo Fledelius syndrome	Warburg Micro Syndrome	BEFREE	23124039		★★★★★ ★☆☆☆☆ Found in Text Mining only
Warburg Sjo Fledelius syndrome	Warburg Micro Syndrome	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

ZRANB3 (zinc finger RANBP2-type containing 3)