Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	83903
Gene name	Histone H3 associated protein kinase
Gene symbol	HASPIN
Synonyms (NCBI Gene)	GSG2
Chromosome	17
Chromosome location	17p13.2

171

Show/Hide all (171)

miRTarBase ID	miRNA	Experiments	Reference
MIRT694449	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT694448	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT694447	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT639536	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT458514	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT684906	hsa-miR-3160-3p	HITS-CLIP	23313552
MIRT684905	hsa-miR-558	HITS-CLIP	23313552
MIRT684904	hsa-miR-4487	HITS-CLIP	23313552
MIRT458508	hsa-miR-6087	HITS-CLIP	23313552
MIRT684903	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT551310	hsa-miR-658	HITS-CLIP	23313552
MIRT458506	hsa-miR-25-5p	HITS-CLIP	23313552
MIRT684902	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT684901	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT551308	hsa-miR-4459	HITS-CLIP	23313552
MIRT551326	hsa-miR-302f	HITS-CLIP	23706177
MIRT551325	hsa-miR-6888-5p	HITS-CLIP	23706177
MIRT523383	hsa-miR-3929	HITS-CLIP	23706177
MIRT523382	hsa-miR-4419b	HITS-CLIP	23706177
MIRT523381	hsa-miR-4478	HITS-CLIP	23706177
MIRT681427	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT551324	hsa-miR-7162-3p	HITS-CLIP	23706177
MIRT551323	hsa-miR-219b-3p	HITS-CLIP	23706177
MIRT523380	hsa-miR-485-5p	HITS-CLIP	23706177
MIRT523379	hsa-miR-6884-5p	HITS-CLIP	23706177
MIRT551322	hsa-let-7a-5p	HITS-CLIP	23706177
MIRT551321	hsa-let-7b-5p	HITS-CLIP	23706177
MIRT551320	hsa-let-7c-5p	HITS-CLIP	23706177
MIRT551319	hsa-let-7d-5p	HITS-CLIP	23706177
MIRT551318	hsa-let-7e-5p	HITS-CLIP	23706177
MIRT551317	hsa-let-7f-5p	HITS-CLIP	23706177
MIRT551316	hsa-let-7g-5p	HITS-CLIP	23706177
MIRT551315	hsa-let-7i-5p	HITS-CLIP	23706177
MIRT551314	hsa-miR-4458	HITS-CLIP	23706177
MIRT551313	hsa-miR-4500	HITS-CLIP	23706177
MIRT551312	hsa-miR-98-5p	HITS-CLIP	23706177
MIRT551311	hsa-miR-202-3p	HITS-CLIP	23706177
MIRT523378	hsa-miR-7160-5p	HITS-CLIP	23706177
MIRT681426	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT551309	hsa-miR-1273e	HITS-CLIP	23706177
MIRT523377	hsa-miR-665	HITS-CLIP	23706177
MIRT639542	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT639541	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT639540	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT639539	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639538	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT639537	hsa-miR-3926	HITS-CLIP	23824327
MIRT639536	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT639535	hsa-miR-548s	HITS-CLIP	23824327
MIRT639542	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT639541	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT639540	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT639539	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT639538	hsa-miR-4786-5p	HITS-CLIP	23824327
MIRT639537	hsa-miR-3926	HITS-CLIP	23824327
MIRT639536	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT639535	hsa-miR-548s	HITS-CLIP	23824327
MIRT551326	hsa-miR-302f	PAR-CLIP	20371350
MIRT551325	hsa-miR-6888-5p	PAR-CLIP	20371350
MIRT523383	hsa-miR-3929	PAR-CLIP	20371350
MIRT523382	hsa-miR-4419b	PAR-CLIP	20371350
MIRT523381	hsa-miR-4478	PAR-CLIP	20371350
MIRT458514	hsa-miR-1247-3p	PAR-CLIP	20371350
MIRT551324	hsa-miR-7162-3p	PAR-CLIP	20371350
MIRT551323	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT458508	hsa-miR-6087	PAR-CLIP	20371350
MIRT551322	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT551321	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT551320	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT551319	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT551318	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT551317	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT551316	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT551315	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT551314	hsa-miR-4458	PAR-CLIP	20371350
MIRT551313	hsa-miR-4500	PAR-CLIP	20371350
MIRT551312	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT551311	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT551310	hsa-miR-658	PAR-CLIP	20371350
MIRT523378	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT458506	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT551309	hsa-miR-1273e	PAR-CLIP	20371350
MIRT551308	hsa-miR-4459	PAR-CLIP	20371350
MIRT523377	hsa-miR-665	PAR-CLIP	20371350
MIRT551326	hsa-miR-302f	PAR-CLIP	21572407
MIRT551325	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT523383	hsa-miR-3929	PAR-CLIP	21572407
MIRT523382	hsa-miR-4419b	PAR-CLIP	21572407
MIRT523381	hsa-miR-4478	PAR-CLIP	21572407
MIRT458514	hsa-miR-1247-3p	PAR-CLIP	21572407
MIRT551324	hsa-miR-7162-3p	PAR-CLIP	21572407
MIRT551323	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT458508	hsa-miR-6087	PAR-CLIP	21572407
MIRT551322	hsa-let-7a-5p	PAR-CLIP	21572407
MIRT551321	hsa-let-7b-5p	PAR-CLIP	21572407
MIRT551320	hsa-let-7c-5p	PAR-CLIP	21572407
MIRT551319	hsa-let-7d-5p	PAR-CLIP	21572407
MIRT551318	hsa-let-7e-5p	PAR-CLIP	21572407
MIRT551317	hsa-let-7f-5p	PAR-CLIP	21572407
MIRT551316	hsa-let-7g-5p	PAR-CLIP	21572407
MIRT551315	hsa-let-7i-5p	PAR-CLIP	21572407
MIRT551314	hsa-miR-4458	PAR-CLIP	21572407
MIRT551313	hsa-miR-4500	PAR-CLIP	21572407
MIRT551312	hsa-miR-98-5p	PAR-CLIP	21572407
MIRT551311	hsa-miR-202-3p	PAR-CLIP	21572407
MIRT551310	hsa-miR-658	PAR-CLIP	21572407
MIRT523378	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT458506	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT551309	hsa-miR-1273e	PAR-CLIP	21572407
MIRT551308	hsa-miR-4459	PAR-CLIP	21572407
MIRT458519	hsa-miR-3940-3p	PAR-CLIP	21572407
MIRT458518	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT458517	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT458516	hsa-miR-940	PAR-CLIP	21572407
MIRT458515	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT458513	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT458512	hsa-miR-4790-3p	PAR-CLIP	21572407
MIRT458511	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT458510	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT458509	hsa-miR-1827	PAR-CLIP	21572407
MIRT523380	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT523379	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT458507	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT458505	hsa-miR-3650	PAR-CLIP	21572407
MIRT523377	hsa-miR-665	PAR-CLIP	21572407
MIRT458519	hsa-miR-3940-3p	PAR-CLIP	23446348
MIRT458518	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT458517	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT458516	hsa-miR-940	PAR-CLIP	23446348
MIRT523383	hsa-miR-3929	PAR-CLIP	23446348
MIRT523382	hsa-miR-4419b	PAR-CLIP	23446348
MIRT523381	hsa-miR-4478	PAR-CLIP	23446348
MIRT458515	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT458514	hsa-miR-1247-3p	PAR-CLIP	23446348
MIRT458513	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT458512	hsa-miR-4790-3p	PAR-CLIP	23446348
MIRT458511	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT458510	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT458509	hsa-miR-1827	PAR-CLIP	23446348
MIRT523380	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT523379	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT458507	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT523378	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT458505	hsa-miR-3650	PAR-CLIP	23446348
MIRT523377	hsa-miR-665	PAR-CLIP	23446348
MIRT458519	hsa-miR-3940-3p	PAR-CLIP	23446348
MIRT458518	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT458517	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT458516	hsa-miR-940	PAR-CLIP	23446348
MIRT458515	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT458512	hsa-miR-4790-3p	PAR-CLIP	23446348
MIRT458511	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT458510	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT458509	hsa-miR-1827	PAR-CLIP	23446348
MIRT458507	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT458505	hsa-miR-3650	PAR-CLIP	23446348
MIRT458519	hsa-miR-3940-3p	PAR-CLIP	23592263
MIRT458518	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT458517	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT458516	hsa-miR-940	PAR-CLIP	23592263
MIRT458515	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT458514	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT458513	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT458512	hsa-miR-4790-3p	PAR-CLIP	23592263
MIRT458511	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT458510	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT458509	hsa-miR-1827	PAR-CLIP	23592263
MIRT458508	hsa-miR-6087	PAR-CLIP	23592263
MIRT458507	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT458506	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT458505	hsa-miR-3650	PAR-CLIP	23592263

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	IBA
GO:0004672	Function	Protein kinase activity	IDA	11228240
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	19918049, 22939624, 32296183
GO:0005524	Function	ATP binding	IDA	11228240
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11228240, 15681610
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	11228240
GO:0005819	Component	Spindle	IDA	15681610
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006468	Process	Protein phosphorylation	IDA	11228240
GO:0007064	Process	Mitotic sister chromatid cohesion	IMP	20705812
GO:0007094	Process	Mitotic spindle assembly checkpoint signaling	IMP	23071153
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035173	Function	Histone kinase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	11228240
GO:0051276	Process	Chromosome organization	IEA
GO:0071459	Process	Protein localization to chromosome, centromeric region	IMP	20705812
GO:0072354	Function	Histone H3T3 kinase activity	IBA
GO:0072354	Function	Histone H3T3 kinase activity	IMP	15681610
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1901991	Process	Negative regulation of mitotic cell cycle phase transition	IEA

MIM	HGNC	e!Ensembl
609240	19682	ENSG00000177602

Q8TF76

Protein name

Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)

Protein function

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centro

PDB

2VUW , 2WB8 , 3DLZ , 3E7V , 3F2N , 3FMD , 3IQ7 , 4OUC , 4QTC , 5HTB , 5HTC , 6G34 , 6G35 , 6G36 , 6G37 , 6G38 , 6G39 , 6G3A , 6Z56 , 6Z57 , 6Z58 , 6Z59 , 6Z5A , 6Z5B , 6Z5C , 6Z5D , 6Z5E , 7AVQ , 7OPS , 7SQM , 8RDK , 9B2S , 9B2T , 9B2U , 9FLB , 9FLC , 9FLO , 9FLQ , 9FLR , 9FLT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12330	Haspin_kinase	407 → 796		Family

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but

Sequence

MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQS
DDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRA
RPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSP
TPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRAS
LRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSC
QERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQ
KLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSEC
SNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLP
TEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISK
ELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLF
IVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKT
SLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFD
IYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRT
MLNFSSATDLLCQHSLFK

Sequence length

798

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	35972887	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	37537694	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	38613588	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	35972887	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	31493385		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31493385		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	35972887, 38613588	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	31493385		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32300176	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	35972887	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HASPIN (histone H3 associated protein kinase)