Gene Gene information from NCBI Gene database.
Entrez ID 832
Gene name Capping actin protein of muscle Z-line subunit beta
Gene symbol CAPZB
Synonyms (NCBI Gene)
CAPBCAPPBCAPZ
Chromosome 1
Chromosome location 1p36.13
Summary This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast g
miRNA miRNA information provided by mirtarbase database.
222
miRTarBase ID miRNA Experiments Reference
MIRT020263 hsa-miR-130b-3p Sequencing 20371350
MIRT025479 hsa-miR-34a-5p Proteomics 21566225
MIRT042833 hsa-miR-324-3p CLASH 23622248
MIRT041682 hsa-miR-484 CLASH 23622248
MIRT035771 hsa-miR-1915-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IDA 28493397
GO:0003779 Function Actin binding IEA
GO:0003779 Function Actin binding TAS 7665558
GO:0005515 Function Protein binding IPI 26618866, 28493397, 29924966, 30021884, 30361697, 33961781, 35156780, 35271311, 36012204
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601572 1491 ENSG00000077549
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P47756
Protein name F-actin-capping protein subunit beta (CapZ beta)
Protein function F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these pr
PDB 8F8Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01115 F_actin_cap_B 6 240 F-actin capping protein, beta subunit Family
Sequence
Sequence length 277
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
Motor proteins
Cytoskeleton in muscle cells
  MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome CTD_human_DG 21751358
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma CTD_human_DG 16316942
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 22493691
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune disease Pubtator 22493691 Associate
★☆☆☆☆
Found in Text Mining only
Behcet Syndrome Behcet disease Pubtator 31223615 Associate
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 11536309
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma CTD_human_DG 16316942
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 39209986 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma, Spindle-Cell Carcinoma CTD_human_DG 16316942
★☆☆☆☆
Found in Text Mining only
Hypothyroidism Hypothyroidism BEFREE 22493691
★★☆☆☆
Found in Text Mining + Unknown/Other Associations