CD99L2 (CD99 molecule like 2)

Gene

• Entrez ID: 83692
• Gene name: CD99 molecule like 2
• Gene symbol: CD99L2
• Synonyms (NCBI Gene): CD99B, MIC2L1
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017538	hsa-miR-335-5p	Microarray	18185580
MIRT876615	hsa-miR-106a	CLIP-seq
MIRT876616	hsa-miR-106b	CLIP-seq
MIRT876617	hsa-miR-125a-5p	CLIP-seq
MIRT876618	hsa-miR-125b	CLIP-seq
MIRT876619	hsa-miR-1302	CLIP-seq
MIRT876620	hsa-miR-134	CLIP-seq
MIRT876621	hsa-miR-17	CLIP-seq
MIRT876622	hsa-miR-20a	CLIP-seq
MIRT876623	hsa-miR-20b	CLIP-seq
MIRT876624	hsa-miR-2110	CLIP-seq
MIRT876625	hsa-miR-3118	CLIP-seq
MIRT876626	hsa-miR-3122	CLIP-seq
MIRT876627	hsa-miR-3124-3p	CLIP-seq
MIRT876628	hsa-miR-3138	CLIP-seq
MIRT876629	hsa-miR-3160-3p	CLIP-seq
MIRT876630	hsa-miR-3164	CLIP-seq
MIRT876631	hsa-miR-3609	CLIP-seq
MIRT876632	hsa-miR-3616-5p	CLIP-seq
MIRT876633	hsa-miR-3647-5p	CLIP-seq
MIRT876634	hsa-miR-3913-5p	CLIP-seq
MIRT876635	hsa-miR-3926	CLIP-seq
MIRT876636	hsa-miR-4271	CLIP-seq
MIRT876637	hsa-miR-4275	CLIP-seq
MIRT876638	hsa-miR-4279	CLIP-seq
MIRT876639	hsa-miR-4298	CLIP-seq
MIRT876640	hsa-miR-4319	CLIP-seq
MIRT876641	hsa-miR-4487	CLIP-seq
MIRT876642	hsa-miR-4496	CLIP-seq
MIRT876643	hsa-miR-4499	CLIP-seq
MIRT876644	hsa-miR-4632	CLIP-seq
MIRT876645	hsa-miR-4711-3p	CLIP-seq
MIRT876646	hsa-miR-4725-3p	CLIP-seq
MIRT876647	hsa-miR-4795-5p	CLIP-seq
MIRT876648	hsa-miR-4796-3p	CLIP-seq
MIRT876649	hsa-miR-490-3p	CLIP-seq
MIRT876650	hsa-miR-502-5p	CLIP-seq
MIRT876651	hsa-miR-519d	CLIP-seq
MIRT876652	hsa-miR-543	CLIP-seq
MIRT876653	hsa-miR-544b	CLIP-seq
MIRT876654	hsa-miR-548ag	CLIP-seq
MIRT876655	hsa-miR-548ah	CLIP-seq
MIRT876656	hsa-miR-548ai	CLIP-seq
MIRT876657	hsa-miR-558	CLIP-seq
MIRT876658	hsa-miR-573	CLIP-seq
MIRT876659	hsa-miR-617	CLIP-seq
MIRT876660	hsa-miR-665	CLIP-seq
MIRT876661	hsa-miR-7	CLIP-seq
MIRT876662	hsa-miR-720	CLIP-seq
MIRT876663	hsa-miR-93	CLIP-seq
MIRT1959763	hsa-miR-1291	CLIP-seq
MIRT1959764	hsa-miR-203	CLIP-seq
MIRT1959765	hsa-miR-2276	CLIP-seq
MIRT1959766	hsa-miR-3140-5p	CLIP-seq
MIRT1959767	hsa-miR-3184	CLIP-seq
MIRT1959768	hsa-miR-3646	CLIP-seq
MIRT1959769	hsa-miR-3929	CLIP-seq
MIRT1959770	hsa-miR-423-5p	CLIP-seq
MIRT1959771	hsa-miR-4419b	CLIP-seq
MIRT1959772	hsa-miR-4428	CLIP-seq
MIRT1959773	hsa-miR-4434	CLIP-seq
MIRT1959774	hsa-miR-4478	CLIP-seq
MIRT1959775	hsa-miR-4516	CLIP-seq
MIRT1959776	hsa-miR-4533	CLIP-seq
MIRT1959777	hsa-miR-4648	CLIP-seq
MIRT1959778	hsa-miR-4654	CLIP-seq
MIRT1959779	hsa-miR-4747-5p	CLIP-seq
MIRT1959780	hsa-miR-4755-3p	CLIP-seq
MIRT1959781	hsa-miR-4769-5p	CLIP-seq
MIRT1959782	hsa-miR-4772-3p	CLIP-seq
MIRT1959783	hsa-miR-544	CLIP-seq
MIRT1959784	hsa-miR-654-3p	CLIP-seq
MIRT876637	hsa-miR-4275	CLIP-seq
MIRT876638	hsa-miR-4279	CLIP-seq
MIRT876644	hsa-miR-4632	CLIP-seq
MIRT2196830	hsa-miR-4728-5p	CLIP-seq
MIRT2446640	hsa-miR-1283	CLIP-seq
MIRT2446641	hsa-miR-140-3p	CLIP-seq
MIRT2446642	hsa-miR-224	CLIP-seq
MIRT2446643	hsa-miR-3193	CLIP-seq
MIRT2446644	hsa-miR-3622a-3p	CLIP-seq
MIRT2446645	hsa-miR-3622b-3p	CLIP-seq
MIRT2446646	hsa-miR-520d-5p	CLIP-seq
MIRT2446647	hsa-miR-524-5p	CLIP-seq
MIRT2499979	hsa-miR-1200	CLIP-seq
MIRT2499980	hsa-miR-125a-3p	CLIP-seq
MIRT2499981	hsa-miR-1273g	CLIP-seq
MIRT2446640	hsa-miR-1283	CLIP-seq
MIRT1959763	hsa-miR-1291	CLIP-seq
MIRT876619	hsa-miR-1302	CLIP-seq
MIRT2499982	hsa-miR-1305	CLIP-seq
MIRT2446641	hsa-miR-140-3p	CLIP-seq
MIRT2499983	hsa-miR-1825	CLIP-seq
MIRT2499984	hsa-miR-1909	CLIP-seq
MIRT2499985	hsa-miR-1910	CLIP-seq
MIRT2499986	hsa-miR-1972	CLIP-seq
MIRT2499987	hsa-miR-199a-3p	CLIP-seq
MIRT2499988	hsa-miR-199a-5p	CLIP-seq
MIRT2499989	hsa-miR-199b-3p	CLIP-seq
MIRT2499990	hsa-miR-199b-5p	CLIP-seq
MIRT2446642	hsa-miR-224	CLIP-seq
MIRT1959765	hsa-miR-2276	CLIP-seq
MIRT2499991	hsa-miR-299-3p	CLIP-seq
MIRT2499992	hsa-miR-3120-3p	CLIP-seq
MIRT876626	hsa-miR-3122	CLIP-seq
MIRT876627	hsa-miR-3124-3p	CLIP-seq
MIRT2499993	hsa-miR-3126-3p	CLIP-seq
MIRT2499994	hsa-miR-3127-3p	CLIP-seq
MIRT2499995	hsa-miR-3129-5p	CLIP-seq
MIRT1959766	hsa-miR-3140-5p	CLIP-seq
MIRT2499996	hsa-miR-3176	CLIP-seq
MIRT1959767	hsa-miR-3184	CLIP-seq
MIRT2499997	hsa-miR-3187-3p	CLIP-seq
MIRT2499998	hsa-miR-3194-3p	CLIP-seq
MIRT2446644	hsa-miR-3622a-3p	CLIP-seq
MIRT2446645	hsa-miR-3622b-3p	CLIP-seq
MIRT2499999	hsa-miR-3659	CLIP-seq
MIRT2500000	hsa-miR-3660	CLIP-seq
MIRT2500001	hsa-miR-3670	CLIP-seq
MIRT2500002	hsa-miR-3689a-3p	CLIP-seq
MIRT2500003	hsa-miR-3689c	CLIP-seq
MIRT2500004	hsa-miR-3691-3p	CLIP-seq
MIRT876634	hsa-miR-3913-5p	CLIP-seq
MIRT2500005	hsa-miR-3922-3p	CLIP-seq
MIRT2500006	hsa-miR-3925-3p	CLIP-seq
MIRT876635	hsa-miR-3926	CLIP-seq
MIRT2500007	hsa-miR-3944-5p	CLIP-seq
MIRT2500008	hsa-miR-3976	CLIP-seq
MIRT2500009	hsa-miR-411	CLIP-seq
MIRT1959770	hsa-miR-423-5p	CLIP-seq
MIRT2500010	hsa-miR-4261	CLIP-seq
MIRT2500011	hsa-miR-4265	CLIP-seq
MIRT2500012	hsa-miR-4267	CLIP-seq
MIRT2500013	hsa-miR-4283	CLIP-seq
MIRT2500014	hsa-miR-4296	CLIP-seq
MIRT876639	hsa-miR-4298	CLIP-seq
MIRT2500015	hsa-miR-4302	CLIP-seq
MIRT2500016	hsa-miR-4308	CLIP-seq
MIRT2500017	hsa-miR-4322	CLIP-seq
MIRT2500018	hsa-miR-4417	CLIP-seq
MIRT2500019	hsa-miR-4435	CLIP-seq
MIRT2500020	hsa-miR-4448	CLIP-seq
MIRT2500021	hsa-miR-4449	CLIP-seq
MIRT2500022	hsa-miR-4491	CLIP-seq
MIRT876642	hsa-miR-4496	CLIP-seq
MIRT2500023	hsa-miR-4514	CLIP-seq
MIRT2500024	hsa-miR-4526	CLIP-seq
MIRT2500025	hsa-miR-455-3p	CLIP-seq
MIRT2500026	hsa-miR-4637	CLIP-seq
MIRT2500027	hsa-miR-4640-5p	CLIP-seq
MIRT2500028	hsa-miR-4645-5p	CLIP-seq
MIRT1959777	hsa-miR-4648	CLIP-seq
MIRT2500029	hsa-miR-4649-5p	CLIP-seq
MIRT1959778	hsa-miR-4654	CLIP-seq
MIRT2500030	hsa-miR-4657	CLIP-seq
MIRT2500031	hsa-miR-4658	CLIP-seq
MIRT2500032	hsa-miR-4660	CLIP-seq
MIRT2500033	hsa-miR-4673	CLIP-seq
MIRT2500034	hsa-miR-4690-3p	CLIP-seq
MIRT2500035	hsa-miR-4692	CLIP-seq
MIRT2500036	hsa-miR-4701-5p	CLIP-seq
MIRT2500037	hsa-miR-4710	CLIP-seq
MIRT876645	hsa-miR-4711-3p	CLIP-seq
MIRT2500038	hsa-miR-4726-5p	CLIP-seq
MIRT2196830	hsa-miR-4728-5p	CLIP-seq
MIRT1959779	hsa-miR-4747-5p	CLIP-seq
MIRT1959781	hsa-miR-4769-5p	CLIP-seq
MIRT2500039	hsa-miR-4786-5p	CLIP-seq
MIRT876650	hsa-miR-502-5p	CLIP-seq
MIRT2500040	hsa-miR-508-5p	CLIP-seq
MIRT2500041	hsa-miR-513b	CLIP-seq
MIRT2500042	hsa-miR-516a-5p	CLIP-seq
MIRT2446646	hsa-miR-520d-5p	CLIP-seq
MIRT2446647	hsa-miR-524-5p	CLIP-seq
MIRT876652	hsa-miR-543	CLIP-seq
MIRT2500043	hsa-miR-545	CLIP-seq
MIRT2500044	hsa-miR-548s	CLIP-seq
MIRT2500045	hsa-miR-549	CLIP-seq
MIRT2500046	hsa-miR-574-5p	CLIP-seq
MIRT2500047	hsa-miR-588	CLIP-seq
MIRT2500048	hsa-miR-642b	CLIP-seq
MIRT2500049	hsa-miR-648	CLIP-seq
MIRT876660	hsa-miR-665	CLIP-seq
MIRT876662	hsa-miR-720	CLIP-seq
MIRT2500050	hsa-miR-766	CLIP-seq
MIRT2500051	hsa-miR-767-3p	CLIP-seq
MIRT2500052	hsa-miR-875-3p	CLIP-seq
MIRT2500053	hsa-miR-892a	CLIP-seq
MIRT2500054	hsa-miR-936	CLIP-seq
MIRT2499979	hsa-miR-1200	CLIP-seq
MIRT2677777	hsa-miR-1225-3p	CLIP-seq
MIRT2677778	hsa-miR-1233	CLIP-seq
MIRT2499981	hsa-miR-1273g	CLIP-seq
MIRT2677779	hsa-miR-128	CLIP-seq
MIRT1959763	hsa-miR-1291	CLIP-seq
MIRT876619	hsa-miR-1302	CLIP-seq
MIRT2499982	hsa-miR-1305	CLIP-seq
MIRT2677780	hsa-miR-1343	CLIP-seq
MIRT2677781	hsa-miR-147	CLIP-seq
MIRT2499983	hsa-miR-1825	CLIP-seq
MIRT2499984	hsa-miR-1909	CLIP-seq
MIRT2499985	hsa-miR-1910	CLIP-seq
MIRT2499986	hsa-miR-1972	CLIP-seq
MIRT2499987	hsa-miR-199a-3p	CLIP-seq
MIRT2499988	hsa-miR-199a-5p	CLIP-seq
MIRT2499989	hsa-miR-199b-3p	CLIP-seq
MIRT2499990	hsa-miR-199b-5p	CLIP-seq
MIRT2677782	hsa-miR-2114	CLIP-seq
MIRT1959765	hsa-miR-2276	CLIP-seq
MIRT2677783	hsa-miR-27a	CLIP-seq
MIRT2677784	hsa-miR-27b	CLIP-seq
MIRT2499991	hsa-miR-299-3p	CLIP-seq
MIRT2499992	hsa-miR-3120-3p	CLIP-seq
MIRT876626	hsa-miR-3122	CLIP-seq
MIRT2499993	hsa-miR-3126-3p	CLIP-seq
MIRT2499995	hsa-miR-3129-5p	CLIP-seq
MIRT1959766	hsa-miR-3140-5p	CLIP-seq
MIRT2499996	hsa-miR-3176	CLIP-seq
MIRT2499997	hsa-miR-3187-3p	CLIP-seq
MIRT2499998	hsa-miR-3194-3p	CLIP-seq
MIRT2499999	hsa-miR-3659	CLIP-seq
MIRT2500000	hsa-miR-3660	CLIP-seq
MIRT2500001	hsa-miR-3670	CLIP-seq
MIRT2500002	hsa-miR-3689a-3p	CLIP-seq
MIRT2500003	hsa-miR-3689c	CLIP-seq
MIRT2500004	hsa-miR-3691-3p	CLIP-seq
MIRT2677785	hsa-miR-3907	CLIP-seq
MIRT2677786	hsa-miR-3911	CLIP-seq
MIRT876634	hsa-miR-3913-5p	CLIP-seq
MIRT2500005	hsa-miR-3922-3p	CLIP-seq
MIRT2500006	hsa-miR-3925-3p	CLIP-seq
MIRT876635	hsa-miR-3926	CLIP-seq
MIRT1959769	hsa-miR-3929	CLIP-seq
MIRT2500007	hsa-miR-3944-5p	CLIP-seq
MIRT2500008	hsa-miR-3976	CLIP-seq
MIRT2500009	hsa-miR-411	CLIP-seq
MIRT2500010	hsa-miR-4261	CLIP-seq
MIRT2500011	hsa-miR-4265	CLIP-seq
MIRT2500012	hsa-miR-4267	CLIP-seq
MIRT2500013	hsa-miR-4283	CLIP-seq
MIRT2500014	hsa-miR-4296	CLIP-seq
MIRT876639	hsa-miR-4298	CLIP-seq
MIRT2500015	hsa-miR-4302	CLIP-seq
MIRT2500016	hsa-miR-4308	CLIP-seq
MIRT2500017	hsa-miR-4322	CLIP-seq
MIRT2500018	hsa-miR-4417	CLIP-seq
MIRT1959771	hsa-miR-4419b	CLIP-seq
MIRT2500019	hsa-miR-4435	CLIP-seq
MIRT2500020	hsa-miR-4448	CLIP-seq
MIRT2500021	hsa-miR-4449	CLIP-seq
MIRT1959774	hsa-miR-4478	CLIP-seq
MIRT2500022	hsa-miR-4491	CLIP-seq
MIRT876642	hsa-miR-4496	CLIP-seq
MIRT2677787	hsa-miR-4520a-5p	CLIP-seq
MIRT2677788	hsa-miR-4520b-5p	CLIP-seq
MIRT2500024	hsa-miR-4526	CLIP-seq
MIRT2500025	hsa-miR-455-3p	CLIP-seq
MIRT2500026	hsa-miR-4637	CLIP-seq
MIRT2500027	hsa-miR-4640-5p	CLIP-seq
MIRT2677789	hsa-miR-4641	CLIP-seq
MIRT1959777	hsa-miR-4648	CLIP-seq
MIRT1959778	hsa-miR-4654	CLIP-seq
MIRT2500030	hsa-miR-4657	CLIP-seq
MIRT2500031	hsa-miR-4658	CLIP-seq
MIRT2677790	hsa-miR-4663	CLIP-seq
MIRT2677791	hsa-miR-4694-5p	CLIP-seq
MIRT2500036	hsa-miR-4701-5p	CLIP-seq
MIRT876645	hsa-miR-4711-3p	CLIP-seq
MIRT2500038	hsa-miR-4726-5p	CLIP-seq
MIRT2196830	hsa-miR-4728-5p	CLIP-seq
MIRT1959781	hsa-miR-4769-5p	CLIP-seq
MIRT2677792	hsa-miR-4780	CLIP-seq
MIRT2677793	hsa-miR-4793-5p	CLIP-seq
MIRT876650	hsa-miR-502-5p	CLIP-seq
MIRT2500040	hsa-miR-508-5p	CLIP-seq
MIRT2500041	hsa-miR-513b	CLIP-seq
MIRT876652	hsa-miR-543	CLIP-seq
MIRT2500043	hsa-miR-545	CLIP-seq
MIRT2500044	hsa-miR-548s	CLIP-seq
MIRT2500045	hsa-miR-549	CLIP-seq
MIRT2500046	hsa-miR-574-5p	CLIP-seq
MIRT2500047	hsa-miR-588	CLIP-seq
MIRT2677794	hsa-miR-623	CLIP-seq
MIRT2677795	hsa-miR-628-5p	CLIP-seq
MIRT2500048	hsa-miR-642b	CLIP-seq
MIRT2677796	hsa-miR-644	CLIP-seq
MIRT2500049	hsa-miR-648	CLIP-seq
MIRT876660	hsa-miR-665	CLIP-seq
MIRT2677797	hsa-miR-671-3p	CLIP-seq
MIRT876662	hsa-miR-720	CLIP-seq
MIRT2500052	hsa-miR-875-3p	CLIP-seq
MIRT2677798	hsa-miR-890	CLIP-seq
MIRT2500053	hsa-miR-892a	CLIP-seq
MIRT2500054	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005912	Component	Adherens junction	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0050904	Process	Diapedesis	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:2000391	Process	Positive regulation of neutrophil extravasation	IEA
GO:2000409	Process	Positive regulation of T cell extravasation	IEA

Other IDs

• MIM: 300846
• HGNC: 18237
• e!Ensembl: ENSG00000102181

Protein

• UniProt ID: Q8TCZ2
• Protein name: CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99)
• Protein function: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12301	CD99L2	71 → 239	CD99 antigen like protein 2	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Expressed in many tissues, with low expression in thymus. {ECO:0000269|PubMed:12706889, ECO:0000269|PubMed:25326458}.
• Sequence:

  MVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQPWDHTTTTTTNRPGTT
  RAPAKPPGSGLDLADALDDQDDGRRKPGIGGRERWNHVTTTTKRPVTTRAPANTLGNDFD
  LADALDDRNDRDDGRRKPIAGGGGFSDKDLEDIVGGGEYKPDKGKGDGRYGSNDDPGSGM
  VAEPGTIAGVASALAMALIGAVSSYISYQQKKFCFSIQQGLNADYVKGENLEAVVCEEPQ
  VKYSTLHTQSAEPPPPPEPARI

• Sequence length: 262

Pathways

KEGG:

Cell adhesion molecules
Leukocyte transendothelial migration

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MYOSITIS, INCLUSION BODY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	23338758		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	38199832	Associate	★☆☆☆☆ Found in Text Mining only
Spasms Infantile	Infantile spasms	Pubtator	29667327	Associate	★☆☆☆☆ Found in Text Mining only