Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	83939
Gene name	Eukaryotic translation initiation factor 2A
Gene symbol	EIF2A
Synonyms (NCBI Gene)	CDA02EIF-2AMST089MSTP004MSTP089
Chromosome	3
Chromosome location	3q25.1
Summary	This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be co

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031752	hsa-miR-16-5p	Proteomics	18668040
MIRT048013	hsa-miR-30c-5p	CLASH	23622248
MIRT044991	hsa-miR-186-5p	CLASH	23622248
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678083	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678078	hsa-miR-6131	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT444534	hsa-miR-320a	PAR-CLIP	22100165
MIRT444533	hsa-miR-320b	PAR-CLIP	22100165
MIRT444532	hsa-miR-320c	PAR-CLIP	22100165
MIRT444531	hsa-miR-320d	PAR-CLIP	22100165
MIRT444530	hsa-miR-4429	PAR-CLIP	22100165
MIRT444529	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444528	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT444527	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT444526	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT208659	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT440742	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440742	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT736852	hsa-miR-26a-5p	Western blottingqRT-PCR	32567701
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678083	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678078	hsa-miR-6131	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT444534	hsa-miR-320a	PAR-CLIP	22100165
MIRT444533	hsa-miR-320b	PAR-CLIP	22100165
MIRT444532	hsa-miR-320c	PAR-CLIP	22100165
MIRT444531	hsa-miR-320d	PAR-CLIP	22100165
MIRT444530	hsa-miR-4429	PAR-CLIP	22100165
MIRT444529	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444528	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT444527	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT444526	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT208659	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT956329	hsa-miR-10a	CLIP-seq
MIRT956330	hsa-miR-10b	CLIP-seq
MIRT956331	hsa-miR-1245	CLIP-seq
MIRT956332	hsa-miR-1254	CLIP-seq
MIRT956333	hsa-miR-1285	CLIP-seq
MIRT956334	hsa-miR-1827	CLIP-seq
MIRT956335	hsa-miR-3116	CLIP-seq
MIRT956336	hsa-miR-3176	CLIP-seq
MIRT956337	hsa-miR-3180-5p	CLIP-seq
MIRT956338	hsa-miR-3187-5p	CLIP-seq
MIRT956339	hsa-miR-320e	CLIP-seq
MIRT956340	hsa-miR-330-3p	CLIP-seq
MIRT956341	hsa-miR-339-5p	CLIP-seq
MIRT956342	hsa-miR-3612	CLIP-seq
MIRT956343	hsa-miR-3672	CLIP-seq
MIRT956344	hsa-miR-3685	CLIP-seq
MIRT956345	hsa-miR-384	CLIP-seq
MIRT956346	hsa-miR-3919	CLIP-seq
MIRT956347	hsa-miR-3922-3p	CLIP-seq
MIRT956348	hsa-miR-3945	CLIP-seq
MIRT956349	hsa-miR-4253	CLIP-seq
MIRT956350	hsa-miR-4477b	CLIP-seq
MIRT956351	hsa-miR-4725-5p	CLIP-seq
MIRT956352	hsa-miR-4786-5p	CLIP-seq
MIRT956353	hsa-miR-495	CLIP-seq
MIRT956354	hsa-miR-504	CLIP-seq
MIRT956355	hsa-miR-513a-3p	CLIP-seq
MIRT956356	hsa-miR-520a-5p	CLIP-seq
MIRT956357	hsa-miR-525-5p	CLIP-seq
MIRT956358	hsa-miR-607	CLIP-seq
MIRT956359	hsa-miR-612	CLIP-seq
MIRT956360	hsa-miR-650	CLIP-seq
MIRT956361	hsa-miR-661	CLIP-seq
MIRT956362	hsa-miR-759	CLIP-seq
MIRT956363	hsa-miR-769-5p	CLIP-seq
MIRT1548258	hsa-miR-150	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983215	hsa-miR-1271	CLIP-seq
MIRT1548258	hsa-miR-150	CLIP-seq
MIRT1983216	hsa-miR-182	CLIP-seq
MIRT1983217	hsa-miR-18a	CLIP-seq
MIRT1983218	hsa-miR-18b	CLIP-seq
MIRT1983219	hsa-miR-3155	CLIP-seq
MIRT1983220	hsa-miR-3155b	CLIP-seq
MIRT1983221	hsa-miR-34a	CLIP-seq
MIRT1983222	hsa-miR-34c-5p	CLIP-seq
MIRT1983223	hsa-miR-3545-3p	CLIP-seq
MIRT1983224	hsa-miR-3653	CLIP-seq
MIRT1983225	hsa-miR-3658	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT1983227	hsa-miR-4325	CLIP-seq
MIRT1983228	hsa-miR-449a	CLIP-seq
MIRT1983229	hsa-miR-449b	CLIP-seq
MIRT1983230	hsa-miR-4506	CLIP-seq
MIRT1983231	hsa-miR-4729	CLIP-seq
MIRT1983232	hsa-miR-4731-5p	CLIP-seq
MIRT1983233	hsa-miR-4735-3p	CLIP-seq
MIRT1983234	hsa-miR-4761-5p	CLIP-seq
MIRT1983235	hsa-miR-4772-5p	CLIP-seq
MIRT1983236	hsa-miR-484	CLIP-seq
MIRT1983237	hsa-miR-507	CLIP-seq
MIRT1983238	hsa-miR-5095	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983239	hsa-miR-552	CLIP-seq
MIRT1983240	hsa-miR-557	CLIP-seq
MIRT1983241	hsa-miR-576-3p	CLIP-seq
MIRT1983242	hsa-miR-579	CLIP-seq
MIRT1983243	hsa-miR-629	CLIP-seq
MIRT1983244	hsa-miR-96	CLIP-seq
MIRT2218463	hsa-miR-1238	CLIP-seq
MIRT2218464	hsa-miR-129-5p	CLIP-seq
MIRT2218465	hsa-miR-132	CLIP-seq
MIRT2218466	hsa-miR-139-3p	CLIP-seq
MIRT2218467	hsa-miR-147	CLIP-seq
MIRT1548258	hsa-miR-150	CLIP-seq
MIRT1983217	hsa-miR-18a	CLIP-seq
MIRT1983218	hsa-miR-18b	CLIP-seq
MIRT2218468	hsa-miR-2113	CLIP-seq
MIRT2218469	hsa-miR-212	CLIP-seq
MIRT2218470	hsa-miR-3120-5p	CLIP-seq
MIRT2218471	hsa-miR-3160-5p	CLIP-seq
MIRT2218472	hsa-miR-338-3p	CLIP-seq
MIRT2218473	hsa-miR-340	CLIP-seq
MIRT2218474	hsa-miR-346	CLIP-seq
MIRT2218475	hsa-miR-3689d	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT2218476	hsa-miR-4284	CLIP-seq
MIRT2218477	hsa-miR-4288	CLIP-seq
MIRT1983232	hsa-miR-4731-5p	CLIP-seq
MIRT1983233	hsa-miR-4735-3p	CLIP-seq
MIRT1983234	hsa-miR-4761-5p	CLIP-seq
MIRT2218478	hsa-miR-4772-3p	CLIP-seq
MIRT956353	hsa-miR-495	CLIP-seq
MIRT1983238	hsa-miR-5095	CLIP-seq
MIRT1983239	hsa-miR-552	CLIP-seq
MIRT2218479	hsa-miR-562	CLIP-seq
MIRT2218480	hsa-miR-599	CLIP-seq
MIRT2218481	hsa-miR-632	CLIP-seq
MIRT2218482	hsa-miR-802	CLIP-seq
MIRT2387315	hsa-miR-3591-5p	CLIP-seq
MIRT2218475	hsa-miR-3689d	CLIP-seq
MIRT2387316	hsa-miR-4255	CLIP-seq
MIRT956332	hsa-miR-1254	CLIP-seq
MIRT2521946	hsa-miR-1265	CLIP-seq
MIRT2521947	hsa-miR-1279	CLIP-seq
MIRT2521948	hsa-miR-2392	CLIP-seq
MIRT2521949	hsa-miR-3074-3p	CLIP-seq
MIRT956335	hsa-miR-3116	CLIP-seq
MIRT2521950	hsa-miR-3117-5p	CLIP-seq
MIRT2218471	hsa-miR-3160-5p	CLIP-seq
MIRT956336	hsa-miR-3176	CLIP-seq
MIRT2218472	hsa-miR-338-3p	CLIP-seq
MIRT2521951	hsa-miR-3675-3p	CLIP-seq
MIRT956347	hsa-miR-3922-3p	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT2521952	hsa-miR-4265	CLIP-seq
MIRT2521953	hsa-miR-4296	CLIP-seq
MIRT2521954	hsa-miR-4322	CLIP-seq
MIRT1983227	hsa-miR-4325	CLIP-seq
MIRT2521955	hsa-miR-4417	CLIP-seq
MIRT1983230	hsa-miR-4506	CLIP-seq
MIRT2521956	hsa-miR-4696	CLIP-seq
MIRT2521957	hsa-miR-4753-3p	CLIP-seq
MIRT2521958	hsa-miR-4778-5p	CLIP-seq
MIRT2521959	hsa-miR-489	CLIP-seq
MIRT1983237	hsa-miR-507	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983240	hsa-miR-557	CLIP-seq
MIRT1983241	hsa-miR-576-3p	CLIP-seq
MIRT2521960	hsa-miR-595	CLIP-seq
MIRT1983243	hsa-miR-629	CLIP-seq
MIRT2521961	hsa-miR-633	CLIP-seq
MIRT956361	hsa-miR-661	CLIP-seq
MIRT956332	hsa-miR-1254	CLIP-seq
MIRT2521946	hsa-miR-1265	CLIP-seq
MIRT2521947	hsa-miR-1279	CLIP-seq
MIRT2521948	hsa-miR-2392	CLIP-seq
MIRT2521949	hsa-miR-3074-3p	CLIP-seq
MIRT956335	hsa-miR-3116	CLIP-seq
MIRT2521950	hsa-miR-3117-5p	CLIP-seq
MIRT2218471	hsa-miR-3160-5p	CLIP-seq
MIRT956336	hsa-miR-3176	CLIP-seq
MIRT2218472	hsa-miR-338-3p	CLIP-seq
MIRT2521951	hsa-miR-3675-3p	CLIP-seq
MIRT956347	hsa-miR-3922-3p	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT2521952	hsa-miR-4265	CLIP-seq
MIRT2521953	hsa-miR-4296	CLIP-seq
MIRT2521954	hsa-miR-4322	CLIP-seq
MIRT1983227	hsa-miR-4325	CLIP-seq
MIRT2521955	hsa-miR-4417	CLIP-seq
MIRT1983230	hsa-miR-4506	CLIP-seq
MIRT2521956	hsa-miR-4696	CLIP-seq
MIRT2521957	hsa-miR-4753-3p	CLIP-seq
MIRT2521958	hsa-miR-4778-5p	CLIP-seq
MIRT2521959	hsa-miR-489	CLIP-seq
MIRT1983237	hsa-miR-507	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983240	hsa-miR-557	CLIP-seq
MIRT1983241	hsa-miR-576-3p	CLIP-seq
MIRT2521960	hsa-miR-595	CLIP-seq
MIRT1983243	hsa-miR-629	CLIP-seq
MIRT956361	hsa-miR-661	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0000049	Function	TRNA binding	IMP	12133843
GO:0003729	Function	MRNA binding	IBA
GO:0003743	Function	Translation initiation factor activity	IBA
GO:0003743	Function	Translation initiation factor activity	IDA	10563826
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0003743	Function	Translation initiation factor activity	IMP	12133843
GO:0005515	Function	Protein binding	IPI
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005737	Component	Cytoplasm	IDA	12133843
GO:0005850	Component	Eukaryotic translation initiation factor 2 complex	IDA	12133843
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IDA	10563826
GO:0006413	Process	Translational initiation	IDA	12133843
GO:0006413	Process	Translational initiation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006417	Process	Regulation of translation	IMP	12133843
GO:0009967	Process	Positive regulation of signal transduction	IEA
GO:0032933	Process	SREBP signaling pathway	IEA
GO:0042255	Process	Ribosome assembly	IMP	12133843
GO:0043022	Function	Ribosome binding	IBA
GO:0043022	Function	Ribosome binding	IMP	12133843
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1990928	Process	Response to amino acid starvation	IEA

MIM	HGNC	e!Ensembl
609234	3254	ENSG00000144895

Q9BY44

Protein name

Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]

Protein function

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a co

PDB

8DYS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08662	eIF2A	216 → 411	Eukaryotic translation initiation factor eIF2A	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. {ECO:0000269|PubMed:12133843}.

Sequence

MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVN
IISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCL
KSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQ
PYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIAS
TDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKAT
IFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDS
TYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGI
FPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPL
SKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNL
KKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI

Sequence length

585

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DYSTONIA 33	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EIF2A-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MARINESCO-SJOGREN SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (69)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	27631436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	20463975, 26512942, 32665027, 34153352	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	37862122	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	40141133	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	24205197, 28081747	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	19188486	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31211507		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18559534, 23029376, 24204783, 25590579, 27109102, 30655322, 31211507, 32427827, 39187325	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28294178	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	14747531	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33749640	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	23973991, 24525736, 35724265	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	30747823	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	36012132	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	26091066	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	24587347, 35683032	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	35185383	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	12942578	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28300830, 31199053, 31243264, 32323831, 33749640, 34663797	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	26986695	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	29274870		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Major depressive disorder	Pubtator	40015617	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	26159176, 31615341	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dystonia	Dystonia	Pubtator	33049316, 33144327	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	GENOMICS_ENGLAND_DG	31130284		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	33144327	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis IGA	Iga nephropathy	Pubtator	30415257	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	26055788	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemoglobinopathies	Hemoglobinopathy	Pubtator	23690448	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	24486950	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	17488873, 18268023	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	22028783		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	22028783	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	31130284		★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	Pubtator	30029277	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	19129918, 26542945	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	34201614	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	18694499, 30305853, 36521248	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	11120763, 26090483	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31211507		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malnutrition	Malnutrition	Pubtator	31398886	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	20022965, 25759478	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	30634982	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	29921948	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	26787461, 27708226, 32132706, 32132707	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	30380689	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	34318593	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	LHGDN	19190324		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	19190324, 28119225	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	CTD_human_DG	19041636		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myopia	Myopia	Pubtator	26091066	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Myopia	Pubtator	26351848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	20479119, 33856033	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	15699214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	19122239, 20022965	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	11238455, 20463975	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	27481183	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oropharyngeal Neoplasms	Oropharyngeal neoplasm	Pubtator	28418119, 30414263	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	26091066	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	22429849	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	29720726	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	40015617	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia vera	Pubtator	17113348	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27587023	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sleep Deprivation	Sleep deprivation	Pubtator	21555338	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	27708226, 29587440	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tauopathies	Tauopathies	BEFREE	28148553		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	28294178, 37834012	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	34201614	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

EIF2A (eukaryotic translation initiation factor 2A)