KRTAP4-6 (keratin associated protein 4-6)

Gene

• Entrez ID: 81871
• Gene name: Keratin associated protein 4-6
• Gene symbol: KRTAP4-6
• Synonyms (NCBI Gene): KAP4.15, KAP4.6, KRTAP4-15, KRTAP4.15
• Chromosome: 17
• Chromosome location: 17q21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018064	hsa-miR-335-5p	Microarray	18185580
MIRT2027769	hsa-miR-15a	CLIP-seq
MIRT2027770	hsa-miR-15b	CLIP-seq
MIRT2027771	hsa-miR-16	CLIP-seq
MIRT2027772	hsa-miR-195	CLIP-seq
MIRT2027773	hsa-miR-3200-5p	CLIP-seq
MIRT2027774	hsa-miR-424	CLIP-seq
MIRT2027775	hsa-miR-4251	CLIP-seq
MIRT2027776	hsa-miR-4261	CLIP-seq
MIRT2027777	hsa-miR-4329	CLIP-seq
MIRT2027778	hsa-miR-4693-3p	CLIP-seq
MIRT2027779	hsa-miR-4757-5p	CLIP-seq
MIRT2027780	hsa-miR-4762-5p	CLIP-seq
MIRT2027781	hsa-miR-497	CLIP-seq
MIRT2027782	hsa-miR-541	CLIP-seq
MIRT2027783	hsa-miR-545	CLIP-seq
MIRT2027784	hsa-miR-548p	CLIP-seq
MIRT2027785	hsa-miR-654-5p	CLIP-seq
MIRT2027776	hsa-miR-4261	CLIP-seq
MIRT2027779	hsa-miR-4757-5p	CLIP-seq
MIRT2027782	hsa-miR-541	CLIP-seq
MIRT2027785	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0045095	Component	Keratin filament	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BYQ5
• Protein name: Keratin-associated protein 4-6 (Keratin-associated protein 4-15) (Keratin-associated protein 4.15) (Keratin-associated protein 4.6) (Ultrahigh sulfur keratin-associated protein 4.15)
• Protein function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their e
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13885	Keratin_B2_2	1 → 33	Keratin, high sulfur B2 protein	Family
  PF13885	Keratin_B2_2	15 → 59	Keratin, high sulfur B2 protein	Family
  PF13885	Keratin_B2_2	30 → 68	Keratin, high sulfur B2 protein	Family
  PF13885	Keratin_B2_2	60 → 103	Keratin, high sulfur B2 protein	Family
  PF13885	Keratin_B2_2	92 → 143	Keratin, high sulfur B2 protein	Family
  PF13885	Keratin_B2_2	124 → 178	Keratin, high sulfur B2 protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the hair follicles. {ECO:0000269|PubMed:15955084}.
• Sequence:

  MVSSCCGSVCSDQGCGLETCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTC
  CRPSCCPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCRPSCSISSCCRPSCC
  VSRCCRSQCCQSVCCQPTCCRPSCCISSCCRPSCCESSCCRPCCCRPCCCLRPVCGRVSC
  HTTCYRPTCVISTCPRPLCCASSCC

• Sequence length: 205

Pathways

Reactome:

Keratinization

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC FATIGUE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations