Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	824
Gene name	Calpain 2
Gene symbol	CAPN2
Synonyms (NCBI Gene)	CANP2CANPL2CANPmlmCANP
Chromosome	1
Chromosome location	1q41
Summary	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025966	hsa-miR-7-5p	Sequencing	20371350
MIRT027353	hsa-miR-101-3p	Sequencing	20371350
MIRT028659	hsa-miR-30a-5p	Proteomics	18668040
MIRT736216	hsa-miR-147a	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCR	33731671
MIRT861925	hsa-miR-1253	CLIP-seq
MIRT861926	hsa-miR-1264	CLIP-seq
MIRT861927	hsa-miR-1283	CLIP-seq
MIRT861928	hsa-miR-1304	CLIP-seq
MIRT861929	hsa-miR-140-5p	CLIP-seq
MIRT861930	hsa-miR-142-5p	CLIP-seq
MIRT861931	hsa-miR-1468	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861933	hsa-miR-2052	CLIP-seq
MIRT861934	hsa-miR-21	CLIP-seq
MIRT861935	hsa-miR-2355-3p	CLIP-seq
MIRT861936	hsa-miR-3117-5p	CLIP-seq
MIRT861937	hsa-miR-3121-5p	CLIP-seq
MIRT861938	hsa-miR-3189-3p	CLIP-seq
MIRT861939	hsa-miR-323-5p	CLIP-seq
MIRT861940	hsa-miR-3545-5p	CLIP-seq
MIRT861941	hsa-miR-3688-5p	CLIP-seq
MIRT861942	hsa-miR-4269	CLIP-seq
MIRT861943	hsa-miR-4421	CLIP-seq
MIRT861944	hsa-miR-4460	CLIP-seq
MIRT861945	hsa-miR-4470	CLIP-seq
MIRT861946	hsa-miR-4514	CLIP-seq
MIRT861947	hsa-miR-4528	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT861949	hsa-miR-4646-3p	CLIP-seq
MIRT861950	hsa-miR-4670-3p	CLIP-seq
MIRT861951	hsa-miR-4692	CLIP-seq
MIRT861952	hsa-miR-4704-5p	CLIP-seq
MIRT861953	hsa-miR-4711-3p	CLIP-seq
MIRT861954	hsa-miR-4742-5p	CLIP-seq
MIRT861955	hsa-miR-4761-5p	CLIP-seq
MIRT861956	hsa-miR-4775	CLIP-seq
MIRT861957	hsa-miR-487a	CLIP-seq
MIRT861958	hsa-miR-511	CLIP-seq
MIRT861959	hsa-miR-561	CLIP-seq
MIRT861960	hsa-miR-587	CLIP-seq
MIRT861961	hsa-miR-590-3p	CLIP-seq
MIRT861962	hsa-miR-590-5p	CLIP-seq
MIRT861963	hsa-miR-593	CLIP-seq
MIRT861964	hsa-miR-647	CLIP-seq
MIRT861965	hsa-miR-649	CLIP-seq
MIRT861966	hsa-miR-676	CLIP-seq
MIRT861967	hsa-miR-876-3p	CLIP-seq
MIRT861925	hsa-miR-1253	CLIP-seq
MIRT861926	hsa-miR-1264	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861938	hsa-miR-3189-3p	CLIP-seq
MIRT2193370	hsa-miR-3688-3p	CLIP-seq
MIRT861942	hsa-miR-4269	CLIP-seq
MIRT861946	hsa-miR-4514	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT861951	hsa-miR-4692	CLIP-seq
MIRT861954	hsa-miR-4742-5p	CLIP-seq
MIRT2193371	hsa-miR-520d-5p	CLIP-seq
MIRT2193372	hsa-miR-520g	CLIP-seq
MIRT2193373	hsa-miR-520h	CLIP-seq
MIRT2193374	hsa-miR-524-5p	CLIP-seq
MIRT861960	hsa-miR-587	CLIP-seq
MIRT861964	hsa-miR-647	CLIP-seq
MIRT2193375	hsa-miR-671-5p	CLIP-seq
MIRT2427014	hsa-miR-1200	CLIP-seq
MIRT2427015	hsa-miR-1207-3p	CLIP-seq
MIRT2427016	hsa-miR-137	CLIP-seq
MIRT2427017	hsa-miR-192	CLIP-seq
MIRT2427018	hsa-miR-215	CLIP-seq
MIRT2427019	hsa-miR-3074-5p	CLIP-seq
MIRT2427020	hsa-miR-3160-5p	CLIP-seq
MIRT2427021	hsa-miR-320a	CLIP-seq
MIRT2427022	hsa-miR-320b	CLIP-seq
MIRT2427023	hsa-miR-320c	CLIP-seq
MIRT2427024	hsa-miR-320d	CLIP-seq
MIRT2427025	hsa-miR-33a	CLIP-seq
MIRT2427026	hsa-miR-33b	CLIP-seq
MIRT2427027	hsa-miR-4429	CLIP-seq
MIRT2427028	hsa-miR-579	CLIP-seq
MIRT2427029	hsa-miR-875-5p	CLIP-seq
MIRT2427030	hsa-miR-889	CLIP-seq
MIRT2496430	hsa-miR-1254	CLIP-seq
MIRT2496431	hsa-miR-1269	CLIP-seq
MIRT2496432	hsa-miR-1269b	CLIP-seq
MIRT2496433	hsa-miR-1271	CLIP-seq
MIRT2496434	hsa-miR-1288	CLIP-seq
MIRT861928	hsa-miR-1304	CLIP-seq
MIRT861929	hsa-miR-140-5p	CLIP-seq
MIRT861930	hsa-miR-142-5p	CLIP-seq
MIRT2496435	hsa-miR-144	CLIP-seq
MIRT861931	hsa-miR-1468	CLIP-seq
MIRT2496436	hsa-miR-182	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861933	hsa-miR-2052	CLIP-seq
MIRT861934	hsa-miR-21	CLIP-seq
MIRT861935	hsa-miR-2355-3p	CLIP-seq
MIRT2496437	hsa-miR-24	CLIP-seq
MIRT2496438	hsa-miR-299-5p	CLIP-seq
MIRT2496439	hsa-miR-3116	CLIP-seq
MIRT861936	hsa-miR-3117-5p	CLIP-seq
MIRT2496440	hsa-miR-3153	CLIP-seq
MIRT861939	hsa-miR-323-5p	CLIP-seq
MIRT2496441	hsa-miR-3529	CLIP-seq
MIRT861940	hsa-miR-3545-5p	CLIP-seq
MIRT2496442	hsa-miR-3682-5p	CLIP-seq
MIRT2193370	hsa-miR-3688-3p	CLIP-seq
MIRT861941	hsa-miR-3688-5p	CLIP-seq
MIRT2496443	hsa-miR-379	CLIP-seq
MIRT2496444	hsa-miR-421	CLIP-seq
MIRT2496445	hsa-miR-4284	CLIP-seq
MIRT2496446	hsa-miR-432	CLIP-seq
MIRT2496447	hsa-miR-433	CLIP-seq
MIRT2496448	hsa-miR-4451	CLIP-seq
MIRT861944	hsa-miR-4460	CLIP-seq
MIRT861945	hsa-miR-4470	CLIP-seq
MIRT2496449	hsa-miR-4515	CLIP-seq
MIRT861947	hsa-miR-4528	CLIP-seq
MIRT2496450	hsa-miR-4529-3p	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT2496451	hsa-miR-4642	CLIP-seq
MIRT2496452	hsa-miR-4645-3p	CLIP-seq
MIRT861949	hsa-miR-4646-3p	CLIP-seq
MIRT2496453	hsa-miR-4650-3p	CLIP-seq
MIRT2496454	hsa-miR-4668-5p	CLIP-seq
MIRT861950	hsa-miR-4670-3p	CLIP-seq
MIRT861952	hsa-miR-4704-5p	CLIP-seq
MIRT2496455	hsa-miR-4709-5p	CLIP-seq
MIRT2496456	hsa-miR-4715-5p	CLIP-seq
MIRT2496457	hsa-miR-4716-5p	CLIP-seq
MIRT2496458	hsa-miR-4740-5p	CLIP-seq
MIRT861956	hsa-miR-4775	CLIP-seq
MIRT861957	hsa-miR-487a	CLIP-seq
MIRT2193371	hsa-miR-520d-5p	CLIP-seq
MIRT2193372	hsa-miR-520g	CLIP-seq
MIRT2193373	hsa-miR-520h	CLIP-seq
MIRT2496459	hsa-miR-522	CLIP-seq
MIRT2193374	hsa-miR-524-5p	CLIP-seq
MIRT861959	hsa-miR-561	CLIP-seq
MIRT861961	hsa-miR-590-3p	CLIP-seq
MIRT861962	hsa-miR-590-5p	CLIP-seq
MIRT2496460	hsa-miR-661	CLIP-seq
MIRT2193375	hsa-miR-671-5p	CLIP-seq
MIRT861966	hsa-miR-676	CLIP-seq
MIRT861967	hsa-miR-876-3p	CLIP-seq
MIRT2496461	hsa-miR-96	CLIP-seq
MIRT2496430	hsa-miR-1254	CLIP-seq
MIRT2496431	hsa-miR-1269	CLIP-seq
MIRT2496432	hsa-miR-1269b	CLIP-seq
MIRT2496433	hsa-miR-1271	CLIP-seq
MIRT2496434	hsa-miR-1288	CLIP-seq
MIRT861928	hsa-miR-1304	CLIP-seq
MIRT861929	hsa-miR-140-5p	CLIP-seq
MIRT861930	hsa-miR-142-5p	CLIP-seq
MIRT2496435	hsa-miR-144	CLIP-seq
MIRT861931	hsa-miR-1468	CLIP-seq
MIRT2496436	hsa-miR-182	CLIP-seq
MIRT861932	hsa-miR-198	CLIP-seq
MIRT861933	hsa-miR-2052	CLIP-seq
MIRT861934	hsa-miR-21	CLIP-seq
MIRT861935	hsa-miR-2355-3p	CLIP-seq
MIRT2496437	hsa-miR-24	CLIP-seq
MIRT2496438	hsa-miR-299-5p	CLIP-seq
MIRT2496439	hsa-miR-3116	CLIP-seq
MIRT861936	hsa-miR-3117-5p	CLIP-seq
MIRT2496440	hsa-miR-3153	CLIP-seq
MIRT861938	hsa-miR-3189-3p	CLIP-seq
MIRT861939	hsa-miR-323-5p	CLIP-seq
MIRT2496441	hsa-miR-3529	CLIP-seq
MIRT861940	hsa-miR-3545-5p	CLIP-seq
MIRT2496442	hsa-miR-3682-5p	CLIP-seq
MIRT2193370	hsa-miR-3688-3p	CLIP-seq
MIRT861941	hsa-miR-3688-5p	CLIP-seq
MIRT2496443	hsa-miR-379	CLIP-seq
MIRT2496444	hsa-miR-421	CLIP-seq
MIRT2496445	hsa-miR-4284	CLIP-seq
MIRT2496446	hsa-miR-432	CLIP-seq
MIRT2496447	hsa-miR-433	CLIP-seq
MIRT2496448	hsa-miR-4451	CLIP-seq
MIRT861944	hsa-miR-4460	CLIP-seq
MIRT861945	hsa-miR-4470	CLIP-seq
MIRT2496449	hsa-miR-4515	CLIP-seq
MIRT861947	hsa-miR-4528	CLIP-seq
MIRT2496450	hsa-miR-4529-3p	CLIP-seq
MIRT861948	hsa-miR-4540	CLIP-seq
MIRT2496451	hsa-miR-4642	CLIP-seq
MIRT2496452	hsa-miR-4645-3p	CLIP-seq
MIRT861949	hsa-miR-4646-3p	CLIP-seq
MIRT2496453	hsa-miR-4650-3p	CLIP-seq
MIRT2496454	hsa-miR-4668-5p	CLIP-seq
MIRT861950	hsa-miR-4670-3p	CLIP-seq
MIRT861952	hsa-miR-4704-5p	CLIP-seq
MIRT2496455	hsa-miR-4709-5p	CLIP-seq
MIRT2496456	hsa-miR-4715-5p	CLIP-seq
MIRT2496457	hsa-miR-4716-5p	CLIP-seq
MIRT2496458	hsa-miR-4740-5p	CLIP-seq
MIRT861956	hsa-miR-4775	CLIP-seq
MIRT861957	hsa-miR-487a	CLIP-seq
MIRT2193371	hsa-miR-520d-5p	CLIP-seq
MIRT2193372	hsa-miR-520g	CLIP-seq
MIRT2193373	hsa-miR-520h	CLIP-seq
MIRT2496459	hsa-miR-522	CLIP-seq
MIRT2193374	hsa-miR-524-5p	CLIP-seq
MIRT861959	hsa-miR-561	CLIP-seq
MIRT861961	hsa-miR-590-3p	CLIP-seq
MIRT861962	hsa-miR-590-5p	CLIP-seq
MIRT861964	hsa-miR-647	CLIP-seq
MIRT2496460	hsa-miR-661	CLIP-seq
MIRT2193375	hsa-miR-671-5p	CLIP-seq
MIRT861966	hsa-miR-676	CLIP-seq
MIRT861967	hsa-miR-876-3p	CLIP-seq
MIRT2496461	hsa-miR-96	CLIP-seq

Show/Hide all (75)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0001824	Process	Blastocyst development	IEA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IDA	12150984
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IEA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IEA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	ISS
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	TAS
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	10639123, 18519038, 24705354, 28319173, 31911079, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005764	Component	Lysosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	14559243
GO:0005794	Component	Golgi apparatus	IDA	14559243
GO:0005829	Component	Cytosol	IDA	12150984, 14559243
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	12150984
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IEA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	ISS
GO:0006508	Process	Proteolysis	NAS	28319173
GO:0007520	Process	Myoblast fusion	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0008092	Function	Cytoskeletal protein binding	NAS	12150984
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	TAS	2209092
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016540	Process	Protein autoprocessing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019899	Function	Enzyme binding	IEA
GO:0030163	Process	Protein catabolic process	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0030864	Component	Cortical actin cytoskeleton	TAS	12150984
GO:0031143	Component	Pseudopodium	IDA	14559243
GO:0032675	Process	Regulation of interleukin-6 production	IEA
GO:0035458	Process	Cellular response to interferon-beta	IEA
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IDA	12150984
GO:0045121	Component	Membrane raft	IDA	14559243
GO:0046872	Function	Metal ion binding	IEA
GO:0048266	Process	Behavioral response to pain	IEA
GO:0048488	Process	Synaptic vesicle endocytosis	IEA
GO:0051493	Process	Regulation of cytoskeleton organization	TAS	12150984
GO:0051603	Process	Proteolysis involved in protein catabolic process	IDA	12150984
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071230	Process	Cellular response to amino acid stimulus	IEA
GO:0071230	Process	Cellular response to amino acid stimulus	ISS
GO:0097038	Component	Perinuclear endoplasmic reticulum	IDA	14559243
GO:0097700	Process	Vascular endothelial cell response to laminar fluid shear stress	TAS
GO:0097706	Process	Vascular endothelial cell response to oscillatory fluid shear stress	TAS
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA
GO:0110158	Component	Calpain complex	IPI	10639123
GO:0140249	Process	Protein catabolic process at postsynapse	IEA
GO:1901741	Process	Positive regulation of myoblast fusion	IEA
GO:2001247	Process	Positive regulation of phosphatidylcholine biosynthetic process	IEA

MIM	HGNC	e!Ensembl
114230	1479	ENSG00000162909

P17655

Protein name

Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)

Protein function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CP

PDB

1KFU , 1KFX , 2NQA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00648	Peptidase_C2	46 → 342	Calpain family cysteine protease	Family
PF01067	Calpain_III	363 → 502	Calpain large subunit, domain III	Domain
PF13833	EF-hand_8	544 → 603	EF-hand domain pair	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF
KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI
LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC
SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN
CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR
KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG
EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL
WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD
NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL

Sequence length

700

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum Apoptosis Necroptosis Cellular senescence Focal adhesion Alzheimer disease Pathways of neurodegeneration - multiple diseases Shigellosis		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COGNITION DISORDERS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DELIRIUM, DEMENTIA, AMNESTIC, COGNITIVE DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOPLASTIC LEFT HEART SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA, MYELOID, ACUTE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (79)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Myeloid Leukemia (AML-M2)	Leukemia	CTD_human_DG	17330099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Myeloid Leukemia, M1	Myeloid Leukemia	CTD_human_DG	17330099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	27487486		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	35355568	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	9562261		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	9562261		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm	Aortic aneurysm	Pubtator	19720936	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	Pubtator	15501405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	15501405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	27123462		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Ischemia	Brain ischemia	Pubtator	16524385	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18332219, 29848352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18332219, 22745213, 25539577, 27323818	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	29228653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	21829505, 22745213	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36328501	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Small Cell	Small cell carcinoma	Pubtator	27456359	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Basal Cell	Carcinoma	BEFREE	12635142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	22435971		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	29848352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	BEFREE	9196396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	11516996		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	26076056		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26076056, 29210197, 29507677		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	29228653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	31029038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	27123462, 30778623		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	27123462, 30778623		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	30598071	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	17151322, 30598071		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	27077802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	31680308		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	20730561, 22183788		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20730561	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	20730561, 22183788		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Heart valve disease	Cardiac valvular disease	BEFREE	27123462		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	26358320	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	39351249	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	26248159, 28235949, 30817168		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral disc disease	Pubtator	21839844	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	27456359	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	26358320	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	CTD_human_DG	17330099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	15471877, 16982626, 19568240	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	31029038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18332219, 29848352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	22435971, 30448882		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	12907643, 29601651, 31243108		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28927135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26076056, 28112201, 30279968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	16322214		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	18332219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Marfan Syndrome	Marfan syndrome	Pubtator	19720936	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	31029038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Duchenne	Duchenne Muscular Dystrophy	LHGDN	16598790		★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Duchenne	Duchenne Muscular Dystrophy	BEFREE	16815350, 8088891		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopathy	Myopathy	BEFREE	8088891		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16652152, 22435971, 26076056, 29210197, 30662353		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	11516996		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	LHGDN	12070670		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30106446, 30662353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	17151322		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	22435971		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	22435971, 30448882, 30737623, 35370009	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	23140395, 39351249	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	23875735	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pelizaeus-Merzbacher Disease	Pelizaeus-Merzbacher disease	BEFREE	9562261		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	12907643, 29601651, 31243108		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	12393869, 24297527, 28280729, 31243108	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	26248159		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	29228653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Salaam Seizures	Salaam Seizures	BEFREE	31495081		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	12635142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28927135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32951272	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tauopathies	Tauopathies	BEFREE	12127682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	30266074		★★★★★ ★☆☆☆☆ Found in Text Mining only
Wolfram Syndrome	Wolfram Syndrome	BEFREE	25422446		★★★★★ ★☆☆☆☆ Found in Text Mining only
WOLFRAM SYNDROME 2	Wolfram Syndrome	BEFREE	25422446		★★★★★ ★☆☆☆☆ Found in Text Mining only

CAPN2 (calpain 2)