MARVELD1 (MARVEL domain containing 1)

Gene

• Entrez ID: 83742
• Gene name: MARVEL domain containing 1
• Gene symbol: MARVELD1
• Synonyms (NCBI Gene): GB14, MARVD1, MRVLDC1, bA548K23.8
• Chromosome: 10
• Chromosome location: 10q24.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT719201	hsa-miR-6499-5p	HITS-CLIP	19536157
MIRT574148	hsa-miR-3960	HITS-CLIP	19536157
MIRT574146	hsa-miR-8072	HITS-CLIP	19536157
MIRT574143	hsa-miR-4467	HITS-CLIP	19536157
MIRT719200	hsa-miR-4750-5p	HITS-CLIP	19536157
MIRT648848	hsa-miR-5700	HITS-CLIP	23824327
MIRT648847	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648846	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT648845	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT648844	hsa-miR-345-5p	HITS-CLIP	23824327
MIRT648843	hsa-miR-155-5p	HITS-CLIP	23824327
MIRT648842	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT648841	hsa-miR-554	HITS-CLIP	23824327
MIRT648848	hsa-miR-5700	HITS-CLIP	23824327
MIRT648847	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648846	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT648845	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT648844	hsa-miR-345-5p	HITS-CLIP	23824327
MIRT648843	hsa-miR-155-5p	HITS-CLIP	23824327
MIRT648842	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT648841	hsa-miR-554	HITS-CLIP	23824327
MIRT574149	hsa-miR-7515	PAR-CLIP	20371350
MIRT574147	hsa-miR-2277-5p	PAR-CLIP	20371350
MIRT574148	hsa-miR-3960	PAR-CLIP	20371350
MIRT574146	hsa-miR-8072	PAR-CLIP	20371350
MIRT574145	hsa-miR-744-5p	PAR-CLIP	20371350
MIRT574144	hsa-miR-3202	PAR-CLIP	20371350
MIRT574143	hsa-miR-4467	PAR-CLIP	20371350
MIRT574142	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT574141	hsa-miR-663a	PAR-CLIP	20371350
MIRT574140	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT574139	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT574138	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT574137	hsa-miR-4271	PAR-CLIP	20371350
MIRT574136	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT574134	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT574135	hsa-miR-3180	PAR-CLIP	20371350
MIRT574133	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT574132	hsa-miR-3196	PAR-CLIP	20371350
MIRT574131	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT574130	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT719201	hsa-miR-6499-5p	HITS-CLIP	19536157
MIRT574148	hsa-miR-3960	HITS-CLIP	19536157
MIRT574146	hsa-miR-8072	HITS-CLIP	19536157
MIRT574143	hsa-miR-4467	HITS-CLIP	19536157
MIRT719200	hsa-miR-4750-5p	HITS-CLIP	19536157
MIRT648848	hsa-miR-5700	HITS-CLIP	23824327
MIRT648847	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648846	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT648845	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT648844	hsa-miR-345-5p	HITS-CLIP	23824327
MIRT648843	hsa-miR-155-5p	HITS-CLIP	23824327
MIRT648842	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT648841	hsa-miR-554	HITS-CLIP	23824327
MIRT648848	hsa-miR-5700	HITS-CLIP	23824327
MIRT648847	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648846	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT648845	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT648844	hsa-miR-345-5p	HITS-CLIP	23824327
MIRT648843	hsa-miR-155-5p	HITS-CLIP	23824327
MIRT648842	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT648841	hsa-miR-554	HITS-CLIP	23824327
MIRT574149	hsa-miR-7515	PAR-CLIP	20371350
MIRT574147	hsa-miR-2277-5p	PAR-CLIP	20371350
MIRT574148	hsa-miR-3960	PAR-CLIP	20371350
MIRT574146	hsa-miR-8072	PAR-CLIP	20371350
MIRT574145	hsa-miR-744-5p	PAR-CLIP	20371350
MIRT574144	hsa-miR-3202	PAR-CLIP	20371350
MIRT574143	hsa-miR-4467	PAR-CLIP	20371350
MIRT574142	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT574141	hsa-miR-663a	PAR-CLIP	20371350
MIRT574140	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT574139	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT574138	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT574137	hsa-miR-4271	PAR-CLIP	20371350
MIRT574136	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT574134	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT574135	hsa-miR-3180	PAR-CLIP	20371350
MIRT574133	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT574132	hsa-miR-3196	PAR-CLIP	20371350
MIRT574131	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT574130	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT1132842	hsa-miR-1207-5p	CLIP-seq
MIRT1132843	hsa-miR-1270	CLIP-seq
MIRT1132844	hsa-miR-1280	CLIP-seq
MIRT1132845	hsa-miR-143	CLIP-seq
MIRT1132846	hsa-miR-1908	CLIP-seq
MIRT1132847	hsa-miR-197	CLIP-seq
MIRT1132848	hsa-miR-2054	CLIP-seq
MIRT1132849	hsa-miR-214	CLIP-seq
MIRT1132850	hsa-miR-3120-3p	CLIP-seq
MIRT1132851	hsa-miR-3122	CLIP-seq
MIRT1132852	hsa-miR-3135b	CLIP-seq
MIRT1132853	hsa-miR-3184	CLIP-seq
MIRT1132854	hsa-miR-34b	CLIP-seq
MIRT1132855	hsa-miR-3616-3p	CLIP-seq
MIRT1132856	hsa-miR-3619-5p	CLIP-seq
MIRT1132857	hsa-miR-3689a-3p	CLIP-seq
MIRT1132858	hsa-miR-3689c	CLIP-seq
MIRT1132859	hsa-miR-374c	CLIP-seq
MIRT1132860	hsa-miR-3913-5p	CLIP-seq
MIRT1132861	hsa-miR-423-5p	CLIP-seq
MIRT1132862	hsa-miR-4270	CLIP-seq
MIRT1132863	hsa-miR-4279	CLIP-seq
MIRT1132864	hsa-miR-4291	CLIP-seq
MIRT1132865	hsa-miR-4300	CLIP-seq
MIRT1132866	hsa-miR-4422	CLIP-seq
MIRT1132867	hsa-miR-4436b-3p	CLIP-seq
MIRT1132868	hsa-miR-4441	CLIP-seq
MIRT1132869	hsa-miR-4474-5p	CLIP-seq
MIRT1132870	hsa-miR-4479	CLIP-seq
MIRT1132871	hsa-miR-4488	CLIP-seq
MIRT1132872	hsa-miR-4683	CLIP-seq
MIRT1132873	hsa-miR-4697-5p	CLIP-seq
MIRT1132874	hsa-miR-4723-5p	CLIP-seq
MIRT1132875	hsa-miR-4728-5p	CLIP-seq
MIRT1132876	hsa-miR-4746-5p	CLIP-seq
MIRT1132877	hsa-miR-4763-3p	CLIP-seq
MIRT1132878	hsa-miR-4770	CLIP-seq
MIRT1132879	hsa-miR-545	CLIP-seq
MIRT1132880	hsa-miR-620	CLIP-seq
MIRT1132881	hsa-miR-625	CLIP-seq
MIRT1132882	hsa-miR-655	CLIP-seq
MIRT1132883	hsa-miR-663	CLIP-seq
MIRT1132884	hsa-miR-744	CLIP-seq
MIRT1132885	hsa-miR-761	CLIP-seq
MIRT1132886	hsa-miR-920	CLIP-seq
MIRT1132887	hsa-miR-922	CLIP-seq
MIRT1132888	hsa-miR-944	CLIP-seq
MIRT1132846	hsa-miR-1908	CLIP-seq
MIRT1551166	hsa-miR-4750	CLIP-seq
MIRT1132881	hsa-miR-625	CLIP-seq
MIRT1132883	hsa-miR-663	CLIP-seq
MIRT1551166	hsa-miR-4750	CLIP-seq
MIRT1132846	hsa-miR-1908	CLIP-seq
MIRT1132881	hsa-miR-625	CLIP-seq
MIRT1132883	hsa-miR-663	CLIP-seq
MIRT1132884	hsa-miR-744	CLIP-seq
MIRT2037857	hsa-miR-1184	CLIP-seq
MIRT2037858	hsa-miR-1202	CLIP-seq
MIRT2037859	hsa-miR-1205	CLIP-seq
MIRT2037860	hsa-miR-1236	CLIP-seq
MIRT2037861	hsa-miR-1285	CLIP-seq
MIRT1132846	hsa-miR-1908	CLIP-seq
MIRT2037862	hsa-miR-1972	CLIP-seq
MIRT1132849	hsa-miR-214	CLIP-seq
MIRT2037863	hsa-miR-28-5p	CLIP-seq
MIRT2037864	hsa-miR-2909	CLIP-seq
MIRT2037865	hsa-miR-3065-3p	CLIP-seq
MIRT2037866	hsa-miR-3119	CLIP-seq
MIRT2037867	hsa-miR-3139	CLIP-seq
MIRT2037868	hsa-miR-3150b-3p	CLIP-seq
MIRT2037869	hsa-miR-3158-5p	CLIP-seq
MIRT2037870	hsa-miR-3161	CLIP-seq
MIRT2037871	hsa-miR-3187-5p	CLIP-seq
MIRT2037872	hsa-miR-3192	CLIP-seq
MIRT2037873	hsa-miR-3194-5p	CLIP-seq
MIRT2037874	hsa-miR-335	CLIP-seq
MIRT2037875	hsa-miR-3591-5p	CLIP-seq
MIRT1132856	hsa-miR-3619-5p	CLIP-seq
MIRT2037876	hsa-miR-3657	CLIP-seq
MIRT1132857	hsa-miR-3689a-3p	CLIP-seq
MIRT1132858	hsa-miR-3689c	CLIP-seq
MIRT2037877	hsa-miR-378g	CLIP-seq
MIRT2037878	hsa-miR-3922-5p	CLIP-seq
MIRT2037879	hsa-miR-3972	CLIP-seq
MIRT2037880	hsa-miR-4264	CLIP-seq
MIRT2037881	hsa-miR-4314	CLIP-seq
MIRT2037882	hsa-miR-4432	CLIP-seq
MIRT2037883	hsa-miR-4433	CLIP-seq
MIRT2037884	hsa-miR-4436a	CLIP-seq
MIRT2037885	hsa-miR-4449	CLIP-seq
MIRT1132870	hsa-miR-4479	CLIP-seq
MIRT2037886	hsa-miR-4486	CLIP-seq
MIRT2037887	hsa-miR-4492	CLIP-seq
MIRT2037888	hsa-miR-4498	CLIP-seq
MIRT2037889	hsa-miR-4505	CLIP-seq
MIRT2037890	hsa-miR-4508	CLIP-seq
MIRT2037891	hsa-miR-4522	CLIP-seq
MIRT2037892	hsa-miR-4530	CLIP-seq
MIRT2037893	hsa-miR-4532	CLIP-seq
MIRT2037894	hsa-miR-4639-3p	CLIP-seq
MIRT2037895	hsa-miR-4646-3p	CLIP-seq
MIRT2037896	hsa-miR-4669	CLIP-seq
MIRT2037897	hsa-miR-4672	CLIP-seq
MIRT2037898	hsa-miR-4700-3p	CLIP-seq
MIRT2037899	hsa-miR-4712-3p	CLIP-seq
MIRT2037900	hsa-miR-4714-5p	CLIP-seq
MIRT1132875	hsa-miR-4728-5p	CLIP-seq
MIRT2037901	hsa-miR-4738-5p	CLIP-seq
MIRT1132876	hsa-miR-4746-5p	CLIP-seq
MIRT2037902	hsa-miR-4753-3p	CLIP-seq
MIRT2037903	hsa-miR-4753-5p	CLIP-seq
MIRT2037904	hsa-miR-4766-5p	CLIP-seq
MIRT2037905	hsa-miR-4784	CLIP-seq
MIRT2037906	hsa-miR-4797-3p	CLIP-seq
MIRT2037907	hsa-miR-515-5p	CLIP-seq
MIRT2037908	hsa-miR-544	CLIP-seq
MIRT2037909	hsa-miR-581	CLIP-seq
MIRT2037910	hsa-miR-592	CLIP-seq
MIRT2037911	hsa-miR-599	CLIP-seq
MIRT2037912	hsa-miR-612	CLIP-seq
MIRT2037913	hsa-miR-622	CLIP-seq
MIRT1132881	hsa-miR-625	CLIP-seq
MIRT2037914	hsa-miR-648	CLIP-seq
MIRT1132883	hsa-miR-663	CLIP-seq
MIRT2037915	hsa-miR-708	CLIP-seq
MIRT1132884	hsa-miR-744	CLIP-seq
MIRT1132885	hsa-miR-761	CLIP-seq
MIRT2037916	hsa-miR-762	CLIP-seq
MIRT2037917	hsa-miR-765	CLIP-seq
MIRT2267906	hsa-miR-200b	CLIP-seq
MIRT2267907	hsa-miR-200c	CLIP-seq
MIRT2267908	hsa-miR-429	CLIP-seq
MIRT2267909	hsa-miR-4645-5p	CLIP-seq
MIRT2267910	hsa-miR-4673	CLIP-seq
MIRT1132879	hsa-miR-545	CLIP-seq
MIRT2267911	hsa-miR-665	CLIP-seq
MIRT1132872	hsa-miR-4683	CLIP-seq
MIRT2390642	hsa-miR-4731-5p	CLIP-seq
MIRT2567536	hsa-miR-1269	CLIP-seq
MIRT2567537	hsa-miR-1269b	CLIP-seq
MIRT2567538	hsa-miR-1288	CLIP-seq
MIRT2567539	hsa-miR-2276	CLIP-seq
MIRT2567540	hsa-miR-3925-3p	CLIP-seq
MIRT2037881	hsa-miR-4314	CLIP-seq
MIRT1132871	hsa-miR-4488	CLIP-seq
MIRT2567541	hsa-miR-4515	CLIP-seq
MIRT2567542	hsa-miR-4667-5p	CLIP-seq
MIRT1132873	hsa-miR-4697-5p	CLIP-seq
MIRT2567543	hsa-miR-4700-5p	CLIP-seq
MIRT2567544	hsa-miR-4712-5p	CLIP-seq
MIRT2567545	hsa-miR-4736	CLIP-seq
MIRT2567546	hsa-miR-4740-5p	CLIP-seq
MIRT2567547	hsa-miR-486-3p	CLIP-seq
MIRT2567548	hsa-miR-637	CLIP-seq
MIRT2567549	hsa-miR-770-5p	CLIP-seq
MIRT2567550	hsa-miR-891b	CLIP-seq
MIRT2684621	hsa-miR-183	CLIP-seq
MIRT2567540	hsa-miR-3925-3p	CLIP-seq
MIRT2037881	hsa-miR-4314	CLIP-seq
MIRT1132871	hsa-miR-4488	CLIP-seq
MIRT2567542	hsa-miR-4667-5p	CLIP-seq
MIRT1132873	hsa-miR-4697-5p	CLIP-seq
MIRT2567543	hsa-miR-4700-5p	CLIP-seq
MIRT2684622	hsa-miR-4701-5p	CLIP-seq
MIRT2567544	hsa-miR-4712-5p	CLIP-seq
MIRT2567545	hsa-miR-4736	CLIP-seq
MIRT2567547	hsa-miR-486-3p	CLIP-seq
MIRT2684623	hsa-miR-588	CLIP-seq
MIRT2567548	hsa-miR-637	CLIP-seq
MIRT2567549	hsa-miR-770-5p	CLIP-seq
MIRT2567550	hsa-miR-891b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0019911	Function	Structural constituent of myelin sheath	IBA
GO:0042552	Process	Myelination	IBA

Other IDs

• MIM: 616970
• HGNC: 28674
• e!Ensembl: ENSG00000155254

Protein

• UniProt ID: Q9BSK0
• Protein name: MARVEL domain-containing protein 1
• Protein function: Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01284	MARVEL	26 → 160	Membrane-associating domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed in normal tissues. Down-regulated in multiple primary tumors. {ECO:0000269|PubMed:19364627}.
• Sequence:

  MLPPPPRQPPPQARAARGAVRLQRPFLRSPLGVLRLLQLLAGAAFWITIATSKYQGPVHF
  ALFVSVLFWLLTLGLYFLTLLGKHELVPVLGSRWLMVNVAHDVLAAALYGAATGIMSDQM
  QRHSYCNLKDYPLPCAYHAFLAAAVCGGVCHGLYLLSALYGCGRRCQGKQEVA

• Sequence length: 173

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	19364627		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	25520033	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	22320884	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	25520033		★☆☆☆☆ Found in Text Mining only
Epithelioma	Epithelioma	BEFREE	31066116		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	30250269		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22320884, 31066116		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	25520033	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19364627		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31205918		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	25520033		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22320884, 25299200, 26509557, 31066116, 31205918		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	26509557		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	23773523	Associate	★☆☆☆☆ Found in Text Mining only