Gene Gene information from NCBI Gene database.
Entrez ID 819
Gene name Calcium modulating ligand
Gene symbol CAMLG
Synonyms (NCBI Gene)
CAMLCDG2ZGET2
Chromosome 5
Chromosome location 5q31.1
Summary The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin
miRNA miRNA information provided by mirtarbase database.
375
miRTarBase ID miRNA Experiments Reference
MIRT041724 hsa-miR-484 CLASH 23622248
MIRT039963 hsa-miR-615-3p CLASH 23622248
MIRT690276 hsa-miR-890 HITS-CLIP 23313552
MIRT690275 hsa-miR-6808-5p HITS-CLIP 23313552
MIRT690274 hsa-miR-6893-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0001782 Process B cell homeostasis IEA
GO:0001782 Process B cell homeostasis ISS
GO:0001881 Process Receptor recycling IEA
GO:0005515 Function Protein binding IPI 15451437, 16243292, 22046132, 24658140, 25416956, 28514442, 31417168, 31980649, 32187542, 32296183, 33961781
GO:0005737 Component Cytoplasm IDA 20553626
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601118 1471 ENSG00000164615
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P49069
Protein name Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand)
Protein function Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recog
PDB 6SO5 , 8CR1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14963 CAML 23 292 Calcium signal-modulating cyclophilin ligand Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Highest levels in brain, testis and ovary.
Sequence
Sequence length 296
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Congenital disorder of glycosylation, type IIz no classifications from unflagged records ClinVar
ClinGen, ClinVar, Disgenet, GenCC, HPO
ClinGen, ClinVar, Disgenet, GenCC, HPO
ClinGen, ClinVar, Disgenet, GenCC, HPO
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acquired Hypogammaglobulinemia Common Variable Immunodeficiency BEFREE 17983875
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 19804625 Associate
★☆☆☆☆
Found in Text Mining only
Brain Diseases Brain disease Pubtator 35262690 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 21128111
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 35806301 Associate
★☆☆☆☆
Found in Text Mining only
Common Variable Immunodeficiency Common Variable Immunodeficiency BEFREE 17983875
★☆☆☆☆
Found in Text Mining only
Congenital disorder of glycosylation type II Congenital disorder of glycosylation Pubtator 35262690 Associate
★☆☆☆☆
Found in Text Mining only
Congenital Disorders of Glycosylation Congenital disorder of glycosylation Pubtator 35262690 Associate
★☆☆☆☆
Found in Text Mining only
Coronary Restenosis Coronary restenosis Pubtator 37468836 Associate
★☆☆☆☆
Found in Text Mining only
Epilepsy Epilepsy Pubtator 35262690 Associate
★☆☆☆☆
Found in Text Mining only