Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	83658
Gene name	Dynein light chain roadblock-type 1
Gene symbol	DYNLRB1
Synonyms (NCBI Gene)	BITHBLPDNCL2ADNLC2AROBLD1
Chromosome	20
Chromosome location	20q11.22
Summary	This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulat

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Show/Hide all (227)

miRTarBase ID	miRNA	Experiments
MIRT949311	hsa-miR-1203	CLIP-seq
MIRT949312	hsa-miR-1252	CLIP-seq
MIRT949313	hsa-miR-1275	CLIP-seq
MIRT949314	hsa-miR-186	CLIP-seq
MIRT949315	hsa-miR-2110	CLIP-seq
MIRT949316	hsa-miR-3074-5p	CLIP-seq
MIRT949317	hsa-miR-3133	CLIP-seq
MIRT949318	hsa-miR-3143	CLIP-seq
MIRT949319	hsa-miR-3160-5p	CLIP-seq
MIRT949320	hsa-miR-320e	CLIP-seq
MIRT949321	hsa-miR-326	CLIP-seq
MIRT949322	hsa-miR-330-5p	CLIP-seq
MIRT949323	hsa-miR-3545-3p	CLIP-seq
MIRT949324	hsa-miR-3609	CLIP-seq
MIRT949325	hsa-miR-3974	CLIP-seq
MIRT949326	hsa-miR-425	CLIP-seq
MIRT949327	hsa-miR-4270	CLIP-seq
MIRT949328	hsa-miR-4271	CLIP-seq
MIRT949329	hsa-miR-4441	CLIP-seq
MIRT949330	hsa-miR-4466	CLIP-seq
MIRT949331	hsa-miR-4477b	CLIP-seq
MIRT949332	hsa-miR-4665-5p	CLIP-seq
MIRT949333	hsa-miR-4667-5p	CLIP-seq
MIRT949334	hsa-miR-4700-5p	CLIP-seq
MIRT949335	hsa-miR-4725-3p	CLIP-seq
MIRT949336	hsa-miR-4747-5p	CLIP-seq
MIRT949337	hsa-miR-4767	CLIP-seq
MIRT949338	hsa-miR-489	CLIP-seq
MIRT949339	hsa-miR-493	CLIP-seq
MIRT949340	hsa-miR-516a-3p	CLIP-seq
MIRT949341	hsa-miR-520g	CLIP-seq
MIRT949342	hsa-miR-520h	CLIP-seq
MIRT949343	hsa-miR-543	CLIP-seq
MIRT949344	hsa-miR-548ah	CLIP-seq
MIRT949345	hsa-miR-635	CLIP-seq
MIRT949346	hsa-miR-637	CLIP-seq
MIRT949347	hsa-miR-642b	CLIP-seq
MIRT949348	hsa-miR-675	CLIP-seq
MIRT949313	hsa-miR-1275	CLIP-seq
MIRT949318	hsa-miR-3143	CLIP-seq
MIRT949323	hsa-miR-3545-3p	CLIP-seq
MIRT949324	hsa-miR-3609	CLIP-seq
MIRT949325	hsa-miR-3974	CLIP-seq
MIRT949326	hsa-miR-425	CLIP-seq
MIRT949327	hsa-miR-4270	CLIP-seq
MIRT949329	hsa-miR-4441	CLIP-seq
MIRT949331	hsa-miR-4477b	CLIP-seq
MIRT1981303	hsa-miR-4659a-5p	CLIP-seq
MIRT1981304	hsa-miR-4659b-5p	CLIP-seq
MIRT949332	hsa-miR-4665-5p	CLIP-seq
MIRT949338	hsa-miR-489	CLIP-seq
MIRT949339	hsa-miR-493	CLIP-seq
MIRT949341	hsa-miR-520g	CLIP-seq
MIRT949342	hsa-miR-520h	CLIP-seq
MIRT949343	hsa-miR-543	CLIP-seq
MIRT949344	hsa-miR-548ah	CLIP-seq
MIRT1981305	hsa-miR-554	CLIP-seq
MIRT949345	hsa-miR-635	CLIP-seq
MIRT949347	hsa-miR-642b	CLIP-seq
MIRT949311	hsa-miR-1203	CLIP-seq
MIRT2216308	hsa-miR-1243	CLIP-seq
MIRT949312	hsa-miR-1252	CLIP-seq
MIRT2216309	hsa-miR-1273	CLIP-seq
MIRT2216310	hsa-miR-1273c	CLIP-seq
MIRT949313	hsa-miR-1275	CLIP-seq
MIRT2216311	hsa-miR-1468	CLIP-seq
MIRT949314	hsa-miR-186	CLIP-seq
MIRT949315	hsa-miR-2110	CLIP-seq
MIRT2216312	hsa-miR-2276	CLIP-seq
MIRT949316	hsa-miR-3074-5p	CLIP-seq
MIRT949317	hsa-miR-3133	CLIP-seq
MIRT949318	hsa-miR-3143	CLIP-seq
MIRT2216313	hsa-miR-3150b-3p	CLIP-seq
MIRT949319	hsa-miR-3160-5p	CLIP-seq
MIRT949320	hsa-miR-320e	CLIP-seq
MIRT949321	hsa-miR-326	CLIP-seq
MIRT949322	hsa-miR-330-5p	CLIP-seq
MIRT949323	hsa-miR-3545-3p	CLIP-seq
MIRT949324	hsa-miR-3609	CLIP-seq
MIRT2216314	hsa-miR-3650	CLIP-seq
MIRT949325	hsa-miR-3974	CLIP-seq
MIRT949326	hsa-miR-425	CLIP-seq
MIRT949327	hsa-miR-4270	CLIP-seq
MIRT949328	hsa-miR-4271	CLIP-seq
MIRT949329	hsa-miR-4441	CLIP-seq
MIRT949330	hsa-miR-4466	CLIP-seq
MIRT949331	hsa-miR-4477b	CLIP-seq
MIRT2216315	hsa-miR-4481	CLIP-seq
MIRT1981303	hsa-miR-4659a-5p	CLIP-seq
MIRT1981304	hsa-miR-4659b-5p	CLIP-seq
MIRT949332	hsa-miR-4665-5p	CLIP-seq
MIRT949333	hsa-miR-4667-5p	CLIP-seq
MIRT2216316	hsa-miR-4689	CLIP-seq
MIRT2216317	hsa-miR-4693-3p	CLIP-seq
MIRT949334	hsa-miR-4700-5p	CLIP-seq
MIRT949335	hsa-miR-4725-3p	CLIP-seq
MIRT2216318	hsa-miR-4745-5p	CLIP-seq
MIRT949336	hsa-miR-4747-5p	CLIP-seq
MIRT2216319	hsa-miR-4758-5p	CLIP-seq
MIRT949337	hsa-miR-4767	CLIP-seq
MIRT2216320	hsa-miR-4769-3p	CLIP-seq
MIRT2216321	hsa-miR-4784	CLIP-seq
MIRT949338	hsa-miR-489	CLIP-seq
MIRT2216322	hsa-miR-490-3p	CLIP-seq
MIRT949339	hsa-miR-493	CLIP-seq
MIRT2216323	hsa-miR-509-3p	CLIP-seq
MIRT2216324	hsa-miR-515-5p	CLIP-seq
MIRT949340	hsa-miR-516a-3p	CLIP-seq
MIRT949341	hsa-miR-520g	CLIP-seq
MIRT949342	hsa-miR-520h	CLIP-seq
MIRT949343	hsa-miR-543	CLIP-seq
MIRT949344	hsa-miR-548ah	CLIP-seq
MIRT1981305	hsa-miR-554	CLIP-seq
MIRT2216325	hsa-miR-619	CLIP-seq
MIRT949345	hsa-miR-635	CLIP-seq
MIRT949346	hsa-miR-637	CLIP-seq
MIRT949347	hsa-miR-642b	CLIP-seq
MIRT949348	hsa-miR-675	CLIP-seq
MIRT949311	hsa-miR-1203	CLIP-seq
MIRT2216308	hsa-miR-1243	CLIP-seq
MIRT2216309	hsa-miR-1273	CLIP-seq
MIRT2216310	hsa-miR-1273c	CLIP-seq
MIRT949313	hsa-miR-1275	CLIP-seq
MIRT949315	hsa-miR-2110	CLIP-seq
MIRT949318	hsa-miR-3143	CLIP-seq
MIRT949321	hsa-miR-326	CLIP-seq
MIRT949322	hsa-miR-330-5p	CLIP-seq
MIRT949324	hsa-miR-3609	CLIP-seq
MIRT2216314	hsa-miR-3650	CLIP-seq
MIRT949328	hsa-miR-4271	CLIP-seq
MIRT2216315	hsa-miR-4481	CLIP-seq
MIRT949332	hsa-miR-4665-5p	CLIP-seq
MIRT949333	hsa-miR-4667-5p	CLIP-seq
MIRT949334	hsa-miR-4700-5p	CLIP-seq
MIRT949335	hsa-miR-4725-3p	CLIP-seq
MIRT2216318	hsa-miR-4745-5p	CLIP-seq
MIRT949336	hsa-miR-4747-5p	CLIP-seq
MIRT2216319	hsa-miR-4758-5p	CLIP-seq
MIRT2216322	hsa-miR-490-3p	CLIP-seq
MIRT2216323	hsa-miR-509-3p	CLIP-seq
MIRT949341	hsa-miR-520g	CLIP-seq
MIRT949342	hsa-miR-520h	CLIP-seq
MIRT949343	hsa-miR-543	CLIP-seq
MIRT949344	hsa-miR-548ah	CLIP-seq
MIRT2216325	hsa-miR-619	CLIP-seq
MIRT949345	hsa-miR-635	CLIP-seq
MIRT949346	hsa-miR-637	CLIP-seq
MIRT949311	hsa-miR-1203	CLIP-seq
MIRT2216308	hsa-miR-1243	CLIP-seq
MIRT2520290	hsa-miR-1253	CLIP-seq
MIRT949313	hsa-miR-1275	CLIP-seq
MIRT2216311	hsa-miR-1468	CLIP-seq
MIRT949315	hsa-miR-2110	CLIP-seq
MIRT949318	hsa-miR-3143	CLIP-seq
MIRT2520291	hsa-miR-3175	CLIP-seq
MIRT2520292	hsa-miR-3194-5p	CLIP-seq
MIRT949321	hsa-miR-326	CLIP-seq
MIRT949322	hsa-miR-330-5p	CLIP-seq
MIRT2216314	hsa-miR-3650	CLIP-seq
MIRT949328	hsa-miR-4271	CLIP-seq
MIRT2520293	hsa-miR-4434	CLIP-seq
MIRT2520294	hsa-miR-4447	CLIP-seq
MIRT2520295	hsa-miR-4472	CLIP-seq
MIRT949331	hsa-miR-4477b	CLIP-seq
MIRT2216315	hsa-miR-4481	CLIP-seq
MIRT2520296	hsa-miR-4516	CLIP-seq
MIRT2520297	hsa-miR-4525	CLIP-seq
MIRT1981303	hsa-miR-4659a-5p	CLIP-seq
MIRT1981304	hsa-miR-4659b-5p	CLIP-seq
MIRT949332	hsa-miR-4665-5p	CLIP-seq
MIRT949333	hsa-miR-4667-5p	CLIP-seq
MIRT2520298	hsa-miR-4690-3p	CLIP-seq
MIRT949334	hsa-miR-4700-5p	CLIP-seq
MIRT2520299	hsa-miR-4723-5p	CLIP-seq
MIRT949335	hsa-miR-4725-3p	CLIP-seq
MIRT2216318	hsa-miR-4745-5p	CLIP-seq
MIRT949336	hsa-miR-4747-5p	CLIP-seq
MIRT2216319	hsa-miR-4758-5p	CLIP-seq
MIRT949338	hsa-miR-489	CLIP-seq
MIRT2216323	hsa-miR-509-3p	CLIP-seq
MIRT2520300	hsa-miR-541	CLIP-seq
MIRT949343	hsa-miR-543	CLIP-seq
MIRT1981305	hsa-miR-554	CLIP-seq
MIRT2520301	hsa-miR-625	CLIP-seq
MIRT949345	hsa-miR-635	CLIP-seq
MIRT949346	hsa-miR-637	CLIP-seq
MIRT2520302	hsa-miR-654-5p	CLIP-seq
MIRT949311	hsa-miR-1203	CLIP-seq
MIRT2216308	hsa-miR-1243	CLIP-seq
MIRT2520290	hsa-miR-1253	CLIP-seq
MIRT949313	hsa-miR-1275	CLIP-seq
MIRT2216311	hsa-miR-1468	CLIP-seq
MIRT949315	hsa-miR-2110	CLIP-seq
MIRT949318	hsa-miR-3143	CLIP-seq
MIRT2520291	hsa-miR-3175	CLIP-seq
MIRT2520292	hsa-miR-3194-5p	CLIP-seq
MIRT949321	hsa-miR-326	CLIP-seq
MIRT949322	hsa-miR-330-5p	CLIP-seq
MIRT2216314	hsa-miR-3650	CLIP-seq
MIRT949328	hsa-miR-4271	CLIP-seq
MIRT2520293	hsa-miR-4434	CLIP-seq
MIRT2520294	hsa-miR-4447	CLIP-seq
MIRT2520295	hsa-miR-4472	CLIP-seq
MIRT2216315	hsa-miR-4481	CLIP-seq
MIRT2520296	hsa-miR-4516	CLIP-seq
MIRT2520297	hsa-miR-4525	CLIP-seq
MIRT1981303	hsa-miR-4659a-5p	CLIP-seq
MIRT1981304	hsa-miR-4659b-5p	CLIP-seq
MIRT949332	hsa-miR-4665-5p	CLIP-seq
MIRT949333	hsa-miR-4667-5p	CLIP-seq
MIRT2520298	hsa-miR-4690-3p	CLIP-seq
MIRT949334	hsa-miR-4700-5p	CLIP-seq
MIRT2520299	hsa-miR-4723-5p	CLIP-seq
MIRT949335	hsa-miR-4725-3p	CLIP-seq
MIRT2216318	hsa-miR-4745-5p	CLIP-seq
MIRT949336	hsa-miR-4747-5p	CLIP-seq
MIRT2216319	hsa-miR-4758-5p	CLIP-seq
MIRT949338	hsa-miR-489	CLIP-seq
MIRT2216323	hsa-miR-509-3p	CLIP-seq
MIRT2520300	hsa-miR-541	CLIP-seq
MIRT949343	hsa-miR-543	CLIP-seq
MIRT1981305	hsa-miR-554	CLIP-seq
MIRT2520301	hsa-miR-625	CLIP-seq
MIRT949345	hsa-miR-635	CLIP-seq
MIRT949346	hsa-miR-637	CLIP-seq
MIRT949347	hsa-miR-642b	CLIP-seq
MIRT2520302	hsa-miR-654-5p	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003777	Function	Microtubule motor activity	NAS	11750132
GO:0005515	Function	Protein binding	IPI	16189514, 24986880, 25416956, 30649997, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005856	Component	Cytoskeleton	IEA
GO:0005868	Component	Cytoplasmic dynein complex	IBA
GO:0005868	Component	Cytoplasmic dynein complex	IEA
GO:0005868	Component	Cytoplasmic dynein complex	IPI	24986880
GO:0005868	Component	Cytoplasmic dynein complex	ISS
GO:0005868	Component	Cytoplasmic dynein complex	NAS	11750132
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	TAS
GO:0007018	Process	Microtubule-based movement	IBA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0007018	Process	Microtubule-based movement	NAS	11750132
GO:0007632	Process	Visual behavior	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0030286	Component	Dynein complex	IEA
GO:0032388	Process	Positive regulation of intracellular transport	NAS	33957056
GO:0042802	Function	Identical protein binding	IEA
GO:0045505	Function	Dynein intermediate chain binding	IBA
GO:0097542	Component	Ciliary tip	IEA
GO:0097542	Component	Ciliary tip	TAS

MIM	HGNC	e!Ensembl
607167	15468	ENSG00000125971

Q9NP97

Protein name

Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)

Protein function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor

PDB

1Z09 , 2B95 , 2E8J , 2HZ5 , 6F1T , 6F1Z , 6F38 , 6F3A , 6RLB , 6SC2 , 7Z8F , 8J07 , 8PR1 , 8PTK , 8RGG , 8RGH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03259	Robl_LC7	3 → 93	Roadblock/LC7 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC)

Sequence

MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDI
DPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Motor proteins Salmonella infection		Intraflagellar transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma of lung	Lung carcinoma	BEFREE	8959679	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31393067	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	16778097	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	11750132	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	8959679	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	10545285, 8959679	★★★★★ ★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	8959679	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	17556076	★★★★★ ★☆☆☆☆ Found in Text Mining only

DYNLRB1 (dynein light chain roadblock-type 1)