Gene Gene information from NCBI Gene database.
Entrez ID 81844
Gene name Tripartite motif containing 56
Gene symbol TRIM56
Synonyms (NCBI Gene)
RNF109
Chromosome 7
Chromosome location 7q22.1
miRNA miRNA information provided by mirtarbase database.
372
miRTarBase ID miRNA Experiments Reference
MIRT611468 hsa-miR-6890-5p HITS-CLIP 23824327
MIRT611467 hsa-miR-1273f HITS-CLIP 23824327
MIRT611468 hsa-miR-6890-5p HITS-CLIP 23824327
MIRT611467 hsa-miR-1273f HITS-CLIP 23824327
MIRT611468 hsa-miR-6890-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0004842 Function Ubiquitin-protein transferase activity TAS
GO:0005515 Function Protein binding IPI 22948160
GO:0005654 Component Nucleoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616996 19028 ENSG00000169871
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BRZ2
Protein name E3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56)
Protein function E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STIN
PDB 5JW7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13445 zf-RING_UBOX 21 57 RING-type zinc-finger Domain
PF00643 zf-B_box 164 205 B-box zinc finger Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed (at protein level). {ECO:0000269|PubMed:21289118}.
Sequence
MVSHGSSPSLLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECR
ETVPVPPEGVASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARC
LDCADDLCQACADGHRCTRQTHTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFL
CQPCSQLLCRECRLDPHLDHPCLPL
AEAVRARRPGLEGLLAGVDNNLVELEAARRVEKEA
LARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAHVEAAEEAARERLAELEGREQ
VARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPAPCLLPQLELHPGLLD
KNCHLLRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPK
EEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRPNKKKKFKGRLKSISREPSPALGP
NLDGSGLLPRPIFYCSFPTRMPGDKRSPRITGLCPFGPREILVADEQNRALKRFSLNGDY
KGTVPVPEGCSPCSVAALQSAVAFSASARLYLINPNGEVQWRRALSLSQASHAVAALPSG
DRVAVSVAGHVEVYNMEGSLATRFIPGGKASRGLRALVFLTTSPQGHFVGSDWQQNSVVI
CDGLGQVVGEYKGPGLHGCQPGSVSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYH
GLEKPRVTTMVDGRYLVVSLSNGTIHIFRVRSPDS
Sequence length 755
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of innate immune responses to cytosolic DNA
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 31000690
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 33577026 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 28771721, 30281912
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 36870986 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 31000690
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of ovary Ovarian cancer BEFREE 28771721, 30281912
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 21685375
★☆☆☆☆
Found in Text Mining only
Mood swings Mood swings BEFREE 30281912
★☆☆☆☆
Found in Text Mining only
Multiple Myeloma Multiple myeloma BEFREE 29214775, 30637864
★☆☆☆☆
Found in Text Mining only
Multiple Myeloma Multiple myeloma Pubtator 29214775 Inhibit
★☆☆☆☆
Found in Text Mining only