Gene Gene information from NCBI Gene database.
Entrez ID 83716
Gene name Cysteine rich secretory protein LCCL domain containing 2
Gene symbol CRISPLD2
Synonyms (NCBI Gene)
CRISP11LCRISP2LGL1
Chromosome 16
Chromosome location 16q24.1
miRNA miRNA information provided by mirtarbase database.
1157
miRTarBase ID miRNA Experiments Reference
MIRT016863 hsa-miR-335-5p Microarray 18185580
MIRT719620 hsa-miR-300 HITS-CLIP 19536157
MIRT719619 hsa-miR-381-3p HITS-CLIP 19536157
MIRT719618 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT719617 hsa-miR-642a-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005539 Function Glycosaminoglycan binding IBA
GO:0005539 Function Glycosaminoglycan binding IEA
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612434 25248 ENSG00000103196
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H0B8
Protein name Cysteine-rich secretory protein LCCL domain-containing 2 (Cysteine-rich secretory protein 11) (CRISP-11) (LCCL domain-containing cysteine-rich secretory protein 2)
Protein function Promotes matrix assembly.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00188 CAP 60 200 Cysteine-rich secretory protein family Domain
PF03815 LCCL 288 379 LCCL domain Domain
PF03815 LCCL 389 488 LCCL domain Domain
Sequence
Sequence length 497
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
23
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma BEFREE 24926665, 31557467
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma Pubtator 24926665, 31557467 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autosomal Dominant Lateral Temporal Lobe Epilepsy Temporal lobe epilepsy BEFREE 15119829
★☆☆☆☆
Found in Text Mining only
Bone Diseases Bone disease Pubtator 37021796 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 20557135, 28231808
★☆☆☆☆
Found in Text Mining only
Bronchopulmonary Dysplasia Bronchopulmonary Dysplasia BEFREE 16492977, 25480331
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 27685836
★☆☆☆☆
Found in Text Mining only
Cleft Lip Cleft lip Pubtator 20815724 Associate
★☆☆☆☆
Found in Text Mining only
Cleft Lip with or without Cleft Palate Cleft Lip With Or Without Cleft Palate BEFREE 20662919, 20815724, 21244519, 29899370
★☆☆☆☆
Found in Text Mining only
Cleft Palate Cleft palate Pubtator 20815724, 27369588 Associate
★☆☆☆☆
Found in Text Mining only