Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	81669
Gene name	Cyclin L2
Gene symbol	CCNL2
Synonyms (NCBI Gene)	ANIA-6BCCNMCCNSHCLA-ISOHLA-ISOPCEESB138
Chromosome	1
Chromosome location	1p36.33
Summary	The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process

163

Show/Hide all (163)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030118	hsa-miR-26b-5p	Microarray	19088304
MIRT053433	hsa-miR-512-5p	Microarray	23807165
MIRT527222	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT527221	hsa-miR-4668-3p	PAR-CLIP	22012620
MIRT527220	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT527219	hsa-miR-8063	PAR-CLIP	22012620
MIRT527218	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT527217	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT527216	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT527215	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT527214	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT527213	hsa-miR-222-5p	PAR-CLIP	22012620
MIRT527212	hsa-miR-548aw	PAR-CLIP	22012620
MIRT440983	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440983	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT728028	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT728027	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT527222	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT527221	hsa-miR-4668-3p	PAR-CLIP	22012620
MIRT527220	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT527219	hsa-miR-8063	PAR-CLIP	22012620
MIRT527218	hsa-miR-548aj-5p	PAR-CLIP	22012620
MIRT527217	hsa-miR-548f-5p	PAR-CLIP	22012620
MIRT527216	hsa-miR-548g-5p	PAR-CLIP	22012620
MIRT527215	hsa-miR-548x-5p	PAR-CLIP	22012620
MIRT527214	hsa-miR-1468-3p	PAR-CLIP	22012620
MIRT527213	hsa-miR-222-5p	PAR-CLIP	22012620
MIRT527212	hsa-miR-548aw	PAR-CLIP	22012620
MIRT872637	hsa-miR-1179	CLIP-seq
MIRT872638	hsa-miR-1297	CLIP-seq
MIRT872639	hsa-miR-217	CLIP-seq
MIRT872640	hsa-miR-26a	CLIP-seq
MIRT872641	hsa-miR-26b	CLIP-seq
MIRT872642	hsa-miR-3658	CLIP-seq
MIRT872643	hsa-miR-4328	CLIP-seq
MIRT872644	hsa-miR-4418	CLIP-seq
MIRT872645	hsa-miR-4465	CLIP-seq
MIRT872646	hsa-miR-4475	CLIP-seq
MIRT872647	hsa-miR-485-3p	CLIP-seq
MIRT872648	hsa-miR-487a	CLIP-seq
MIRT872649	hsa-miR-509-3-5p	CLIP-seq
MIRT872650	hsa-miR-509-5p	CLIP-seq
MIRT872651	hsa-miR-548m	CLIP-seq
MIRT872652	hsa-miR-552	CLIP-seq
MIRT872653	hsa-miR-935	CLIP-seq
MIRT872654	hsa-miR-141	CLIP-seq
MIRT872655	hsa-miR-1914	CLIP-seq
MIRT872656	hsa-miR-197	CLIP-seq
MIRT872657	hsa-miR-1976	CLIP-seq
MIRT872658	hsa-miR-200a	CLIP-seq
MIRT872659	hsa-miR-296-5p	CLIP-seq
MIRT872660	hsa-miR-3151	CLIP-seq
MIRT872661	hsa-miR-3936	CLIP-seq
MIRT872662	hsa-miR-3939	CLIP-seq
MIRT872663	hsa-miR-4279	CLIP-seq
MIRT872664	hsa-miR-4313	CLIP-seq
MIRT872665	hsa-miR-4433	CLIP-seq
MIRT872666	hsa-miR-4481	CLIP-seq
MIRT872667	hsa-miR-4688	CLIP-seq
MIRT872668	hsa-miR-4717-5p	CLIP-seq
MIRT872669	hsa-miR-4733-3p	CLIP-seq
MIRT872670	hsa-miR-4745-5p	CLIP-seq
MIRT872671	hsa-miR-4753-5p	CLIP-seq
MIRT872672	hsa-miR-486-3p	CLIP-seq
MIRT872673	hsa-miR-494	CLIP-seq
MIRT872674	hsa-miR-496	CLIP-seq
MIRT872675	hsa-miR-578	CLIP-seq
MIRT872676	hsa-miR-665	CLIP-seq
MIRT872637	hsa-miR-1179	CLIP-seq
MIRT1958913	hsa-miR-1229	CLIP-seq
MIRT1958914	hsa-miR-1236	CLIP-seq
MIRT1958915	hsa-miR-1276	CLIP-seq
MIRT1958916	hsa-miR-137	CLIP-seq
MIRT1958917	hsa-miR-140-3p	CLIP-seq
MIRT872639	hsa-miR-217	CLIP-seq
MIRT1958918	hsa-miR-3127-5p	CLIP-seq
MIRT1958919	hsa-miR-3158-3p	CLIP-seq
MIRT1958920	hsa-miR-3159	CLIP-seq
MIRT1958921	hsa-miR-330-3p	CLIP-seq
MIRT1958922	hsa-miR-338-5p	CLIP-seq
MIRT1958923	hsa-miR-342-3p	CLIP-seq
MIRT1958924	hsa-miR-3616-5p	CLIP-seq
MIRT1958925	hsa-miR-3647-5p	CLIP-seq
MIRT872642	hsa-miR-3658	CLIP-seq
MIRT1958926	hsa-miR-3918	CLIP-seq
MIRT1958927	hsa-miR-3919	CLIP-seq
MIRT1958928	hsa-miR-3925-5p	CLIP-seq
MIRT872644	hsa-miR-4418	CLIP-seq
MIRT1958929	hsa-miR-4666-3p	CLIP-seq
MIRT1958930	hsa-miR-4718	CLIP-seq
MIRT1958931	hsa-miR-4742-3p	CLIP-seq
MIRT1958932	hsa-miR-4756-3p	CLIP-seq
MIRT1958933	hsa-miR-4795-5p	CLIP-seq
MIRT872647	hsa-miR-485-3p	CLIP-seq
MIRT872648	hsa-miR-487a	CLIP-seq
MIRT872649	hsa-miR-509-3-5p	CLIP-seq
MIRT872650	hsa-miR-509-5p	CLIP-seq
MIRT1958934	hsa-miR-518d-5p	CLIP-seq
MIRT1958935	hsa-miR-519b-5p	CLIP-seq
MIRT1958936	hsa-miR-519c-5p	CLIP-seq
MIRT1958937	hsa-miR-520c-5p	CLIP-seq
MIRT1958938	hsa-miR-526a	CLIP-seq
MIRT872651	hsa-miR-548m	CLIP-seq
MIRT1958939	hsa-miR-573	CLIP-seq
MIRT1958940	hsa-miR-587	CLIP-seq
MIRT1958941	hsa-miR-589	CLIP-seq
MIRT1958942	hsa-miR-593	CLIP-seq
MIRT1958943	hsa-miR-642b	CLIP-seq
MIRT1958944	hsa-miR-891b	CLIP-seq
MIRT872637	hsa-miR-1179	CLIP-seq
MIRT1958913	hsa-miR-1229	CLIP-seq
MIRT1958914	hsa-miR-1236	CLIP-seq
MIRT2195882	hsa-miR-1243	CLIP-seq
MIRT1958915	hsa-miR-1276	CLIP-seq
MIRT872638	hsa-miR-1297	CLIP-seq
MIRT2195883	hsa-miR-185	CLIP-seq
MIRT872639	hsa-miR-217	CLIP-seq
MIRT872640	hsa-miR-26a	CLIP-seq
MIRT872641	hsa-miR-26b	CLIP-seq
MIRT2195884	hsa-miR-3194-5p	CLIP-seq
MIRT2195885	hsa-miR-320a	CLIP-seq
MIRT2195886	hsa-miR-320b	CLIP-seq
MIRT2195887	hsa-miR-320c	CLIP-seq
MIRT2195888	hsa-miR-320d	CLIP-seq
MIRT1958922	hsa-miR-338-5p	CLIP-seq
MIRT1958923	hsa-miR-342-3p	CLIP-seq
MIRT2195889	hsa-miR-3614-3p	CLIP-seq
MIRT872642	hsa-miR-3658	CLIP-seq
MIRT2195890	hsa-miR-371b-5p	CLIP-seq
MIRT2195891	hsa-miR-4306	CLIP-seq
MIRT872643	hsa-miR-4328	CLIP-seq
MIRT872644	hsa-miR-4418	CLIP-seq
MIRT2195892	hsa-miR-4429	CLIP-seq
MIRT872645	hsa-miR-4465	CLIP-seq
MIRT872646	hsa-miR-4475	CLIP-seq
MIRT2195893	hsa-miR-4644	CLIP-seq
MIRT2195894	hsa-miR-4699-5p	CLIP-seq
MIRT2195895	hsa-miR-4793-3p	CLIP-seq
MIRT872647	hsa-miR-485-3p	CLIP-seq
MIRT872648	hsa-miR-487a	CLIP-seq
MIRT872649	hsa-miR-509-3-5p	CLIP-seq
MIRT872650	hsa-miR-509-5p	CLIP-seq
MIRT2195896	hsa-miR-518a-5p	CLIP-seq
MIRT2195897	hsa-miR-527	CLIP-seq
MIRT872651	hsa-miR-548m	CLIP-seq
MIRT872652	hsa-miR-552	CLIP-seq
MIRT1958940	hsa-miR-587	CLIP-seq
MIRT1958942	hsa-miR-593	CLIP-seq
MIRT2195898	hsa-miR-596	CLIP-seq
MIRT1958943	hsa-miR-642b	CLIP-seq
MIRT2195899	hsa-miR-647	CLIP-seq
MIRT2195900	hsa-miR-767-3p	CLIP-seq
MIRT872653	hsa-miR-935	CLIP-seq
MIRT872659	hsa-miR-296-5p	CLIP-seq
MIRT872660	hsa-miR-3151	CLIP-seq
MIRT872664	hsa-miR-4313	CLIP-seq
MIRT872665	hsa-miR-4433	CLIP-seq
MIRT872666	hsa-miR-4481	CLIP-seq
MIRT872669	hsa-miR-4733-3p	CLIP-seq
MIRT872670	hsa-miR-4745-5p	CLIP-seq
MIRT872676	hsa-miR-665	CLIP-seq
MIRT872643	hsa-miR-4328	CLIP-seq
MIRT872646	hsa-miR-4475	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IEA
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IPI	18216018
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17494991
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0016538	Function	Cyclin-dependent protein serine/threonine kinase regulator activity	IBA
GO:0016538	Function	Cyclin-dependent protein serine/threonine kinase regulator activity	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0042981	Process	Regulation of apoptotic process	NAS	17516030
GO:0043484	Process	Regulation of RNA splicing	IDA	18216018
GO:0043484	Process	Regulation of RNA splicing	ISS
GO:0046605	Process	Regulation of centrosome cycle	NAS	24436071
GO:0051726	Process	Regulation of cell cycle	NAS	2217177

MIM	HGNC	e!Ensembl
613482	20570	ENSG00000221978

Q96S94

Protein name

Cyclin-L2 (Paneth cell-enhanced expression protein)

Protein function

Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00134	Cyclin_N	55 → 192	Cyclin, N-terminal domain	Domain
PF02984	Cyclin_C	195 → 308	Cyclin, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14684736, ECO:0000269|PubMed:18216018}.

Sequence

MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
EHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAE
RRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESI
ACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYARKKVDLTHLEGEVEK
RKHAIEEAKAQARGLLPGGTQVLDGTSGFSPAPKLVESPKEGKGSKPSPLSVKNTKRRLE
GAKKAKADSPVNGLPKGRESRSRSRSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSR
SRSRSDSPPRQAPRSAPYKGSEIRGSRKSKDCKYPQKPHKSRSRSSSRSRSRSRERADNP
GKYKKKSHYYRDQRRERSRSYERTGRRYERDHPGHSRHRR

Sequence length

520

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CCNL2-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (35)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	17543181		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	10903423, 10934345, 24406729, 35945910, 8430082	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	16569260, 17217624, 20496072, 23815208	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ductal Breast	Ductal carcinoma of breast	Pubtator	10957889	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Endometrioid	Endometrioid carcinoma	Pubtator	29633253	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	11752456, 15777850, 29397868	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33246501	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	10957889	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	22950635	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Endometrioid	Endometrioid cancer	BEFREE	29633253		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	27381447		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29719626		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystinosis	Cystinosis	Pubtator	32690634	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	26091668, 31010146, 33760141	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulosclerosis Focal Segmental	Focal segmental glomerulosclerosis	Pubtator	15100731	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin disease	Pubtator	15389259	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	27381447, 30476181		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	10854234	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyosarcoma	Leiomyosarcoma	Pubtator	10854234	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	33924032, 37814227	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	26486083	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	14684736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	29435072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28178678, 30476181		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29719626		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	29214525	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	14684736		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	15028555, 19386116, 29633253	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	11469683, 30514293	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	22763964	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	29785357, 40076816	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	22799343, 8797888	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	26706989	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
TOE SYNDACTYLY, TELECANTHUS, AND ANOGENITAL AND RENAL MALFORMATIONS	Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	BEFREE	24218572, 27104747		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	28678584	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CCNL2 (cyclin L2)