Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	83443
Gene name	Splicing factor 3b subunit 5
Gene symbol	SF3B5
Synonyms (NCBI Gene)	SF3b10Ysf3
Chromosome	6
Chromosome location	6q24.2

121

Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT035819	hsa-miR-1307-3p	CLASH	23622248
MIRT739912	hsa-miR-1226	CLIP-seq
MIRT739908	hsa-miR-1266	CLIP-seq
MIRT739903	hsa-miR-1289	CLIP-seq
MIRT1341577	hsa-miR-3148	CLIP-seq
MIRT739907	hsa-miR-3664-3p	CLIP-seq
MIRT1341578	hsa-miR-3688-3p	CLIP-seq
MIRT1341579	hsa-miR-370	CLIP-seq
MIRT1341580	hsa-miR-371-5p	CLIP-seq
MIRT1341581	hsa-miR-371b-5p	CLIP-seq
MIRT1341582	hsa-miR-4263	CLIP-seq
MIRT739910	hsa-miR-4277	CLIP-seq
MIRT739904	hsa-miR-4433	CLIP-seq
MIRT739906	hsa-miR-4459	CLIP-seq
MIRT739909	hsa-miR-4518	CLIP-seq
MIRT1341583	hsa-miR-4724-5p	CLIP-seq
MIRT739905	hsa-miR-4768-3p	CLIP-seq
MIRT1341584	hsa-miR-4799-5p	CLIP-seq
MIRT1341585	hsa-miR-513c	CLIP-seq
MIRT1341586	hsa-miR-514b-5p	CLIP-seq
MIRT1341587	hsa-miR-576-5p	CLIP-seq
MIRT739911	hsa-miR-634	CLIP-seq
MIRT1553624	hsa-miR-3714	CLIP-seq
MIRT1553625	hsa-miR-4493	CLIP-seq
MIRT1553626	hsa-miR-4736	CLIP-seq
MIRT1553627	hsa-miR-940	CLIP-seq
MIRT2101131	hsa-miR-1270	CLIP-seq
MIRT2101132	hsa-miR-150	CLIP-seq
MIRT2101133	hsa-miR-182	CLIP-seq
MIRT2101134	hsa-miR-1825	CLIP-seq
MIRT2101135	hsa-miR-185	CLIP-seq
MIRT2101136	hsa-miR-3121-5p	CLIP-seq
MIRT1341582	hsa-miR-4263	CLIP-seq
MIRT2101137	hsa-miR-4306	CLIP-seq
MIRT2101138	hsa-miR-4470	CLIP-seq
MIRT2101139	hsa-miR-4521	CLIP-seq
MIRT2101140	hsa-miR-4531	CLIP-seq
MIRT2101141	hsa-miR-4644	CLIP-seq
MIRT2101142	hsa-miR-4713-5p	CLIP-seq
MIRT2101143	hsa-miR-512-3p	CLIP-seq
MIRT2101144	hsa-miR-532-3p	CLIP-seq
MIRT2101145	hsa-miR-620	CLIP-seq
MIRT2325552	hsa-miR-4738-5p	CLIP-seq
MIRT2325553	hsa-miR-483-3p	CLIP-seq
MIRT2325554	hsa-miR-508-5p	CLIP-seq
MIRT2325555	hsa-miR-766	CLIP-seq
MIRT739912	hsa-miR-1226	CLIP-seq
MIRT739908	hsa-miR-1266	CLIP-seq
MIRT739903	hsa-miR-1289	CLIP-seq
MIRT2621214	hsa-miR-138	CLIP-seq
MIRT2101132	hsa-miR-150	CLIP-seq
MIRT2101134	hsa-miR-1825	CLIP-seq
MIRT2621215	hsa-miR-3663-5p	CLIP-seq
MIRT739907	hsa-miR-3664-3p	CLIP-seq
MIRT1341579	hsa-miR-370	CLIP-seq
MIRT1341580	hsa-miR-371-5p	CLIP-seq
MIRT1341581	hsa-miR-371b-5p	CLIP-seq
MIRT1341582	hsa-miR-4263	CLIP-seq
MIRT739910	hsa-miR-4277	CLIP-seq
MIRT2621216	hsa-miR-4290	CLIP-seq
MIRT739904	hsa-miR-4433	CLIP-seq
MIRT739906	hsa-miR-4459	CLIP-seq
MIRT739909	hsa-miR-4518	CLIP-seq
MIRT2101139	hsa-miR-4521	CLIP-seq
MIRT2101142	hsa-miR-4713-5p	CLIP-seq
MIRT2325552	hsa-miR-4738-5p	CLIP-seq
MIRT739905	hsa-miR-4768-3p	CLIP-seq
MIRT2325553	hsa-miR-483-3p	CLIP-seq
MIRT2325554	hsa-miR-508-5p	CLIP-seq
MIRT2101143	hsa-miR-512-3p	CLIP-seq
MIRT1341585	hsa-miR-513c	CLIP-seq
MIRT1341586	hsa-miR-514b-5p	CLIP-seq
MIRT2101144	hsa-miR-532-3p	CLIP-seq
MIRT2621217	hsa-miR-605	CLIP-seq
MIRT739911	hsa-miR-634	CLIP-seq
MIRT2325555	hsa-miR-766	CLIP-seq
MIRT2621218	hsa-miR-942	CLIP-seq
MIRT739912	hsa-miR-1226	CLIP-seq
MIRT739908	hsa-miR-1266	CLIP-seq
MIRT739903	hsa-miR-1289	CLIP-seq
MIRT2621214	hsa-miR-138	CLIP-seq
MIRT2101132	hsa-miR-150	CLIP-seq
MIRT2101134	hsa-miR-1825	CLIP-seq
MIRT2101135	hsa-miR-185	CLIP-seq
MIRT2690542	hsa-miR-3182	CLIP-seq
MIRT2690543	hsa-miR-3197	CLIP-seq
MIRT2621215	hsa-miR-3663-5p	CLIP-seq
MIRT739907	hsa-miR-3664-3p	CLIP-seq
MIRT2690544	hsa-miR-3686	CLIP-seq
MIRT1341579	hsa-miR-370	CLIP-seq
MIRT1553624	hsa-miR-3714	CLIP-seq
MIRT1341580	hsa-miR-371-5p	CLIP-seq
MIRT1341581	hsa-miR-371b-5p	CLIP-seq
MIRT2690545	hsa-miR-3937	CLIP-seq
MIRT1341582	hsa-miR-4263	CLIP-seq
MIRT739910	hsa-miR-4277	CLIP-seq
MIRT2621216	hsa-miR-4290	CLIP-seq
MIRT2101137	hsa-miR-4306	CLIP-seq
MIRT739904	hsa-miR-4433	CLIP-seq
MIRT739906	hsa-miR-4459	CLIP-seq
MIRT1553625	hsa-miR-4493	CLIP-seq
MIRT739909	hsa-miR-4518	CLIP-seq
MIRT2101139	hsa-miR-4521	CLIP-seq
MIRT2101141	hsa-miR-4644	CLIP-seq
MIRT2690546	hsa-miR-4707-5p	CLIP-seq
MIRT2101142	hsa-miR-4713-5p	CLIP-seq
MIRT2690547	hsa-miR-4722-5p	CLIP-seq
MIRT1553626	hsa-miR-4736	CLIP-seq
MIRT2325552	hsa-miR-4738-5p	CLIP-seq
MIRT739905	hsa-miR-4768-3p	CLIP-seq
MIRT2325553	hsa-miR-483-3p	CLIP-seq
MIRT2325554	hsa-miR-508-5p	CLIP-seq
MIRT2101143	hsa-miR-512-3p	CLIP-seq
MIRT1341585	hsa-miR-513c	CLIP-seq
MIRT1341586	hsa-miR-514b-5p	CLIP-seq
MIRT2101144	hsa-miR-532-3p	CLIP-seq
MIRT2621217	hsa-miR-605	CLIP-seq
MIRT739911	hsa-miR-634	CLIP-seq
MIRT2325555	hsa-miR-766	CLIP-seq
MIRT1553627	hsa-miR-940	CLIP-seq
MIRT2621218	hsa-miR-942	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000124	Component	SAGA complex	NAS	19114550
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	27720643, 28781166, 29360106, 32494006, 34822310, 36797247
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	31744343
GO:0003723	Function	RNA binding	IDA	27720643
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17332742, 27720643, 32296183, 35271311
GO:0005634	Component	Nucleus	IDA	27720643, 28541300, 28781166, 29360106
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	31744343
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	NAS	31744343
GO:0005684	Component	U2-type spliceosomal complex	IDA	32494006, 34822310, 36797247
GO:0005684	Component	U2-type spliceosomal complex	IPI	27720643
GO:0005686	Component	U2 snRNP	IBA
GO:0005686	Component	U2 snRNP	NAS	31744343
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0006282	Process	Regulation of DNA repair	NAS	11564863
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0043484	Process	Regulation of RNA splicing	NAS	11564863
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	18206972
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166, 29360106
GO:0071011	Component	Precatalytic spliceosome	IBA
GO:1903241	Process	U2-type prespliceosome assembly	NAS	31744343
GO:1990935	Function	Splicing factor binding	IDA	27720643, 28541300

MIM	HGNC	e!Ensembl
617847	21083	ENSG00000169976

Q9BWJ5

Protein name

Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)

Protein function

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP c

PDB

5IFE , 5O9Z , 5Z56 , 5Z57 , 5Z58 , 5ZYA , 6AH0 , 6EN4 , 6FF4 , 6FF7 , 6QX9 , 6Y50 , 6Y5Q , 7ABG , 7ABH , 7ABI , 7B0I , 7B91 , 7B92 , 7B9C , 7DVQ , 7EVN , 7EVO , 7KTS , 7OMF , 7ONB , 7OPI , 7Q3L , 7Q4O , 7Q4P , 7QTT , 7VPX , 8CH6 , 8H6E , 8H6J , 8H6K , 8H6L , 8H7G , 8HK1 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8QO9 , 8QXD , 8QZS , 8R08 , 8R09 , 8R0A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07189	SF3b10	3 → 80	Splicing factor 3B subunit 10 (SF3b10)	Family

Sequence

MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENES
KARVRFNLMEKMLQPCGPPADKPEEN

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LEPROSY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

SF3B5 (splicing factor 3b subunit 5)