Gene Gene information from NCBI Gene database.
Entrez ID 83442
Gene name SH3 domain binding glutamate rich protein like 3
Gene symbol SH3BGRL3
Synonyms (NCBI Gene)
HEL-S-297SH3BP-1TIP-B1
Chromosome 1
Chromosome location 1p36.11
miRNA miRNA information provided by mirtarbase database.
335
miRTarBase ID miRNA Experiments Reference
MIRT001334 hsa-miR-1-3p pSILAC 18668040
MIRT001334 hsa-miR-1-3p Proteomics;Other 18668040
MIRT025471 hsa-miR-34a-5p Proteomics 21566225
MIRT1344467 hsa-miR-1182 CLIP-seq
MIRT1344468 hsa-miR-122 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IDA 11137621
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615679 15568 ENSG00000142669
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H299
Protein name SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1)
Protein function Could act as a modulator of glutaredoxin biological activity (Probable). May play a role in cytoskeleton organization (PubMed:34380438).
PDB 1SJ6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04908 SH3BGR 2 93 SH3-binding, glutamic acid-rich protein Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous (PubMed:11404387, PubMed:11444877). Expressed in heart, kidney and liver (at protein level) (PubMed:11404387). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11404387). {ECO:0000269|PubMed:11404387, ECO:0000269
Sequence
Sequence length 93
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 28404947
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus Pubtator 33491460 Associate
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 26286913
★☆☆☆☆
Found in Text Mining only
Carcinoma of bladder Bladder carcinoma BEFREE 26286913
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma BEFREE 31562290
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 17233837 Stimulate
★☆☆☆☆
Found in Text Mining only
Leukemia Promyelocytic Acute Promyelocytic leukemia Pubtator 15907482 Associate
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 26933917
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus, Systemic Lupus Erythematosus BEFREE 16143398
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of urinary bladder Urinary bladder cancer BEFREE 26286913
★☆☆☆☆
Found in Text Mining only