FAM107B (family with sequence similarity 107 member B)

Gene

• Entrez ID: 83641
• Gene name: Family with sequence similarity 107 member B
• Gene symbol: FAM107B
• Synonyms (NCBI Gene): C10orf45, HITS
• Chromosome: 10
• Chromosome location: 10p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030175	hsa-miR-26b-5p	Sequencing	20371350
MIRT039777	hsa-miR-615-3p	CLASH	23622248
MIRT658461	hsa-miR-8485	HITS-CLIP	23824327
MIRT658461	hsa-miR-8485	HITS-CLIP	23824327
MIRT477140	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT477141	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT477139	hsa-miR-6507-3p	PAR-CLIP	20371350
MIRT558012	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT477138	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT477137	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT477136	hsa-miR-759	PAR-CLIP	20371350
MIRT477135	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT558011	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT558010	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT558009	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT558008	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT477140	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT477141	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT477139	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT558012	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT477137	hsa-miR-5197-3p	PAR-CLIP	21572407
MIRT477136	hsa-miR-759	PAR-CLIP	21572407
MIRT477135	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT558011	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT558010	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT558009	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT558008	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT477140	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT477141	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT477139	hsa-miR-6507-3p	PAR-CLIP	23592263
MIRT477138	hsa-miR-6882-5p	PAR-CLIP	23592263
MIRT477137	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT477136	hsa-miR-759	PAR-CLIP	23592263
MIRT477135	hsa-miR-3942-3p	PAR-CLIP	23592263
MIRT658461	hsa-miR-8485	HITS-CLIP	27418678
MIRT658461	hsa-miR-8485	HITS-CLIP	27418678
MIRT658461	hsa-miR-8485	HITS-CLIP	27418678
MIRT658461	hsa-miR-8485	HITS-CLIP	27418678
MIRT658461	hsa-miR-8485	HITS-CLIP	27418678
MIRT658461	hsa-miR-8485	HITS-CLIP	23824327
MIRT658461	hsa-miR-8485	HITS-CLIP	23824327
MIRT477140	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT477141	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT477139	hsa-miR-6507-3p	PAR-CLIP	20371350
MIRT558012	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT477138	hsa-miR-6882-5p	PAR-CLIP	20371350
MIRT477137	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT477136	hsa-miR-759	PAR-CLIP	20371350
MIRT477135	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT558011	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT558010	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT558009	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT558008	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT477140	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT477141	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT477139	hsa-miR-6507-3p	PAR-CLIP	21572407
MIRT558012	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT477137	hsa-miR-5197-3p	PAR-CLIP	21572407
MIRT477136	hsa-miR-759	PAR-CLIP	21572407
MIRT477135	hsa-miR-3942-3p	PAR-CLIP	21572407
MIRT558011	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT558010	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT558009	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT558008	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT477140	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT477141	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT477139	hsa-miR-6507-3p	PAR-CLIP	23592263
MIRT477138	hsa-miR-6882-5p	PAR-CLIP	23592263
MIRT477137	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT477136	hsa-miR-759	PAR-CLIP	23592263
MIRT477135	hsa-miR-3942-3p	PAR-CLIP	23592263
MIRT976715	hsa-miR-1184	CLIP-seq
MIRT976716	hsa-miR-1205	CLIP-seq
MIRT976717	hsa-miR-1207-3p	CLIP-seq
MIRT976718	hsa-miR-1244	CLIP-seq
MIRT976719	hsa-miR-1264	CLIP-seq
MIRT976720	hsa-miR-145	CLIP-seq
MIRT976721	hsa-miR-186	CLIP-seq
MIRT976722	hsa-miR-204	CLIP-seq
MIRT976723	hsa-miR-205	CLIP-seq
MIRT976724	hsa-miR-21	CLIP-seq
MIRT976725	hsa-miR-211	CLIP-seq
MIRT976726	hsa-miR-23a	CLIP-seq
MIRT976727	hsa-miR-23b	CLIP-seq
MIRT976728	hsa-miR-23c	CLIP-seq
MIRT976729	hsa-miR-3123	CLIP-seq
MIRT976730	hsa-miR-3133	CLIP-seq
MIRT976731	hsa-miR-3135	CLIP-seq
MIRT976732	hsa-miR-3148	CLIP-seq
MIRT976733	hsa-miR-3149	CLIP-seq
MIRT976734	hsa-miR-3158-5p	CLIP-seq
MIRT976735	hsa-miR-3187-3p	CLIP-seq
MIRT976736	hsa-miR-3618	CLIP-seq
MIRT976737	hsa-miR-3913-3p	CLIP-seq
MIRT976738	hsa-miR-3914	CLIP-seq
MIRT976739	hsa-miR-3925-5p	CLIP-seq
MIRT976740	hsa-miR-412	CLIP-seq
MIRT976741	hsa-miR-421	CLIP-seq
MIRT976742	hsa-miR-4287	CLIP-seq
MIRT976743	hsa-miR-4435	CLIP-seq
MIRT976744	hsa-miR-4457	CLIP-seq
MIRT976745	hsa-miR-4502	CLIP-seq
MIRT976746	hsa-miR-4658	CLIP-seq
MIRT976747	hsa-miR-4659a-3p	CLIP-seq
MIRT976748	hsa-miR-4659b-3p	CLIP-seq
MIRT976749	hsa-miR-4685-3p	CLIP-seq
MIRT976750	hsa-miR-4701-5p	CLIP-seq
MIRT976751	hsa-miR-4706	CLIP-seq
MIRT976752	hsa-miR-4709-5p	CLIP-seq
MIRT976753	hsa-miR-4749-5p	CLIP-seq
MIRT976754	hsa-miR-4758-5p	CLIP-seq
MIRT976755	hsa-miR-4772-3p	CLIP-seq
MIRT976756	hsa-miR-4789-5p	CLIP-seq
MIRT976757	hsa-miR-4793-5p	CLIP-seq
MIRT976758	hsa-miR-513b	CLIP-seq
MIRT976759	hsa-miR-520d-5p	CLIP-seq
MIRT976760	hsa-miR-524-5p	CLIP-seq
MIRT976761	hsa-miR-539	CLIP-seq
MIRT976762	hsa-miR-544	CLIP-seq
MIRT976763	hsa-miR-548aa	CLIP-seq
MIRT976764	hsa-miR-548s	CLIP-seq
MIRT976765	hsa-miR-570	CLIP-seq
MIRT976766	hsa-miR-577	CLIP-seq
MIRT976767	hsa-miR-579	CLIP-seq
MIRT976768	hsa-miR-588	CLIP-seq
MIRT976769	hsa-miR-590-5p	CLIP-seq
MIRT976770	hsa-miR-628-5p	CLIP-seq
MIRT976771	hsa-miR-656	CLIP-seq
MIRT976772	hsa-miR-744	CLIP-seq
MIRT976773	hsa-miR-885-5p	CLIP-seq
MIRT976774	hsa-miR-891b	CLIP-seq
MIRT976775	hsa-miR-938	CLIP-seq
MIRT1548476	hsa-miR-127-5p	CLIP-seq
MIRT1548477	hsa-miR-320e	CLIP-seq
MIRT1548478	hsa-miR-4724-5p	CLIP-seq
MIRT1989472	hsa-miR-1	CLIP-seq
MIRT1989473	hsa-miR-1229	CLIP-seq
MIRT976720	hsa-miR-145	CLIP-seq
MIRT1989474	hsa-miR-154	CLIP-seq
MIRT1989475	hsa-miR-200b	CLIP-seq
MIRT1989476	hsa-miR-200c	CLIP-seq
MIRT1989477	hsa-miR-206	CLIP-seq
MIRT1989478	hsa-miR-2117	CLIP-seq
MIRT1989479	hsa-miR-24	CLIP-seq
MIRT1989480	hsa-miR-3065-5p	CLIP-seq
MIRT1989481	hsa-miR-3074-5p	CLIP-seq
MIRT1989482	hsa-miR-330-3p	CLIP-seq
MIRT1989483	hsa-miR-3614-5p	CLIP-seq
MIRT1989484	hsa-miR-4273	CLIP-seq
MIRT1989485	hsa-miR-4284	CLIP-seq
MIRT1989486	hsa-miR-429	CLIP-seq
MIRT1548478	hsa-miR-4724-5p	CLIP-seq
MIRT1989487	hsa-miR-548a-3p	CLIP-seq
MIRT1989488	hsa-miR-548e	CLIP-seq
MIRT1989489	hsa-miR-548f	CLIP-seq
MIRT976767	hsa-miR-579	CLIP-seq
MIRT1989490	hsa-miR-607	CLIP-seq
MIRT1989491	hsa-miR-613	CLIP-seq
MIRT1989472	hsa-miR-1	CLIP-seq
MIRT2223797	hsa-miR-1237	CLIP-seq
MIRT976718	hsa-miR-1244	CLIP-seq
MIRT2223798	hsa-miR-1248	CLIP-seq
MIRT976719	hsa-miR-1264	CLIP-seq
MIRT2223799	hsa-miR-1305	CLIP-seq
MIRT2223800	hsa-miR-1324	CLIP-seq
MIRT1989477	hsa-miR-206	CLIP-seq
MIRT976724	hsa-miR-21	CLIP-seq
MIRT1989480	hsa-miR-3065-5p	CLIP-seq
MIRT2223801	hsa-miR-3119	CLIP-seq
MIRT1989482	hsa-miR-330-3p	CLIP-seq
MIRT2223802	hsa-miR-3673	CLIP-seq
MIRT976737	hsa-miR-3913-3p	CLIP-seq
MIRT976741	hsa-miR-421	CLIP-seq
MIRT2223803	hsa-miR-4299	CLIP-seq
MIRT2223804	hsa-miR-4456	CLIP-seq
MIRT2223805	hsa-miR-4539	CLIP-seq
MIRT2223806	hsa-miR-4694-5p	CLIP-seq
MIRT2223807	hsa-miR-4704-3p	CLIP-seq
MIRT976752	hsa-miR-4709-5p	CLIP-seq
MIRT2223808	hsa-miR-4712-3p	CLIP-seq
MIRT2223809	hsa-miR-4742-5p	CLIP-seq
MIRT2223810	hsa-miR-4773	CLIP-seq
MIRT976757	hsa-miR-4793-5p	CLIP-seq
MIRT2223811	hsa-miR-4798-5p	CLIP-seq
MIRT2223812	hsa-miR-498	CLIP-seq
MIRT2223813	hsa-miR-515-5p	CLIP-seq
MIRT2223814	hsa-miR-548q	CLIP-seq
MIRT976769	hsa-miR-590-5p	CLIP-seq
MIRT2223815	hsa-miR-593	CLIP-seq
MIRT2223816	hsa-miR-605	CLIP-seq
MIRT1989491	hsa-miR-613	CLIP-seq
MIRT2223817	hsa-miR-621	CLIP-seq
MIRT1989472	hsa-miR-1	CLIP-seq
MIRT1989473	hsa-miR-1229	CLIP-seq
MIRT2387670	hsa-miR-1273e	CLIP-seq
MIRT2387671	hsa-miR-2052	CLIP-seq
MIRT1989477	hsa-miR-206	CLIP-seq
MIRT1989478	hsa-miR-2117	CLIP-seq
MIRT1989481	hsa-miR-3074-5p	CLIP-seq
MIRT1989483	hsa-miR-3614-5p	CLIP-seq
MIRT2387672	hsa-miR-3668	CLIP-seq
MIRT2223802	hsa-miR-3673	CLIP-seq
MIRT1989484	hsa-miR-4273	CLIP-seq
MIRT2387673	hsa-miR-4293	CLIP-seq
MIRT2387674	hsa-miR-4795-3p	CLIP-seq
MIRT2387675	hsa-miR-556-3p	CLIP-seq
MIRT2387676	hsa-miR-596	CLIP-seq
MIRT1989491	hsa-miR-613	CLIP-seq
MIRT2387677	hsa-miR-668	CLIP-seq
MIRT2527614	hsa-miR-1179	CLIP-seq
MIRT2527615	hsa-miR-141	CLIP-seq
MIRT2527616	hsa-miR-200a	CLIP-seq
MIRT2527617	hsa-miR-4422	CLIP-seq
MIRT2223799	hsa-miR-1305	CLIP-seq
MIRT976720	hsa-miR-145	CLIP-seq
MIRT976721	hsa-miR-186	CLIP-seq
MIRT2223801	hsa-miR-3119	CLIP-seq
MIRT2223812	hsa-miR-498	CLIP-seq

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9H098
• Protein name: Protein FAM107B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06625	DUF1151	9 → 120	Protein of unknown function (DUF1151)	Family

• Sequence:

  MAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEKR
  KRDQVIKQKEEEAQKKKSDLEIELLKRQQKLEQLELEKQKLQEEQENAPEFVKVKGNLRR
  TGQEVAQAQES

• Sequence length: 131

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Abetalipoproteinemia	Abetalipoproteinemia	BEFREE	28539470		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	36342317	Associate	★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	24613350		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	20576088, 24906430		★☆☆☆☆ Found in Text Mining only
Kaposi Sarcoma	Kaposi Sarcoma	BEFREE	22927820, 25710169		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	20576088, 24906430		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gastrointestinal tract	Malignant gastrointestinal tract tumors	BEFREE	22825356		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28675500		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	22825356		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20664927, 28675500		★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	BEFREE	26257173		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20664927, 22825356		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28675500		★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	22825356		★☆☆☆☆ Found in Text Mining only