Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	81627
Gene name	TRNA methyltransferase 1L
Gene symbol	TRMT1L
Synonyms (NCBI Gene)	C1orf25MST070MSTP070TRM1LbG120K12.3
Chromosome	1
Chromosome location	1q25.3
Summary	This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may

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miRTarBase ID	miRNA	Experiments	Reference
MIRT739233	hsa-miR-4325	HITS-CLIP	33718276
MIRT739235	hsa-miR-4538	HITS-CLIP	33718276
MIRT1456741	hsa-let-7a	CLIP-seq
MIRT1456742	hsa-let-7b	CLIP-seq
MIRT1456743	hsa-let-7c	CLIP-seq
MIRT1456744	hsa-let-7d	CLIP-seq
MIRT1456745	hsa-let-7e	CLIP-seq
MIRT1456746	hsa-let-7f	CLIP-seq
MIRT1456747	hsa-let-7g	CLIP-seq
MIRT1456748	hsa-let-7i	CLIP-seq
MIRT1456749	hsa-miR-18a	CLIP-seq
MIRT1456750	hsa-miR-18b	CLIP-seq
MIRT1456751	hsa-miR-196a	CLIP-seq
MIRT1456752	hsa-miR-196b	CLIP-seq
MIRT1456753	hsa-miR-2116	CLIP-seq
MIRT1456754	hsa-miR-3127-5p	CLIP-seq
MIRT1456755	hsa-miR-3143	CLIP-seq
MIRT1456756	hsa-miR-337-3p	CLIP-seq
MIRT1456757	hsa-miR-3607-5p	CLIP-seq
MIRT1456758	hsa-miR-3646	CLIP-seq
MIRT1456759	hsa-miR-3661	CLIP-seq
MIRT1456760	hsa-miR-3682-5p	CLIP-seq
MIRT1456761	hsa-miR-374a	CLIP-seq
MIRT1456762	hsa-miR-374b	CLIP-seq
MIRT1456763	hsa-miR-4251	CLIP-seq
MIRT1456764	hsa-miR-4273	CLIP-seq
MIRT1456765	hsa-miR-4303	CLIP-seq
MIRT739234	hsa-miR-4327	CLIP-seq
MIRT1456766	hsa-miR-4329	CLIP-seq
MIRT739236	hsa-miR-4453	CLIP-seq
MIRT1456767	hsa-miR-4458	CLIP-seq
MIRT1456768	hsa-miR-4500	CLIP-seq
MIRT1456769	hsa-miR-4504	CLIP-seq
MIRT1456770	hsa-miR-4511	CLIP-seq
MIRT739238	hsa-miR-4528	CLIP-seq
MIRT739237	hsa-miR-4661-5p	CLIP-seq
MIRT1456771	hsa-miR-4677-5p	CLIP-seq
MIRT1456772	hsa-miR-4684-5p	CLIP-seq
MIRT1456773	hsa-miR-4735-3p	CLIP-seq
MIRT1456774	hsa-miR-548b-3p	CLIP-seq
MIRT1456775	hsa-miR-587	CLIP-seq
MIRT1456776	hsa-miR-590-3p	CLIP-seq
MIRT1456777	hsa-miR-628-3p	CLIP-seq
MIRT1456778	hsa-miR-631	CLIP-seq
MIRT1456779	hsa-miR-664	CLIP-seq
MIRT1456780	hsa-miR-889	CLIP-seq
MIRT1456781	hsa-miR-935	CLIP-seq
MIRT1456782	hsa-miR-944	CLIP-seq
MIRT1456783	hsa-miR-98	CLIP-seq
MIRT1456784	hsa-miR-219-2-3p	CLIP-seq
MIRT1456785	hsa-miR-2964a-3p	CLIP-seq
MIRT1456786	hsa-miR-3133	CLIP-seq
MIRT1456787	hsa-miR-3613-3p	CLIP-seq
MIRT1456788	hsa-miR-3978	CLIP-seq
MIRT1456770	hsa-miR-4511	CLIP-seq
MIRT1456789	hsa-miR-4680-3p	CLIP-seq
MIRT1456790	hsa-miR-4773	CLIP-seq
MIRT1456791	hsa-miR-488	CLIP-seq
MIRT1456792	hsa-miR-548ae	CLIP-seq
MIRT1456793	hsa-miR-548aj	CLIP-seq
MIRT1456794	hsa-miR-548am	CLIP-seq
MIRT1456795	hsa-miR-548x	CLIP-seq
MIRT1456796	hsa-miR-890	CLIP-seq
MIRT739234	hsa-miR-4327	CLIP-seq
MIRT739236	hsa-miR-4453	CLIP-seq
MIRT739238	hsa-miR-4528	CLIP-seq
MIRT739237	hsa-miR-4661-5p	CLIP-seq
MIRT2136875	hsa-miR-132	CLIP-seq
MIRT2136876	hsa-miR-194	CLIP-seq
MIRT2136877	hsa-miR-212	CLIP-seq
MIRT2136878	hsa-miR-331-5p	CLIP-seq
MIRT2136879	hsa-miR-3622a-3p	CLIP-seq
MIRT2136880	hsa-miR-3622b-3p	CLIP-seq
MIRT2136881	hsa-miR-4643	CLIP-seq
MIRT2136882	hsa-miR-466	CLIP-seq
MIRT2136883	hsa-miR-4789-3p	CLIP-seq
MIRT2136884	hsa-miR-4789-5p	CLIP-seq
MIRT1456741	hsa-let-7a	CLIP-seq
MIRT1456742	hsa-let-7b	CLIP-seq
MIRT1456743	hsa-let-7c	CLIP-seq
MIRT1456744	hsa-let-7d	CLIP-seq
MIRT1456745	hsa-let-7e	CLIP-seq
MIRT1456746	hsa-let-7f	CLIP-seq
MIRT1456747	hsa-let-7g	CLIP-seq
MIRT1456748	hsa-let-7i	CLIP-seq
MIRT2357669	hsa-miR-1183	CLIP-seq
MIRT2136875	hsa-miR-132	CLIP-seq
MIRT2136876	hsa-miR-194	CLIP-seq
MIRT1456751	hsa-miR-196a	CLIP-seq
MIRT1456752	hsa-miR-196b	CLIP-seq
MIRT2357670	hsa-miR-200b	CLIP-seq
MIRT2357671	hsa-miR-200c	CLIP-seq
MIRT2136877	hsa-miR-212	CLIP-seq
MIRT2357672	hsa-miR-3167	CLIP-seq
MIRT2136878	hsa-miR-331-5p	CLIP-seq
MIRT1456758	hsa-miR-3646	CLIP-seq
MIRT1456760	hsa-miR-3682-5p	CLIP-seq
MIRT1456763	hsa-miR-4251	CLIP-seq
MIRT2357673	hsa-miR-429	CLIP-seq
MIRT1456765	hsa-miR-4303	CLIP-seq
MIRT1456766	hsa-miR-4329	CLIP-seq
MIRT1456767	hsa-miR-4458	CLIP-seq
MIRT1456768	hsa-miR-4500	CLIP-seq
MIRT2136881	hsa-miR-4643	CLIP-seq
MIRT2136882	hsa-miR-466	CLIP-seq
MIRT2136883	hsa-miR-4789-3p	CLIP-seq
MIRT2136884	hsa-miR-4789-5p	CLIP-seq
MIRT2357674	hsa-miR-517b	CLIP-seq
MIRT1456776	hsa-miR-590-3p	CLIP-seq
MIRT2357675	hsa-miR-876-5p	CLIP-seq
MIRT1456783	hsa-miR-98	CLIP-seq
MIRT2441513	hsa-miR-146a	CLIP-seq
MIRT2441514	hsa-miR-146b-5p	CLIP-seq
MIRT2136879	hsa-miR-3622a-3p	CLIP-seq
MIRT2136880	hsa-miR-3622b-3p	CLIP-seq
MIRT1456763	hsa-miR-4251	CLIP-seq
MIRT2441515	hsa-miR-4324	CLIP-seq
MIRT2441516	hsa-miR-4659a-3p	CLIP-seq
MIRT2441517	hsa-miR-4659b-3p	CLIP-seq
MIRT1456772	hsa-miR-4684-5p	CLIP-seq
MIRT2441518	hsa-miR-589	CLIP-seq
MIRT2441519	hsa-miR-942	CLIP-seq
MIRT2441513	hsa-miR-146a	CLIP-seq
MIRT2441514	hsa-miR-146b-5p	CLIP-seq
MIRT2136879	hsa-miR-3622a-3p	CLIP-seq
MIRT2136880	hsa-miR-3622b-3p	CLIP-seq
MIRT1456763	hsa-miR-4251	CLIP-seq
MIRT2441515	hsa-miR-4324	CLIP-seq
MIRT2441516	hsa-miR-4659a-3p	CLIP-seq
MIRT2441517	hsa-miR-4659b-3p	CLIP-seq
MIRT1456772	hsa-miR-4684-5p	CLIP-seq
MIRT2441518	hsa-miR-589	CLIP-seq
MIRT2441519	hsa-miR-942	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IEA
GO:0002940	Process	TRNA N2-guanine methylation	IBA
GO:0002940	Process	TRNA N2-guanine methylation	IDA	39786990, 39786998
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	33499731
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA	28784718, 39786998
GO:0005730	Component	Nucleolus	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016423	Function	TRNA (guanine) methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0160248	Function	TRNA (guanine(27)-N2)-dimethyltransferase activity	IDA	39786990, 39786998

MIM	HGNC	e!Ensembl
611673	16782	ENSG00000121486

Q7Z2T5

Protein name

tRNA (guanine(27)-N(2))-dimethyltransferase (EC 2.1.1.-) (tRNA methyltransferase 1-like protein) (TRMT1-like protein)

Protein function

Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient tr

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02005	TRM	226 → 589	N2,N2-dimethylguanosine tRNA methyltransferase	Family
PF02005	TRM	589 → 689	N2,N2-dimethylguanosine tRNA methyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11318611}.

Sequence

MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALDSAPTPASAPAPAPALA
QAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNFDSASSLNSDNLDAGNRQA
CPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCICHLPCRPVKPNIIGEQITSKM
GAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIAASTAKPPKEILKEADTDVQVCP
NYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNA
VKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANV
LMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCN
IVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAK
KIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGF
LKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTT
TDNYIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQ
AGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMS
VNDKAEASGCRRW

Sequence length

733

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TRMT1L (tRNA methyltransferase 1L)