Gene Gene information from NCBI Gene database.
Entrez ID 8407
Gene name Transgelin 2
Gene symbol TAGLN2
Synonyms (NCBI Gene)
HA1756
Chromosome 1
Chromosome location 1q23.2
Summary The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor
miRNA miRNA information provided by mirtarbase database.
783
miRTarBase ID miRNA Experiments Reference
MIRT002788 hsa-miR-1-3p Luciferase reporter assay 20144220
MIRT002788 hsa-miR-1-3p Luciferase reporter assay 20144220
MIRT002788 hsa-miR-1-3p pSILAC 18668040
MIRT002788 hsa-miR-1-3p Microarray 15685193
MIRT002788 hsa-miR-1-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 21304530
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21577206, 28514442, 32814053, 33961781
GO:0005576 Component Extracellular region TAS
GO:0005829 Component Cytosol TAS
GO:0007015 Process Actin filament organization IBA
GO:0015629 Component Actin cytoskeleton IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604634 11554 ENSG00000158710
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P37802
Protein name Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog)
PDB 1WYM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH 24 137 Calponin homology (CH) domain Domain
PF00402 Calponin 174 198 Calponin family repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Expressed in epididymis (at protein level). {ECO:0000269|PubMed:20736409}.
Sequence
Sequence length 199
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, RENAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 19848416
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 28521289, 30041673
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 29437149, 31256982
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 21304530, 30317571, 30405771
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain neoplasms Pubtator 40247723 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 24680370, 26176734, 31144206, 31485630, 31488699, 31625545
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 26176734 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 29424888 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 15756260 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 16750200 Associate
★☆☆☆☆
Found in Text Mining only