TMEM222 (transmembrane protein 222)

Gene

• Entrez ID: 84065
• Gene name: Transmembrane protein 222
• Gene symbol: TMEM222
• Synonyms (NCBI Gene): C1orf160, NEDMOSBA
• Chromosome: 1
• Chromosome location: 1p36.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439432	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439432	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1435602	hsa-miR-1207-5p	CLIP-seq
MIRT1435603	hsa-miR-125a-5p	CLIP-seq
MIRT1435604	hsa-miR-125b	CLIP-seq
MIRT1435605	hsa-miR-1915	CLIP-seq
MIRT1435606	hsa-miR-1972	CLIP-seq
MIRT1435607	hsa-miR-3127-3p	CLIP-seq
MIRT1435608	hsa-miR-3649	CLIP-seq
MIRT1435609	hsa-miR-3660	CLIP-seq
MIRT1435610	hsa-miR-3663-5p	CLIP-seq
MIRT1435611	hsa-miR-4267	CLIP-seq
MIRT1435612	hsa-miR-4281	CLIP-seq
MIRT1435613	hsa-miR-4294	CLIP-seq
MIRT1435614	hsa-miR-4319	CLIP-seq
MIRT1435615	hsa-miR-4433	CLIP-seq
MIRT1435616	hsa-miR-4475	CLIP-seq
MIRT1435617	hsa-miR-4526	CLIP-seq
MIRT1435618	hsa-miR-4717-5p	CLIP-seq
MIRT1435619	hsa-miR-4722-5p	CLIP-seq
MIRT1435620	hsa-miR-4731-5p	CLIP-seq
MIRT1435621	hsa-miR-4732-3p	CLIP-seq
MIRT1435622	hsa-miR-4736	CLIP-seq
MIRT1435623	hsa-miR-4763-3p	CLIP-seq
MIRT1435624	hsa-miR-670	CLIP-seq
MIRT1435625	hsa-miR-939	CLIP-seq
MIRT2130545	hsa-miR-1233	CLIP-seq
MIRT2130546	hsa-miR-129-3p	CLIP-seq
MIRT2130547	hsa-miR-1827	CLIP-seq
MIRT1435605	hsa-miR-1915	CLIP-seq
MIRT2130548	hsa-miR-3064-5p	CLIP-seq
MIRT2130549	hsa-miR-4251	CLIP-seq
MIRT2130550	hsa-miR-4270	CLIP-seq
MIRT2130551	hsa-miR-4303	CLIP-seq
MIRT2130552	hsa-miR-4329	CLIP-seq
MIRT2130553	hsa-miR-4441	CLIP-seq
MIRT2130554	hsa-miR-4687-3p	CLIP-seq
MIRT2130555	hsa-miR-892b	CLIP-seq
MIRT2130556	hsa-miR-940	CLIP-seq
MIRT1435602	hsa-miR-1207-5p	CLIP-seq
MIRT2130547	hsa-miR-1827	CLIP-seq
MIRT1435605	hsa-miR-1915	CLIP-seq
MIRT1435606	hsa-miR-1972	CLIP-seq
MIRT2130548	hsa-miR-3064-5p	CLIP-seq
MIRT2351871	hsa-miR-3918	CLIP-seq
MIRT2130549	hsa-miR-4251	CLIP-seq
MIRT2130551	hsa-miR-4303	CLIP-seq
MIRT2130552	hsa-miR-4329	CLIP-seq
MIRT2351872	hsa-miR-4512	CLIP-seq
MIRT2130554	hsa-miR-4687-3p	CLIP-seq
MIRT1435618	hsa-miR-4717-5p	CLIP-seq
MIRT1435622	hsa-miR-4736	CLIP-seq
MIRT1435623	hsa-miR-4763-3p	CLIP-seq
MIRT2351873	hsa-miR-552	CLIP-seq
MIRT2130555	hsa-miR-892b	CLIP-seq
MIRT1435625	hsa-miR-939	CLIP-seq
MIRT2130556	hsa-miR-940	CLIP-seq
MIRT1435605	hsa-miR-1915	CLIP-seq
MIRT2395997	hsa-miR-2115	CLIP-seq
MIRT2351871	hsa-miR-3918	CLIP-seq
MIRT2395998	hsa-miR-4685-5p	CLIP-seq
MIRT2461817	hsa-miR-3150a-3p	CLIP-seq
MIRT2461818	hsa-miR-3175	CLIP-seq
MIRT2461819	hsa-miR-4650-5p	CLIP-seq
MIRT2461820	hsa-miR-4667-5p	CLIP-seq
MIRT2461821	hsa-miR-4700-5p	CLIP-seq
MIRT2461822	hsa-miR-4779	CLIP-seq
MIRT2461823	hsa-miR-513a-5p	CLIP-seq
MIRT2461824	hsa-miR-661	CLIP-seq
MIRT2461825	hsa-miR-765	CLIP-seq
MIRT1435625	hsa-miR-939	CLIP-seq
MIRT2645575	hsa-miR-1202	CLIP-seq
MIRT2645576	hsa-miR-1205	CLIP-seq
MIRT1435602	hsa-miR-1207-5p	CLIP-seq
MIRT2645577	hsa-miR-1225-3p	CLIP-seq
MIRT2130545	hsa-miR-1233	CLIP-seq
MIRT2645578	hsa-miR-125a-3p	CLIP-seq
MIRT2645579	hsa-miR-1273f	CLIP-seq
MIRT2645580	hsa-miR-1275	CLIP-seq
MIRT2645581	hsa-miR-1285	CLIP-seq
MIRT2645582	hsa-miR-1286	CLIP-seq
MIRT2645583	hsa-miR-1305	CLIP-seq
MIRT2645584	hsa-miR-138	CLIP-seq
MIRT2645585	hsa-miR-139-5p	CLIP-seq
MIRT2645586	hsa-miR-1587	CLIP-seq
MIRT2130547	hsa-miR-1827	CLIP-seq
MIRT2645587	hsa-miR-1908	CLIP-seq
MIRT2645588	hsa-miR-1909	CLIP-seq
MIRT2645589	hsa-miR-1910	CLIP-seq
MIRT1435605	hsa-miR-1915	CLIP-seq
MIRT1435606	hsa-miR-1972	CLIP-seq
MIRT2395997	hsa-miR-2115	CLIP-seq
MIRT2645590	hsa-miR-214	CLIP-seq
MIRT2130548	hsa-miR-3064-5p	CLIP-seq
MIRT1435607	hsa-miR-3127-3p	CLIP-seq
MIRT2645591	hsa-miR-3135b	CLIP-seq
MIRT2645592	hsa-miR-3136-3p	CLIP-seq
MIRT2645593	hsa-miR-3140-5p	CLIP-seq
MIRT2461818	hsa-miR-3175	CLIP-seq
MIRT2645594	hsa-miR-3176	CLIP-seq
MIRT2645595	hsa-miR-3179	CLIP-seq
MIRT2645596	hsa-miR-3183	CLIP-seq
MIRT2645597	hsa-miR-3187-5p	CLIP-seq
MIRT2645598	hsa-miR-3192	CLIP-seq
MIRT2645599	hsa-miR-3194-5p	CLIP-seq
MIRT2645600	hsa-miR-326	CLIP-seq
MIRT2645601	hsa-miR-330-5p	CLIP-seq
MIRT2645602	hsa-miR-3612	CLIP-seq
MIRT2645603	hsa-miR-3619-3p	CLIP-seq
MIRT2645604	hsa-miR-3619-5p	CLIP-seq
MIRT2645605	hsa-miR-3665	CLIP-seq
MIRT2645606	hsa-miR-3667-3p	CLIP-seq
MIRT2645607	hsa-miR-3689a-3p	CLIP-seq
MIRT2645608	hsa-miR-3689c	CLIP-seq
MIRT2645609	hsa-miR-371-5p	CLIP-seq
MIRT2645610	hsa-miR-378	CLIP-seq
MIRT2645611	hsa-miR-378b	CLIP-seq
MIRT2645612	hsa-miR-378c	CLIP-seq
MIRT2645613	hsa-miR-378d	CLIP-seq
MIRT2645614	hsa-miR-378e	CLIP-seq
MIRT2645615	hsa-miR-378f	CLIP-seq
MIRT2645616	hsa-miR-378g	CLIP-seq
MIRT2645617	hsa-miR-378h	CLIP-seq
MIRT2645618	hsa-miR-378i	CLIP-seq
MIRT2645619	hsa-miR-3909	CLIP-seq
MIRT2351871	hsa-miR-3918	CLIP-seq
MIRT2645620	hsa-miR-3922-3p	CLIP-seq
MIRT2645621	hsa-miR-3972	CLIP-seq
MIRT2645622	hsa-miR-3976	CLIP-seq
MIRT2645623	hsa-miR-421	CLIP-seq
MIRT2645624	hsa-miR-422a	CLIP-seq
MIRT2645625	hsa-miR-4264	CLIP-seq
MIRT2645626	hsa-miR-4300	CLIP-seq
MIRT2645627	hsa-miR-4418	CLIP-seq
MIRT2645628	hsa-miR-4447	CLIP-seq
MIRT2645629	hsa-miR-4472	CLIP-seq
MIRT1435616	hsa-miR-4475	CLIP-seq
MIRT2645630	hsa-miR-4487	CLIP-seq
MIRT2645631	hsa-miR-4492	CLIP-seq
MIRT2645632	hsa-miR-4498	CLIP-seq
MIRT2645633	hsa-miR-4525	CLIP-seq
MIRT2645634	hsa-miR-4530	CLIP-seq
MIRT2645635	hsa-miR-455-3p	CLIP-seq
MIRT2645636	hsa-miR-4638-3p	CLIP-seq
MIRT2645637	hsa-miR-4649-3p	CLIP-seq
MIRT2645638	hsa-miR-4653-3p	CLIP-seq
MIRT2645639	hsa-miR-4656	CLIP-seq
MIRT2645640	hsa-miR-4660	CLIP-seq
MIRT2645641	hsa-miR-4665-5p	CLIP-seq
MIRT2645642	hsa-miR-4675	CLIP-seq
MIRT2395998	hsa-miR-4685-5p	CLIP-seq
MIRT2130554	hsa-miR-4687-3p	CLIP-seq
MIRT2645643	hsa-miR-4690-5p	CLIP-seq
MIRT2645644	hsa-miR-4709-5p	CLIP-seq
MIRT2645645	hsa-miR-4716-3p	CLIP-seq
MIRT1435618	hsa-miR-4717-5p	CLIP-seq
MIRT2645646	hsa-miR-4722-3p	CLIP-seq
MIRT2645647	hsa-miR-4723-3p	CLIP-seq
MIRT2645648	hsa-miR-4723-5p	CLIP-seq
MIRT2645649	hsa-miR-4728-5p	CLIP-seq
MIRT1435620	hsa-miR-4731-5p	CLIP-seq
MIRT1435622	hsa-miR-4736	CLIP-seq
MIRT2645650	hsa-miR-4741	CLIP-seq
MIRT2645651	hsa-miR-4743	CLIP-seq
MIRT2645652	hsa-miR-4749-3p	CLIP-seq
MIRT2645653	hsa-miR-4757-5p	CLIP-seq
MIRT1435623	hsa-miR-4763-3p	CLIP-seq
MIRT2645654	hsa-miR-4776-5p	CLIP-seq
MIRT2645655	hsa-miR-4777-5p	CLIP-seq
MIRT2645656	hsa-miR-4786-3p	CLIP-seq
MIRT2645657	hsa-miR-4792	CLIP-seq
MIRT2645658	hsa-miR-4793-5p	CLIP-seq
MIRT2645659	hsa-miR-493	CLIP-seq
MIRT2645660	hsa-miR-509-3-5p	CLIP-seq
MIRT2645661	hsa-miR-509-5p	CLIP-seq
MIRT2645662	hsa-miR-518d-5p	CLIP-seq
MIRT2645663	hsa-miR-519b-5p	CLIP-seq
MIRT2645664	hsa-miR-519c-5p	CLIP-seq
MIRT2645665	hsa-miR-520c-5p	CLIP-seq
MIRT2645666	hsa-miR-526a	CLIP-seq
MIRT2645667	hsa-miR-549	CLIP-seq
MIRT2351873	hsa-miR-552	CLIP-seq
MIRT2645668	hsa-miR-612	CLIP-seq
MIRT2645669	hsa-miR-625	CLIP-seq
MIRT2645670	hsa-miR-646	CLIP-seq
MIRT2645671	hsa-miR-650	CLIP-seq
MIRT2645672	hsa-miR-663	CLIP-seq
MIRT2645673	hsa-miR-671-5p	CLIP-seq
MIRT2645674	hsa-miR-711	CLIP-seq
MIRT2645675	hsa-miR-761	CLIP-seq
MIRT2645676	hsa-miR-762	CLIP-seq
MIRT2645677	hsa-miR-891b	CLIP-seq
MIRT2130555	hsa-miR-892b	CLIP-seq
MIRT2645678	hsa-miR-920	CLIP-seq
MIRT1435625	hsa-miR-939	CLIP-seq
MIRT2130556	hsa-miR-940	CLIP-seq
MIRT2645576	hsa-miR-1205	CLIP-seq
MIRT2645577	hsa-miR-1225-3p	CLIP-seq
MIRT2130545	hsa-miR-1233	CLIP-seq
MIRT2645578	hsa-miR-125a-3p	CLIP-seq
MIRT2645579	hsa-miR-1273f	CLIP-seq
MIRT2645580	hsa-miR-1275	CLIP-seq
MIRT2645581	hsa-miR-1285	CLIP-seq
MIRT2645582	hsa-miR-1286	CLIP-seq
MIRT2645583	hsa-miR-1305	CLIP-seq
MIRT2645584	hsa-miR-138	CLIP-seq
MIRT2645585	hsa-miR-139-5p	CLIP-seq
MIRT2645586	hsa-miR-1587	CLIP-seq
MIRT2130547	hsa-miR-1827	CLIP-seq
MIRT2645587	hsa-miR-1908	CLIP-seq
MIRT2645588	hsa-miR-1909	CLIP-seq
MIRT2645589	hsa-miR-1910	CLIP-seq
MIRT2395997	hsa-miR-2115	CLIP-seq
MIRT2645590	hsa-miR-214	CLIP-seq
MIRT2693506	hsa-miR-3065-5p	CLIP-seq
MIRT1435607	hsa-miR-3127-3p	CLIP-seq
MIRT2645591	hsa-miR-3135b	CLIP-seq
MIRT2645593	hsa-miR-3140-5p	CLIP-seq
MIRT2461818	hsa-miR-3175	CLIP-seq
MIRT2645594	hsa-miR-3176	CLIP-seq
MIRT2645595	hsa-miR-3179	CLIP-seq
MIRT2645596	hsa-miR-3183	CLIP-seq
MIRT2645597	hsa-miR-3187-5p	CLIP-seq
MIRT2645598	hsa-miR-3192	CLIP-seq
MIRT2645599	hsa-miR-3194-5p	CLIP-seq
MIRT2645600	hsa-miR-326	CLIP-seq
MIRT2645601	hsa-miR-330-5p	CLIP-seq
MIRT2645602	hsa-miR-3612	CLIP-seq
MIRT2645603	hsa-miR-3619-3p	CLIP-seq
MIRT2645604	hsa-miR-3619-5p	CLIP-seq
MIRT2645605	hsa-miR-3665	CLIP-seq
MIRT2645607	hsa-miR-3689a-3p	CLIP-seq
MIRT2645608	hsa-miR-3689c	CLIP-seq
MIRT2645609	hsa-miR-371-5p	CLIP-seq
MIRT2645610	hsa-miR-378	CLIP-seq
MIRT2645611	hsa-miR-378b	CLIP-seq
MIRT2645612	hsa-miR-378c	CLIP-seq
MIRT2645613	hsa-miR-378d	CLIP-seq
MIRT2645614	hsa-miR-378e	CLIP-seq
MIRT2645615	hsa-miR-378f	CLIP-seq
MIRT2645616	hsa-miR-378g	CLIP-seq
MIRT2645617	hsa-miR-378h	CLIP-seq
MIRT2645618	hsa-miR-378i	CLIP-seq
MIRT2645619	hsa-miR-3909	CLIP-seq
MIRT2351871	hsa-miR-3918	CLIP-seq
MIRT2645620	hsa-miR-3922-3p	CLIP-seq
MIRT2645622	hsa-miR-3976	CLIP-seq
MIRT2645623	hsa-miR-421	CLIP-seq
MIRT2645624	hsa-miR-422a	CLIP-seq
MIRT2645625	hsa-miR-4264	CLIP-seq
MIRT2693507	hsa-miR-4286	CLIP-seq
MIRT2645626	hsa-miR-4300	CLIP-seq
MIRT2645627	hsa-miR-4418	CLIP-seq
MIRT2645628	hsa-miR-4447	CLIP-seq
MIRT2645629	hsa-miR-4472	CLIP-seq
MIRT1435616	hsa-miR-4475	CLIP-seq
MIRT2645630	hsa-miR-4487	CLIP-seq
MIRT2645631	hsa-miR-4492	CLIP-seq
MIRT2645632	hsa-miR-4498	CLIP-seq
MIRT2645633	hsa-miR-4525	CLIP-seq
MIRT2645634	hsa-miR-4530	CLIP-seq
MIRT2645635	hsa-miR-455-3p	CLIP-seq
MIRT2645636	hsa-miR-4638-3p	CLIP-seq
MIRT2645637	hsa-miR-4649-3p	CLIP-seq
MIRT2645638	hsa-miR-4653-3p	CLIP-seq
MIRT2645639	hsa-miR-4656	CLIP-seq
MIRT2645640	hsa-miR-4660	CLIP-seq
MIRT2645641	hsa-miR-4665-5p	CLIP-seq
MIRT2645642	hsa-miR-4675	CLIP-seq
MIRT2395998	hsa-miR-4685-5p	CLIP-seq
MIRT2645644	hsa-miR-4709-5p	CLIP-seq
MIRT2645645	hsa-miR-4716-3p	CLIP-seq
MIRT2645647	hsa-miR-4723-3p	CLIP-seq
MIRT2645648	hsa-miR-4723-5p	CLIP-seq
MIRT2645649	hsa-miR-4728-5p	CLIP-seq
MIRT1435620	hsa-miR-4731-5p	CLIP-seq
MIRT2645650	hsa-miR-4741	CLIP-seq
MIRT2645651	hsa-miR-4743	CLIP-seq
MIRT2645652	hsa-miR-4749-3p	CLIP-seq
MIRT2645653	hsa-miR-4757-5p	CLIP-seq
MIRT2645654	hsa-miR-4776-5p	CLIP-seq
MIRT2645655	hsa-miR-4777-5p	CLIP-seq
MIRT2645656	hsa-miR-4786-3p	CLIP-seq
MIRT2645657	hsa-miR-4792	CLIP-seq
MIRT2645659	hsa-miR-493	CLIP-seq
MIRT2693508	hsa-miR-495	CLIP-seq
MIRT2645660	hsa-miR-509-3-5p	CLIP-seq
MIRT2645661	hsa-miR-509-5p	CLIP-seq
MIRT2645662	hsa-miR-518d-5p	CLIP-seq
MIRT2645663	hsa-miR-519b-5p	CLIP-seq
MIRT2645664	hsa-miR-519c-5p	CLIP-seq
MIRT2645665	hsa-miR-520c-5p	CLIP-seq
MIRT2645666	hsa-miR-526a	CLIP-seq
MIRT2645667	hsa-miR-549	CLIP-seq
MIRT2351873	hsa-miR-552	CLIP-seq
MIRT2645668	hsa-miR-612	CLIP-seq
MIRT2645669	hsa-miR-625	CLIP-seq
MIRT2645670	hsa-miR-646	CLIP-seq
MIRT2645671	hsa-miR-650	CLIP-seq
MIRT2645672	hsa-miR-663	CLIP-seq
MIRT2645673	hsa-miR-671-5p	CLIP-seq
MIRT2645674	hsa-miR-711	CLIP-seq
MIRT2645675	hsa-miR-761	CLIP-seq
MIRT2645676	hsa-miR-762	CLIP-seq
MIRT2645677	hsa-miR-891b	CLIP-seq
MIRT2645678	hsa-miR-920	CLIP-seq
MIRT1435625	hsa-miR-939	CLIP-seq
MIRT2130556	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IDA	33824500
GO:0030425	Component	Dendrite	IEA
GO:0042995	Component	Cell projection	IEA

Other IDs

• MIM: 619469
• HGNC: 25363
• e!Ensembl: ENSG00000186501

Protein

• UniProt ID: Q9H0R3
• Protein name: Transmembrane protein 222
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05608	DUF778	61 → 118	Protein of unknown function (DUF778)	Family
  PF05608	DUF778	111 → 178	Protein of unknown function (DUF778)	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. The highest expression is observed in the brain. {ECO:0000269|PubMed:33824500}.
• Sequence:

  MAEAEGSSLLLLPPPPPPPRMAEVEAPTAAETDMKQYQGSGGVAMDVERSRFPYCVVWTP
  IPVLTWFFPIIGHMGICTSTGVIRDFAGPYFVSEDNMAFGKPAKYWKLDPAQVYASGPNA
  WDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYNNSTNWNMVTLCFFCLLYGKYVS
  VGAFVKTWLPFILLLGIILTVSLVFNLR

• Sequence length: 208

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Neurodevelopmental disorder with motor and speech delay and behavioral abnormalities	Pathogenic	rs2148019133, rs757750599, rs2148019138, rs2148016438, rs774049520	RCV001559137 RCV001559138 RCV001559139 RCV001559140 RCV001559141	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TMEM222-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Developmental Disabilities	Developmental disability	Pubtator	33824500	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	33824500	Associate	★☆☆☆☆ Found in Text Mining only
Tremor	Tremor	Pubtator	33824500	Associate	★☆☆☆☆ Found in Text Mining only