CDT1 (chromatin licensing and DNA replication factor 1)

Gene

• Entrez ID: 81620
• Gene name: Chromatin licensing and DNA replication factor 1
• Gene symbol: CDT1
• Synonyms (NCBI Gene): DUP, RIS2
• Chromosome: 16
• Chromosome location: 16q24.3
• Summary: The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating r

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs3218727	C>T	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs144843732	A>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs147914553	C>A,G,T	Pathogenic	Coding sequence variant, stop gained, synonymous variant
rs200652608	G>A,C	Pathogenic	Missense variant, coding sequence variant
rs387906917	G>A	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs387906918	G>A	Pathogenic	Missense variant, coding sequence variant
rs587780305	G>A,C,T	Pathogenic	Splice donor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016534	hsa-miR-193b-3p	Microarray	20304954
MIRT050529	hsa-miR-20a-5p	CLASH	23622248
MIRT045201	hsa-miR-186-5p	CLASH	23622248
MIRT635630	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT718835	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT637710	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT637709	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT635629	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT718834	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT718833	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT718832	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT635627	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT635626	hsa-miR-1976	HITS-CLIP	19536157
MIRT635625	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT718831	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT718830	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT718829	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT718828	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT718827	hsa-miR-1271-3p	HITS-CLIP	19536157
MIRT718826	hsa-miR-550a-3-5p	HITS-CLIP	19536157
MIRT718825	hsa-miR-550a-5p	HITS-CLIP	19536157
MIRT635624	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT718824	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT718823	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT635623	hsa-miR-4279	HITS-CLIP	19536157
MIRT718821	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT718822	hsa-miR-550b-2-5p	HITS-CLIP	19536157
MIRT635630	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT637710	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT637709	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT635629	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT635628	hsa-miR-325	HITS-CLIP	23824327
MIRT635627	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635626	hsa-miR-1976	HITS-CLIP	23824327
MIRT635625	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635623	hsa-miR-4279	HITS-CLIP	23824327
MIRT635630	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT635629	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT635628	hsa-miR-325	HITS-CLIP	23824327
MIRT635627	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635626	hsa-miR-1976	HITS-CLIP	23824327
MIRT635625	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635624	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT635623	hsa-miR-4279	HITS-CLIP	23824327
MIRT285542	hsa-miR-4753-5p	PAR-CLIP	20371350
MIRT285538	hsa-miR-4476	PAR-CLIP	20371350
MIRT285546	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT344142	hsa-miR-2681-3p	PAR-CLIP	20371350
MIRT344141	hsa-miR-96-3p	PAR-CLIP	20371350
MIRT285530	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT285531	hsa-miR-520h	PAR-CLIP	20371350
MIRT285540	hsa-miR-4667-5p	PAR-CLIP	20371350
MIRT285541	hsa-miR-4700-5p	PAR-CLIP	20371350
MIRT285547	hsa-miR-8089	PAR-CLIP	20371350
MIRT285539	hsa-miR-4493	PAR-CLIP	20371350
MIRT564062	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT285536	hsa-miR-3926	PAR-CLIP	20371350
MIRT285533	hsa-miR-3153	PAR-CLIP	20371350
MIRT285544	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT285545	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT564061	hsa-miR-4271	PAR-CLIP	20371350
MIRT564060	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT564059	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT285532	hsa-miR-2110	PAR-CLIP	20371350
MIRT635630	hsa-miR-1228-3p	HITS-CLIP	19536157
MIRT718835	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT637710	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT637709	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT635629	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT718834	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT718833	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT718832	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT635627	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT635626	hsa-miR-1976	HITS-CLIP	19536157
MIRT635625	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT718831	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT718830	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT718829	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT718828	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT718827	hsa-miR-1271-3p	HITS-CLIP	19536157
MIRT718826	hsa-miR-550a-3-5p	HITS-CLIP	19536157
MIRT718825	hsa-miR-550a-5p	HITS-CLIP	19536157
MIRT635624	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT718824	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT718823	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT635623	hsa-miR-4279	HITS-CLIP	19536157
MIRT718821	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT718822	hsa-miR-550b-2-5p	HITS-CLIP	19536157
MIRT635630	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT637710	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT637709	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT635629	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT635628	hsa-miR-325	HITS-CLIP	23824327
MIRT635627	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635626	hsa-miR-1976	HITS-CLIP	23824327
MIRT635625	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635623	hsa-miR-4279	HITS-CLIP	23824327
MIRT635630	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT635629	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT635628	hsa-miR-325	HITS-CLIP	23824327
MIRT635627	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT635626	hsa-miR-1976	HITS-CLIP	23824327
MIRT635625	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635624	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT635623	hsa-miR-4279	HITS-CLIP	23824327
MIRT285542	hsa-miR-4753-5p	PAR-CLIP	20371350
MIRT285538	hsa-miR-4476	PAR-CLIP	20371350
MIRT285546	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT344142	hsa-miR-2681-3p	PAR-CLIP	20371350
MIRT344141	hsa-miR-96-3p	PAR-CLIP	20371350
MIRT285530	hsa-miR-520g-3p	PAR-CLIP	20371350
MIRT285531	hsa-miR-520h	PAR-CLIP	20371350
MIRT285540	hsa-miR-4667-5p	PAR-CLIP	20371350
MIRT285541	hsa-miR-4700-5p	PAR-CLIP	20371350
MIRT285547	hsa-miR-8089	PAR-CLIP	20371350
MIRT285539	hsa-miR-4493	PAR-CLIP	20371350
MIRT564062	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT285536	hsa-miR-3926	PAR-CLIP	20371350
MIRT285533	hsa-miR-3153	PAR-CLIP	20371350
MIRT285544	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT285545	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT564061	hsa-miR-4271	PAR-CLIP	20371350
MIRT564060	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT564059	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT285532	hsa-miR-2110	PAR-CLIP	20371350
MIRT882654	hsa-miR-1184	CLIP-seq
MIRT882655	hsa-miR-1193	CLIP-seq
MIRT882656	hsa-miR-1224-3p	CLIP-seq
MIRT882657	hsa-miR-1225-3p	CLIP-seq
MIRT882658	hsa-miR-1228	CLIP-seq
MIRT882659	hsa-miR-1279	CLIP-seq
MIRT882660	hsa-miR-1343	CLIP-seq
MIRT882661	hsa-miR-1913	CLIP-seq
MIRT882662	hsa-miR-192	CLIP-seq
MIRT882663	hsa-miR-200b	CLIP-seq
MIRT882664	hsa-miR-200c	CLIP-seq
MIRT882665	hsa-miR-215	CLIP-seq
MIRT882666	hsa-miR-2392	CLIP-seq
MIRT882667	hsa-miR-3064-3p	CLIP-seq
MIRT882668	hsa-miR-3176	CLIP-seq
MIRT882669	hsa-miR-324-3p	CLIP-seq
MIRT882670	hsa-miR-3677-5p	CLIP-seq
MIRT882671	hsa-miR-377	CLIP-seq
MIRT882672	hsa-miR-3922-3p	CLIP-seq
MIRT882673	hsa-miR-3943	CLIP-seq
MIRT882674	hsa-miR-4266	CLIP-seq
MIRT882675	hsa-miR-429	CLIP-seq
MIRT882676	hsa-miR-4313	CLIP-seq
MIRT882677	hsa-miR-4687-3p	CLIP-seq
MIRT882678	hsa-miR-4690-3p	CLIP-seq
MIRT882679	hsa-miR-4695-5p	CLIP-seq
MIRT882680	hsa-miR-4715-3p	CLIP-seq
MIRT882681	hsa-miR-4724-5p	CLIP-seq
MIRT882682	hsa-miR-4761-5p	CLIP-seq
MIRT882683	hsa-miR-4763-5p	CLIP-seq
MIRT882684	hsa-miR-4779	CLIP-seq
MIRT882685	hsa-miR-550a	CLIP-seq
MIRT882686	hsa-miR-651	CLIP-seq
MIRT882687	hsa-miR-877	CLIP-seq
MIRT1961555	hsa-miR-106a	CLIP-seq
MIRT1961556	hsa-miR-106b	CLIP-seq
MIRT882655	hsa-miR-1193	CLIP-seq
MIRT1961557	hsa-miR-1207-5p	CLIP-seq
MIRT882656	hsa-miR-1224-3p	CLIP-seq
MIRT1961558	hsa-miR-1237	CLIP-seq
MIRT1961559	hsa-miR-1266	CLIP-seq
MIRT1961560	hsa-miR-1291	CLIP-seq
MIRT1961561	hsa-miR-1299	CLIP-seq
MIRT1961562	hsa-miR-150	CLIP-seq
MIRT1961563	hsa-miR-17	CLIP-seq
MIRT882661	hsa-miR-1913	CLIP-seq
MIRT882662	hsa-miR-192	CLIP-seq
MIRT1961564	hsa-miR-203	CLIP-seq
MIRT1961565	hsa-miR-20a	CLIP-seq
MIRT1961566	hsa-miR-20b	CLIP-seq
MIRT882665	hsa-miR-215	CLIP-seq
MIRT882666	hsa-miR-2392	CLIP-seq
MIRT1961567	hsa-miR-2467-5p	CLIP-seq
MIRT1961568	hsa-miR-2964a-5p	CLIP-seq
MIRT1961569	hsa-miR-302a	CLIP-seq
MIRT1961570	hsa-miR-302b	CLIP-seq
MIRT1961571	hsa-miR-302c	CLIP-seq
MIRT1961572	hsa-miR-302d	CLIP-seq
MIRT1961573	hsa-miR-302e	CLIP-seq
MIRT1961574	hsa-miR-3170	CLIP-seq
MIRT882668	hsa-miR-3176	CLIP-seq
MIRT882669	hsa-miR-324-3p	CLIP-seq
MIRT1961575	hsa-miR-328	CLIP-seq
MIRT1961576	hsa-miR-3612	CLIP-seq
MIRT1961577	hsa-miR-372	CLIP-seq
MIRT1961578	hsa-miR-373	CLIP-seq
MIRT1961579	hsa-miR-3918	CLIP-seq
MIRT882672	hsa-miR-3922-3p	CLIP-seq
MIRT1961580	hsa-miR-3925-3p	CLIP-seq
MIRT1961581	hsa-miR-4438	CLIP-seq
MIRT1961582	hsa-miR-4443	CLIP-seq
MIRT1961583	hsa-miR-4508	CLIP-seq
MIRT1961584	hsa-miR-4518	CLIP-seq
MIRT1961585	hsa-miR-4635	CLIP-seq
MIRT1961586	hsa-miR-4638-3p	CLIP-seq
MIRT1961587	hsa-miR-4685-5p	CLIP-seq
MIRT1961588	hsa-miR-4716-5p	CLIP-seq
MIRT882681	hsa-miR-4724-5p	CLIP-seq
MIRT1961589	hsa-miR-4757-5p	CLIP-seq
MIRT882682	hsa-miR-4761-5p	CLIP-seq
MIRT1961590	hsa-miR-4763-3p	CLIP-seq
MIRT1961591	hsa-miR-4782-5p	CLIP-seq
MIRT1961592	hsa-miR-486-3p	CLIP-seq
MIRT1961593	hsa-miR-5095	CLIP-seq
MIRT1961594	hsa-miR-512-3p	CLIP-seq
MIRT1961595	hsa-miR-516b	CLIP-seq
MIRT1961596	hsa-miR-519d	CLIP-seq
MIRT1961597	hsa-miR-520a-3p	CLIP-seq
MIRT1961598	hsa-miR-520b	CLIP-seq
MIRT1961599	hsa-miR-520c-3p	CLIP-seq
MIRT1961600	hsa-miR-520d-3p	CLIP-seq
MIRT1961601	hsa-miR-520e	CLIP-seq
MIRT1961602	hsa-miR-520g	CLIP-seq
MIRT1961603	hsa-miR-650	CLIP-seq
MIRT1961604	hsa-miR-676	CLIP-seq
MIRT1961605	hsa-miR-766	CLIP-seq
MIRT1961606	hsa-miR-93	CLIP-seq
MIRT882655	hsa-miR-1193	CLIP-seq
MIRT1961557	hsa-miR-1207-5p	CLIP-seq
MIRT882656	hsa-miR-1224-3p	CLIP-seq
MIRT882658	hsa-miR-1228	CLIP-seq
MIRT1961559	hsa-miR-1266	CLIP-seq
MIRT882659	hsa-miR-1279	CLIP-seq
MIRT1961560	hsa-miR-1291	CLIP-seq
MIRT1961561	hsa-miR-1299	CLIP-seq
MIRT882660	hsa-miR-1343	CLIP-seq
MIRT882662	hsa-miR-192	CLIP-seq
MIRT882665	hsa-miR-215	CLIP-seq
MIRT2198224	hsa-miR-2276	CLIP-seq
MIRT2198225	hsa-miR-2355-3p	CLIP-seq
MIRT882666	hsa-miR-2392	CLIP-seq
MIRT1961567	hsa-miR-2467-5p	CLIP-seq
MIRT1961568	hsa-miR-2964a-5p	CLIP-seq
MIRT882667	hsa-miR-3064-3p	CLIP-seq
MIRT2198226	hsa-miR-3121-5p	CLIP-seq
MIRT882668	hsa-miR-3176	CLIP-seq
MIRT2198227	hsa-miR-320a	CLIP-seq
MIRT2198228	hsa-miR-320b	CLIP-seq
MIRT2198229	hsa-miR-320c	CLIP-seq
MIRT2198230	hsa-miR-320d	CLIP-seq
MIRT1961575	hsa-miR-328	CLIP-seq
MIRT2198231	hsa-miR-330-3p	CLIP-seq
MIRT1961576	hsa-miR-3612	CLIP-seq
MIRT2198232	hsa-miR-3620	CLIP-seq
MIRT2198233	hsa-miR-3689a-3p	CLIP-seq
MIRT2198234	hsa-miR-3689c	CLIP-seq
MIRT882671	hsa-miR-377	CLIP-seq
MIRT1961579	hsa-miR-3918	CLIP-seq
MIRT882672	hsa-miR-3922-3p	CLIP-seq
MIRT1961580	hsa-miR-3925-3p	CLIP-seq
MIRT2198235	hsa-miR-4429	CLIP-seq
MIRT1961582	hsa-miR-4443	CLIP-seq
MIRT1961584	hsa-miR-4518	CLIP-seq
MIRT2198236	hsa-miR-4648	CLIP-seq
MIRT2198237	hsa-miR-4654	CLIP-seq
MIRT1961587	hsa-miR-4685-5p	CLIP-seq
MIRT882680	hsa-miR-4715-3p	CLIP-seq
MIRT2198238	hsa-miR-4728-5p	CLIP-seq
MIRT1961589	hsa-miR-4757-5p	CLIP-seq
MIRT1961590	hsa-miR-4763-3p	CLIP-seq
MIRT2198239	hsa-miR-4769-5p	CLIP-seq
MIRT1961591	hsa-miR-4782-5p	CLIP-seq
MIRT1961592	hsa-miR-486-3p	CLIP-seq
MIRT1961595	hsa-miR-516b	CLIP-seq
MIRT1961602	hsa-miR-520g	CLIP-seq
MIRT882685	hsa-miR-550a	CLIP-seq
MIRT2198240	hsa-miR-552	CLIP-seq
MIRT1961603	hsa-miR-650	CLIP-seq
MIRT1961604	hsa-miR-676	CLIP-seq
MIRT2198241	hsa-miR-764	CLIP-seq
MIRT1961605	hsa-miR-766	CLIP-seq
MIRT2198224	hsa-miR-2276	CLIP-seq
MIRT2446766	hsa-miR-1273f	CLIP-seq
MIRT2446767	hsa-miR-129-5p	CLIP-seq
MIRT2446768	hsa-miR-3149	CLIP-seq
MIRT1961574	hsa-miR-3170	CLIP-seq
MIRT2446769	hsa-miR-411	CLIP-seq
MIRT2446770	hsa-miR-4735-5p	CLIP-seq
MIRT2446771	hsa-miR-4775	CLIP-seq
MIRT2446772	hsa-miR-590-3p	CLIP-seq
MIRT2446773	hsa-miR-941	CLIP-seq
MIRT2446766	hsa-miR-1273f	CLIP-seq
MIRT2446767	hsa-miR-129-5p	CLIP-seq
MIRT2501425	hsa-miR-197	CLIP-seq
MIRT2446768	hsa-miR-3149	CLIP-seq
MIRT1961574	hsa-miR-3170	CLIP-seq
MIRT2446769	hsa-miR-411	CLIP-seq
MIRT2446770	hsa-miR-4735-5p	CLIP-seq
MIRT2446771	hsa-miR-4775	CLIP-seq
MIRT2501426	hsa-miR-5096	CLIP-seq
MIRT2446772	hsa-miR-590-3p	CLIP-seq
MIRT2446773	hsa-miR-941	CLIP-seq
MIRT2446766	hsa-miR-1273f	CLIP-seq
MIRT2446767	hsa-miR-129-5p	CLIP-seq
MIRT2446768	hsa-miR-3149	CLIP-seq
MIRT1961574	hsa-miR-3170	CLIP-seq
MIRT2446769	hsa-miR-411	CLIP-seq
MIRT2446770	hsa-miR-4735-5p	CLIP-seq
MIRT2446771	hsa-miR-4775	CLIP-seq
MIRT2446772	hsa-miR-590-3p	CLIP-seq
MIRT2446773	hsa-miR-941	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000076	Process	DNA replication checkpoint signaling	IBA
GO:0000076	Process	DNA replication checkpoint signaling	IDA	14672932
GO:0000076	Process	DNA replication checkpoint signaling	IEA
GO:0000278	Process	Mitotic cell cycle	IBA
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	22581055
GO:0000776	Component	Kinetochore	IEA
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	ISS
GO:0003682	Function	Chromatin binding	IDA	11125146
GO:0005515	Function	Protein binding	IPI	11125146, 14672932, 14993212, 15232106, 16482215, 17318181, 19906994, 20202939, 20932478, 21543332, 21856198, 22581055, 25990725, 26496610, 26842564, 27107012, 27296872, 28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11125146, 24217620, 26842564
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	19906994
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006260	Process	DNA replication	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0030174	Process	Regulation of DNA-templated DNA replication initiation	IBA
GO:0030174	Process	Regulation of DNA-templated DNA replication initiation	IDA	11125146
GO:0030174	Process	Regulation of DNA-templated DNA replication initiation	IEA
GO:0033262	Process	Regulation of nuclear cell cycle DNA replication	IEA
GO:0035563	Process	Positive regulation of chromatin binding	IDA	11125146
GO:0045740	Process	Positive regulation of DNA replication	IMP	26842564
GO:0045786	Process	Negative regulation of cell cycle	IDA	19906994
GO:0051301	Process	Cell division	IEA
GO:0051315	Process	Attachment of mitotic spindle microtubules to kinetochore	IMP	22581055
GO:0070182	Function	DNA polymerase binding	IBA
GO:0071163	Process	DNA replication preinitiation complex assembly	IBA
GO:0071163	Process	DNA replication preinitiation complex assembly	IDA	11125146
GO:0071163	Process	DNA replication preinitiation complex assembly	IEA
GO:0072708	Process	Response to sorbitol	IDA	21856198
GO:2000104	Process	Negative regulation of DNA-templated DNA replication	IDA	19906994
GO:2000105	Process	Positive regulation of DNA-templated DNA replication	IDA	11125146

Other IDs

• MIM: 605525
• HGNC: 24576
• e!Ensembl: ENSG00000167513

Protein

• UniProt ID: Q9H211
• Protein name: DNA replication factor Cdt1 (Double parked homolog) (DUP)
• Protein function: Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the or
• PDB: 2LE8, 2WVR, 6QCG, 8RWV, 8S0E, 8S0F
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08839	CDT1	186 → 349	DNA replication factor CDT1 like	Domain
  PF16679	CDT1_C	421 → 516	DNA replication factor Cdt1 C-terminal domain	Domain

• Sequence:

  MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRD
  QARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTI
  SELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPG
  LPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIK
  TVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQ
  KLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTA
  QEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQ
  DLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACA
  RMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQT
  RAEEGL

• Sequence length: 546

Pathways

KEGG:

Cell cycle

Reactome:

CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
G1/S-Specific Transcription

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Meier-Gorlin syndrome	Likely pathogenic; Pathogenic	rs387906917	RCV000825514	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Meier-Gorlin syndrome 4	Pathogenic; Likely pathogenic	rs1567502140, rs2142945856, rs776483689, rs587780305, rs1409329871, rs2508193346, rs387906917, rs147914553, rs779871947, rs387906918, rs200652608	RCV001527361 RCV001527362 RCV001780745 RCV000116636 RCV003225900 RCV003230823 RCV000023455 RCV000023456 RCV000023457 RCV000023458 RCV000023459	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Adenine phosphoribosyltransferase deficiency	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CDT1-related disorder	Benign; Conflicting classifications of pathogenicity; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DESBUQUOIS SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR-PATELLA-SHORT STATURE SYNDROME	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign; Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIPLE NEGATIVE BREAST NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aneuploidy	Aneuploidy	Pubtator	22479651	Associate	★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	18367492		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28428557		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22479651	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36443564, 40255404	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	38423594	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34872567	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	32196466	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	21418584	Associate	★☆☆☆☆ Found in Text Mining only
Chronic myeloproliferative disorder	Myeloproliferative disorder	GENOMICS_ENGLAND_DG	21358632		★☆☆☆☆ Found in Text Mining only
Clinodactyly of the 5th finger	Camptodactyly of fingers	HPO_DG			★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25634203	Inhibit	★☆☆☆☆ Found in Text Mining only
Congenital absence of breast	Breast aplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital absence of external ear	Anotia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital absence of mandible	Mandibular aplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	16261166		★☆☆☆☆ Found in Text Mining only
Congenital genu recurvatum	Congenital genu recurvatum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of breast	Breast hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of penis	Congenital Hypoplasia Of Penis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital small ears	Microtia	GENOMICS_ENGLAND_DG	15286659		★☆☆☆☆ Found in Text Mining only
Congenital small ears	Microtia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Craniosynostosis	Craniosynostosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	BEFREE	29036220, 30281379		★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ear Diseases	Ear disease	Pubtator	23516378	Associate	★☆☆☆☆ Found in Text Mining only
EAR, PATELLA, SHORT STATURE SYNDROME	Ear Diseases	CLINVAR_DG	21358632, 22333897, 23023959		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	Ear Diseases	CTD_human_DG	21358632		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	Ear Diseases	ORPHANET_DG	21358632, 23516378		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EAR, PATELLA, SHORT STATURE SYNDROME	Ear Diseases	BEFREE	29036220, 30281379		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ear-patella-short stature syndrome	Ear-Patella-Short Stature Syndrome	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epispadias	Epispadias	HPO_DG			★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi anemia	Pubtator	34404366	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	21358632	Associate	★☆☆☆☆ Found in Text Mining only
Hyperlipoproteinemia Type II	Hyperlipoproteinemia	Pubtator	21418584	Associate	★☆☆☆☆ Found in Text Mining only
Hypertrophy of clitoris	Hypertrophy Of Clitoris	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypoplasia of the maxilla	Hypoplasia of the maxilla	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Isodicentric Chromosome 15 Syndrome	Isodicentric Chromosome 15 Syndrome	BEFREE	31014393		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★☆☆☆☆ Found in Text Mining only
Lubs X-linked mental retardation syndrome	Syndromic Mental Retardation, X-linked	BEFREE	25749076		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	37790630	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	38423594	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28428557		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15291814, 18084328, 18508524		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17029205		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	17036332		★☆☆☆☆ Found in Text Mining only
MEIER-GORLIN SYNDROME 4	Meier-Gorlin Syndrome	GENOMICS_ENGLAND_DG	15286659, 21358632		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
MEIER-GORLIN SYNDROME 4	Meier-Gorlin Syndrome	UNIPROT_DG	21358631, 21358632		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
MEIER-GORLIN SYNDROME 4	Meier-Gorlin Syndrome	CLINVAR_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
melanoma	Melanoma	BEFREE	27974665		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Metabolic Syndrome	Metabolic syndrome	Pubtator	19680237	Associate	★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Micrognathism	Micrognathism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Microstomia	Microstomia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16261166, 24309437, 27721020, 27783255		★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	28601717, 29971958		★☆☆☆☆ Found in Text Mining only
Pelizaeus-Merzbacher Disease	Pelizaeus-Merzbacher disease	BEFREE	25749076		★☆☆☆☆ Found in Text Mining only
Pituitary dwarfism 1	Pituitary dwarfism	Pubtator	23516378	Associate	★☆☆☆☆ Found in Text Mining only
PITUITARY DWARFISM I	Pituitary dwarfism	BEFREE	30281379		★☆☆☆☆ Found in Text Mining only
Posteriorly rotated ear	Posteriorly Rotated Ear	HPO_DG			★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	16261166		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	21321528		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35253732	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35412947	Stimulate	★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	28601717, 29971958		★☆☆☆☆ Found in Text Mining only
Pulmonary Emphysema	Pulmonary Emphysema	BEFREE	22333897		★☆☆☆☆ Found in Text Mining only
Respiratory Failure	Respiratory Failure	HPO_DG			★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	30257992		★☆☆☆☆ Found in Text Mining only
Seckel syndrome	Seckel Syndrome	GENOMICS_ENGLAND_DG	21358632		★☆☆☆☆ Found in Text Mining only
Specific learning disability	Specific Learning Disorder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	19116018		★☆☆☆☆ Found in Text Mining only
Submucous cleft of hard palate	Submucosal cleft palate	HPO_DG			★☆☆☆☆ Found in Text Mining only
Temple syndrome	Temple syndrome	Pubtator	31014393	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Dysplasia	Uterine disease	Pubtator	34404366	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	34404366	Associate	★☆☆☆☆ Found in Text Mining only
Xanthomatosis	Xanthomatosis	Pubtator	21418584	Associate	★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum	Xeroderma pigmentosum	Pubtator	20929861	Associate	★☆☆☆☆ Found in Text Mining only