Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	83871
Gene name	RAB34, member RAS oncogene family
Gene symbol	RAB34
Synonyms (NCBI Gene)	NARROFD20RAB39RAH
Chromosome	17
Chromosome location	17q11.2
Summary	This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the acti

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Show/Hide all (179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001202	hsa-miR-9-5p	Luciferase reporter assayWestern blot	19531230
MIRT001202	hsa-miR-9-5p	Luciferase reporter assayWestern blot	19531230
MIRT001511	hsa-miR-155-5p	pSILAC	18668040
MIRT020139	hsa-miR-130b-3p	Sequencing	20371350
MIRT001511	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT022170	hsa-miR-124-3p	Microarray	18668037
MIRT023490	hsa-miR-1-3p	Proteomics	18668040
MIRT026008	hsa-miR-148a-3p	Sequencing	20371350
MIRT028393	hsa-miR-30a-5p	Proteomics	18668040
MIRT031104	hsa-miR-19b-3p	Sequencing	20371350
MIRT051828	hsa-let-7c-5p	CLASH	23622248
MIRT038817	hsa-miR-93-3p	CLASH	23622248
MIRT001202	hsa-miR-9-5p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	23627607
MIRT031104	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT541137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT541136	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT541135	hsa-miR-3666	PAR-CLIP	21572407
MIRT541134	hsa-miR-4295	PAR-CLIP	21572407
MIRT541133	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT541132	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT020139	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT541131	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT541130	hsa-miR-148b-3p	PAR-CLIP	21572407
MIRT541129	hsa-miR-152-3p	PAR-CLIP	21572407
MIRT026008	hsa-miR-148a-3p	PAR-CLIP	21572407
MIRT541128	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT541127	hsa-miR-6796-3p	PAR-CLIP	21572407
MIRT541126	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT541125	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT541124	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT541123	hsa-miR-4685-5p	PAR-CLIP	21572407
MIRT541122	hsa-miR-6837-5p	PAR-CLIP	21572407
MIRT541121	hsa-miR-518c-5p	PAR-CLIP	21572407
MIRT541120	hsa-miR-766-5p	PAR-CLIP	21572407
MIRT541119	hsa-miR-7154-3p	PAR-CLIP	21572407
MIRT541118	hsa-miR-765	PAR-CLIP	21572407
MIRT541117	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT541116	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT541115	hsa-miR-198	PAR-CLIP	21572407
MIRT541114	hsa-miR-516b-5p	PAR-CLIP	21572407
MIRT031104	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT541137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT541136	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT541135	hsa-miR-3666	PAR-CLIP	21572407
MIRT541134	hsa-miR-4295	PAR-CLIP	21572407
MIRT541133	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT541132	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT020139	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT541131	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT541130	hsa-miR-148b-3p	PAR-CLIP	21572407
MIRT541129	hsa-miR-152-3p	PAR-CLIP	21572407
MIRT026008	hsa-miR-148a-3p	PAR-CLIP	21572407
MIRT541128	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT541127	hsa-miR-6796-3p	PAR-CLIP	21572407
MIRT541126	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT541125	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT541124	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT541123	hsa-miR-4685-5p	PAR-CLIP	21572407
MIRT541122	hsa-miR-6837-5p	PAR-CLIP	21572407
MIRT541121	hsa-miR-518c-5p	PAR-CLIP	21572407
MIRT541120	hsa-miR-766-5p	PAR-CLIP	21572407
MIRT541119	hsa-miR-7154-3p	PAR-CLIP	21572407
MIRT541118	hsa-miR-765	PAR-CLIP	21572407
MIRT541117	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT541116	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT541115	hsa-miR-198	PAR-CLIP	21572407
MIRT541114	hsa-miR-516b-5p	PAR-CLIP	21572407
MIRT031104	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT541137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT541136	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT541135	hsa-miR-3666	PAR-CLIP	21572407
MIRT541134	hsa-miR-4295	PAR-CLIP	21572407
MIRT541133	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT541132	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT020139	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT541131	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT541130	hsa-miR-148b-3p	PAR-CLIP	21572407
MIRT541129	hsa-miR-152-3p	PAR-CLIP	21572407
MIRT026008	hsa-miR-148a-3p	PAR-CLIP	21572407
MIRT541128	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT541127	hsa-miR-6796-3p	PAR-CLIP	21572407
MIRT541126	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT541125	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT541124	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT541123	hsa-miR-4685-5p	PAR-CLIP	21572407
MIRT541122	hsa-miR-6837-5p	PAR-CLIP	21572407
MIRT541121	hsa-miR-518c-5p	PAR-CLIP	21572407
MIRT541120	hsa-miR-766-5p	PAR-CLIP	21572407
MIRT541119	hsa-miR-7154-3p	PAR-CLIP	21572407
MIRT541118	hsa-miR-765	PAR-CLIP	21572407
MIRT541117	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT541116	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT541115	hsa-miR-198	PAR-CLIP	21572407
MIRT541114	hsa-miR-516b-5p	PAR-CLIP	21572407
MIRT031104	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT541137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT541136	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT541135	hsa-miR-3666	PAR-CLIP	21572407
MIRT541134	hsa-miR-4295	PAR-CLIP	21572407
MIRT541133	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT541132	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT020139	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT541131	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT541130	hsa-miR-148b-3p	PAR-CLIP	21572407
MIRT541129	hsa-miR-152-3p	PAR-CLIP	21572407
MIRT026008	hsa-miR-148a-3p	PAR-CLIP	21572407
MIRT541128	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT541127	hsa-miR-6796-3p	PAR-CLIP	21572407
MIRT541126	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT541125	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT541124	hsa-miR-7113-5p	PAR-CLIP	21572407
MIRT541123	hsa-miR-4685-5p	PAR-CLIP	21572407
MIRT541122	hsa-miR-6837-5p	PAR-CLIP	21572407
MIRT541121	hsa-miR-518c-5p	PAR-CLIP	21572407
MIRT541120	hsa-miR-766-5p	PAR-CLIP	21572407
MIRT541119	hsa-miR-7154-3p	PAR-CLIP	21572407
MIRT541118	hsa-miR-765	PAR-CLIP	21572407
MIRT541117	hsa-miR-6894-5p	PAR-CLIP	21572407
MIRT541116	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT541115	hsa-miR-198	PAR-CLIP	21572407
MIRT541114	hsa-miR-516b-5p	PAR-CLIP	21572407
MIRT1283595	hsa-miR-1261	CLIP-seq
MIRT1283596	hsa-miR-130a	CLIP-seq
MIRT1283597	hsa-miR-130b	CLIP-seq
MIRT1283598	hsa-miR-148a	CLIP-seq
MIRT1283599	hsa-miR-148b	CLIP-seq
MIRT1283600	hsa-miR-152	CLIP-seq
MIRT1283601	hsa-miR-19a	CLIP-seq
MIRT1283602	hsa-miR-19b	CLIP-seq
MIRT1283603	hsa-miR-301a	CLIP-seq
MIRT1283604	hsa-miR-301b	CLIP-seq
MIRT1283605	hsa-miR-454	CLIP-seq
MIRT1283606	hsa-miR-4782-5p	CLIP-seq
MIRT1283607	hsa-miR-486-3p	CLIP-seq
MIRT1283596	hsa-miR-130a	CLIP-seq
MIRT1283597	hsa-miR-130b	CLIP-seq
MIRT1283598	hsa-miR-148a	CLIP-seq
MIRT1283599	hsa-miR-148b	CLIP-seq
MIRT1283600	hsa-miR-152	CLIP-seq
MIRT1283601	hsa-miR-19a	CLIP-seq
MIRT1283602	hsa-miR-19b	CLIP-seq
MIRT1283603	hsa-miR-301a	CLIP-seq
MIRT1283604	hsa-miR-301b	CLIP-seq
MIRT1283605	hsa-miR-454	CLIP-seq
MIRT2442540	hsa-miR-1271	CLIP-seq
MIRT2442541	hsa-miR-182	CLIP-seq
MIRT2442542	hsa-miR-564	CLIP-seq
MIRT2442543	hsa-miR-9	CLIP-seq
MIRT2442544	hsa-miR-96	CLIP-seq
MIRT1283595	hsa-miR-1261	CLIP-seq
MIRT2606098	hsa-miR-133a	CLIP-seq
MIRT2606099	hsa-miR-133b	CLIP-seq
MIRT2606100	hsa-miR-1827	CLIP-seq
MIRT2606101	hsa-miR-200b	CLIP-seq
MIRT2606102	hsa-miR-200c	CLIP-seq
MIRT2606103	hsa-miR-429	CLIP-seq
MIRT2606104	hsa-miR-4527	CLIP-seq
MIRT2606105	hsa-miR-4648	CLIP-seq
MIRT2606106	hsa-miR-4654	CLIP-seq
MIRT2606107	hsa-miR-4660	CLIP-seq
MIRT2606108	hsa-miR-4715-3p	CLIP-seq
MIRT2606109	hsa-miR-4769-5p	CLIP-seq
MIRT1283606	hsa-miR-4782-5p	CLIP-seq
MIRT2442543	hsa-miR-9	CLIP-seq
MIRT1283595	hsa-miR-1261	CLIP-seq
MIRT2606098	hsa-miR-133a	CLIP-seq
MIRT2606099	hsa-miR-133b	CLIP-seq
MIRT2606100	hsa-miR-1827	CLIP-seq
MIRT2606101	hsa-miR-200b	CLIP-seq
MIRT2606102	hsa-miR-200c	CLIP-seq
MIRT2606103	hsa-miR-429	CLIP-seq
MIRT2606104	hsa-miR-4527	CLIP-seq
MIRT2606105	hsa-miR-4648	CLIP-seq
MIRT2606106	hsa-miR-4654	CLIP-seq
MIRT2606107	hsa-miR-4660	CLIP-seq
MIRT2606108	hsa-miR-4715-3p	CLIP-seq
MIRT2606109	hsa-miR-4769-5p	CLIP-seq
MIRT1283606	hsa-miR-4782-5p	CLIP-seq
MIRT2442543	hsa-miR-9	CLIP-seq

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	16138900, 25910212
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	16138900
GO:0005794	Component	Golgi apparatus	IEA
GO:0005795	Component	Golgi stack	IDA	17881736
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IDA	37384395
GO:0005814	Component	Centriole	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005929	Component	Cilium	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019882	Process	Antigen processing and presentation	IMP	19717423
GO:0030030	Process	Cell projection organization	IEA
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0030742	Function	GTP-dependent protein binding	IPI	16138900
GO:0031267	Function	Small GTPase binding	IPI	24056301
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031982	Component	Vesicle	IDA	17881736
GO:0031985	Component	Golgi cisterna	IBA
GO:0031985	Component	Golgi cisterna	IDA	17881736
GO:0032418	Process	Lysosome localization	IDA	17881736
GO:0032587	Component	Ruffle membrane	IDA	17881736
GO:0042995	Component	Cell projection	IEA
GO:0043001	Process	Golgi to plasma membrane protein transport	IBA
GO:0043001	Process	Golgi to plasma membrane protein transport	IDA	17881736
GO:0044351	Process	Macropinocytosis	IDA	17881736
GO:0045335	Component	Phagocytic vesicle	IBA
GO:0045335	Component	Phagocytic vesicle	IDA	21255211
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045880	Process	Positive regulation of smoothened signaling pathway	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	16138900
GO:0060271	Process	Cilium assembly	IMP	37384395
GO:0061824	Process	Cytosolic ciliogenesis	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0072659	Process	Protein localization to plasma membrane	IDA	17881736
GO:0090382	Process	Phagosome maturation	IMP	21255211
GO:0090385	Process	Phagosome-lysosome fusion	IBA
GO:0090385	Process	Phagosome-lysosome fusion	IMP	21255211

MIM	HGNC	e!Ensembl
610917	16519	ENSG00000109113

P0DI83

Protein name

Ras-related protein Rab-34, isoform NARR (Nine amino-acid residue-repeats)

Family and domains

Sequence

MVGQPQPRDDVGSPRPRVIVGTIRPRVIVGTIRPRVIVGSARARPPPDGTPRPQLAAEES
PRPRVIFGTPRARVILGSPRPRVIVSSPWPAVVVASPRPRTPVGSPWPRVVVGTPRPRVI
VGSPRARVADADPASAPSQGALQGRRQDEHSGTRAEGSRPGGAAPVPEEGGRFARAQRLP
PPRHLRLPGAPDRHRGQI

Sequence length

198

Q9BZG1

Protein name

Ras-related protein Rab-34 (EC 3.6.5.2) (Ras-related protein Rab-39) (Ras-related protein Rah)

Protein function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	54 → 218	Ras family	Domain

Sequence

MNILAPVRRDRVLAELPQCLRKEAALHGHKDFHPRVTCACQEHRTGTVGFKISKVIVVGD
LSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGIPFSLQLWDTAGQERFKCIAST
YYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSTPAQYALME
KDALQVAQEMKAEYWAVSSLTGENVREFFFRVAALTFEANVLAELEKSGARRIGDVVRIN
SDDSNLYLTASKKKPTCCP

Sequence length

259

Interactions

View interactions

	Reactome
			RAB geranylgeranylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Jeune thoracic dystrophy	Likely pathogenic	rs750408092, rs757465924	RCV003237334 RCV003237335	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Orofaciodigital syndrome 20	Likely pathogenic; Pathogenic	rs750408092, rs757465924, rs2544303152, rs910197266	RCV003761642 RCV003761643 RCV003764496 RCV003764497	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OROFACIODIGITAL SYNDROME XX	—	Disgenet, HPO Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	29622794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	38159835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	25501506		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	25501506, 36222286	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary hemochromatosis	Hereditary Hemochromatosis	BEFREE	31465935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension Diastolic Resistance to	Resistant hypertension	Pubtator	36222286	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29048615		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	28912048		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29622794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29622794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19531230, 29048615		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	38183057	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Orofaciodigital Syndromes	Orofaciodigital syndrome	Pubtator	37384395	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly	Polydactyly	BEFREE	30301781		★★★★★ ★☆☆☆☆ Found in Text Mining only
Subarachnoid Hemorrhage	Subarachnoid hemorrhage	BEFREE	30952121		★★★★★ ★☆☆☆☆ Found in Text Mining only

RAB34 (RAB34, member RAS oncogene family)