Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84079
Gene name	Ankyrin repeat domain 27
Gene symbol	ANKRD27
Synonyms (NCBI Gene)	PP12899VARP
Chromosome	19
Chromosome location	19q13.11

306

Show/Hide all (306)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002637	hsa-miR-124-3p	Microarray	15685193
MIRT002637	hsa-miR-124-3p	Microarray	18668037
MIRT002637	hsa-miR-124-3p	Microarray	15685193
MIRT050984	hsa-miR-17-5p	CLASH	23622248
MIRT042819	hsa-miR-324-3p	CLASH	23622248
MIRT041158	hsa-miR-500a-3p	CLASH	23622248
MIRT038857	hsa-miR-93-3p	CLASH	23622248
MIRT409697	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT559592	hsa-miR-4750-3p	PAR-CLIP	21572407
MIRT559591	hsa-miR-29b-1-5p	PAR-CLIP	21572407
MIRT559590	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT559589	hsa-miR-3661	PAR-CLIP	21572407
MIRT559588	hsa-miR-631	PAR-CLIP	21572407
MIRT559587	hsa-miR-5087	PAR-CLIP	21572407
MIRT559586	hsa-miR-2052	PAR-CLIP	21572407
MIRT559584	hsa-miR-4256	PAR-CLIP	21572407
MIRT559585	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT559583	hsa-miR-4452	PAR-CLIP	21572407
MIRT559582	hsa-miR-2113	PAR-CLIP	21572407
MIRT409697	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT559592	hsa-miR-4750-3p	PAR-CLIP	21572407
MIRT559591	hsa-miR-29b-1-5p	PAR-CLIP	21572407
MIRT559590	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT559589	hsa-miR-3661	PAR-CLIP	21572407
MIRT559588	hsa-miR-631	PAR-CLIP	21572407
MIRT559587	hsa-miR-5087	PAR-CLIP	21572407
MIRT559586	hsa-miR-2052	PAR-CLIP	21572407
MIRT559584	hsa-miR-4256	PAR-CLIP	21572407
MIRT559585	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT559583	hsa-miR-4452	PAR-CLIP	21572407
MIRT559582	hsa-miR-2113	PAR-CLIP	21572407
MIRT783274	hsa-miR-124	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT783276	hsa-miR-1257	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783278	hsa-miR-1273d	CLIP-seq
MIRT783279	hsa-miR-1321	CLIP-seq
MIRT783280	hsa-miR-142-5p	CLIP-seq
MIRT783281	hsa-miR-181a	CLIP-seq
MIRT783282	hsa-miR-181b	CLIP-seq
MIRT783283	hsa-miR-181c	CLIP-seq
MIRT783284	hsa-miR-181d	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783286	hsa-miR-29a	CLIP-seq
MIRT783287	hsa-miR-29b	CLIP-seq
MIRT783288	hsa-miR-29c	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT783290	hsa-miR-3122	CLIP-seq
MIRT783291	hsa-miR-3168	CLIP-seq
MIRT783292	hsa-miR-3647-3p	CLIP-seq
MIRT783293	hsa-miR-3664-3p	CLIP-seq
MIRT783294	hsa-miR-3689a-3p	CLIP-seq
MIRT783295	hsa-miR-3689c	CLIP-seq
MIRT783296	hsa-miR-3913-5p	CLIP-seq
MIRT783297	hsa-miR-3919	CLIP-seq
MIRT783298	hsa-miR-3974	CLIP-seq
MIRT783299	hsa-miR-4262	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783302	hsa-miR-4436a	CLIP-seq
MIRT783303	hsa-miR-4446-5p	CLIP-seq
MIRT783304	hsa-miR-4457	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783306	hsa-miR-4672	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783308	hsa-miR-4676-5p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT783310	hsa-miR-4728-5p	CLIP-seq
MIRT783311	hsa-miR-4739	CLIP-seq
MIRT783312	hsa-miR-4746-3p	CLIP-seq
MIRT783313	hsa-miR-4755-5p	CLIP-seq
MIRT783314	hsa-miR-4756-3p	CLIP-seq
MIRT783315	hsa-miR-4756-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT783317	hsa-miR-4802-3p	CLIP-seq
MIRT783318	hsa-miR-490-5p	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783320	hsa-miR-510	CLIP-seq
MIRT783321	hsa-miR-513b	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT783329	hsa-miR-548aa	CLIP-seq
MIRT783330	hsa-miR-561	CLIP-seq
MIRT783331	hsa-miR-570	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783333	hsa-miR-575	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783337	hsa-miR-624	CLIP-seq
MIRT783338	hsa-miR-671-5p	CLIP-seq
MIRT783339	hsa-miR-765	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783274	hsa-miR-124	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT783276	hsa-miR-1257	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT1931086	hsa-miR-1273g	CLIP-seq
MIRT783280	hsa-miR-142-5p	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783286	hsa-miR-29a	CLIP-seq
MIRT783287	hsa-miR-29b	CLIP-seq
MIRT783288	hsa-miR-29c	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT1931087	hsa-miR-3611	CLIP-seq
MIRT783292	hsa-miR-3647-3p	CLIP-seq
MIRT1931088	hsa-miR-3682-5p	CLIP-seq
MIRT783297	hsa-miR-3919	CLIP-seq
MIRT1931089	hsa-miR-3925-3p	CLIP-seq
MIRT1931090	hsa-miR-425	CLIP-seq
MIRT1931091	hsa-miR-4267	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783306	hsa-miR-4672	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT783314	hsa-miR-4756-3p	CLIP-seq
MIRT1931092	hsa-miR-4768-5p	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783330	hsa-miR-561	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT1931093	hsa-miR-758	CLIP-seq
MIRT1931094	hsa-miR-766	CLIP-seq
MIRT1931095	hsa-miR-942	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT2171723	hsa-miR-1237	CLIP-seq
MIRT783274	hsa-miR-124	CLIP-seq
MIRT2171724	hsa-miR-1243	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT2171725	hsa-miR-1248	CLIP-seq
MIRT783276	hsa-miR-1257	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783278	hsa-miR-1273d	CLIP-seq
MIRT1931086	hsa-miR-1273g	CLIP-seq
MIRT783280	hsa-miR-142-5p	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT783291	hsa-miR-3168	CLIP-seq
MIRT2171726	hsa-miR-3182	CLIP-seq
MIRT1931087	hsa-miR-3611	CLIP-seq
MIRT783292	hsa-miR-3647-3p	CLIP-seq
MIRT2171727	hsa-miR-3654	CLIP-seq
MIRT783293	hsa-miR-3664-3p	CLIP-seq
MIRT2171728	hsa-miR-3667-3p	CLIP-seq
MIRT1931088	hsa-miR-3682-5p	CLIP-seq
MIRT2171729	hsa-miR-3686	CLIP-seq
MIRT2171730	hsa-miR-3907	CLIP-seq
MIRT1931089	hsa-miR-3925-3p	CLIP-seq
MIRT783298	hsa-miR-3974	CLIP-seq
MIRT1931091	hsa-miR-4267	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783302	hsa-miR-4436a	CLIP-seq
MIRT783304	hsa-miR-4457	CLIP-seq
MIRT2171731	hsa-miR-4477b	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783308	hsa-miR-4676-5p	CLIP-seq
MIRT2171732	hsa-miR-4684-3p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT2171733	hsa-miR-4731-3p	CLIP-seq
MIRT1931092	hsa-miR-4768-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT2171734	hsa-miR-4782-5p	CLIP-seq
MIRT2171735	hsa-miR-4801	CLIP-seq
MIRT783318	hsa-miR-490-5p	CLIP-seq
MIRT2171736	hsa-miR-500a	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783320	hsa-miR-510	CLIP-seq
MIRT783321	hsa-miR-513b	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT783330	hsa-miR-561	CLIP-seq
MIRT783331	hsa-miR-570	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783333	hsa-miR-575	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783337	hsa-miR-624	CLIP-seq
MIRT783338	hsa-miR-671-5p	CLIP-seq
MIRT1931093	hsa-miR-758	CLIP-seq
MIRT783339	hsa-miR-765	CLIP-seq
MIRT1931094	hsa-miR-766	CLIP-seq
MIRT2171737	hsa-miR-873	CLIP-seq
MIRT1931095	hsa-miR-942	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783274	hsa-miR-124	CLIP-seq
MIRT2171724	hsa-miR-1243	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT2171727	hsa-miR-3654	CLIP-seq
MIRT2171731	hsa-miR-4477b	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT2171734	hsa-miR-4782-5p	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT2443666	hsa-miR-3064-3p	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT2474771	hsa-miR-1252	CLIP-seq
MIRT783279	hsa-miR-1321	CLIP-seq
MIRT783281	hsa-miR-181a	CLIP-seq
MIRT783282	hsa-miR-181b	CLIP-seq
MIRT783283	hsa-miR-181c	CLIP-seq
MIRT783284	hsa-miR-181d	CLIP-seq
MIRT2474772	hsa-miR-200b	CLIP-seq
MIRT2474773	hsa-miR-200c	CLIP-seq
MIRT2474774	hsa-miR-221	CLIP-seq
MIRT2474775	hsa-miR-222	CLIP-seq
MIRT2443666	hsa-miR-3064-3p	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT2474776	hsa-miR-3154	CLIP-seq
MIRT783291	hsa-miR-3168	CLIP-seq
MIRT2474777	hsa-miR-3662	CLIP-seq
MIRT2171730	hsa-miR-3907	CLIP-seq
MIRT783299	hsa-miR-4262	CLIP-seq
MIRT2474778	hsa-miR-429	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783308	hsa-miR-4676-5p	CLIP-seq
MIRT2171732	hsa-miR-4684-3p	CLIP-seq
MIRT783311	hsa-miR-4739	CLIP-seq
MIRT783315	hsa-miR-4756-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT783318	hsa-miR-490-5p	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT2474779	hsa-miR-548v	CLIP-seq
MIRT2474780	hsa-miR-552	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783333	hsa-miR-575	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783338	hsa-miR-671-5p	CLIP-seq
MIRT2474781	hsa-miR-764	CLIP-seq
MIRT2474782	hsa-miR-802	CLIP-seq
MIRT2171737	hsa-miR-873	CLIP-seq
MIRT2474771	hsa-miR-1252	CLIP-seq
MIRT783278	hsa-miR-1273d	CLIP-seq
MIRT783279	hsa-miR-1321	CLIP-seq
MIRT783281	hsa-miR-181a	CLIP-seq
MIRT783282	hsa-miR-181b	CLIP-seq
MIRT783283	hsa-miR-181c	CLIP-seq
MIRT783284	hsa-miR-181d	CLIP-seq
MIRT2474772	hsa-miR-200b	CLIP-seq
MIRT2474773	hsa-miR-200c	CLIP-seq
MIRT2474774	hsa-miR-221	CLIP-seq
MIRT2474775	hsa-miR-222	CLIP-seq
MIRT2443666	hsa-miR-3064-3p	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT2474776	hsa-miR-3154	CLIP-seq
MIRT2474777	hsa-miR-3662	CLIP-seq
MIRT783293	hsa-miR-3664-3p	CLIP-seq
MIRT783299	hsa-miR-4262	CLIP-seq
MIRT2474778	hsa-miR-429	CLIP-seq
MIRT783302	hsa-miR-4436a	CLIP-seq
MIRT783311	hsa-miR-4739	CLIP-seq
MIRT783315	hsa-miR-4756-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT783320	hsa-miR-510	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT2474779	hsa-miR-548v	CLIP-seq
MIRT2474780	hsa-miR-552	CLIP-seq
MIRT2474781	hsa-miR-764	CLIP-seq
MIRT2474782	hsa-miR-802	CLIP-seq
MIRT2171737	hsa-miR-873	CLIP-seq

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	16525121
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	16525121, 19745841, 22705394, 23104059
GO:0005764	Component	Lysosome	IDA	24856514
GO:0005764	Component	Lysosome	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	IDA	16525121, 24856514
GO:0005769	Component	Early endosome	IEA
GO:0005770	Component	Late endosome	IBA
GO:0005770	Component	Late endosome	IDA	24856514
GO:0005770	Component	Late endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24856514
GO:0005886	Component	Plasma membrane	IEA
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0030133	Component	Transport vesicle	IBA
GO:0030133	Component	Transport vesicle	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031267	Function	Small GTPase binding	IDA	16525121
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032456	Process	Endocytic recycling	IMP	24856514
GO:0035544	Process	Negative regulation of SNARE complex assembly	IDA	24856514
GO:0035646	Process	Endosome to melanosome transport	IEA
GO:0042470	Component	Melanosome	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043005	Component	Neuron projection	IEA
GO:0045022	Process	Early endosome to late endosome transport	IBA
GO:0045022	Process	Early endosome to late endosome transport	IDA	16525121
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0048812	Process	Neuron projection morphogenesis	IEA
GO:0050775	Process	Positive regulation of dendrite morphogenesis	IEA
GO:0097422	Component	Tubular endosome	IBA
GO:0097422	Component	Tubular endosome	IDA	24856514

MIM	HGNC	e!Ensembl
618957	25310	ENSG00000105186

Q96NW4

Protein name

Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)

Protein function

May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE comple

PDB

4B93 , 4CYM , 4CZ2 , 6TL0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02204	VPS9	264 → 367	Vacuolar sorting protein 9 (VPS9) domain	Family
PF12796	Ank_2	401 → 526	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	500 → 595	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	673 → 807	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	781 → 873	Ankyrin repeats (3 copies)	Repeat

Sequence

MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIP
VEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKR
ESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFN
KITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQ
RVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQE
DHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLID
LLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG
HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKET
PLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQ
EETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKC
APAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVP
LHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN
NKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCV
ASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARD
RSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLR
RHTVEDAVVSQGPEAAGPLSTPQEVSASRS

Sequence length

1050

Interactions

View interactions

	Reactome
			RAB GEFs exchange GTP for GDP on RABs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EOSINOPHILIC ESOPHAGITIS	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atrial Fibrillation	Atrial fibrillation	Pubtator	24148610	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34965262	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilic esophagitis	Eosinophilia	GWASCAT_DG	25407941		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Eosinophilic Esophagitis	Eosinophilia	Pubtator	25407941	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	GWASCAT_DG	23377640		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	GWASDB_DG	23377640		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Myeloma	Multiple myeloma	GWASCAT_DG	29594489		★★★★★ ★☆☆☆☆ Found in Text Mining only

ANKRD27 (ankyrin repeat domain 27)