CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 830 |
| Gene name | Capping actin protein of muscle Z-line subunit alpha 2 |
| Gene symbol | CAPZA2 |
| Synonyms (NCBI Gene) |
CAPPA2CAPZ
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| Chromosome | 7 |
| Chromosome location | 7q31.2 |
| Summary | The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin |
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miRNA
miRNA information provided by mirtarbase database.
705
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P47755 | ||||||||||
| Protein name | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | ||||||||||
| Protein function | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these pr | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 286 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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