SH3BGRL2 (SH3 domain binding glutamate rich protein like 2)

Gene

• Entrez ID: 83699
• Gene name: SH3 domain binding glutamate rich protein like 2
• Gene symbol: SH3BGRL2
• Synonyms (NCBI Gene): -
• Chromosome: 6
• Chromosome location: 6q14.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044871	hsa-miR-195-5p	CLASH	23622248
MIRT1344413	hsa-miR-128	CLIP-seq
MIRT1344414	hsa-miR-1287	CLIP-seq
MIRT1344415	hsa-miR-190	CLIP-seq
MIRT1344416	hsa-miR-190b	CLIP-seq
MIRT1344417	hsa-miR-203	CLIP-seq
MIRT1344418	hsa-miR-27a	CLIP-seq
MIRT1344419	hsa-miR-27b	CLIP-seq
MIRT1344420	hsa-miR-3064-3p	CLIP-seq
MIRT1344421	hsa-miR-31	CLIP-seq
MIRT1344422	hsa-miR-3119	CLIP-seq
MIRT1344423	hsa-miR-3120-5p	CLIP-seq
MIRT1344424	hsa-miR-3140-3p	CLIP-seq
MIRT1344425	hsa-miR-324-5p	CLIP-seq
MIRT1344426	hsa-miR-331-5p	CLIP-seq
MIRT1344427	hsa-miR-337-3p	CLIP-seq
MIRT1344428	hsa-miR-339-5p	CLIP-seq
MIRT1344429	hsa-miR-365	CLIP-seq
MIRT1344430	hsa-miR-3685	CLIP-seq
MIRT1344431	hsa-miR-3688-5p	CLIP-seq
MIRT1344432	hsa-miR-384	CLIP-seq
MIRT1344433	hsa-miR-3938	CLIP-seq
MIRT1344434	hsa-miR-4278	CLIP-seq
MIRT1344435	hsa-miR-4300	CLIP-seq
MIRT1344436	hsa-miR-431	CLIP-seq
MIRT1344437	hsa-miR-4474-3p	CLIP-seq
MIRT1344438	hsa-miR-4487	CLIP-seq
MIRT1344439	hsa-miR-4503	CLIP-seq
MIRT1344440	hsa-miR-4517	CLIP-seq
MIRT1344441	hsa-miR-4635	CLIP-seq
MIRT1344442	hsa-miR-4636	CLIP-seq
MIRT1344443	hsa-miR-4668-3p	CLIP-seq
MIRT1344444	hsa-miR-4742-5p	CLIP-seq
MIRT1344445	hsa-miR-4775	CLIP-seq
MIRT1344446	hsa-miR-4778-5p	CLIP-seq
MIRT1344447	hsa-miR-4780	CLIP-seq
MIRT1344448	hsa-miR-513a-5p	CLIP-seq
MIRT1344449	hsa-miR-548c-3p	CLIP-seq
MIRT1344450	hsa-miR-548p	CLIP-seq
MIRT1344451	hsa-miR-556-5p	CLIP-seq
MIRT1344452	hsa-miR-586	CLIP-seq
MIRT1344453	hsa-miR-590-3p	CLIP-seq
MIRT1344454	hsa-miR-603	CLIP-seq
MIRT1344455	hsa-miR-644	CLIP-seq
MIRT1344456	hsa-miR-920	CLIP-seq
MIRT1344457	hsa-miR-938	CLIP-seq
MIRT1344458	hsa-miR-939	CLIP-seq
MIRT1344458	hsa-miR-939	CLIP-seq
MIRT2101807	hsa-miR-1179	CLIP-seq
MIRT2101808	hsa-miR-3065-5p	CLIP-seq
MIRT2101809	hsa-miR-3167	CLIP-seq
MIRT2101810	hsa-miR-3194-3p	CLIP-seq
MIRT2101811	hsa-miR-3607-5p	CLIP-seq
MIRT2101812	hsa-miR-3613-3p	CLIP-seq
MIRT2101813	hsa-miR-3662	CLIP-seq
MIRT2101814	hsa-miR-421	CLIP-seq
MIRT2101815	hsa-miR-4272	CLIP-seq
MIRT2101816	hsa-miR-4497	CLIP-seq
MIRT2101817	hsa-miR-4528	CLIP-seq
MIRT2101818	hsa-miR-4735-5p	CLIP-seq
MIRT2101819	hsa-miR-4753-3p	CLIP-seq
MIRT2101820	hsa-miR-4766-5p	CLIP-seq
MIRT1344445	hsa-miR-4775	CLIP-seq
MIRT2101821	hsa-miR-4795-3p	CLIP-seq
MIRT2101822	hsa-miR-510	CLIP-seq
MIRT2101823	hsa-miR-512-5p	CLIP-seq
MIRT1344453	hsa-miR-590-3p	CLIP-seq
MIRT2101824	hsa-miR-607	CLIP-seq
MIRT2101825	hsa-miR-616	CLIP-seq
MIRT2101826	hsa-miR-876-5p	CLIP-seq
MIRT2326211	hsa-miR-1205	CLIP-seq
MIRT2326212	hsa-miR-1258	CLIP-seq
MIRT2326213	hsa-miR-125a-3p	CLIP-seq
MIRT2326214	hsa-miR-1276	CLIP-seq
MIRT2326215	hsa-miR-1299	CLIP-seq
MIRT2326216	hsa-miR-15a	CLIP-seq
MIRT2326217	hsa-miR-15b	CLIP-seq
MIRT2326218	hsa-miR-16	CLIP-seq
MIRT2326219	hsa-miR-1827	CLIP-seq
MIRT2326220	hsa-miR-183	CLIP-seq
MIRT2326221	hsa-miR-18a	CLIP-seq
MIRT2326222	hsa-miR-18b	CLIP-seq
MIRT2326223	hsa-miR-194	CLIP-seq
MIRT2326224	hsa-miR-195	CLIP-seq
MIRT2326225	hsa-miR-2392	CLIP-seq
MIRT2326226	hsa-miR-2682	CLIP-seq
MIRT2326227	hsa-miR-299-5p	CLIP-seq
MIRT1344423	hsa-miR-3120-5p	CLIP-seq
MIRT2326228	hsa-miR-3121-3p	CLIP-seq
MIRT2326229	hsa-miR-3121-5p	CLIP-seq
MIRT2326230	hsa-miR-3132	CLIP-seq
MIRT2326231	hsa-miR-3137	CLIP-seq
MIRT2101809	hsa-miR-3167	CLIP-seq
MIRT2326232	hsa-miR-3180-5p	CLIP-seq
MIRT2326233	hsa-miR-3182	CLIP-seq
MIRT2101810	hsa-miR-3194-3p	CLIP-seq
MIRT1344427	hsa-miR-337-3p	CLIP-seq
MIRT2326234	hsa-miR-338-3p	CLIP-seq
MIRT2326235	hsa-miR-3614-5p	CLIP-seq
MIRT2326236	hsa-miR-3653	CLIP-seq
MIRT2326237	hsa-miR-3658	CLIP-seq
MIRT2326238	hsa-miR-3663-5p	CLIP-seq
MIRT2326239	hsa-miR-3680	CLIP-seq
MIRT1344430	hsa-miR-3685	CLIP-seq
MIRT2326240	hsa-miR-382	CLIP-seq
MIRT1344432	hsa-miR-384	CLIP-seq
MIRT2326241	hsa-miR-424	CLIP-seq
MIRT2326242	hsa-miR-4261	CLIP-seq
MIRT1344434	hsa-miR-4278	CLIP-seq
MIRT2326243	hsa-miR-4311	CLIP-seq
MIRT2326244	hsa-miR-4316	CLIP-seq
MIRT2326245	hsa-miR-4418	CLIP-seq
MIRT2326246	hsa-miR-4423-3p	CLIP-seq
MIRT2326247	hsa-miR-449c	CLIP-seq
MIRT2326248	hsa-miR-4514	CLIP-seq
MIRT2326249	hsa-miR-451b	CLIP-seq
MIRT2326250	hsa-miR-4524	CLIP-seq
MIRT2326251	hsa-miR-4527	CLIP-seq
MIRT2101817	hsa-miR-4528	CLIP-seq
MIRT2326252	hsa-miR-4530	CLIP-seq
MIRT2326253	hsa-miR-4645-5p	CLIP-seq
MIRT2326254	hsa-miR-4659a-3p	CLIP-seq
MIRT2326255	hsa-miR-4659b-3p	CLIP-seq
MIRT2326256	hsa-miR-4673	CLIP-seq
MIRT2326257	hsa-miR-4690-5p	CLIP-seq
MIRT2326258	hsa-miR-4692	CLIP-seq
MIRT2326259	hsa-miR-4700-3p	CLIP-seq
MIRT2326260	hsa-miR-4704-3p	CLIP-seq
MIRT2326261	hsa-miR-4719	CLIP-seq
MIRT2326262	hsa-miR-4735-3p	CLIP-seq
MIRT1344444	hsa-miR-4742-5p	CLIP-seq
MIRT2326263	hsa-miR-4762-3p	CLIP-seq
MIRT2326264	hsa-miR-4765	CLIP-seq
MIRT2101820	hsa-miR-4766-5p	CLIP-seq
MIRT2326265	hsa-miR-4782-5p	CLIP-seq
MIRT2101821	hsa-miR-4795-3p	CLIP-seq
MIRT2326266	hsa-miR-4795-5p	CLIP-seq
MIRT2326267	hsa-miR-4798-3p	CLIP-seq
MIRT2326268	hsa-miR-494	CLIP-seq
MIRT2326269	hsa-miR-497	CLIP-seq
MIRT2326270	hsa-miR-503	CLIP-seq
MIRT2326271	hsa-miR-509-3-5p	CLIP-seq
MIRT2326272	hsa-miR-509-5p	CLIP-seq
MIRT2326273	hsa-miR-513a-3p	CLIP-seq
MIRT2326274	hsa-miR-513b	CLIP-seq
MIRT2326275	hsa-miR-516b	CLIP-seq
MIRT1344449	hsa-miR-548c-3p	CLIP-seq
MIRT2326276	hsa-miR-548k	CLIP-seq
MIRT2326277	hsa-miR-549	CLIP-seq
MIRT2326278	hsa-miR-583	CLIP-seq
MIRT2101824	hsa-miR-607	CLIP-seq
MIRT2326279	hsa-miR-626	CLIP-seq
MIRT2326280	hsa-miR-629	CLIP-seq
MIRT2326281	hsa-miR-646	CLIP-seq
MIRT2326282	hsa-miR-766	CLIP-seq
MIRT2326283	hsa-miR-875-3p	CLIP-seq
MIRT2101826	hsa-miR-876-5p	CLIP-seq
MIRT2326284	hsa-miR-889	CLIP-seq
MIRT2326285	hsa-miR-940	CLIP-seq
MIRT2621902	hsa-miR-146a	CLIP-seq
MIRT2621903	hsa-miR-146b-5p	CLIP-seq
MIRT2326216	hsa-miR-15a	CLIP-seq
MIRT2326217	hsa-miR-15b	CLIP-seq
MIRT2326218	hsa-miR-16	CLIP-seq
MIRT2326224	hsa-miR-195	CLIP-seq
MIRT2621904	hsa-miR-218	CLIP-seq
MIRT2621905	hsa-miR-2467-5p	CLIP-seq
MIRT2326229	hsa-miR-3121-5p	CLIP-seq
MIRT2621906	hsa-miR-3188	CLIP-seq
MIRT2326234	hsa-miR-338-3p	CLIP-seq
MIRT2101813	hsa-miR-3662	CLIP-seq
MIRT2621907	hsa-miR-3664-5p	CLIP-seq
MIRT2326240	hsa-miR-382	CLIP-seq
MIRT2621908	hsa-miR-3975	CLIP-seq
MIRT2326241	hsa-miR-424	CLIP-seq
MIRT2621909	hsa-miR-4496	CLIP-seq
MIRT2621910	hsa-miR-4511	CLIP-seq
MIRT1344440	hsa-miR-4517	CLIP-seq
MIRT2326250	hsa-miR-4524	CLIP-seq
MIRT2326252	hsa-miR-4530	CLIP-seq
MIRT2621911	hsa-miR-4714-5p	CLIP-seq
MIRT2621912	hsa-miR-4718	CLIP-seq
MIRT2101818	hsa-miR-4735-5p	CLIP-seq
MIRT2621913	hsa-miR-4742-3p	CLIP-seq
MIRT2101820	hsa-miR-4766-5p	CLIP-seq
MIRT1344445	hsa-miR-4775	CLIP-seq
MIRT2621914	hsa-miR-4777-5p	CLIP-seq
MIRT2621915	hsa-miR-485-5p	CLIP-seq
MIRT2326269	hsa-miR-497	CLIP-seq
MIRT2326270	hsa-miR-503	CLIP-seq
MIRT2621916	hsa-miR-518d-5p	CLIP-seq
MIRT2621917	hsa-miR-519b-5p	CLIP-seq
MIRT2621918	hsa-miR-519c-5p	CLIP-seq
MIRT2621919	hsa-miR-520c-5p	CLIP-seq
MIRT2621920	hsa-miR-526a	CLIP-seq
MIRT2621921	hsa-miR-589	CLIP-seq
MIRT1344453	hsa-miR-590-3p	CLIP-seq
MIRT2326281	hsa-miR-646	CLIP-seq
MIRT2326282	hsa-miR-766	CLIP-seq
MIRT1344413	hsa-miR-128	CLIP-seq
MIRT1344418	hsa-miR-27a	CLIP-seq
MIRT1344419	hsa-miR-27b	CLIP-seq
MIRT1344422	hsa-miR-3119	CLIP-seq
MIRT1344424	hsa-miR-3140-3p	CLIP-seq
MIRT2690614	hsa-miR-4276	CLIP-seq
MIRT2690615	hsa-miR-4302	CLIP-seq
MIRT1344437	hsa-miR-4474-3p	CLIP-seq
MIRT2101822	hsa-miR-510	CLIP-seq
MIRT2101823	hsa-miR-512-5p	CLIP-seq
MIRT1344455	hsa-miR-644	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0017124	Function	SH3 domain binding	IEA
GO:0031965	Component	Nuclear membrane	IDA

Other IDs

• MIM: 615678
• HGNC: 15567
• e!Ensembl: ENSG00000198478

Protein

• UniProt ID: Q9UJC5
• Protein name: SH3 domain-binding glutamic acid-rich-like protein 2 (Fovea-associated SH3 domain-binding protein)
• PDB: 2CT6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04908	SH3BGR	1 → 98	SH3-binding, glutamic acid-rich protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain, placenta, liver and kidney. Expressed in retina. {ECO:0000269|PubMed:12095696}.
• Sequence:

  MVIRVFIASSSGFVAIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPT
  QGNPLPPQIFNGDRYCGDYDSFFESKESNTVFSFLGLKPRLASKAEP

• Sequence length: 107

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARTHRITIS, JUVENILE	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	35716043	Associate	★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile psoriatic arthritis	Juvenile arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile-Onset Still Disease	Still Disease	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Negative	Seronegative polyarthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Positive	Polyarthritis, Rheumatoid Factor Positive	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only