Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	81847
Gene name	Ring finger protein 146
Gene symbol	RNF146
Synonyms (NCBI Gene)	-
Chromosome	6
Chromosome location	6q22.33

115

Show/Hide all (115)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051033	hsa-miR-17-5p	CLASH	23622248
MIRT712224	hsa-miR-9-5p	HITS-CLIP	19536157
MIRT712223	hsa-miR-5690	HITS-CLIP	19536157
MIRT712222	hsa-miR-4267	HITS-CLIP	19536157
MIRT712221	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT712220	hsa-miR-1248	HITS-CLIP	19536157
MIRT712219	hsa-miR-4287	HITS-CLIP	19536157
MIRT712218	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT712217	hsa-miR-6844	HITS-CLIP	19536157
MIRT554719	hsa-miR-18a-5p	PAR-CLIP	21572407
MIRT554718	hsa-miR-18b-5p	PAR-CLIP	21572407
MIRT554717	hsa-miR-4735-3p	PAR-CLIP	21572407
MIRT167732	hsa-miR-3133	PAR-CLIP	21572407
MIRT554716	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT554715	hsa-miR-4700-3p	PAR-CLIP	21572407
MIRT554714	hsa-miR-4773	PAR-CLIP	21572407
MIRT554713	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT554711	hsa-miR-4270	PAR-CLIP	21572407
MIRT554712	hsa-miR-4441	PAR-CLIP	21572407
MIRT554710	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT554709	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT554708	hsa-miR-92b-5p	PAR-CLIP	21572407
MIRT554707	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT554706	hsa-miR-5687	PAR-CLIP	21572407
MIRT167719	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT167723	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT712224	hsa-miR-9-5p	HITS-CLIP	19536157
MIRT712223	hsa-miR-5690	HITS-CLIP	19536157
MIRT712222	hsa-miR-4267	HITS-CLIP	19536157
MIRT712221	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT712220	hsa-miR-1248	HITS-CLIP	19536157
MIRT712219	hsa-miR-4287	HITS-CLIP	19536157
MIRT712218	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT712217	hsa-miR-6844	HITS-CLIP	19536157
MIRT554719	hsa-miR-18a-5p	PAR-CLIP	21572407
MIRT554718	hsa-miR-18b-5p	PAR-CLIP	21572407
MIRT554717	hsa-miR-4735-3p	PAR-CLIP	21572407
MIRT167732	hsa-miR-3133	PAR-CLIP	21572407
MIRT554716	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT554715	hsa-miR-4700-3p	PAR-CLIP	21572407
MIRT554714	hsa-miR-4773	PAR-CLIP	21572407
MIRT554713	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT554711	hsa-miR-4270	PAR-CLIP	21572407
MIRT554712	hsa-miR-4441	PAR-CLIP	21572407
MIRT554710	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT554709	hsa-miR-16-1-3p	PAR-CLIP	21572407
MIRT554708	hsa-miR-92b-5p	PAR-CLIP	21572407
MIRT554707	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT554706	hsa-miR-5687	PAR-CLIP	21572407
MIRT167732	hsa-miR-3133	Luciferase reporter assayWestern blottingqRT-PCRImmunoprecipitaion (IP)Immunohistochemistry (IHC)Immunofluorescence	37555915
MIRT1310625	hsa-miR-30a	CLIP-seq
MIRT1310626	hsa-miR-30b	CLIP-seq
MIRT1310627	hsa-miR-30c	CLIP-seq
MIRT1310628	hsa-miR-30d	CLIP-seq
MIRT1310629	hsa-miR-30e	CLIP-seq
MIRT1310630	hsa-miR-3613-3p	CLIP-seq
MIRT1310631	hsa-miR-371-5p	CLIP-seq
MIRT1310632	hsa-miR-4432	CLIP-seq
MIRT1310633	hsa-miR-499-5p	CLIP-seq
MIRT1310634	hsa-miR-548a-3p	CLIP-seq
MIRT1310635	hsa-miR-548ac	CLIP-seq
MIRT1310636	hsa-miR-548d-3p	CLIP-seq
MIRT1310637	hsa-miR-548e	CLIP-seq
MIRT1310638	hsa-miR-548f	CLIP-seq
MIRT1310639	hsa-miR-548z	CLIP-seq
MIRT1310640	hsa-miR-1224-5p	CLIP-seq
MIRT1310641	hsa-miR-1245b-3p	CLIP-seq
MIRT1310642	hsa-miR-1286	CLIP-seq
MIRT1310643	hsa-miR-323-3p	CLIP-seq
MIRT1310644	hsa-miR-3619-3p	CLIP-seq
MIRT1310645	hsa-miR-4433	CLIP-seq
MIRT1310646	hsa-miR-4722-5p	CLIP-seq
MIRT1310647	hsa-miR-4751	CLIP-seq
MIRT1310648	hsa-miR-513a-3p	CLIP-seq
MIRT2316858	hsa-miR-1224-3p	CLIP-seq
MIRT1310640	hsa-miR-1224-5p	CLIP-seq
MIRT1310641	hsa-miR-1245b-3p	CLIP-seq
MIRT2316859	hsa-miR-1255a	CLIP-seq
MIRT2316860	hsa-miR-1255b	CLIP-seq
MIRT2316861	hsa-miR-1260	CLIP-seq
MIRT2316862	hsa-miR-1260b	CLIP-seq
MIRT2316863	hsa-miR-1280	CLIP-seq
MIRT1310642	hsa-miR-1286	CLIP-seq
MIRT2316864	hsa-miR-188-3p	CLIP-seq
MIRT2316865	hsa-miR-298	CLIP-seq
MIRT2316866	hsa-miR-299-3p	CLIP-seq
MIRT2316867	hsa-miR-3156-3p	CLIP-seq
MIRT2316868	hsa-miR-3617	CLIP-seq
MIRT1310644	hsa-miR-3619-3p	CLIP-seq
MIRT2316869	hsa-miR-409-3p	CLIP-seq
MIRT2316870	hsa-miR-4265	CLIP-seq
MIRT2316871	hsa-miR-4296	CLIP-seq
MIRT2316872	hsa-miR-4322	CLIP-seq
MIRT2316873	hsa-miR-4417	CLIP-seq
MIRT1310645	hsa-miR-4433	CLIP-seq
MIRT2316874	hsa-miR-4491	CLIP-seq
MIRT2316875	hsa-miR-4633-5p	CLIP-seq
MIRT2316876	hsa-miR-4657	CLIP-seq
MIRT2316877	hsa-miR-4687-3p	CLIP-seq
MIRT2316878	hsa-miR-4698	CLIP-seq
MIRT1310646	hsa-miR-4722-5p	CLIP-seq
MIRT1310647	hsa-miR-4751	CLIP-seq
MIRT2316879	hsa-miR-496	CLIP-seq
MIRT2316880	hsa-miR-5095	CLIP-seq
MIRT2316881	hsa-miR-552	CLIP-seq
MIRT2316882	hsa-miR-579	CLIP-seq
MIRT2316883	hsa-miR-587	CLIP-seq
MIRT2316884	hsa-miR-641	CLIP-seq
MIRT2689824	hsa-miR-362-5p	CLIP-seq
MIRT2689825	hsa-miR-3667-3p	CLIP-seq
MIRT2689826	hsa-miR-500b	CLIP-seq
MIRT2689827	hsa-miR-501-5p	CLIP-seq
MIRT2689828	hsa-miR-627	CLIP-seq
MIRT2689829	hsa-miR-924	CLIP-seq
MIRT2689830	hsa-miR-944	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	21478859
GO:0005515	Function	Protein binding	IPI	21478859, 21799911, 25327252, 25416956, 27107012, 32296183, 32814053, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	15813938
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	21478859
GO:0008270	Function	Zinc ion binding	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	IDA	21478859
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	TAS
GO:0070936	Process	Protein K48-linked ubiquitination	IMP	21478859
GO:0072572	Function	Poly-ADP-D-ribose binding	IBA
GO:0072572	Function	Poly-ADP-D-ribose binding	IDA	21478859
GO:0072572	Function	Poly-ADP-D-ribose binding	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	21478859
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	TAS

MIM	HGNC	e!Ensembl
612137	21336	ENSG00000118518

Q9NTX7

Protein name

E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)

Protein function

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation (PubMed:21478859, PubMed:21799911, PubMed:22267412). May regulate many important biologic

PDB

2D8T , 3V3L , 6CF6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13920	zf-C3HC4_3	34 → 80		Domain
PF02825	WWE	104 → 168	WWE domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.

Sequence

MMAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLC
VKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDER
TSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAG
LRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDAS
TSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSEDVS
AVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRPDGQCTVTEV

Sequence length

359

Interactions

View interactions

	Reactome
			TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (27)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Brain Ischemia	Brain ischemia	Pubtator	28430183	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18326623, 19517271, 19690183, 21791674		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	18326623		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	18326623, 21791674, 22269215, 22768030	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	24454854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	19517271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Cerebral Infarction	BEFREE	28430183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	29290984		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleidocranial Dysplasia	Cleidocranial Dysplasia	BEFREE	28581440		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29932918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	29932918		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	28430183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	24454854	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24454854	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18326623, 19517271, 19690183, 21791674		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	GWASDB_DG	18326623		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	24454854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	19517271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31554794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	GWASDB_DG	20512145		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24454854, 26102504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	15813938		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24454854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteopenia	Osteopenia	BEFREE	28581440		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	19517271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29290984, 30974833		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	33443209	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RNF146 (ring finger protein 146)