Gene Gene information from NCBI Gene database.
Entrez ID 81631
Gene name Microtubule associated protein 1 light chain 3 beta
Gene symbol MAP1LC3B
Synonyms (NCBI Gene)
ATG8FLC3BMAP1A/1BLC3MAP1LC3B-a
Chromosome 16
Chromosome location 16q24.2
Summary The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process
miRNA miRNA information provided by mirtarbase database.
648
miRTarBase ID miRNA Experiments Reference
MIRT006449 hsa-miR-204-5p ImmunoblotImmunofluorescenceqRT-PCRWestern blot 22516261
MIRT006449 hsa-miR-204-5p ImmunoblotImmunofluorescenceqRT-PCRWestern blot 22516261
MIRT006449 hsa-miR-204-5p ImmunoblotImmunofluorescenceqRT-PCRWestern blot 22516261
MIRT006449 hsa-miR-204-5p ImmunoblotImmunofluorescenceqRT-PCRWestern blot 22516261
MIRT006449 hsa-miR-204-5p ImmunoblotImmunofluorescenceqRT-PCRWestern blot 22516261
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
ATF1 Activation 20514020
ATF4 Activation 20038797;20514020
DDIT3 Activation 20038797
TFDP3 Activation 22482402
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA
GO:0000045 Process Autophagosome assembly IDA 37943659
GO:0000045 Process Autophagosome assembly IEA
GO:0000421 Component Autophagosome membrane IBA
GO:0000421 Component Autophagosome membrane IDA 33499712
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609604 13352 ENSG00000140941
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9GZQ8
Protein name Microtubule-associated protein 1 light chain 3 beta (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (Microtubule-associated proteins 1A/1B light chain 3B) (MAP1A/MAP1B LC3 B) (MAP1A/M
Protein function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20418806, PubMed:23209295, PubMed:28017329). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminat
PDB 1V49 , 2LUE , 2N9X , 2ZJD , 3VTU , 3VTV , 3VTW , 3WAO , 3X0W , 4WAA , 5D94 , 5DCN , 5GMV , 5MS2 , 5MS5 , 5MS6 , 5V4K , 5W9A , 5XAC , 5XAD , 5XAE , 6J04 , 6LAN , 7ELG , 7GA8 , 7GA9 , 7GAA , 7GAB , 7GAC , 7GAD , 7GAE , 7GAF , 7GAG , 7GAH , 7GAI , 7GAJ , 7GAK , 7GAL , 7GAM , 7GAN , 7GAO , 7GAP , 7GAQ , 7GAR , 7GAS , 7GAU , 8Q53 , 8Q7K , 8YV6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02991 Atg8 15 120 Autophagy protein Atg8 ubiquitin like Domain
Tissue specificity TISSUE SPECIFICITY: Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. {ECO:0000269|PubMed:12740394}.
Sequence
Sequence length 125
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mitophagy - animal
Autophagy - animal
Ferroptosis
Apelin signaling pathway
NOD-like receptor signaling pathway
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Shigellosis
Kaposi sarcoma-associated herpesvirus infection
  Macroautophagy
Pink/Parkin Mediated Mitophagy
TBC/RABGAPs
Receptor Mediated Mitophagy
Pexophagy
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MITOCHONDRIAL DISEASES CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 29897944, 31665193, 31810936
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 31795977
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 34638836 Stimulate
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 28757413
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 28945989, 36719634 Inhibit
★☆☆☆☆
Found in Text Mining only
Amyloidosis Amyloidosis BEFREE 27737765
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 34929165 Associate
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia BEFREE 30703554
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma BEFREE 28257096
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 31177911
★☆☆☆☆
Found in Text Mining only